Pappa (pappalysin) - Rat Genome Database

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Gene: Pappa (pappalysin) Rattus norvegicus
Analyze
Symbol: Pappa
Name: pappalysin
RGD ID: 1307742
Description: Predicted to enable metalloendopeptidase activity. Involved in several processes, including female pregnancy; response to dexamethasone; and response to follicle-stimulating hormone. Located in extracellular space. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human PAPPA (pappalysin 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC313262; Pappa1; pappalysin 1; pappalysin-1; pregnancy-associated plasma protein A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2578,497,660 - 78,735,873 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl578,498,300 - 78,730,666 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx580,896,842 - 81,127,185 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0582,714,097 - 82,944,461 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0582,689,523 - 82,919,890 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0580,919,932 - 81,153,904 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl580,920,568 - 81,150,940 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0585,016,666 - 85,250,825 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4581,826,649 - 82,096,446 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1581,831,223 - 82,101,515 (+)NCBI
Celera577,424,809 - 77,652,094 (+)NCBICelera
Cytogenetic Map5q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,4-dichloroaniline  (ISO)
3-chloropropane-1,2-diol  (EXP)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
formaldehyde  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
gentamycin  (EXP)
levonorgestrel  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
N(6)-methyladenosine  (ISO)
naphthalene  (ISO)
Octicizer  (ISO)
ozone  (ISO)
paracetamol  (EXP)
phenethyl isothiocyanate  (ISO)
phenylmercury acetate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
testosterone undecanoate  (ISO)
titanium dioxide  (ISO)
triadimefon  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Elevated pregnancy-associated plasma protein-a in sera from type 2 diabetic patients with hypercholesterolemia: associations with carotid atherosclerosis and toe-brachial index. Aso Y, etal., J Clin Endocrinol Metab. 2004 Nov;89(11):5713-7.
2. Serum plasma pregnancy-associated protein A: a potential marker of echogenic carotid atherosclerotic plaques in asymptomatic hyperlipidemic subjects at high cardiovascular risk. Beaudeux JL, etal., Arterioscler Thromb Vasc Biol. 2003 Jan 1;23(1):e7-10.
3. Relationship among pregnancy associated plasma protein-A levels, clinical characteristics, and coronary artery disease extent in patients with chronic stable angina pectoris. Cosin-Sales J, etal., Eur Heart J. 2005 Oct;26(20):2093-8. Epub 2005 Jul 29.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Immunolocalization and biochemical evidence of pregnancy-associated plasma protein A in the intervertebral disc. Gruber HE, etal., Spine (Phila Pa 1976). 2008 Jun 15;33(14):E447-54. doi: 10.1097/BRS.0b013e318178e642.
7. Genetic deletion of pregnancy-associated plasma protein-A is associated with resistance to atherosclerotic lesion development in apolipoprotein E-deficient mice challenged with a high-fat diet. Harrington SC, etal., Circ Res. 2007 Jun 22;100(12):1696-702. Epub 2007 May 17.
8. Pregnancy-associated plasma protein-A proteolytic activity in rat vertebral cell cultures: stimulation by dexamethasone--a potential mechanism for glucocorticoid regulation of osteoprogenitor proliferation and differentiation. Jia D and Heersche JN, J Cell Physiol. 2005 Sep;204(3):848-58.
9. Pregnancy-associated plasma protein-a production in rat granulosa cells: stimulation by follicle-stimulating hormone and inhibition by the oocyte-derived bone morphogenetic protein-15. Matsui M, etal., Endocrinology. 2004 Aug;145(8):3686-95. Epub 2004 Apr 15.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Increased pregnancy-associated plasma protein-A as a marker for peripheral atherosclerosis: results from the Linz Peripheral Arterial Disease Study. Mueller T, etal., Clin Chem. 2006 Jun;52(6):1096-103. Epub 2006 Apr 13.
12. Genetic polymorphism in the pregnancy-associated plasma protein-A associated with acute myocardial infarction. Park S, etal., Coron Artery Dis. 2007 Sep;18(6):417-22.
13. Serum levels of human placental lactogen, pregnancy-associated plasma protein A and endometrial secretory protein PP14 in first trimester of diabetic pregnancy. Pedersen JF, etal., Acta Obstet Gynecol Scand. 1998 Feb;77(2):155-8.
14. Pregnancy-associated plasma protein-a levels are related to glycemic control but not to lipid profile or hemostatic parameters in type 2 diabetes. Pellitero S, etal., Diabetes Care. 2007 Dec;30(12):3083-5. Epub 2007 Aug 29.
