Pole3 (DNA polymerase epsilon 3, accessory subunit)

Gene: Pole3 (DNA polymerase epsilon 3, accessory subunit) Rattus norvegicus

Analyze

Symbol:

Pole3

Name:

DNA polymerase epsilon 3, accessory subunit

RGD ID:

1359475

Description:

Predicted to enable chromatin DNA binding activity. Predicted to be involved in several processes, including chromatin remodeling; leading strand elongation; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in nucleus. Predicted to be part of chromosome. Orthologous to human POLE3 (DNA polymerase epsilon 3, accessory subunit); PARTICIPATES IN ISWI family mediated chromatin remodeling pathway; nucleotide excision repair pathway; RNA polymerase II transcription initiation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

DNA polymerase epsilon subunit 3; DNA polymerase epsilon subunit p17; DNA polymerase II subunit 3; DNA-directed DNA polymerase epsilon 3; MGC94182; MGC94830; polymerase (DNA directed), epsilon 3 (p17 subunit); polymerase (DNA directed), epsilon 3, accessory subunit; polymerase (DNA) epsilon 3, accessory subunit; similar to DNA polymerase epsilon p17 subunit (DNA polymerase epsilon subunit 3) (Chromatin accessibility complex 17) (HuCHRAC17) (CHRAC-17)

RGD Orthologs

Alliance Genes

More Info

more info ...

Related Pseudogenes:

Pole3-ps3

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	80,989,508 - 80,992,742 (-)	NCBI		GRCr8
mRatBN7.2	5	75,973,941 - 75,977,175 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	75,974,717 - 75,977,231 (-)	Ensembl		mRatBN7.2 Ensembl
mRatBN7.2 Ensembl	7	109,236,321 - 109,236,758 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	78,373,292 - 78,376,528 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	80,190,389 - 80,193,625 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	80,165,904 - 80,169,140 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	78,380,813 - 78,384,047 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	78,380,816 - 78,384,047 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	82,500,184 - 82,503,419 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	79,517,590 - 79,520,825 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	79,522,705 - 79,525,938 (-)	NCBI
Celera	5	74,915,292 - 74,918,526 (-)	NCBI		Celera
Cytogenetic Map	5	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

4,4'-diaminodiphenylmethane (ISO)

4-(ethoxymethylene)-2-phenyloxazol-5-one (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

amitrole (EXP)

antimycin A (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (ISO)

cannabidiol (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

choline (ISO)

clotrimazole (EXP)

copper(II) sulfate (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

deguelin (ISO)

diclofenac (ISO)

disodium selenite (ISO)

doxorubicin (ISO)

Enterolactone (ISO)

fenpyroximate (ISO)

finasteride (EXP)

fipronil (EXP)

flutamide (EXP)

folic acid (ISO)

FR900359 (ISO)

gentamycin (EXP)

ivermectin (ISO)

L-methionine (ISO)

leflunomide (ISO)

N-nitrosodiethylamine (EXP)

nimesulide (EXP)

ozone (ISO)

paracetamol (ISO)

phenobarbital (EXP)

pirinixic acid (EXP,ISO)

piroxicam (ISO)

potassium chromate (ISO)

pyrimidifen (ISO)

rotenone (ISO)

sodium dichromate (EXP)

sulfadimethoxine (EXP)

tebufenpyrad (ISO)

topotecan (EXP)

trimellitic anhydride (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

chromatin remodeling (ISO)

DNA damage response (IBA,IEA)

DNA-templated DNA replication (ISO)

heterochromatin formation (IBA,IEA)

leading strand elongation (IBA,IEA)

negative regulation of transcription by RNA polymerase II (ISO)

nucleosome assembly (ISO)

regulation of DNA replication (ISO)

Cellular Component

ATAC complex (ISO)

CHRAC (IBA,IEA)

epsilon DNA polymerase complex (IBA,IEA,ISO,ISS)

pericentric heterochromatin (ISO)

Molecular Function

chromatin DNA binding (IBA,IEA)

protein binding (ISO)

protein heterodimerization activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

base excision repair pathway (IEA)

DNA replication pathway (IEA)

ISWI family mediated chromatin remodeling pathway (ISO)

nucleotide excision repair pathway (IEA,ISO)

purine metabolic pathway (IEA)

pyrimidine metabolic pathway (IEA)

RNA polymerase II transcription initiation pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ATP-dependent chromatin remodeling: genetics, genomics and mechanisms.	Hargreaves DC and Crabtree GR, Cell Res. 2011 Mar;21(3):396-420. doi: 10.1038/cr.2011.32. Epub 2011 Mar 1.
3.	Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon.	Li Y, etal., J Biol Chem 2000 Jul 28;275(30):23247-52.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	DNA polymerase epsilon - more than a polymerase.	Pospiech H and Syvaoja JE, ScientificWorldJournal. 2003 Mar 24;3:87-104.
7.	GOA pipeline	RGD automated data pipeline
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Comprehensive gene review and curation	RGD comprehensive gene curation
10.	ATAC-king the complexity of SAGA during evolution.	Spedale G, etal., Genes Dev. 2012 Mar 15;26(6):527-41. doi: 10.1101/gad.184705.111.
11.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:15489334	PMID:18838386

Genomics

Comparative Map Data

Pole3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	80,989,508 - 80,992,742 (-)	NCBI		GRCr8
mRatBN7.2	5	75,973,941 - 75,977,175 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	75,974,717 - 75,977,231 (-)	Ensembl		mRatBN7.2 Ensembl
mRatBN7.2 Ensembl	7	109,236,321 - 109,236,758 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	78,373,292 - 78,376,528 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	80,190,389 - 80,193,625 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	80,165,904 - 80,169,140 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	78,380,813 - 78,384,047 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	78,380,816 - 78,384,047 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	82,500,184 - 82,503,419 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	79,517,590 - 79,520,825 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	79,522,705 - 79,525,938 (-)	NCBI
Celera	5	74,915,292 - 74,918,526 (-)	NCBI		Celera
Cytogenetic Map	5	q24	NCBI

POLE3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	113,407,235 - 113,410,749 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	113,407,235 - 113,410,675 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	116,169,515 - 116,173,029 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	115,209,342 - 115,212,773 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	113,249,074 - 113,252,506	NCBI
Celera	9	86,817,115 - 86,820,629 (-)	NCBI		Celera
Cytogenetic Map	9	q32	NCBI
HuRef	9	85,776,442 - 85,779,955 (-)	NCBI		HuRef
CHM1_1	9	116,316,144 - 116,319,658 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	125,606,053 - 125,609,566 (-)	NCBI		T2T-CHM13v2.0

Pole3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	62,440,889 - 62,443,305 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	62,440,886 - 62,443,305 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	62,523,798 - 62,525,014 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	62,522,649 - 62,525,068 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	62,184,832 - 62,186,048 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	62,010,159 - 62,011,375 (-)	NCBI		MGSCv36	mm8
Celera	4	61,191,011 - 61,192,227 (-)	NCBI		Celera
Cytogenetic Map	4	B3	NCBI
cM Map	4	33.17	NCBI

Pole3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955419	14,086,940 - 14,089,330 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955419	14,086,940 - 14,089,906 (+)	NCBI	ChiLan1.0	ChiLan1.0

POLE3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	25,962,959 - 25,966,434 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	25,965,670 - 25,968,781 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	84,509,237 - 84,512,651 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	112,879,325 - 112,883,051 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	112,879,047 - 112,882,951 (-)	Ensembl	panpan1.1		panPan2

POLE3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	67,757,779 - 67,760,417 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	67,758,918 - 67,760,374 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	66,162,467 - 66,165,109 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	68,882,601 - 68,884,601 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	68,881,948 - 68,884,589 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	67,400,021 - 67,402,671 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	67,430,940 - 67,433,593 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	68,167,899 - 68,170,545 (-)	NCBI		UU_Cfam_GSD_1.0

Pole3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	183,043,822 - 183,045,595 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936559	220,941 - 222,783 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

POLE3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	254,033,385 - 254,035,978 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	254,033,378 - 254,036,224 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	284,828,761 - 284,831,384 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

POLE3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	26,162,934 - 26,164,931 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	26,163,107 - 26,165,214 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666035	16,634,891 - 16,637,389 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pole3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	21,692,715 - 21,695,826 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624760	21,692,734 - 21,695,636 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pole3
16 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	316
Count of miRNA genes:	195
Interacting mature miRNAs:	242
Transcripts:	ENSRNOT00000020722
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331756	Rf34	Renal function QTL 34	4.16275		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	1	90450412	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	1	131345958	Rat
1331771	Rf35	Renal function QTL 35	4.36965		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	729470	86724018	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
7394712	Emca13	Estrogen-induced mammary cancer QTL 13			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	9823266	99753708	Rat
634305	Mamtr1	Mammary tumor resistance QTL 1		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	12789751	113558310	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	31663789	131345958	Rat
1598807	Glom12	Glomerulus QTL 12	2.7		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	5	33215665	78215665	Rat
1298067	Scl15	Serum cholesterol level QTL 15	4.8	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	33215665	78215665	Rat
1302786	Kidm8	Kidney mass QTL 8	28.15		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	5	33215665	78215665	Rat
1576317	Eutr2	Estrogen induced uterine response QTL 2		0.01	uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	34730116	104251008	Rat
2316959	Gluco59	Glucose level QTL 59	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	34944474	113558310	Rat
1641912	Alcrsp18	Alcohol response QTL 18			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	35189153	141643988	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	40128307	148607290	Rat
1331773	Scl26	Serum cholesterol level QTL 26	3.065		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	43726656	86724018	Rat
1331801	Rf33	Renal function QTL 33	4.149		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	43726656	129132602	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
1300115	Hrtrt7	Heart rate QTL 7	2.76		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	5	47869062	90099692	Rat
9589025	Epfw7	Epididymal fat weight QTL 7	20.66	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	5	49463600	94463600	Rat
7411561	Bw134	Body weight QTL 134	24	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	49463600	94463600	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	50328551	141643988	Rat
2303615	Vencon7	Ventilatory control QTL 7		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	5	50983895	95983895	Rat
2303574	Gluco42	Glucose level QTL 42	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	53496719	98496719	Rat
61359	Eaex	Experimental allergic encephalomyelitis QTL x	3		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	5	55715622	100715622	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55805606	132207589	Rat
1358895	Bp254	Blood pressure QTL 254	3.6	0.0003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	58829236	128034027	Rat
61426	Scl2	Serum cholesterol level QTL 2	7.3	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	59793399	143070159	Rat
2316954	Rf57	Renal function QTL 57	0		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	5	59793528	90450144	Rat
2316957	Pur21	Proteinuria QTL 21	6.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	5	59793528	113558156	Rat
61386	Bp49	Blood pressure QTL 49	16.6		cerebrum integrity trait (VT:0010549)	brain infarction volume (CMO:0001013)	5	60293434	98603051	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	60293434	161481680	Rat
2290005	Mcs24	Mammary carcinoma susceptibility QTL 24			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	64719390	109719390	Rat
2306971	Anxrr21	Anxiety related response QTL 21	9.47		fear/anxiety-related behavior trait (VT:1000241)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	5	66174080	124160948	Rat
2312671	Scl64	Serum cholesterol level QTL 64		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	68984307	104251008	Rat
61380	Edpm5	Estrogen-dependent pituitary mass QTL 5	4.5	0.92	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	5	68984307	104251008	Rat
1357396	Bw44	Body weight QTL 44	4.19		body mass (VT:0001259)	body weight (CMO:0000012)	5	68984307	104251008	Rat
1357402	Bw46	Body weight QTL 46	4.47		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	5	68984307	104251008	Rat
2302381	Bw84	Body weight QTL 84	4.47		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	5	68984307	104251008	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	69540295	151018848	Rat

Markers in Region

RH134463

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	75,974,842 - 75,975,309 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	78,381,715 - 78,382,181	NCBI	Rnor6.0
Rnor_5.0	5	82,501,087 - 82,501,553	UniSTS	Rnor5.0
RGSC_v3.4	5	79,518,493 - 79,518,959	UniSTS	RGSC3.4
Celera	5	74,916,194 - 74,916,660	UniSTS
RH 3.4 Map	5	559.0	UniSTS
Cytogenetic Map	5	q24	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	34	51	35	19	35		3	74	35	41	11
Low		9	6	6		6	8	8					8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001007652	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC099453	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC081988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC083800	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473978	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000112884 ⟹ ENSRNOP00000093308

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	75,974,717 - 75,977,231 (-)	Ensembl

RefSeq Acc Id:

NM_001007652 ⟹ NP_001007653

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	80,989,508 - 80,992,742 (-)	NCBI
mRatBN7.2	5	75,973,941 - 75,977,175 (-)	NCBI
Rnor_6.0	5	78,380,813 - 78,384,047 (-)	NCBI
Rnor_5.0	5	82,500,184 - 82,503,419 (-)	NCBI
RGSC_v3.4	5	79,517,590 - 79,520,825 (-)	RGD
Celera	5	74,915,292 - 74,918,526 (-)	RGD

Sequence:

show sequence

CCAAGCGGAGGCAATGGCGGAGAGGCCTGAGGACCTAAATCTGCCCAACGCCGTCATTACCAGG
ATCATCAAGGAGGCGCTACCGGACGGTGTCAACATCTCCAAGGAGGCCCGAAGCGCCATCTCCC
GCGCGGCCAGTGTTTTCGTTTTGTATGCCACATCCTGTGCCAATAACTTTGCAATGAAAGGAAA
GCGCAAGACTCTCAATGCCAGTGATGTACTGTCAGCCATGGAAGAGATGGAGTTCCAACGGTTC
GTAACGCCATTGAAAGAAGCGCTAGAAGCATACAGGCGGGAGCAGAAAGGCAAGAAGGAAGCCT
CAGAGCAAAAGAAGAAGGACAAAGACAAAAAAGATTGCGAAGAGCAGGACAAAAGCAGAGAGGA
GGAGGATGAAGATGAAGAAAGACTGGATGAGGAAGAACAGAACGAAGAGGAGGAGGTAGACAAC
TGACTGGAGAGAGTGGGCAGACTCTGACACGGTGGAAGGGACCCTCAGATACTGAGATGTGTTT
ATGTGAAGCCTCTCCCTGCAAGGCAGAGCCATCTTCCGCAACGGTGCCTGAGATCAAAATAAAA
ACTGACCAGAAAGATCAAAGCTAGCTAGCTCTTCCCAAACTCAGAGCGTCTGAGTTACAGAAAC
CAGCTTTGCTTCATCAGTCTGCAGGTTATGCCTTATTAGTGTAAGGGATTCCGAATGACTACAT
AGTTTGGTATTGCTTGTTTACTTAAAGTGTATAGCTAGCTAGTTTTTGATCCTATTTCCCTGCT
CCTCCAAAAAAGTAATAACATGTTTCTTGCTGCGTTCCAAGTTGCAGAGTTGCTAACCGGTCAG
GGGGAAATGGGGCTTGGACCATGGTCACCCTGTTTGACTGTACAGTAATTGACAATAGATATTA
ATGCTCAGAATGGTTGCTCTTTAGGAAATGACTAAAAAGCTGTGAGAGAATAAGGAAATCTCCT
CACTCGATGGTAGCATTGCTTGGCTTCTGGCTTTCTACACTTAGCTTTGTAGTCCTGTAGTGAC
TGTAGATGCCCAGTGCTCTGGTGTGGCTCCACTCCTAAGACATATACTCTTAAATTCTGAGTGT
TGGTTAGAATCTGTCAAAAAAGGGTGCCAACTCCCCACCCCCACCCCCCCAGAGATGAGGATTG
AACTCAGGGCCTTGCTAGGCAAGCGCTCAACCACTGAGCTAAATCCTCAACCCCAAGGGTGCCA
ATTCTTAAAAGCAGGTGGCTTAAACTTGGCGGTAACTCAGTGCCTGCCACTGTAGAACCTAGTG
CCACCTCTTGGAAGGTATAAAATCCCAGATTGTCTCTTCTCTAGTCCACCTCTCAGATGATGGC
TGCTGCTTTTTATCCCCTGAACTCATAGCAAGTTCCAGAGACTTTATCTCCTCCAGGCACAGCC
TTTCTGTCTCCATCTCTCCCGCCTCTGCTTCCCAGCCCTGCTTTCTCCTCCTCTTATTCATTTC
ATCTTCTAGTCTAGGGACTCTGATAAAGTGCAAGGTCCTCAGATTGTTTCCTCATCTCCTGTCT
TTTAAAGAGACTTGAGAAGCACCTCTGACCCTGAAGGTGAGAGAAACGGTGCTCAGGAATGTGG
CACCACTGCTGCAGCTTTGAGCGTGCCTGTTGGCCTTTCTTTTCCCCATTTAGTGCTCCAAGCA
CTTTCTCTGTCTTAGTTGTGCACATGAGGCTGACAGGTAATGTAATATAGTTGAACACTGTTAA
CTAGTCAGGGAAATACAGGGAAGAGTTTGTTGAAAGTGACTGGAGACTGTTGAGAAGATTTTAA
TGCTTTCTACAAATAAATTCTTGTTTAAATGATGACCCACACAATGTACTTTTGGAAAGGACTC
ACCAAGACACCCCTCTTTTACCCCCTAACCTCAGCACACATACAGAGTCCTGTGTCTTCTTGGG
TTACCAGCAGGTGAATAAGTAATCACAATTTAAGGGCACTGCTCTTCCTGAGATTCTCCTGGTT
ACTTTGTATATCTCACTAGCTCCCACTTCCTAAGCTCTTCCAGTGTCTAGCATTGTTCTAAGTG
CTTTCAAGTATCAATTCCTATCCATAGATGTTGCCTCTATTAGCTCTCAACCACAGCTCTGTAT
CTCCAGTACACACAGTTCTCAAGTCATATTCACAAAGAACCCCAGTGGTCCTTTGGTTTATAGG
CTTTTTCCTTCACAGCAGAAACATTGTTTAATTCCCATAAGCACAGTGCTAGACCTACTCAAGT
CCCATTTATAATCCTGTGATTTCCTTTGAACTCAGTTTCAAATGTATAACTATATGCCAAGTAG
ATCTTCCTAGAATATACCTTTGCTTTCAGTGAGATCAAATCCATAGTTAAACCTGTTATTCAAG
GCTTGTGTAAGAAGGGCTTACCCTACCATCTAATCTCCACTCTAAGGCTGTCAAGAATTGGAAG
GGGCTCAGTCACAGAGCACTTGCCTAGCATGTTCAAACAAAACAAAAACCAAACTCTTCCATGT
CTCGGGTTTGTCCTGCCCAATCGCTTAACTATAACATTCTAAGAGAAACCTTTTCTGGGAATGG
AGGTTTGGATTTAAAAGTAAAGAATTCAACATCTGGAAAAAAAAAAAAAAAAAAAAAAAAAAAA
A

hide sequence

Protein Sequences


Protein RefSeqs	NP_001007653	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH81988	(Get FASTA)	NCBI Sequence Viewer
	AAH83800	(Get FASTA)	NCBI Sequence Viewer
	EDM10547	(Get FASTA)	NCBI Sequence Viewer
	EDM10548	(Get FASTA)	NCBI Sequence Viewer
	EDM10549	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000006416.1
	ENSRNOP00000093308
	ENSRNOP00000093308.1
	ENSRNOP00055046433
	ENSRNOP00060044186
	ENSRNOP00065047350
GenBank Protein	Q642A5	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001007653 ⟸ NM_001007652
- UniProtKB:	Q642A5 (UniProtKB/Swiss-Prot), A6J7V8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAERPEDLNLPNAVITRIIKEALPDGVNISKEARSAISRAASVFVLYATSCANNFAMKGKRKTL NASDVLSAMEEMEFQRFVTPLKEALEAYRREQKGKKEASEQKKKDKDKKDCEEQDKSREEEDED EERLDEEEQNEEEEVDN hide sequence

RefSeq Acc Id:

ENSRNOP00000093308 ⟸ ENSRNOT00000112884

Protein Domains

Transcription factor CBF/NF-Y/archaeal histone

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q642A5-F1-model_v2	AlphaFold	Q642A5	1-145	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693795

Promoter ID:

EPDNEW_R4318

Type:

initiation region

Name:

Pole3_1

Description:

DNA polymerase epsilon 3, accessory subunit

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	78,384,086 - 78,384,146	EPDNEW

RGD ID:

13693802

Promoter ID:

EPDNEW_R4320

Type:

multiple initiation site

Name:

AC099453_1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	78,393,110 - 78,393,170	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359475	AgrOrtholog
BioCyc Gene	G2FUF-41087	BioCyc
Ensembl Genes	ENSRNOG00000004843	Ensembl, UniProtKB/Swiss-Prot
	ENSRNOG00000055277	Ensembl
	ENSRNOG00000070688	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00055032562	UniProtKB/Swiss-Prot
	ENSRNOG00060030596	UniProtKB/Swiss-Prot
	ENSRNOG00065033454	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000006416.3	UniProtKB/Swiss-Prot
	ENSRNOT00000112884	ENTREZGENE
	ENSRNOT00000112884.1	UniProtKB/TrEMBL
	ENSRNOT00055056281	UniProtKB/Swiss-Prot
	ENSRNOT00060053138	UniProtKB/Swiss-Prot
	ENSRNOT00065057509	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.20.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7108773	IMAGE-MGC_LOAD
	IMAGE:7129121	IMAGE-MGC_LOAD
InterPro	CBFA_NFYB_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Histone-fold	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:100362333	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	rno:298098	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:94182	IMAGE-MGC_LOAD
	MGC:94830	IMAGE-MGC_LOAD
NCBI Gene	298098	ENTREZGENE
PANTHER	DNA POLYMERASE EPSILON SUBUNIT 3	UniProtKB/Swiss-Prot
	DNA POLYMERASE EPSILON SUBUNIT 3	UniProtKB/Swiss-Prot
	DNA POLYMERASE EPSILON SUBUNIT 3	UniProtKB/TrEMBL
	DNA POLYMERASE EPSILON SUBUNIT 3	UniProtKB/TrEMBL
Pfam	CBFD_NFYB_HMF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Pole3	PhenoGen
RatGTEx	ENSRNOG00000004843	RatGTEx
	ENSRNOG00000055277	RatGTEx
	ENSRNOG00000070688	RatGTEx
	ENSRNOG00055032562	RatGTEx
	ENSRNOG00060030596	RatGTEx
	ENSRNOG00065033454	RatGTEx
Superfamily-SCOP	SSF47113	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6AK16_RAT	UniProtKB/TrEMBL
	A6J7V8	ENTREZGENE, UniProtKB/TrEMBL
	A6J7W0_RAT	UniProtKB/TrEMBL
	DPOE3_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-07-21	Pole3	DNA polymerase epsilon 3, accessory subunit	Pole3	polymerase (DNA) epsilon 3, accessory subunit	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-03-09	Pole3	polymerase (DNA) epsilon 3, accessory subunit	Pole3	polymerase (DNA directed), epsilon 3, accessory subunit	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-10-10	Pole3	polymerase (DNA directed), epsilon 3, accessory subunit	Pole3	polymerase (DNA directed), epsilon 3 (p17 subunit)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Pole3	polymerase (DNA directed), epsilon 3 (p17 subunit)	MGC94182	similar to DNA polymerase epsilon p17 subunit (DNA polymerase epsilon subunit 3) (Chromatin accessibility complex 17) (HuCHRAC17) (CHRAC-17)	Symbol and Name updated	1299863	APPROVED
2005-07-29	MGC94182	similar to DNA polymerase epsilon p17 subunit (DNA polymerase epsilon subunit 3) (Chromatin accessibility complex 17) (HuCHRAC17) (CHRAC-17)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)