Ak4 (adenylate kinase 4) - Rat Genome Database

Name: Ak4
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Ak4 (adenylate kinase 4) Rattus norvegicus

Analyze

Symbol:

Ak4

Name:

adenylate kinase 4

RGD ID:

2078

Description:

Predicted to enable adenylate kinase activity; nucleoside diphosphate kinase activity; and nucleoside triphosphate adenylate kinase activity. Involved in liver development and response to xenobiotic stimulus. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Biomarker of acute kidney tubular necrosis. Orthologous to human AK4 (adenylate kinase 4); PARTICIPATES IN de novo purine biosynthetic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

adenylate kinase 3 alpha-like 1; adenylate kinase 3-like 1; adenylate kinase 3-like 2; adenylate kinase 4, mitochondrial; adenylate kinase isoenzyme 4; adenylate kinase isoenzyme 4, mitochondrial; AK 4; Ak3l1; Ak3l2; ATP-AMP transphosphorylase; GTP:AMP phosphotransferase AK4; GTP:AMP phosphotransferase AK4, mitochondrial; MGC93541

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	AK4 (adenylate kinase 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):	Ak4 (adenylate kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ak4 (adenylate kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	AK4 (adenylate kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DNAJC6 (DnaJ heat shock protein family (Hsp40) member C6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ak4 (adenylate kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	AK4 (adenylate kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	AK4 (adenylate kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ak4 (adenylate kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	AK4P3 (adenylate kinase 4 pseudogene 3)	HGNC	Ensembl
Homo sapiens (human):	OR52N5 (olfactory receptor family 52 subfamily N member 5)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Ak4 (adenylate kinase 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	AK4 (adenylate kinase 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ak4 (adenylate kinase 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ADK2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Adk3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ZK673.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	ak4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	116,039,222 - 116,099,064 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	116,039,616 - 116,098,618 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	118,605,105 - 118,655,660 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	120,330,473 - 120,381,010 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	120,381,768 - 120,432,320 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	120,250,318 - 120,309,153 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	120,250,616 - 120,305,897 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	124,129,933 - 124,189,606 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	122,062,872 - 122,119,335 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	122,068,045 - 122,127,564 (+)	NCBI
Celera	5	114,576,993 - 114,626,919 (+)	NCBI		Celera
Cytogenetic Map	5	q33	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute kidney tubular necrosis (IEP)

Chemical and Drug Induced Liver Injury (IEP)

COVID-19 (ISO)

genetic disease (ISO)

intellectual disability (ISO)

osteoarthritis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-dexrazoxane (ISO)

1,1-dichloroethene (ISO)

1,2-dichloroethane (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,2,2-tetramine (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3,3',4,4'-tetrachlorobiphenyl (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (ISO)

adefovir pivoxil (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amiodarone (EXP)

ammonium chloride (EXP)

aristolochic acid A (ISO)

beauvericin (ISO)

benzene (EXP)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-naphthoflavone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

buspirone (EXP)

butanal (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloroacetaldehyde (ISO)

chlorpyrifos (ISO)

choline (ISO)

chromium(6+) (ISO)

cidofovir anhydrous (ISO)

cisplatin (ISO)

clofibrate (ISO)

cobalt dichloride (EXP,ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

Cuprizon (EXP,ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

diazinon (ISO)

dibenz[a,h]anthracene (ISO)

dimethylarsinic acid (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

enniatin (ISO)

entinostat (ISO)

epoxiconazole (ISO)

ethanol (ISO)

fenofibrate (EXP)

flavonoids (EXP)

fluoranthene (ISO)

flutamide (EXP)

folic acid (ISO)

fulvestrant (ISO)

gamma-hexachlorocyclohexane (ISO)

genistein (EXP,ISO)

gentamycin (EXP)

haloperidol (ISO)

ibuprofen (ISO)

ifosfamide (ISO)

indometacin (ISO)

isoprenaline (ISO)

ivermectin (ISO)