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Increased levels of pregnancy-associated plasma protein-A in patients with hypercholesterolemia: the effect of atorvastatin treatment. Stulc T, etal., Am Heart J. 2003 Dec;146(6):E21.
18. Detection and immunohistochemical localization of alpha 1-pregnancy-associated protein (alpha 1-PAP) in rats. Waites GT, etal., Immunology. 1986 Jun;58(2):303-9.
19. Decreased first trimester PAPP-A is a predictor of adverse pregnancy outcome. Yaron Y, etal., Prenat Diagn. 2002 Sep;22(9):778-82.
Additional References at PubMed
PMID:10077652   PMID:11513734   PMID:11985604   PMID:22204188   PMID:23169786   PMID:24006456   PMID:27537370   PMID:34906040  


Genomics

Comparative Map Data
Pappa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2578,497,660 - 78,735,873 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl578,498,300 - 78,730,666 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx580,896,842 - 81,127,185 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0582,714,097 - 82,944,461 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0582,689,523 - 82,919,890 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0580,919,932 - 81,153,904 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl580,920,568 - 81,150,940 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0585,016,666 - 85,250,825 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4581,826,649 - 82,096,446 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1581,831,223 - 82,101,515 (+)NCBI
Celera577,424,809 - 77,652,094 (+)NCBICelera
Cytogenetic Map5q24NCBI
PAPPA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389116,153,791 - 116,402,321 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9116,153,791 - 116,402,321 (+)EnsemblGRCh38hg38GRCh38
GRCh379118,916,070 - 119,164,600 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369117,955,892 - 118,204,421 (+)NCBINCBI36Build 36hg18NCBI36
Build 349115,995,624 - 116,244,153NCBI
Celera989,563,743 - 89,812,291 (+)NCBICelera
Cytogenetic Map9q33.1NCBI
HuRef988,522,043 - 88,770,156 (+)NCBIHuRef
CHM1_19119,062,528 - 119,311,011 (+)NCBICHM1_1
T2T-CHM13v2.09128,346,843 - 128,595,327 (+)NCBIT2T-CHM13v2.0
Pappa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39465,041,993 - 65,276,776 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl465,042,411 - 65,275,746 (+)EnsemblGRCm39 Ensembl
GRCm38465,124,174 - 65,357,509 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl465,124,174 - 65,357,509 (+)EnsemblGRCm38mm10GRCm38
MGSCv37464,785,208 - 65,018,543 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36464,610,535 - 64,843,870 (+)NCBIMGSCv36mm8
Celera463,757,793 - 63,990,719 (+)NCBICelera
Cytogenetic Map4C1NCBI
cM Map434.14NCBI
Pappa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541911,420,638 - 11,646,145 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541911,415,666 - 11,645,994 (-)NCBIChiLan1.0ChiLan1.0
PAPPA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1922,944,917 - 23,192,972 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0987,287,289 - 87,535,414 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19115,671,212 - 115,889,135 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9115,671,212 - 115,883,435 (+)Ensemblpanpan1.1panPan2
PAPPA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11169,979,295 - 70,220,256 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1169,982,268 - 70,219,550 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1168,392,497 - 68,629,030 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01171,108,595 - 71,345,430 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1171,107,725 - 71,343,011 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11169,628,797 - 69,865,662 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01169,664,343 - 69,901,964 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01170,393,453 - 70,630,160 (+)NCBIUU_Cfam_GSD_1.0
Pappa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947185,275,435 - 185,613,104 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364875,144,044 - 5,376,367 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364875,000,279 - 5,379,786 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAPPA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1256,544,928 - 256,780,760 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11256,544,496 - 256,784,813 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21287,904,036 - 288,142,436 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PAPPA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11223,182,856 - 23,427,092 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1223,184,704 - 23,427,165 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603519,450,870 - 19,695,969 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pappa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476018,848,021 - 19,078,657 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476018,842,353 - 19,078,657 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pappa
1166 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:165
Count of miRNA genes:120
Interacting mature miRNAs:144
Transcripts:ENSRNOT00000040898
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)55979352890450144Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)568984307104251008Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1598845Mcs14Mammary carcinoma susceptibility QTL 140.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)57636977680813390Rat

Markers in Region
RH139343  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2578,723,105 - 78,723,237 (+)MAPPERmRatBN7.2
Rnor_6.0581,144,580 - 81,144,711NCBIRnor6.0
Rnor_5.0585,241,510 - 85,241,641UniSTSRnor5.0
RGSC_v3.4582,090,073 - 82,090,204UniSTSRGSC3.4
Celera577,645,706 - 77,645,837UniSTS
RH 3.4 Map3946.9UniSTS
Cytogenetic Map5q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 2 1
Low 2 25 21 8 14 8 5 5 68 27 34 10 5
Below cutoff 1 18 17 14 5 14 3 5 6 5 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000040898   ⟹   ENSRNOP00000046248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl580,920,621 - 81,150,940 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076111   ⟹   ENSRNOP00000068120
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl578,498,949 - 78,729,466 (+)Ensembl
Rnor_6.0 Ensembl580,920,568 - 81,150,929 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076467   ⟹   ENSRNOP00000068419
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl578,498,300 - 78,730,666 (+)Ensembl
Rnor_6.0 Ensembl580,920,568 - 81,150,929 (+)Ensembl
RefSeq Acc Id: NM_001401319   ⟹   NP_001388248
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2578,497,863 - 78,735,870 (+)NCBI
RefSeq Acc Id: XM_039109883   ⟹   XP_038965811
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2578,497,660 - 78,735,873 (+)NCBI
RefSeq Acc Id: XM_039109884   ⟹   XP_038965812
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2578,563,829 - 78,735,873 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001388248 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965811 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965812 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM10508 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068120
  ENSRNOP00000068120.1
  ENSRNOP00000068419
  ENSRNOP00000068419.2
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000046248   ⟸   ENSRNOT00000040898
RefSeq Acc Id: ENSRNOP00000068120   ⟸   ENSRNOT00000076111
RefSeq Acc Id: ENSRNOP00000068419   ⟸   ENSRNOT00000076467
RefSeq Acc Id: XP_038965811   ⟸   XM_039109883
- Peptide Label: isoform X1
- UniProtKB: A0A096MJG5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965812   ⟸   XM_039109884
- Peptide Label: isoform X3
RefSeq Acc Id: NP_001388248   ⟸   NM_001401319
- Peptide Label: precursor
- UniProtKB: A0A096MK86 (UniProtKB/TrEMBL)
Protein Domains
Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A096MJG5-F1-model_v2 AlphaFold A0A096MJG5 1-1502 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693811
Promoter ID:EPDNEW_R4330
Type:single initiation site
Name:Pappa1_1
Description:pappalysin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0580,920,555 - 80,920,615EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307742 AgrOrtholog
BioCyc Gene G2FUF-41040 BioCyc
Ensembl Genes ENSRNOG00000033527 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000076111 ENTREZGENE
  ENSRNOT00000076111.3 UniProtKB/TrEMBL
  ENSRNOT00000076467 ENTREZGENE
  ENSRNOT00000076467.3 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/TrEMBL
  3.30.300.320 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/TrEMBL
InterPro ConA-like_subgrp UniProtKB/TrEMBL
  LamG-like UniProtKB/TrEMBL
  MetalloPept_cat_dom UniProtKB/TrEMBL
  Myxo_disulph_rpt UniProtKB/TrEMBL
  Notch_dom UniProtKB/TrEMBL
  PAPPA/PAPPA2 UniProtKB/TrEMBL
  Peptidase_M43 UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/TrEMBL
  Sushi_SCR_CCP UniProtKB/TrEMBL
NCBI Gene 313262 ENTREZGENE
PANTHER PTHR46130 UniProtKB/TrEMBL
  PTHR46130:SF2 UniProtKB/TrEMBL
Pfam Laminin_G_3 UniProtKB/TrEMBL
  Peptidase_M43 UniProtKB/TrEMBL
  Sushi UniProtKB/TrEMBL
PhenoGen Pappa PhenoGen
PROSITE SUSHI UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033527 RatGTEx
SMART CCP UniProtKB/TrEMBL
  LamGL UniProtKB/TrEMBL
  SM00004 UniProtKB/TrEMBL
Superfamily-SCOP Complement_control_module UniProtKB/TrEMBL
  ConA_like_lec_gl UniProtKB/TrEMBL
  Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
UniProt A0A096MJG5 ENTREZGENE, UniProtKB/TrEMBL
  A0A096MK86 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-09-30 Pappa  pappalysin  Pappa1  pappalysin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-03-27 Pappa1  pappalysin 1  Pappa  pregnancy-associated plasma protein A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Pappa  pregnancy-associated plasma protein A   Pappa_predicted  pregnancy-associated plasma protein A (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Pappa_predicted  pregnancy-associated plasma protein A (predicted)      Symbol and Name status set to approved 70820 APPROVED