CYP2J2 (cytochrome P450 family 2 subfamily J member 2)

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Gene: CYP2J2 (cytochrome P450 family 2 subfamily J member 2) Chlorocebus sabaeus

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Symbol:

CYP2J2

Name:

cytochrome P450 family 2 subfamily J member 2

RGD ID:

18533976

Description:

ENCODES a protein that exhibits arachidonate monooxygenase activity (ortholog); NADPH-hemoprotein reductase activity (ortholog); INVOLVED IN arachidonate metabolic process (ortholog); female pregnancy (ortholog); negative regulation of collagen biosynthetic process (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); bacterial pneumonia (ortholog); chronic obstructive pulmonary disease (ortholog); FOUND IN cytoplasm (inferred); endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cytochrome P450 2J2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	73,083,312 - 73,115,174 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	73,083,389 - 73,115,077 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	44,276,757 - 44,308,738 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

bacterial pneumonia (ISO)

chronic obstructive pulmonary disease (ISO)

Coronary Disease (ISO)

Diabetic Nephropathies (ISO)

hypertension (ISO)

intellectual disability (ISO)

myocardial infarction (ISO)

nephritis (ISO)

pre-eclampsia (ISO)

pulmonary hypertension (ISO)

renal fibrosis (ISO)

renal hypertension (ISO)

Sepsis (ISO)

ureteral obstruction (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

arachidonate metabolic process (ISO)

epoxygenase P450 pathway (IEA)

female pregnancy (ISO)

icosanoid metabolic process (IEA)

linoleic acid metabolic process (IEA)

negative regulation of collagen biosynthetic process (ISO)

negative regulation of peroxisome proliferator activated receptor signaling pathway (ISO)

organic acid metabolic process (IEA)

positive regulation of extracellular matrix organization (ISO)

positive regulation of gluconeogenesis (ISO)

positive regulation of tumor necrosis factor production (ISO)

retinoid metabolic process (ISO)

xenobiotic metabolic process (IEA)

Cellular Component

cytoplasm (IEA)

endoplasmic reticulum (IEA)

endoplasmic reticulum membrane (IEA)

intracellular membrane-bounded organelle (IEA)

membrane (IEA)

Molecular Function

arachidonate 11,12-epoxygenase activity (IEA)

arachidonate 14,15-epoxygenase activity (IEA)

arachidonate epoxygenase activity (IEA)

arachidonate monooxygenase activity (ISO)

heme binding (IEA)

iron ion binding (IEA)

isomerase activity (IEA)

linoleic acid epoxygenase activity (IEA)

metal ion binding (IEA)

monooxygenase activity (IEA)

NADPH-hemoprotein reductase activity (ISO)

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

acetylsalicylic acid pharmacodynamics pathway (ISO)

antipyrine drug pathway (ISO)

arachidonic acid metabolic pathway (ISO)

celecoxib pharmacodynamics pathway (ISO)

diclofenac pharmacodynamics pathway (ISO)

diflunisal pharmacodynamics pathway (ISO)

etodolac pharmacodynamics pathway (ISO)

fenoprofen pharmacodynamics pathway (ISO)

flurbiprofen pharmacodynamics pathway (ISO)

ibuprofen pharmacodynamics pathway (ISO)

indometacin pharmacodynamics pathway (ISO)

ketoprofen pharmacodynamics pathway (ISO)

ketorolac pharmacodynamics pathway (ISO)

leukotriene C4 synthase deficiency pathway (ISO)

lornoxicam pharmacodynamics pathway (ISO)

magnesium salicylate pharmacodynamics pathway (ISO)

mefenamic acid pharmacodynamics pathway (ISO)

meloxicam pharmacodynamics pathway (ISO)

nabumetone pharmacodynamics pathway (ISO)

naproxen pharmacodynamics pathway (ISO)

paracetamol drug pathway (ISO)

piroxicam pharmacodynamics pathway (ISO)

salicylic acid pharmacodynamics pathway (ISO)

sodium salicylate pharmacodynamics pathway (ISO)

sulindac pharmacodynamics pathway (ISO)

tenoxicam pharmacodynamics pathway (ISO)

tiaprofenic acid pharmacodynamics pathway (ISO)

tolmetin pharmacodynamics pathway (ISO)

valdecoxib pharmacodynamics pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

