Cyp2j4<i><sup>em1Sage</sup></i> (cytochrome P450, family 2, subfamily j, polypeptide 4, ZFN induced mutant 1, Sage) - Rat Genome Database

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Gene: Cyp2j4em1Sage (cytochrome P450, family 2, subfamily j, polypeptide 4, ZFN induced mutant 1, Sage) Rattus norvegicus
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Symbol: Cyp2j4em1Sage
Name: cytochrome P450, family 2, subfamily j, polypeptide 4, ZFN induced mutant 1, Sage
RGD ID: 12904681
Description: ZFN system was used to introduce a 25-bp deletion mutation in the exon 4 of Cyp2j4 gene of WKY/NCrl rat embryos. This deletion results in premature stop of protein translation.
ASSOCIATED WITH abnormal extracellular matrix morphology; abnormal tumor necrosis factor level; increased body weight; ASSOCIATED WITH nephritis; ureteral obstruction
Type: allele  of Cyp2j4  
Previously known as: Cyp2j4-KO; Cyp2j4^[em1Sage]; Cyp2j4em1Sage
Is Marker For: Strains:   WKY-Cyp2j4em1Sage/Tja  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References

References - curated
# Reference Title Reference Citation
1. Macrophage epoxygenase determines a profibrotic transcriptome signature. Behmoaras J, etal., J Immunol. 2015 May 15;194(10):4705-16. doi: 10.4049/jimmunol.1402979. Epub 2015 Apr 3.
2. Epoxygenase inactivation exacerbates diet and aging-associated metabolic dysfunction resulting from impaired adipogenesis. Olona A, etal., Mol Metab. 2018 May;11:18-32. doi: 10.1016/j.molmet.2018.03.003. Epub 2018 Mar 9.

Genomics


Related Rat Strains
The following Strains have been annotated to Cyp2j4em1Sage


Expression


Sequence

Nucleotide Sequences


Additional Information