Cyp2j4 (cytochrome P450, family 2, subfamily j, polypeptide 4) - Rat Genome Database

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Gene: Cyp2j4 (cytochrome P450, family 2, subfamily j, polypeptide 4) Rattus norvegicus
Analyze
Symbol: Cyp2j4 (Ensembl: Cyp2j3)
Name: cytochrome P450, family 2, subfamily j, polypeptide 4 (Ensembl:cytochrome P450, family 2, subfamily j, polypeptide 3)
RGD ID: 620007
Description: Enables NADPH-hemoprotein reductase activity and arachidonate monooxygenase activity. Involved in several processes, including arachidonate metabolic process; negative regulation of peroxisome proliferator activated receptor signaling pathway; and regulation of biosynthetic process. Located in endoplasmic reticulum membrane. Used to study nephritis; pre-eclampsia; and ureteral obstruction. Biomarker of bacterial pneumonia and renal hypertension. Human ortholog(s) of this gene implicated in hypertension; myocardial infarction; pulmonary hypertension; renal fibrosis; and renal hypertension. Orthologous to human CYP2J2 (cytochrome P450 family 2 subfamily J member 2); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 1H-pyrazole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CYP2J2; CYPIIJ4; cytochrome P450 2J4
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: Cyp2j4em1Sage  
Genetic Models: WKY-Cyp2j4em1Sage/Tja
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85116,295,691 - 116,323,219 (-)NCBIGRCr8
mRatBN7.25111,179,981 - 111,207,490 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5111,178,703 - 111,244,794 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5113,748,215 - 113,775,559 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05115,473,589 - 115,500,933 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05115,536,117 - 115,563,461 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05119,546,458 - 119,564,843 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5119,546,461 - 119,564,846 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05119,130,644 - 119,130,903 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.05123,437,429 - 123,455,814 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45116,702,370 - 116,729,722 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15116,707,598 - 116,734,948 (-)NCBI
Celera5109,770,343 - 109,797,690 (-)NCBICelera
Cytogenetic Map5q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
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Original Reference(s)
Cyp2j4Ratbacterial pneumonia  IEP 1625385protein:decreased expression:lungRGD 
Cyp2j4RatCoronary Disease resistanceISOCYP2J2 (Homo sapiens)1625377DNA:polymorphism:promoter:-50G>T (human)RGD 
Cyp2j4RatDiabetic Nephropathies  ISOCYP2J2 (Homo sapiens)7243153associated with Diabetes Mellitus and ExperimentalRGD 
Cyp2j4Rathypertension susceptibilityISOCYP2J2 (Homo sapiens)1625379DNA:SNPRGD 
Cyp2j4Rathypertension  ISOCYP2J2 (Homo sapiens)7243136 RGD 
Cyp2j4Ratmyocardial infarction susceptibilityISOCYP2J2 (Homo sapiens)1625380DNA:polymorphismRGD 
Cyp2j4Ratnephritis  IMP 12904676 RGD 
Cyp2j4Ratpre-eclampsia  ISOCYP2J2 (Homo sapiens)7243127mRNA:increased expression:placenta and deciduaRGD 
Cyp2j4Ratpre-eclampsia  IMP 7243127 RGD 
Cyp2j4Ratpulmonary hypertension  ISOCYP2J2 (Homo sapiens)7243137 RGD 
Cyp2j4Ratrenal fibrosis  ISOCYP2J2 (Homo sapiens)7243130 RGD 
Cyp2j4Ratrenal hypertension  IEP 1625381protein:increased expression:kidneyRGD 
Cyp2j4Ratrenal hypertension  ISOCYP2J2 (Homo sapiens)7243143 RGD 
Cyp2j4RatSepsis  IEP 1625384 RGD 
Cyp2j4Ratureteral obstruction  IMP 12904676 RGD 
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Cyp2j4Ratchronic obstructive pulmonary disease  ISOCYP2J2 (Homo sapiens)8554872ClinVar Annotator: match by term: Pulmonary disease more ...ClinVar 
Cyp2j4Ratintellectual disability  ISOCYP2J2 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disability and severeClinVarPMID:25741868
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Original Reference(s)
Cyp2j4Ratautism spectrum disorder  ISOCYP2J2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35663546

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Cyp2j4Rat1,1-dichloroethene decreases expressionISOCyp2j9 (Mus musculus)6480464vinylidene chloride results in decreased expression of CYP2J9 mRNACTDPMID:26682919
Cyp2j4Rat1,2-dichloroethane decreases expressionISOCyp2j9 (Mus musculus)6480464ethylene dichloride results in decreased expression of CYP2J9 mRNACTDPMID:28960355
Cyp2j4Rat1,2-dimethylhydrazine decreases expressionEXP 64804641 and 2-Dimethylhydrazine results in decreased expression of CYP2J4 mRNACTDPMID:32387197
Cyp2j4Rat1,2-dimethylhydrazine decreases expressionISOCyp2j9 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of CYP2J9 mRNACTDPMID:22206623
Cyp2j4Rat17alpha-ethynylestradiol affects expressionISOCyp2j9 (Mus musculus)6480464Ethinyl Estradiol affects the expression of CYP2J9 mRNACTDPMID:17555576
Cyp2j4Rat17beta-estradiol multiple interactionsISOCYP2J2 (Homo sapiens)6480464[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CYP2J2 mRNACTDPMID:19619570
Cyp2j4Rat17beta-estradiol increases expressionISOCyp2j9 (Mus musculus)6480464Estradiol results in increased expression of CYP2J9 mRNACTDPMID:39298647
Cyp2j4Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of CYP2J4 mRNACTDPMID:32145629
Cyp2j4Rat17beta-estradiol increases expressionISOCYP2J2 (Homo sapiens)6480464Estradiol results in increased expression of CYP2J2 mRNACTDPMID:19619570
Cyp2j4Rat1H-pyrazole multiple interactionsEXP 6480464pyrazole results in increased expression of and results in increased activity of CYP2J4 protein and pyrazole results in increased stability of and results in increased expression of CYP2J4 mRNACTDPMID:10497137
Cyp2j4Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsEXP 6480464[3 more ...CTDPMID:16984957
Cyp2j4Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOCYP2J2 (Homo sapiens)6480464[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CYP2J2 mRNACTDPMID:19619570
Cyp2j4Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of CYP2J4 mRNACTDPMID:32109520
Cyp2j4Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOCyp2j9 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of CYP2J9 mRNACTDPMID:28213091
Cyp2j4Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOCYP2J2 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of CYP2J2 mRNACTDPMID:19619570 more ...
Cyp2j4Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOCyp2j9 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of CYP2J9 mRNACTDPMID:26377647
Cyp2j4Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOCyp2j9 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of CYP2J9 mRNACTDPMID:16960034 and PMID:19465110
Cyp2j4Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of CYP2J4 mRNA and Tetrachlorodibenzodioxin results in decreased expression of CYP2J9 mRNACTDPMID:16984957 more ...
Cyp2j4Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of CYP2J9 mRNACTDPMID:21346803
Cyp2j4Rat2,6-di-tert-butyl-4-methylphenol increases expressionISOCYP2J2 (Homo sapiens)6480464Butylated Hydroxytoluene results in increased expression of CYP2J2 mRNACTDPMID:24021950

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Biological Process
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Original Reference(s)
Cyp2j4Ratarachidonate metabolic process  IDA 632631 RGD 
Cyp2j4Ratarachidonate metabolic process involved_inIEAUniPathway:UPA003831600115GO_REF:0000041UniProtGO_REF:0000041
Cyp2j4Ratepoxygenase P450 pathway involved_inISOCYP2J2 (Homo sapiens)1624291 PMID:11901223 and PMID:8631948RGDPMID:11901223 and PMID:8631948
Cyp2j4Ratfemale pregnancy  IEP 7243140 RGD 
Cyp2j4Raticosanoid metabolic process involved_inISOCYP2J2 (Homo sapiens)1624291 PMID:19737933RGDPMID:19737933
Cyp2j4Ratlinoleic acid metabolic process involved_inISOCYP2J2 (Homo sapiens)1624291 PMID:11901223RGDPMID:11901223
Cyp2j4Ratlipid metabolic process involved_inIEAUniProtKB-KW:KW-04431600115GO_REF:0000043UniProtGO_REF:0000043
Cyp2j4Ratnegative regulation of collagen biosynthetic process  IMP 12904676 RGD 
Cyp2j4Ratnegative regulation of collagen biosynthetic process  IMP 150520032 RGD 
Cyp2j4Ratnegative regulation of peroxisome proliferator activated receptor signaling pathway  IMP 12904676 RGD 
Cyp2j4Ratorganic acid metabolic process involved_inIBAMGI:103238 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp2j4Ratpositive regulation of extracellular matrix organization  IMP 150520032 RGD 
Cyp2j4Ratpositive regulation of gluconeogenesis  IMP 150520032 RGD 
Cyp2j4Ratpositive regulation of tumor necrosis factor production  IMP 12904676 RGD 
Cyp2j4Ratpositive regulation of tumor necrosis factor production  IMP 150520032 RGD 
Cyp2j4Ratretinoid metabolic process  IDA 1625388 RGD 
Cyp2j4Ratretinol metabolic process involved_inIEAUniPathway:UPA009121600115GO_REF:0000041UniProtGO_REF:0000041
Cyp2j4Ratxenobiotic metabolic process involved_inIBAPANTHER:PTN000670347 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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Cellular Component

  
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Original Reference(s)
Cyp2j4Ratcytoplasm is_active_inIBAFB:FBgn0004959 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp2j4Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Cyp2j4Ratendoplasmic reticulum located_inIEAUniProtKB:O54750 and ensembl:ENSMUSP000000303031600115GO_REF:0000107EnsemblGO_REF:0000107
Cyp2j4Ratendoplasmic reticulum located_inISOCyp2j9 (Mus musculus)1624291 PMID:19801493RGDPMID:19801493
Cyp2j4Ratendoplasmic reticulum membrane located_inIDA 632631PMID:9143331UniProt 
Cyp2j4Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
Cyp2j4Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function
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Original Reference(s)
Cyp2j4Ratarachidonate 11,12-epoxygenase activity enablesISOCYP2J2 (Homo sapiens)1624291 PMID:11901223RGDPMID:11901223
Cyp2j4Ratarachidonate 14,15-epoxygenase activity enablesISOCYP2J2 (Homo sapiens)1624291 PMID:11901223RGDPMID:11901223
Cyp2j4Ratarachidonate epoxygenase activity enablesISOCYP2J2 (Homo sapiens)1624291 PMID:11901223 and PMID:8631948RGDPMID:11901223 and PMID:8631948
Cyp2j4Ratarachidonate epoxygenase activity enablesIEAUniProtKB:O54750 and ensembl:ENSMUSP000000303031600115GO_REF:0000107EnsemblGO_REF:0000107
Cyp2j4Ratarachidonate monooxygenase activity enablesIDA 632631PMID:9143331UniProt 
Cyp2j4Ratheme binding enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp2j4Ratheme binding enablesIBAPANTHER:PTN000670347 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp2j4Ratiron ion binding enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp2j4Ratisomerase activity enablesISOCYP2J2 (Homo sapiens)1624291 PMID:19737933RGDPMID:19737933
Cyp2j4Ratlinoleic acid epoxygenase activity enablesISOCYP2J2 (Homo sapiens)1624291 PMID:11901223RGDPMID:11901223
Cyp2j4Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Cyp2j4Ratmonooxygenase activity enablesIEAUniProtKB-KW:KW-05031600115GO_REF:0000043UniProtGO_REF:0000043
Cyp2j4Ratmonooxygenase activity enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp2j4RatNADPH-hemoprotein reductase activity  IDA 632631 RGD 
Cyp2j4Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Cyp2j4Ratoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp2j4Ratoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen enablesIBAPANTHER:PTN000670347 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp2j4Ratoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen enablesIEAEC:1.14.14.11600115GO_REF:0000003UniProtGO_REF:0000003
Cyp2j4Ratoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen enablesIEAInterPro:IPR0080711600115GO_REF:0000002InterProGO_REF:0000002
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Imported Annotations - SMPDB

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Original Reference(s)
Cyp2j4Ratacetylsalicylic acid pharmacodynamics pathway  ISOCYP2J2 (Homo sapiens)10402751 SMPDBSMP:00083
Cyp2j4Ratantipyrine drug pathway  ISOCYP2J2 (Homo sapiens)10402751 SMPDBSMP:00692
Cyp2j4Ratarachidonic acid metabolic pathway  ISOCYP2J2 (Homo sapiens)10402751 SMPDBSMP:00075
Cyp2j4Ratcelecoxib pharmacodynamics pathway  ISOCYP2J2 (Homo sapiens)10402751 SMPDBSMP:00096
Cyp2j4Ratdiclofenac pharmacodynamics pathway  ISOCYP2J2 (Homo sapiens)10402751 SMPDBSMP:00093
Cyp2j4Ratdiflunisal pharmacodynamics pathway  ISOCYP2J2 (Homo sapiens)10402751 SMPDBSMP:00289
Cyp2j4Ratetodolac pharmacodynamics pathway  ISOCYP2J2 (Homo sapiens)10402751 SMPDBSMP:00084
Cyp2j4Ratfenoprofen pharmacodynamics pathway  ISOCYP2J2 (Homo sapiens)10402751 SMPDBSMP:00696
Cyp2j4Ratflurbiprofen pharmacodynamics pathway  ISOCYP2J2 (Homo sapiens)10402751 SMPDBSMP:00697
Cyp2j4Ratibuprofen pharmacodynamics pathway  ISOCYP2J2 (Homo sapiens)10402751 SMPDBSMP:00086
Cyp2j4Ratindometacin pharmacodynamics pathway  ISOCYP2J2 (Homo sapiens)10402751 SMPDBSMP:00104
Cyp2j4Ratindometacin pharmacodynamics pathway  ISOCYP2J2 (Homo sapiens)10402751 SMPDBSMP:00104
Cyp2j4Ratketoprofen pharmacodynamics pathway  ISOCYP2J2 (Homo sapiens)10402751 SMPDBSMP:00085
Cyp2j4Ratketorolac pharmacodynamics pathway  ISOCYP2J2 (Homo sapiens)10402751 SMPDBSMP:00098
Cyp2j4Ratleukotriene C4 synthase deficiency pathway  ISOCYP2J2 (Homo sapiens)10402751 SMPDBSMP:00353
Cyp2j4Ratlornoxicam pharmacodynamics pathway  ISOCYP2J2 (Homo sapiens)10402751 SMPDBSMP:00700
Cyp2j4Ratmagnesium salicylate pharmacodynamics pathway  ISOCYP2J2 (Homo sapiens)10402751 SMPDBSMP:00698
Cyp2j4Ratmefenamic acid pharmacodynamics pathway  ISOCYP2J2 (Homo sapiens)10402751 SMPDBSMP:00109
Cyp2j4Ratmeloxicam pharmacodynamics pathway  ISOCYP2J2 (Homo sapiens)10402751 SMPDBSMP:00106
Cyp2j4Ratnabumetone pharmacodynamics pathway  ISOCYP2J2 (Homo sapiens)10402751 SMPDBSMP:00114
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Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Cyp2j4Ratarachidonic acid metabolic pathway  IEA 6907045 KEGGrno:00590
Cyp2j4Ratlinoleic acid metabolic pathway  IEA 6907045 KEGGrno:00591
1 to 10 of 10 rows
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Cyp2j4Ratabnormal extracellular matrix morphology inducesIMPcafeteria diet150520032compared to standard dietRGD 
Cyp2j4Ratabnormal tumor necrosis factor level inducesIMPcafeteria diet150520032compared to standard dietRGD 
Cyp2j4Ratincreased body weight inducesIMPcafeteria diet150520032compared to standard dietRGD 
Cyp2j4Ratincreased body weight onsetIMP 150520032compared to wild typeRGD 
Cyp2j4Ratincreased circulating glucose level inducesIMPcafeteria diet150520032compared to wild typeRGD 
Cyp2j4Ratincreased circulating insulin level  IMP 150520032compared to wild typeRGD 
Cyp2j4Ratincreased collagen level inducesIMPcafeteria diet150520032compared to wild typeRGD 
Cyp2j4Ratincreased fat cell size inducesIMPcafeteria diet150520032compared to standard diet and wild typeRGD 
Cyp2j4Ratincreased liver triglyceride level inducesIMPcafeteria diet150520032compared to wild typeRGD 
Cyp2j4Ratincreased white adipose tissue amount inducesIMPcafeteria diet150520032compared to wild type and standard dietRGD 
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#
Reference Title
Reference Citation
1. Macrophage epoxygenase determines a profibrotic transcriptome signature. Behmoaras J, etal., J Immunol. 2015 May 15;194(10):4705-16. doi: 10.4049/jimmunol.1402979. Epub 2015 Apr 3.
2. Cytochrome P450 epoxygenase CYP2J2 attenuates nephropathy in streptozotocin-induced diabetic mice. Chen G, etal., Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):63-71. doi: 10.1016/j.prostaglandins.2011.06.009. Epub 2011 Jun 30.
3. Differential expression of cytochrome P450 isoforms in the lungs of septic animals. Cui X, etal., Crit Care Med. 2004 May;32(5):1186-91.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Cytochrome P450 subfamily 2J polypeptide 2 expression and circulating epoxyeicosatrienoic metabolites in preeclampsia. Herse F, etal., Circulation. 2012 Dec 18;126(25):2990-9. doi: 10.1161/CIRCULATIONAHA.112.127340. Epub 2012 Nov 15.
7. Epoxyeicosatrienoic Acid inhibition alters renal hemodynamics during pregnancy. Huang H, etal., Exp Biol Med (Maywood). 2006 Dec;231(11):1744-52.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice. Lee CR, etal., FASEB J. 2010 Oct;24(10):3770-81. doi: 10.1096/fj.10-160119. Epub 2010 May 21.
10. CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: the Atherosclerosis Risk in Communities (ARIC) study. Lee CR, etal., Pharmacogenet Genomics. 2007 May;17(5):349-58.
11. Synergistic effect of cytochrome P450 epoxygenase CYP2J2*7 polymorphism with smoking on the onset of premature myocardial infarction. Liu PY, etal., Atherosclerosis. 2006 Nov 24;.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Epoxygenase inactivation exacerbates diet and aging-associated metabolic dysfunction resulting from impaired adipogenesis. Olona A, etal., Mol Metab. 2018 May;11:18-32. doi: 10.1016/j.molmet.2018.03.003. Epub 2018 Mar 9.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Evidence for Association of Polymorphisms in CYP2J2 and Susceptibility to Essential Hypertension. Wu SN, etal., Ann Hum Genet. 2007 Jul;71(Pt 4):519-25. Epub 2007 Feb 5.
20. Overexpression of cytochrome P450 epoxygenases prevents development of hypertension in spontaneously hypertensive rats by enhancing atrial natriuretic peptide. Xiao B, etal., J Pharmacol Exp Ther. 2010 Sep 1;334(3):784-94. doi: 10.1124/jpet.110.167510. Epub 2010 May 25.
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PMID:8631948   PMID:11901223   PMID:12477932   PMID:18570454   PMID:19737933   PMID:19801493   PMID:24903033   PMID:25450017   PMID:30219518   PMID:36269280   PMID:37385478  



Cyp2j4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85116,295,691 - 116,323,219 (-)NCBIGRCr8
mRatBN7.25111,179,981 - 111,207,490 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5111,178,703 - 111,244,794 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5113,748,215 - 113,775,559 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05115,473,589 - 115,500,933 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05115,536,117 - 115,563,461 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05119,546,458 - 119,564,843 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5119,546,461 - 119,564,846 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05119,130,644 - 119,130,903 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.05123,437,429 - 123,455,814 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45116,702,370 - 116,729,722 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15116,707,598 - 116,734,948 (-)NCBI
Celera5109,770,343 - 109,797,690 (-)NCBICelera
Cytogenetic Map5q33NCBI
CYP2J2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38159,893,308 - 59,969,212 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl159,893,308 - 59,926,773 (-)EnsemblGRCh38hg38GRCh38
GRCh37160,358,980 - 60,392,445 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36160,131,568 - 60,165,011 (-)NCBINCBI36Build 36hg18NCBI36
Build 34160,071,001 - 60,104,444NCBI
Celera158,647,783 - 58,681,160 (-)NCBICelera
Cytogenetic Map1p32.1NCBI
HuRef158,469,963 - 58,503,340 (-)NCBIHuRef
CHM1_1160,474,448 - 60,507,891 (-)NCBICHM1_1
T2T-CHM13v2.0159,771,763 - 59,847,665 (-)NCBIT2T-CHM13v2.0
Cyp2j9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39496,456,661 - 96,480,748 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl496,456,666 - 96,479,815 (-)EnsemblGRCm39 Ensembl
GRCm38496,568,424 - 96,592,523 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl496,568,429 - 96,591,578 (-)EnsemblGRCm38mm10GRCm38
MGSCv37496,235,120 - 96,258,176 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36496,060,447 - 96,083,503 (-)NCBIMGSCv36mm8
Celera494,937,695 - 94,960,750 (-)NCBICelera
Cytogenetic Map4C5NCBI
cM Map444.66NCBI
CYP2J2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21166,925,746 - 166,962,880 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11166,076,935 - 166,110,477 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0159,151,079 - 59,184,625 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1160,856,269 - 60,899,562 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl160,856,269 - 60,889,810 (-)Ensemblpanpan1.1panPan2
CYP2J2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1549,942,241 - 49,986,603 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl549,942,193 - 49,984,617 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha550,009,133 - 50,053,501 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0550,122,223 - 50,166,600 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl550,122,301 - 50,223,602 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1550,073,683 - 50,118,028 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0550,019,070 - 50,063,225 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0550,301,607 - 50,345,982 (+)NCBIUU_Cfam_GSD_1.0
LOC110261221
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6152,321,848 - 152,648,979 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16152,321,816 - 152,358,179 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CYP2J2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12073,083,312 - 73,115,174 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2073,083,389 - 73,115,077 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603344,276,757 - 44,308,738 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in Cyp2j4
293 total Variants

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:92
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000012977
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 45 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat

1 to 10 of 45 rows
D5Got242  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25111,179,889 - 111,180,021 (+)MAPPERmRatBN7.2
Rnor_6.05119,546,367 - 119,546,498NCBIRnor6.0
Rnor_5.05123,437,338 - 123,437,469UniSTSRnor5.0
RGSC_v3.45116,702,279 - 116,702,410UniSTSRGSC3.4
Celera5109,770,252 - 109,770,383UniSTS
Cytogenetic Map5q33UniSTS


This gene Cyp2j4 is modified in the following models/strains:
WKY-Cyp2j4em1Sage/Tja    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000012503   ⟹   ENSRNOP00000012503
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5111,178,703 - 111,244,794 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000012977   ⟹   ENSRNOP00000012977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5111,179,984 - 111,207,332 (-)Ensembl
Rnor_6.0 Ensembl5119,546,461 - 119,564,846 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000058163   ⟹   ENSRNOP00000054968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5111,220,049 - 111,244,789 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079786   ⟹   ENSRNOP00000074827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5111,179,984 - 111,198,902 (-)Ensembl
RefSeq Acc Id: NM_023025   ⟹   NP_075414
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85116,295,691 - 116,323,042 (-)NCBI
mRatBN7.25111,179,981 - 111,207,332 (-)NCBI
Rnor_6.05119,546,458 - 119,564,843 (-)NCBI
Rnor_5.05119,130,644 - 119,130,903 (-)NCBI
Rnor_5.05123,437,429 - 123,455,814 (-)NCBI
RGSC_v3.45116,702,370 - 116,729,722 (-)RGD
Celera5109,770,343 - 109,797,690 (-)RGD
Sequence:
RefSeq Acc Id: XM_039110733   ⟹   XP_038966661
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85116,296,399 - 116,323,219 (-)NCBI
mRatBN7.25111,180,689 - 111,207,490 (-)NCBI
Protein RefSeqs NP_075414 (Get FASTA)   NCBI Sequence Viewer  
  XP_038966661 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF21133 (Get FASTA)   NCBI Sequence Viewer  
  AAH91149 (Get FASTA)   NCBI Sequence Viewer  
  EDL97781 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012977
GenBank Protein Q9QXF7 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_075414   ⟸   NM_023025
- UniProtKB: Q9QXF7 (UniProtKB/Swiss-Prot),   Q5BKA2 (UniProtKB/TrEMBL),   F7FF10 (UniProtKB/TrEMBL),   A0A9K3Y868 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012977   ⟸   ENSRNOT00000012977
RefSeq Acc Id: XP_038966661   ⟸   XM_039110733
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000054968   ⟸   ENSRNOT00000058163
Ensembl Acc Id: ENSRNOP00000012503   ⟸   ENSRNOT00000012503

Name Modeler Protein Id AA Range Protein Structure
AF-F7FF10-F1-model_v2 AlphaFold F7FF10 1-432 view protein structure
AF-Q9QXF7-F1-model_v2 AlphaFold Q9QXF7 1-501 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 31 of 31 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-40624 BioCyc
Ensembl Genes ENSRNOG00000031004 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000012977 ENTREZGENE
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7323516 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I_CYP2J-like UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_fam2 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108684 IMAGE-MGC_LOAD
NCBI Gene 65210 ENTREZGENE
PANTHER CYTOCHROME P450 2J2 UniProtKB/Swiss-Prot
  CYTOCHROME P450 508A4-RELATED UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PharmGKB CYP2J2 RGD
PhenoGen Cyp2j4 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot
  EP450ICYP2J UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000031004 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt A0A0G2K921_RAT UniProtKB/TrEMBL
  A0A9K3Y868 ENTREZGENE, UniProtKB/TrEMBL
  CP2J4_RAT UniProtKB/Swiss-Prot
  F1LVB0_RAT UniProtKB/TrEMBL
  F7FF10 ENTREZGENE
  Q5BKA2 ENTREZGENE, UniProtKB/TrEMBL
  Q9QXF7 ENTREZGENE
1 to 31 of 31 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-19 Cyp2j4  cytochrome P450, family 2, subfamily j, polypeptide 4  Cyp2j4  cytochrome P450, family 2, subfamily J, polypeptide 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-02 Cdk5rap3  cytochrome P450, family 2, subfamily J, polypeptide 4  Cyp2j4  CYP2J4  Name updated 1299863 APPROVED
2002-08-07 Cyp2j4  CYP2J4      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_disease may be involved with rat model of acute Pseudomonas pneumonia 1299258
gene_expression expressed in liver, intestine, olfactory mucosa, kidney, heart, and lung 632631
gene_homology 72.5 and 75.8% amino acid identity to rabbit and human, respectively 632631
gene_protein 501 amino acids 632631