L-ascorbic acid (ISO)

L-methionine (ISO)

leflunomide (EXP)

lipopolysaccharide (ISO)

metformin (EXP)

methoxychlor (EXP)

methylarsonic acid (ISO)

methylmercury chloride (ISO)

N-methyl-4-phenylpyridinium (EXP,ISO)

N-nitrosodiethylamine (EXP)

nefazodone (EXP)

nickel dichloride (EXP,ISO)

nickel subsulfide (ISO)

nimesulide (EXP)

nitrofen (EXP)

paracetamol (EXP,ISO)

perfluorooctanoic acid (EXP,ISO)

phenobarbital (EXP,ISO)

phenylephrine (EXP)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

propiconazole (ISO)

pyrogallol (ISO)

quercetin (EXP,ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium arsenite (EXP,ISO)

sodium fluoride (ISO)

Soman (EXP)

streptozocin (EXP)

sunitinib (ISO)

tamibarotene (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP)

tetracycline (EXP)

thapsigargin (ISO)

thimerosal (ISO)

thioacetamide (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

triphenyl phosphate (EXP)

troglitazone (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

vancomycin (ISO)

vorinostat (ISO)

zinc dichloride (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

ADP biosynthetic process (IEA)

AMP metabolic process (IBA,IEA,ISO)

ATP metabolic process (IEA,ISO)

cellular response to hypoxia (ISO,ISS)

GTP metabolic process (IEA,ISO)

liver development (IEP)

nucleoside monophosphate phosphorylation (IEA)

nucleoside triphosphate biosynthetic process (IBA)

phosphorylation (IEA)

regulation of oxidative phosphorylation (ISO,ISS)

response to xenobiotic stimulus (IEP)

ribonucleoside diphosphate biosynthetic process (ISO,ISS)

Cellular Component

cytoplasm (IBA)

mitochondrial matrix (IBA,IEA,ISO)

mitochondrion (ISO)

Molecular Function

adenylate kinase activity (IEA,ISO)

ATP binding (IEA)

GTP binding (IEA)

nucleoside diphosphate kinase activity (IBA,ISO,ISS)

nucleoside triphosphate adenylate kinase activity (IEA,ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

de novo purine biosynthetic pathway (TAS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	Dynamics of nucleotide metabolism as a supporter of life phenomena.	Noma T J Med Invest. 2005 Aug;52(3-4):127-36.
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation
9.	Proteomics investigation on aristolochic acid nephropathy: a case study on rat kidney tissues.	Wu HZ, etal., Anal Bioanal Chem. 2011 Apr;399(10):3431-9. Epub 2010 Dec 9.
10.	Investigation of proteomic biomarkers in in vivo hepatotoxicity study of rat liver: toxicity differentiation in hepatotoxicants.	Yamamoto T, etal., J Toxicol Sci. 2006 Feb;31(1):49-60.
11.	Identification of a novel adenylate kinase system in the brain: cloning of the fourth adenylate kinase.	Yoneda T, etal., Brain Res Mol Brain Res 1998 Nov 20;62(2):187-95.

Additional References at PubMed

PMID:11485571	PMID:12477932	PMID:14651853	PMID:15489334	PMID:18614015	PMID:19130895	PMID:19766732	PMID:23376485	PMID:23416111	PMID:23474458	PMID:24767988	PMID:26980435
PMID:30696468

Genomics

Comparative Map Data

Ak4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	116,039,222 - 116,099,064 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	116,039,616 - 116,098,618 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	118,605,105 - 118,655,660 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	120,330,473 - 120,381,010 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	120,381,768 - 120,432,320 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	120,250,318 - 120,309,153 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	120,250,616 - 120,305,897 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	124,129,933 - 124,189,606 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	122,062,872 - 122,119,335 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	122,068,045 - 122,127,564 (+)	NCBI
Celera	5	114,576,993 - 114,626,919 (+)	NCBI		Celera
Cytogenetic Map	5	q33	NCBI

AK4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	65,147,552 - 65,232,145 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	65,147,549 - 65,232,145 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	65,613,235 - 65,697,828 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	65,385,820 - 65,465,765 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	63,903,944 - 63,988,555 (+)	NCBI		Celera
Cytogenetic Map	1	p31.3	NCBI
HuRef	1	63,722,163 - 63,806,551 (+)	NCBI		HuRef
CHM1_1	1	65,729,523 - 65,814,075 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	65,025,531 - 65,110,134 (+)	NCBI		T2T-CHM13v2.0

Ak4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	101,273,675 - 101,324,968 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	101,276,474 - 101,324,192 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	101,416,478 - 101,467,771 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	101,419,277 - 101,466,995 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	101,091,894 - 101,140,376 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	100,917,690 - 100,964,927 (+)	NCBI		MGSCv36	mm8
Celera	4	99,759,270 - 99,808,044 (+)	NCBI		Celera
Cytogenetic Map	4	C6	NCBI
cM Map	4	46.84	NCBI

Ak4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955423	25,395,836 - 25,427,474 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955423	25,395,086 - 25,402,324 (-)	NCBI	ChiLan1.0	ChiLan1.0

AK4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	1	160,780,900 - 160,865,513 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	64,394,898 - 64,479,536 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	66,283,102 - 66,367,146 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	66,283,102 - 66,361,230 (+)	Ensembl	panpan1.1		panPan2

DNAJC6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	45,055,294 - 45,119,595 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	44,884,283 - 45,120,203 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	45,107,227 - 45,176,810 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	45,230,958 - 45,300,604 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	45,235,891 - 45,300,627 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	45,196,507 - 45,265,914 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	45,140,926 - 45,210,260 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	45,392,014 - 45,461,310 (-)	NCBI		UU_Cfam_GSD_1.0

Ak4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	78,277,939 - 78,342,917 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936692	2,593,409 - 2,654,583 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AK4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	147,177,029 - 147,257,814 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	147,177,029 - 147,257,799 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	135,587,473 - 135,663,801 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AK4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	67,840,572 - 67,924,691 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666033	49,603,493 - 49,717,228 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ak4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624742	29,547,237 - 29,574,160 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ak4
287 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	435
Count of miRNA genes:	231
Interacting mature miRNAs:	305
Transcripts:	ENSRNOT00000070967
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	1	131345958	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	31663789	131345958	Rat
1641912	Alcrsp18	Alcohol response QTL 18			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	35189153	141643988	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	40128307	148607290	Rat
1331801	Rf33	Renal function QTL 33	4.149		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	43726656	129132602	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	50328551	141643988	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55805606	132207589	Rat
1358895	Bp254	Blood pressure QTL 254	3.6	0.0003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	58829236	128034027	Rat
61426	Scl2	Serum cholesterol level QTL 2	7.3	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	59793399	143070159	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	60293434	161481680	Rat
2306971	Anxrr21	Anxiety related response QTL 21	9.47		fear/anxiety-related behavior trait (VT:1000241)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	5	66174080	124160948	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	69540295	151018848	Rat
1298070	Scl18	Serum cholesterol level QTL 18	3.7		blood LDL cholesterol amount (VT:0000181)	calculated plasma low density lipoprotein cholesterol level (CMO:0001245)	5	79584860	124584860	Rat
1598846	Bp293	Blood pressure QTL 293	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	79584860	124584860	Rat
1598859	Cm66	Cardiac mass QTL 66	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	79584860	124584860	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	82394392	166664054	Rat
1298086	Bp156	Blood pressure QTL 156			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	84132602	129132602	Rat
7411601	Foco12	Food consumption QTL 12	19.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	87468046	132468046	Rat
7411564	Bw135	Body weight QTL 135		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	87468046	132468046	Rat
7411582	Foco3	Food consumption QTL 3	7.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	87468046	132468046	Rat
6903316	Bw113	Body weight QTL 113	2	0.0103	body mass (VT:0001259)	body weight (CMO:0000012)	5	87765973	132765973	Rat
1358889	Bp261	Blood pressure QTL 261	2.86		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	90067849	128034027	Rat
1358909	Kidm25	Kidney mass QTL 25	1.87		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	5	90067849	128034027	Rat
631527	Tls1	T-lymphoma susceptibility QTL 1	0	0.001	thymus integrity trait (VT:0010555)	post-insult time to onset of T-cell lymphoma (CMO:0001907)	5	90450144	135450144	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	94858972	143070159	Rat
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	97059760	147465714	Rat
2317753	Glom24	Glomerulus QTL 24	3.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	5	97570330	136479578	Rat
1582212	Livw2	Liver weight QTL 2	3.5	0.0004	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	5	99016066	119085810	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	99216724	148607142	Rat
1578673	Bmd13	Bone mineral density QTL 13	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	5	103689353	148689353	Rat
2317056	Wbc3	White blood cell count QTL 3	2.51	0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	5	105999803	150999803	Rat
7207488	Bss110	Bone structure and strength QTL 1	8.4		femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	5	106906205	151906205	Rat
7207491	Bss112	Bone structure and strength QTL 112	7		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	5	106906205	151906205	Rat
7207481	Bss106	Bone structure and strength QTL 106	7.9		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	106906205	151906205	Rat
7207486	Bss109	Bone structure and strength QTL 109			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	106906205	151906205	Rat
1549838	Bss4	Bone structure and strength QTL 4	9.2		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	5	106906205	151906205	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	108845856	153845856	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	108845856	153845856	Rat
8657050	Bw146	Body weight QTL 146	19.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	108938288	153938288	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	111416838	156416838	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	111416838	156416838	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	111416838	156416838	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	111416838	156416838	Rat
7794743	Bp373	Blood pressure QTL 373		0.0058	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	112175546	116047089	Rat

Markers in Region

RH134316

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	116,098,765 - 116,098,949 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	120,308,853 - 120,309,036	NCBI	Rnor6.0
Rnor_5.0	5	124,189,306 - 124,189,489	UniSTS	Rnor5.0
RGSC_v3.4	5	122,122,486 - 122,122,669	UniSTS	RGSC3.4
Celera	5	114,630,069 - 114,630,252	UniSTS
RH 3.4 Map	5	788.2	UniSTS
Cytogenetic Map	5	q33	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		19	41	41		41			57	29	9
Low	2	24	16		19		7	10	17	6	31	11	7
Below cutoff	1						1	1			1		1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_017135	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593196	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109353	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC087024	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473998	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D87809	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000162	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000070967 ⟹ ENSRNOP00000065349

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	116,039,616 - 116,098,618 (+)	Ensembl
Rnor_6.0 Ensembl	5	120,250,616 - 120,305,897 (+)	Ensembl

RefSeq Acc Id:

NM_017135 ⟹ NP_058831

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	116,039,787 - 116,095,614 (+)	NCBI
Rnor_6.0	5	120,250,770 - 120,305,703 (+)	NCBI
Rnor_5.0	5	124,129,933 - 124,189,606 (+)	NCBI
RGSC_v3.4	5	122,062,872 - 122,119,335 (+)	RGD
Celera	5	114,576,993 - 114,626,919 (+)	RGD

Sequence:

show sequence

CATGGCTTCCAAACTCCTGCGCGCAGTCATCCTGGGGCCGCCTGGCTCTGGCAAGGGCACGGTA
TGCGAAAGGATCGCCCAGAACTTTGGCCTCCAGCATCTCTCCAGCGGCCACTTGTTGCGGGAGA
ACCTAAAGACCAACACGGAAGTTGGTGACGTGGCAAAACAGTACCTAGAAAAAGGTCTTTTGGT
TCCGGACCATGTGATCACGCGCCTAATGATGTCAGAACTGGAGACCCGGAGTGCCCAGCACTGG
CTATTAGATGGATTCCCAAGGACATTAGTGCAGGCAGAAGCTCTGGACAGAATCTGTGATGTGG
ACCTAGTAATCAGTTTGAATATTCCTTTCGAGACACTTAAAGATCGTCTGAGCCGACGGTGGAT
TCACCCTTCCAGCGGGAGGGTCTATAACCTAGACTTCAACCCACCTCAAGTGCTGGGGGTTGAT
GACATCACCGGCGAGCCTCTTGTCCAACAGGAAGATGATAAACCTGAAGCACTTGCTGCCCGGC
TAAGACGGTACAAGGACGCAGCAAAACCAGTCATCGAACTGTACAAGAGCCGTGGAGTGCTCCA
CCAGTTTTCTGGGACGGAGACTAACAGAATCTGGCCTTATGTTTACACGCTCTTCTCCAACAAG
ATCACACCCATTCAATCCAAAGAAGCCTACTGAGCCT

hide sequence

RefSeq Acc Id:

XM_017593196 ⟹ XP_017448685

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	116,039,222 - 116,099,064 (+)	NCBI
Rnor_6.0	5	120,250,318 - 120,309,153 (+)	NCBI

Sequence:

show sequence

TCTCTCCTTTCCGCCGAGGGGTGGCAGGCGAGTCCCGGCGTGCGGAAGGTGCTGAGGCAGGGGC
TGCCGTGCAAAGTGCGCGGGCTGCTGTCCTGGCCACCGCCAAAGCCATGGCTTCCAAACTCCTG
CGCGCAGTCATCCTGGGGCCGCCTGGCTCTGGCAAGGGCACGGTATGCGAAAGGATCGCCCAGA
ACTTTGGCCTCCAGCATCTCTCCAGCGGCCACTTGTTGCGGGAGAACCTAAAGACCAACACGGA
AGTTGGTGACGTGGCAAAACAGTACCTAGAAAAAGGTCTTTTGGTTCCGGACCATGTGATCACG
CGCCTAATGATGTCAGAACTGGAGACCCGGAGTGCCCAGCACTGGCTATTAGATGGATTCCCAA
GGACATTAGTGCAGGCAGAAGCTCTGGACAGAATCTGTGATGTGGACCTAGTAATCAGTTTGAA
TATTCCTTTCGAGACACTTAAAGATCGTCTGAGCCGACGGTGGATTCACCCTTCCAGCGGGAGG
GTCTATAACCTAGACTTCAACCCACCTCAAGTGCTGGGGGTTGATGACATCACCGGCGAGCCTC
TTGTCCAACAGGAAGATGATAAACCTGAAGCACTTGCTGCCCGGCTAAGACGGTACAAGGACGC
AGCAAAACCAGTCATCGAACTGTACAAGAGCCGTGGAGTGCTCCACCAGTTTTCTGGGACGGAG
ACTAACAGAATCTGGCCTTATGTTTACACGCTCTTCTCCAACAAGATCACACCCATTCAATCCA
AAGAAGCCTACTGAGCCTGCCATGGGAAGAGCCAAGAAGACATGGTTGCCCACTCAATCATGCG
TGTAGTCTTGGTGCCCTGGCCGAGTTAGAAGCCAGCTGAGATAGCTTGCAGCATCTTTTCTAGT
TTGAGTGATGATGTAATGAGGAAAATCTAGTAGGTAGAAAGAGTTCAGGAAGAAGGAAACCCTC
CTCTGCCTTTGAAAAGAGGCTCTGCAGGAGCATCACGCCCTTCACAGAGAAGAGTGTAGACTGG
CTTTCCACTAGTGTTGCACCTACACTCTTCGGTGGGTTAACAGCCATGTGCTCGCCATCAGAGC
CTTTTTGCATGCAGTGGTGGGCTCTCCCGGTTTATCCCACCTCCCACAGGTGATTAAACCACAG
CACTGTATGCCTGAGAACTTGAAGGGCTGTGGTCCTGGCTTGTCCACTGCCATACGCTCTGACA
ATTGACGCTAATTGCACTCAGTGGTTGCTTTACCCCGGTCGTCCGTCGTCCGCCCCCCCCCCCC
CCCCCATCTCTCAGCATCCTAGTTTCTATTGTCTGAATCTTCTCATCTGCTTGCTCCCTTCTCA
GGCTATTCAGGACCGTGATAGCTTCTGCATTTATCCCCTCCAACTTCCTTTTTACAAACTGAGA
GGTAGGTGACTGGATTCAGTCTTTTCCTTCTCACTAGGAACTGACCCAGGCTTTCTTGGTTAAA
CAGCTGCTCTTTCTTGAGCACACTCTGTACCTTTTATTGTTTAAAAAAAGATTCCCCCCAAGTC
TTCAGGGTTCTCAAAAACAAGGGAAATGCTTACTTGTGGAAATATGGGGTGATTGTATCTCTCT
GTAGCAGTCGTAGTAATTGTATGGAAATCACTGGACTAATGAGATGGTTGGGCTCAAGGCAAGA
TGGGTATTGAACATGCTGCTAAATATTAACGCTGTCAGTGTTTTTCTTCTGTGAGTGACTAACC
GGACGGCGAGAGGTCAGTAAAGGGAGCAAGCCCGAGGCTTGGGGCGTCTTGCACTAGATATGCA
TAGCACCTGCACTGAGTAAGACAGCTTTACCGTTTGGGGAACGCAGAATCTTTTTGTTTGTTTT
CTTCCTATTCCAAAGATGCAGTCTTTAGGTGGCCATAAAGTCCAGAAATGAAGAGACTAATATT
TTACCAGTCATTATGAGTCAAGAAAGCATTTGTTCAAAGACTCTCCTCCCTGGATTCCAGACTT
GTTGGCCACCTCGTTATAACTTTTACTCCTCTCTGGGAAGAGCAGGGAAATGTCTTCCCACTGC
CTTAAAAAGCTGTCCTGCATCTACCTGTCCCCAGGAGGCAGTTCTTCATTACTGGTGGTGGTTT
AGTGTGACATCTCATAGTCTGTCTGGGGTGGGCGTGTGGGGCGGGCTTAGCACTTTAGTGGAAT
GGAGACATTATTCCATTCTGAAGGTGTCGTGTGAATCCCCAGTCTGTTCACTGCCATGCGCTCT
GTGCTAACAAGTCTGTCTTTCTGCCTTCATGGGCCGCCTGGACTCTGGTTCCTCTTGGTCGTCC
TCTCATGTGCATGTTCTATGGCTGCCTTGGTGGAGATGCAGGCCAGCATCCCCCACTCGTGCTC
TCCGTGCAGAGAAATAAGCGTCGGAAGTGGAGCAGCATGGTGCAGGTCTGTGACCATCTGGGCA
TCTTCATGGTGCTGAATGCTTGGGAAGCTCACATTTGGATGTCACTTGGTAGGGGTTGGGTGAT
AAAAGCCCAGGCTTCCTGGAGGAGCAGGTCAAGAGTGAGAAACCCTGAGATTATTCCCAGGGAC
CAAGGGAAGTAGAGAGTTAAAGGGATTCAGAGTAATCCAAGAGAGGTGGGAAAACTTCAAACTT
ATTTCTCTTCCTCTTGTAGAGTCTGGGGAGAGCAATAGGGTGTGAGCAGGTCCTTGCCTGCACA
CTCTTGTTTCTTTATGCATTTCAAGCTTAATCGACTATGGTAGCCAGCACTGGGACACCAGGGT
CAGGAGAGCAGCAAGGGGCAAAAAGATCTTTTCCAAAGTCTTGGGTGATTTCATGTCCATTGGT
GTTAAGGTGTTTTCTGCAGCAGACTTGGCTGTTCTTTTCTAAAGGATTTTGGAGACATAGACAT
TAATTAATACTGAAAATGTCTTGACAGAGGTAGAATGGAAGGAACACCTTTTCCTTCTCAGGCC
ATGGCCTTCCTTCAGGTGGAAGCCAAGAGGCCGGGTGGTCTTTATATTCGCAGGCTCCACCCCG
CTCCTCGTTGAGTTTGCTTCCCACAATCCTCTTGCTTAGAACTTGGGAAAGAGCATGTTTATTC
CTCCAGTATTTATGACAAAAAGGTGCTATGAAGGAGGCCTTCTGAATGAAGTGCGCACTCTCTT
TATAAGCCTTGTGGTGAATCTTCCCAGGCACAACCAATTTTCCCTATAAACAAGAGTCCAGGAT
ATGAAGTCTTGCCTGGGCTCTTCATATGAGTAAACAGTAGAGCTATGACTTAGTCCCAGGTTTC
CCTGCTTCAGAAACTCTTGGCCTTTTACTGGATGTTAGCTGTCTGTCTTGGCCTAAGCAACTTG
GGGCTATGAGCCTGCTTGTGGGCTCAGGGAGAGTGACAGACATCACTGGAGTGGCGGCATGAGG
CTATTTCTTTTGTATTCTCTGCCTGAGCAAAAGGGGTTGCTAAGTACAAGGCTTTAAGGCAAGG
TTGGGTTTGGACCAGGTTAATCTGCCTCAATTCTAGGTGTCAGGAAGCCATGAAGCCATATGAA
GGAAAACTGGCATCTACTGAAACATTAAAATTAACCATAAATATTACCCCTTATATTTGGTGTG
GCAAACTGCACAATTCTTGCCAGAATAAATGCCATCAGCTGCCTCAGGGCACTCCTCGGTTTGA
CCATTCTGTACGTGGTTGGGTGTGAGAGACAGGCTAAGTGAGTAAGCCATTGCCCACGGCTCCA
CATGGACTCCCTCTAGTGACAGACAATTGTAGGAAGCACAACATCTTTCAATAAAAGACTCTTG
TTTAAAACCTTTGAAAAGAGTACTGCACCTTCTCTCTGGGATTCGGGAAAAGGGAAGAAAAATG
GGAAACCCGGGCTTTGTGTGAACTGCAAGAAATGGTGGGGCTCAAGGCTTCTCTAGTTTTATGA
GAACTTGTACTACTGAATTTGCCAATTTTGTTTTCTGAGCTGAACGGATGTCTGGGGGACTATG
TTGAGCTGTGATGGCGTTTCACTGTGATCCCCCCAAGTTCAAGGCAGTCTTTAATGCAATGTTG
GCTTAAGTCCCCCGGGAGCTGACACATCAGCTTTCCTTCAGTGACAGTTGGTGTTCAAGATGAT
TTTGGCGTATGTGCTTAATCCAGAGTCTGTTCTGTATGTGCTGTCCTAACTATTCATTGTATTA
ATTGATTGTTTTGTTATCTTGCTTGAAGATTGATTTGTATGGAATTTGATAGAAATAAACGTTT
TTCTGCTTAATA