CYP2J2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	73,083,312 - 73,115,174 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	73,083,389 - 73,115,077 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	44,276,757 - 44,308,738 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

CYP2J2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	59,893,308 - 59,969,212 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	59,893,308 - 59,926,773 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	60,358,980 - 60,392,445 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	60,131,568 - 60,165,011 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	60,071,001 - 60,104,444	NCBI
Celera	1	58,647,783 - 58,681,160 (-)	NCBI		Celera
Cytogenetic Map	1	p32.1	NCBI
HuRef	1	58,469,963 - 58,503,340 (-)	NCBI		HuRef
CHM1_1	1	60,474,448 - 60,507,891 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	59,771,763 - 59,847,665 (-)	NCBI		T2T-CHM13v2.0

Cyp2j9
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	96,456,661 - 96,480,748 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	96,456,666 - 96,479,815 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	96,568,424 - 96,592,523 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	96,568,429 - 96,591,578 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	96,235,120 - 96,258,176 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	96,060,447 - 96,083,503 (-)	NCBI		MGSCv36	mm8
Celera	4	94,937,695 - 94,960,750 (-)	NCBI		Celera
Cytogenetic Map	4	C5	NCBI
cM Map	4	44.66	NCBI

Cyp2j4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	116,295,691 - 116,323,219 (-)	NCBI		GRCr8
mRatBN7.2	5	111,179,981 - 111,207,490 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	111,178,703 - 111,244,794 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	113,748,215 - 113,775,559 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	115,473,589 - 115,500,933 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	115,536,117 - 115,563,461 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	119,546,458 - 119,564,843 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	119,546,461 - 119,564,846 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	123,437,429 - 123,455,814 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	5	119,130,644 - 119,130,903 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	116,702,370 - 116,729,722 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	116,707,598 - 116,734,948 (-)	NCBI
Celera	5	109,770,343 - 109,797,690 (-)	NCBI		Celera
Cytogenetic Map	5	q33	NCBI

CYP2J2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	166,925,746 - 166,962,880 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	166,076,935 - 166,110,477 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	59,151,079 - 59,184,625 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	60,856,269 - 60,899,562 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	60,856,269 - 60,889,810 (-)	Ensembl	panpan1.1		panPan2

CYP2J2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	49,942,241 - 49,986,603 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	49,942,193 - 49,984,617 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	50,009,133 - 50,053,501 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	50,122,223 - 50,166,600 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	50,122,301 - 50,223,602 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	50,073,683 - 50,118,028 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	50,019,070 - 50,063,225 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	50,301,607 - 50,345,982 (+)	NCBI		UU_Cfam_GSD_1.0

LOC110261221
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	152,321,848 - 152,648,979 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	152,321,816 - 152,358,179 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	17	33	33	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007978536	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000017202 ⟹ ENSCSAP00000016686

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	20	73,083,389 - 73,115,077 (+)	Ensembl

RefSeq Acc Id:

XM_007978536 ⟹ XP_007976727

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	20	73,083,312 - 73,115,174 (+)	NCBI
Vero_WHO_p1.0	NW_023666033	44,276,757 - 44,308,738 (-)	NCBI

Sequence:

show sequence

GCTGGGAGGCGGGGCGCGGCTAGGAGCGAGGCGGGGCGGGGAGGCGCTGCGGGGGCCGGCGACT
GCTTAGACCGCAGAAAAGCAGGAGGACGTCTGAGACATGCTCGCAGCGCTAGGCTCTCTGGCGG
CTGCCCTCTGGGCAGTGGTCCATCCTCGAACTCTCCTGCTGGGCACTCTCGCCTTTCTGCTCGT
TGCTGACTTTCTCAAAAGACGGCGCCCAAAGAACTACCCGCCGGGGCCCTGGCCCCTGCCCTTC
CTTGGCAACTTCTTCCATGTGAACTTTGAGCAGTCGCACCTGGAGGTTCAGCAGTTTGTGAAGA
AATATGGGAACCTTTTTAGCTTGGAGCTTGGTGACATATCTGCAGTTCTTATTACTGGCTTGCC
CTTAATCAAAGAAGCCCTTATCCACATGGACCAAAACTTTGGGAACCGCCCCATGACCCCTATG
CGAGAACGTACCTTTAAGAAAAATGGATTGATTATGTCAAGTGGCCAGATATGGAAGGAGCAAA
GACGGTTCACTCTGACAGCACTAAGGAACTTTGGTTTAGGAAAGAAGAGCTTAGAGGAACGCAT
TCAGGAGGAGGCCCAACACCTCACTGAAGCAATAAAAGAGGAGAACGGACAGCCTTTTGACCCT
CACTTCAAGATAAACAATGCAGTTTCCAATATCATTTGCTCCATCACCTTTGGAGAACGCTTTG
AGTACCAGGATAGTCAGTTTCAGGAGCTGCTGAAGTTATTGGATGAAGTCACATACTTGGAGGC
TTCAAAAACATGCCAGCTCTACAATGTCTTTCCATGGCTAATGAAATTCCTGCCTGGACCCCAC
CAAACTCTTTTCAGCAACTGGGAAAAACTGAAATTGTTTATTTCTCATATAATTGAAAAACACA
GGAAGGATTGGAATCCTGCAGAAACAAGAGACTTTATTGATGCTTACCTCAAAGAAATGTCAAA
GCACACAGGCAATTCTACTTCAAGTTTCCATGAGGAAAACCTCATCTGCAGCACTCTGGACCTT
TTCTTTGCCGGAACCGAGACAACTTCTACGACTCTGCGATGGGCTCTGCTTTATATGGCCCTCT
ACCCAGAAATCCAAGAAAAAGTACAAGCTGAGATTGACAGAGTGATCGGCCAGGGGCAGCAGCC
GAGCACAGCCGCCCGGGAGTCCATGCCCTACACCAATGCCGTCATCCATGAGGTGCAGAGAATG
GGCAACATCATCCCCCTGAACGTTCCCAGGGAAGCGACAGTTGATACCACTTTGGCTGGGTACC
ACCTGCCCAAGGGGACCATGATCCTGACCAATTTGACGGCGCTGCACAGGGACCCCACAGAGTG
GGCCACCCCTGACACGTTCAATCCAGAGCATTTTCTGGAGAATGGACAGTTTAAGAAAAGGGAA
GCCTTTCTACCCTTCTCAATAGGAAAGCGGGCATGCCTCGGAGAACAGTTGGCCAGGACTGAGC
TGTTTATTTTCTTCACTTCCCTTGTACAAAAATTTACCTTCAGGCCCCCAGACAATGAGAAGCT
GAGCCCGAAGTTTAGAATGGGCATCACTATTTCCCCAGTCAGTCACCACCTCTGCGCTGTTCCT
CGGGTCTGATTTTGCTAAGAAAGAAAGGGGCTTTTTAATGATTGCCATTCTAACTGGTGTGAGA
TGGTATCTCATTGTGGTTTTGATTTGCATTTTTCTGATGGCT

hide sequence

Protein Sequences


Protein RefSeqs	XP_007976727	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000016686.1

RefSeq Acc Id:	XP_007976727 ⟸ XM_007978536
- UniProtKB:	A0A0D9S747 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000016686 ⟸ ENSCSAT00000017202

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000001331	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000017202.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.630.10	UniProtKB/TrEMBL
InterPro	Cyt_P450	UniProtKB/TrEMBL
	Cyt_P450_CS	UniProtKB/TrEMBL
	Cyt_P450_E_grp-I	UniProtKB/TrEMBL
	Cyt_P450_E_grp-I_CYP2J-like	UniProtKB/TrEMBL
	Cyt_P450_sf	UniProtKB/TrEMBL
	Cytochrome_P450_fam2	UniProtKB/TrEMBL
KEGG Report	csab:103224719	UniProtKB/TrEMBL
NCBI Gene	CYP2J2	ENTREZGENE
PANTHER	CYTOCHROME P450 2J2	UniProtKB/TrEMBL
	CYTOCHROME P450 508A4-RELATED	UniProtKB/TrEMBL
Pfam	p450	UniProtKB/TrEMBL
PRINTS	EP450I	UniProtKB/TrEMBL
	EP450ICYP2J	UniProtKB/TrEMBL
	P450	UniProtKB/TrEMBL
PROSITE	CYTOCHROME_P450	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48264	UniProtKB/TrEMBL
UniProt	A0A0D9S747	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:83394	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB