Ptgr1 (prostaglandin reductase 1) - Rat Genome Database

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Gene: Ptgr1 (prostaglandin reductase 1) Rattus norvegicus
Symbol: Ptgr1
Name: prostaglandin reductase 1
RGD ID: 621195
Description: Enables 13-prostaglandin reductase activity and 2-alkenal reductase (NADPH) activity. Involved in several processes, including leukotriene B4 metabolic process; negative regulation of reactive oxygen species biosynthetic process; and response to antineoplastic agent. Located in cytosol and nucleus. Biomarker of hypertension. Orthologous to human PTGR1 (prostaglandin reductase 1); INTERACTS WITH 1,2,4-trimethylbenzene; 1-penten-3-one; 15-dehydro-prostaglandin E2.
Type: protein-coding
Previously known as: 15-oxoprostaglandin 13-reductase; D3T-inducible gene 1 protein; DIG-1; Dig1; dithiolethione-inducible gene 1 protein; dithiolethione-inducible gene-1; leukotriene B4 12-hydroxydehydrogenase; Ltb4dh; NAD(P)H-dependent alkenal/one oxidoreductase; NADP-dependent leukotriene B4 12-hydroxydehydrogenase; PRG-1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8578,579,060 - 78,597,671 (-)NCBIGRCr8
mRatBN7.2573,784,000 - 73,802,624 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl573,784,009 - 73,802,666 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx575,685,300 - 75,703,919 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0577,506,913 - 77,525,540 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0577,479,071 - 77,497,693 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0576,110,746 - 76,129,361 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl576,110,738 - 76,129,441 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0580,255,192 - 80,273,709 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4577,010,809 - 77,029,326 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1577,015,922 - 77,034,439 (-)NCBI
Celera572,607,043 - 72,625,264 (-)NCBICelera
Cytogenetic Map5q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(E)-cinnamyl alcohol  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-Hydroxypyrene  (ISO)
1-penten-3-one  (EXP)
13,14-dihydro-15-keto-PGF2alpha  (ISO)
13,14-dihydro-15-oxo-prostaglandin E2  (ISO)
13,14-dihydro-15-oxoprostaglandin E1  (ISO)
15-dehydro-prostaglandin E2  (EXP,ISO)
15-oxoprostaglandin F2alpha  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (EXP)
2,4-Nonadienal  (EXP)
2-acetamidofluorene  (EXP)
2-butoxyethanol  (ISO)
2-hexenal  (EXP)
2-hydroxypropanoic acid  (ISO)
2-pentenal  (EXP)
2-tert-butylhydroquinone  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-phenylprop-2-enal  (EXP)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyhexenal  (EXP)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (EXP)
aflatoxin B1  (EXP)
alachlor  (EXP)
all-trans-retinoic acid  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
ampicillin  (ISO)
andrographolide  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
Bandrowski's base  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP,ISO)
benzoic acid  (ISO)
benzylideneacetone  (EXP)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buten-2-one  (EXP)
Butylbenzyl phthalate  (EXP)
C60 fullerene  (EXP)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (EXP)
calycosin  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chalcone  (EXP)
chloropicrin  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cinnamyl alcohol  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP)
crocidolite asbestos  (ISO)
crotonaldehyde  (EXP)
cyclosporin A  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibenzo[a,l]pyrene  (EXP)
dibenzoylmethane  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
disulfiram  (ISO)
dithionitrobenzoic acid  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
elemental selenium  (EXP)
endosulfan  (EXP)
eugenol  (ISO)
fenoprofen  (ISO)
fipronil  (EXP)
fluoranthene  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formononetin  (ISO)
furan  (EXP)
gallic acid  (ISO)
gamma-linolenic acid  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hexane  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
indometacin  (EXP,ISO)
isoeugenol  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(II) chloride  (ISO)
leflunomide  (EXP)
manganese(II) chloride  (EXP)
menadione  (ISO)
mercury dichloride  (ISO)
methyl salicylate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
Niflumic acid  (ISO)
nimesulide  (EXP,ISO)
nitrofen  (EXP)
non-2-enal  (EXP)
ochratoxin A  (ISO)
oct-2-enal  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
progesterone  (EXP,ISO)
propan-2-ol  (ISO)
prostaglandin F1alpha  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
resorcinol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
theaflavin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trans-chalcone  (EXP)
trans-isoeugenol  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
undecane  (EXP)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA,IEA,ISO,ISS)
cytosol  (IDA)
nucleus  (IDA)


References - curated
# Reference Title Reference Citation
1. Plant Natural Products Calycosin and Gallic Acid Synergistically Attenuate Neutrophil Infiltration and Subsequent Injury in Isoproterenol-Induced Myocardial Infarction: A Possible Role for Leukotriene B4 12-Hydroxydehydrogenase? Cheng Y, etal., Oxid Med Cell Longev. 2015;2015:434052. doi: 10.1155/2015/434052. Epub 2015 Jul 21.
2. Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase. A new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase. Dick RA, etal., J Biol Chem. 2001 Nov 2;276(44):40803-10. doi: 10.1074/jbc.M105487200. Epub 2001 Aug 27.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Isolation of cDNAs representing dithiolethione-responsive genes. Primiano T, etal., Carcinogenesis 1996 Nov;17(11):2297-303.
8. Identification of dithiolethione-inducible gene-1 as a leukotriene B4 12-hydroxydehydrogenase: implications for chemoprevention. Primiano T, etal., Carcinogenesis. 1998 Jun;19(6):999-1005. doi: 10.1093/carcin/19.6.999.
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Increased expression of prostaglandin reductase 1 in hepatocellular carcinomas from clinical cases and experimental tumors in rats. Sánchez-Rodríguez R, etal., Int J Biochem Cell Biol. 2014 Aug;53:186-94. doi: 10.1016/j.biocel.2014.05.017. Epub 2014 May 20.
12. Excessive leukotriene B4 in nucleus tractus solitarii is prohypertensive in spontaneously hypertensive rats. Waki H, etal., Hypertension. 2013 Jan;61(1):194-201. doi: 10.1161/HYPERTENSIONAHA.112.192252. Epub 2012 Nov 19.
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:18500801   PMID:19056867   PMID:23376485   PMID:23878198   PMID:27867096  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8578,579,060 - 78,597,671 (-)NCBIGRCr8
mRatBN7.2573,784,000 - 73,802,624 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl573,784,009 - 73,802,666 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx575,685,300 - 75,703,919 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0577,506,913 - 77,525,540 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0577,479,071 - 77,497,693 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0576,110,746 - 76,129,361 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl576,110,738 - 76,129,441 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0580,255,192 - 80,273,709 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4577,010,809 - 77,029,326 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1577,015,922 - 77,034,439 (-)NCBI
Celera572,607,043 - 72,625,264 (-)NCBICelera
Cytogenetic Map5q24NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh389111,549,722 - 111,599,647 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9111,549,722 - 111,599,893 (-)EnsemblGRCh38hg38GRCh38
GRCh379114,312,002 - 114,361,927 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369113,365,073 - 113,401,532 (-)NCBINCBI36Build 36hg18NCBI36
Build 349111,404,807 - 111,441,266NCBI
Celera984,811,079 - 84,861,206 (-)NCBICelera
Cytogenetic Map9q31.3NCBI
HuRef983,911,040 - 83,960,627 (-)NCBIHuRef
CHM1_19114,458,441 - 114,508,602 (-)NCBICHM1_1
T2T-CHM13v2.09123,721,096 - 123,771,025 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39458,965,590 - 58,987,131 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl458,965,439 - 58,987,119 (-)EnsemblGRCm39 Ensembl
GRCm38458,965,590 - 58,987,131 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl458,965,439 - 58,987,119 (-)EnsemblGRCm38mm10GRCm38
MGSCv37458,978,462 - 58,999,950 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36459,059,644 - 59,081,132 (-)NCBIMGSCv36mm8
Celera458,878,602 - 58,900,216 (-)NCBICelera
Cytogenetic Map4B3NCBI
cM Map432.36NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541915,708,456 - 15,739,147 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541915,708,456 - 15,738,774 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21127,816,183 - 27,860,132 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1927,824,016 - 27,862,494 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0982,700,541 - 82,739,024 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19110,862,122 - 110,900,829 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9110,848,804 - 110,900,829 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11166,191,155 - 66,212,075 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1166,191,165 - 66,209,219 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1164,601,934 - 64,622,894 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01167,324,103 - 67,345,145 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1167,324,105 - 67,345,298 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11165,841,533 - 65,862,116 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01165,864,869 - 65,885,860 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01166,554,733 - 66,575,785 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404947181,503,868 - 181,535,213 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365591,731,533 - 1,762,671 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365591,731,346 - 1,762,676 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1252,373,282 - 252,395,948 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,373,272 - 252,395,948 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21283,170,868 - 283,177,809 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11227,918,990 - 27,999,736 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603514,779,257 - 14,799,467 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_00462476023,406,085 - 23,433,283 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ptgr1