hide sequence

RefSeq Acc Id:

XM_039109353 ⟹ XP_038965281

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	116,040,107 - 116,099,064 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_058831	(Get FASTA)	NCBI Sequence Viewer
	XP_017448685	(Get FASTA)	NCBI Sequence Viewer
	XP_038965281	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH87024	(Get FASTA)	NCBI Sequence Viewer
	BAA77761	(Get FASTA)	NCBI Sequence Viewer
	EDL97826	(Get FASTA)	NCBI Sequence Viewer
	EDL97827	(Get FASTA)	NCBI Sequence Viewer
	EDL97828	(Get FASTA)	NCBI Sequence Viewer
	Q9WUS0	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_058831 ⟸ NM_017135

- UniProtKB:

Q9WUS0 (UniProtKB/Swiss-Prot), A0A8L2QYP3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASKLLRAVILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTNTEVGDVAKQYLEKGLLV
PDHVITRLMMSELETRSAQHWLLDGFPRTLVQAEALDRICDVDLVISLNIPFETLKDRLSRRWI
HPSSGRVYNLDFNPPQVLGVDDITGEPLVQQEDDKPEALAARLRRYKDAAKPVIELYKSRGVLH
QFSGTETNRIWPYVYTLFSNKITPIQSKEAY

hide sequence

RefSeq Acc Id:	XP_017448685 ⟸ XM_017593196
- Peptide Label:	isoform X1
- UniProtKB:	Q9WUS0 (UniProtKB/Swiss-Prot), A0A8L2QYP3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MASKLLRAVILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTNTEVGDVAKQYLEKGLLV PDHVITRLMMSELETRSAQHWLLDGFPRTLVQAEALDRICDVDLVISLNIPFETLKDRLSRRWI HPSSGRVYNLDFNPPQVLGVDDITGEPLVQQEDDKPEALAARLRRYKDAAKPVIELYKSRGVLH QFSGTETNRIWPYVYTLFSNKITPIQSKEAY hide sequence

RefSeq Acc Id:

ENSRNOP00000065349 ⟸ ENSRNOT00000070967

RefSeq Acc Id:	XP_038965281 ⟸ XM_039109353
- Peptide Label:	isoform X2
- UniProtKB:	A6JRN6 (UniProtKB/TrEMBL)

Protein Domains

Adenylate kinase active site lid

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9WUS0-F1-model_v2	AlphaFold	Q9WUS0	1-223	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2078	AgrOrtholog
BioCyc Gene	G2FUF-40538	BioCyc
BioCyc Pathway	PWY-7219 [adenosine ribonucleotides de novo biosynthesis]	BioCyc
Ensembl Genes	ENSRNOG00000045738	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000065349	ENTREZGENE
	ENSRNOP00000065349.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000070967	ENTREZGENE
	ENSRNOT00000070967.3	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7107348	IMAGE-MGC_LOAD
InterPro	Adenyl_kin_sub	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Adenylat/UMP-CMP_kin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Adenylat_kinase_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Adenylate_kinase_lid-dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	AK3/Ak4_mitochondrial	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	AK4_mitochondrial	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:29223	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93541	IMAGE-MGC_LOAD
NCBI Gene	29223	ENTREZGENE
PANTHER	ADENYLATE KINASE 4, MITOCHONDRIAL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR23359	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	ADK	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ADK_lid	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ak4	PhenoGen
PRINTS	ADENYLTKNASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	ADENYLATE_KINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8L2QYP3	ENTREZGENE, UniProtKB/TrEMBL
	A6JRN6	ENTREZGENE, UniProtKB/TrEMBL
	KAD4_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-07-29	Ak4	adenylate kinase 4	Ak3l1	adenylate kinase 3-like 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-26	Ak3l1	adenylate kinase 3-like 1	Ak3l1	adenylate kinase 3 alpha-like 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-05-19	Ak3l1	adenylate kinase 3 alpha-like 1	Ak3l1	adenylate kinase 3-like 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-04-19	Ak3l1	adenylate kinase 3-like 1	Ak3l2	adenylate kinase 3-like 2	Symbol and Name updated to reflect Human and Mouse nomenclature	1299863	APPROVED
2004-09-10	Ak3l2	adenylate kinase 3-like 2	Ak4	adenylate kinase 4	Symbol and Name updated	1299863	APPROVED
2002-06-10	Ak4	adenylate kinase 4			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_process	may play a role in energy metabolism	632174
gene_product	member of a family of adenylate kinase isozymes	632174
gene_protein	predicted protein contains 223 amino acid residues	632174

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations