Strain Report - Rat Genome Database

Name: WKY- Cyp2j4 em1Sage /Tja
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: WKY-Cyp2j4^em1Sage/Tja

Symbol:

WKY-Cyp2j4^em1Sage/Tja

Strain:

WKY-Cyp2j4^em1Sage

Substrain:

Tja

RGD ID:

12904679

Citation ID:

RRID:RGD_12904679

Ontology ID:

RS:0004589

Alleles:

Cyp2j4^em1Sage

Previously known as:

WKY-Cyp2j4-KO ; Cyp2j4-/-; WKY-Cyp2j4em1Sage /Tja

Type:

mutant

Source:

Not Available

Origin:

ZFN system was used to introduce a 25-bp deletion mutation in the exon 4 of Cyp2j4 gene of WKY/NCrl rat embryos. This deletion results in premature stop of protein translation.

Last Known Status:

Unknown

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	111,179,981 - 111,207,490	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	5	119,546,458 - 119,564,843	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	5	119,130,644 - 123,455,814	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	5	116,702,370 - 116,729,722	RGD_MAPPER_PIPELINE	RGSC3.4

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

nephritis (IMP)

ureteral obstruction (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal extracellular matrix morphology (IMP)

abnormal tumor necrosis factor level (IMP)

increased body weight (IMP)

increased circulating glucose level (IMP)

increased circulating insulin level (IMP)

increased collagen level (IMP)

increased fat cell size (IMP)

increased liver triglyceride level (IMP)

increased white adipose tissue amount (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Macrophage epoxygenase determines a profibrotic transcriptome signature.	Behmoaras J, etal., J Immunol. 2015 May 15;194(10):4705-16. doi: 10.4049/jimmunol.1402979. Epub 2015 Apr 3.
2.	Epoxygenase inactivation exacerbates diet and aging-associated metabolic dysfunction resulting from impaired adipogenesis.	Olona A, etal., Mol Metab. 2018 May;11:18-32. doi: 10.1016/j.molmet.2018.03.003. Epub 2018 Mar 9.

Region

Additional Information

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-03-14	WKY-Cyp2j4^em1Sage/Tja		WKY-Cyp2j4^em1Sage /Tja		Symbol updated	68687	APPROVED
2018-03-14	WKY-Cyp2j4^em1Sage/Tja		WKY-Cyp2j4^em1Sage /Tja		Symbol updated	68687	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: WKY-Cyp2j4em1Sage/Tja

Mammalian Phenotype

Strain: WKY-Cyp2j4^em1Sage/Tja