173 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:18
Count of miRNA genes:17
Interacting mature miRNAs:18
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)55979352890450144Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)568984307104251008Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2573,784,043 - 73,784,173 (+)MAPPERmRatBN7.2
Rnor_6.0576,110,785 - 76,110,914NCBIRnor6.0
Rnor_5.0580,255,224 - 80,255,353UniSTSRnor5.0
RGSC_v3.4577,010,841 - 77,010,970UniSTSRGSC3.4
Celera572,607,075 - 72,607,204UniSTS
Cytogenetic Map5q24UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2573,799,690 - 73,799,871 (+)MAPPERmRatBN7.2
Rnor_6.0576,126,429 - 76,126,609NCBIRnor6.0
Rnor_5.0580,270,777 - 80,270,957UniSTSRnor5.0
RGSC_v3.4577,026,394 - 77,026,574UniSTSRGSC3.4
Celera572,622,332 - 72,622,512UniSTS
RH 3.4 Map5506.3UniSTS
Cytogenetic Map5q24UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2573,798,118 - 73,799,022 (+)MAPPERmRatBN7.2
Rnor_6.0576,124,858 - 76,125,761NCBIRnor6.0
Rnor_5.0580,269,206 - 80,270,109UniSTSRnor5.0
RGSC_v3.4577,024,823 - 77,025,726UniSTSRGSC3.4
Celera572,620,761 - 72,621,664UniSTS
Cytogenetic Map5q24UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 49 41 41 8 35 38 11
Low 8 19 8 11 66 3 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000020335   ⟹   ENSRNOP00000020335
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl573,784,009 - 73,802,666 (-)Ensembl
Rnor_6.0 Ensembl576,110,738 - 76,129,441 (-)Ensembl
RefSeq Acc Id: NM_138863   ⟹   NP_620218
Rat AssemblyChrPosition (strand)Source
GRCr8578,579,060 - 78,597,671 (-)NCBI
mRatBN7.2573,784,012 - 73,802,624 (-)NCBI
Rnor_6.0576,110,753 - 76,129,361 (-)NCBI
Rnor_5.0580,255,192 - 80,273,709 (-)NCBI
RGSC_v3.4577,010,809 - 77,029,326 (-)RGD
Celera572,607,043 - 72,625,264 (-)RGD
RefSeq Acc Id: XM_017593142   ⟹   XP_017448631
Rat AssemblyChrPosition (strand)Source
GRCr8578,579,067 - 78,596,042 (-)NCBI
mRatBN7.2573,784,000 - 73,800,996 (-)NCBI
Rnor_6.0576,110,746 - 76,127,712 (-)NCBI
Protein Sequences
Protein RefSeqs NP_620218 (Get FASTA)   NCBI Sequence Viewer  
  XP_017448631 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB88912 (Get FASTA)   NCBI Sequence Viewer  
  AAH89775 (Get FASTA)   NCBI Sequence Viewer  
  EDL91647 (Get FASTA)   NCBI Sequence Viewer  
  EDL91648 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000020335
GenBank Protein P97584 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_620218   ⟸   NM_138863
- UniProtKB: Q5EBD3 (UniProtKB/Swiss-Prot),   P97584 (UniProtKB/Swiss-Prot),   A0A8L2QAI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448631   ⟸   XM_017593142
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QAI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020335   ⟸   ENSRNOT00000020335
Protein Domains
Enoyl reductase (ER)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97584-F1-model_v2 AlphaFold P97584 1-329 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693766
Promoter ID:EPDNEW_R4291
Type:multiple initiation site
Description:prostaglandin reductase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0576,129,377 - 76,129,437EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621195 AgrOrtholog
BioCyc Gene G2FUF-41164 BioCyc
BioCyc Pathway PWY3DJ-11470 [sphingosine and sphingosine-1-phosphate metabolism] BioCyc
BioCyc Pathway Image PWY3DJ-11470 BioCyc
Ensembl Genes ENSRNOG00000015072 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020335 ENTREZGENE
  ENSRNOT00000020335.7 UniProtKB/TrEMBL
Gene3D-CATH Medium-chain alcohol dehydrogenases, catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ADH-like_C UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  ADH_N_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GroES-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MDR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKS_ER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTGR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:192227 UniProtKB/Swiss-Prot
  PTHR43205 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ADH_N_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADH_zinc_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ptgr1 PhenoGen
RatGTEx ENSRNOG00000015072 RatGTEx
SMART PKS_ER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50129 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P97584 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q5EBD3 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Ptgr1  prostaglandin reductase 1  Ltb4dh  leukotriene B4 12-hydroxydehydrogenase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ltb4dh  leukotriene B4 12-hydroxydehydrogenase  Dig1  dithiolethione-inducible gene-1  Symbol and Name updated 1299863 APPROVED
2002-08-07 Dig1  dithiolethione-inducible gene-1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation greatly induced in liver by 1,2-dithiole-3-thione (D3T) 632607