Grin3a (glutamate ionotropic receptor NMDA type subunit 3A) - Rat Genome Database

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Gene: Grin3a (glutamate ionotropic receptor NMDA type subunit 3A) Rattus norvegicus
Analyze
Symbol: Grin3a
Name: glutamate ionotropic receptor NMDA type subunit 3A
RGD ID: 621704
Description: Enables glycine binding activity; ionotropic glutamate receptor activity; and protein phosphatase 2A binding activity. Contributes to NMDA glutamate receptor activity. Involved in several processes, including calcium ion transport; ionotropic glutamate receptor signaling pathway; and negative regulation of dendritic spine development. Located in cytoplasm and postsynaptic membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human GRIN3A (glutamate ionotropic receptor NMDA type subunit 3A); PARTICIPATES IN excitatory synaptic transmission pathway; alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chi-1; GluN3A; glutamate [NMDA] receptor subunit 3A; glutamate receptor chi-1; glutamate receptor ionotropic, NMDA 3A; glutamate receptor, ionotropic, N-methyl-D-aspartate 3A; N-methyl-D-aspartate receptor subtype 3A; NMDAR-L; NMDAR-L1; NMDAR3A; NR3; NR3 ,chi-1; NR3 chi-1; NR3A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2564,006,847 - 64,206,408 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl564,009,980 - 64,206,085 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx565,943,276 - 66,142,503 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0567,762,618 - 67,961,860 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0567,731,985 - 67,931,195 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0564,928,620 - 65,073,012 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl564,928,620 - 65,073,012 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0569,420,058 - 69,564,696 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4566,406,451 - 66,602,353 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1566,411,563 - 66,607,247 (-)NCBI
Celera563,404,358 - 63,599,048 (+)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
excitatory synaptic transmission pathway  (IDA)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
glutamate signaling pathway  (IEA)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
methadone pharmacokinetics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Cloning and characterization of chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family. Ciabarra AM, etal., J Neurosci 1995 Oct;15(10):6498-508.
2. The NMDAR subunit NR3A interacts with microtubule-associated protein 1S in the brain. Eriksson M, etal., Biochem Biophys Res Commun. 2007 Sep 14;361(1):127-32. Epub 2007 Jul 16.
3. GluN3A expression restricts spine maturation via inhibition of GIT1/Rac1 signaling. Fiuza M, etal., Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20807-12. doi: 10.1073/pnas.1312211110. Epub 2013 Dec 2.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Prenatal development of NMDA receptor composition and function in trigeminal neurons. Ishihama K, etal., Arch Histol Cytol. 2005 Dec;68(4):321-35.
6. Molecular interaction of NMDA receptor subunit NR3A with protein phosphatase 2A. Ma OK and Sucher NJ, Neuroreport. 2004 Jun 28;15(9):1447-50.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1. Pérez-Otaño I, etal., Nat Neurosci. 2006 May;9(5):611-21. doi: 10.1038/nn1680. Epub 2006 Apr 16.
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Developmental and regional expression pattern of a novel NMDA receptor-like subunit (NMDAR-L) in the rodent brain. Sucher NJ, etal., J Neurosci 1995 Oct;15(10):6509-20.
15. Identification of a long variant of mRNA encoding the NR3 subunit of the NMDA receptor: its regional distribution and developmental expression in the rat brain. Sun L, etal., FEBS Lett 1998 Dec 28;441(3):392-6.
16. NR3A modulates the outer vestibule of the "NMDA" receptor channel. Wada A, etal., J Neurosci. 2006 Dec 20;26(51):13156-66.
Additional References at PubMed
PMID:8889548   PMID:9620802   PMID:11160393   PMID:11588171   PMID:11929923   PMID:12391275   PMID:14499953   PMID:14507892   PMID:14760703   PMID:15866554   PMID:17320117   PMID:17502428  
PMID:17997397   PMID:18445116   PMID:19361480   PMID:19452450   PMID:20813147   PMID:21697368   PMID:21697378   PMID:22870318   PMID:23285183   PMID:23883441   PMID:23972471   PMID:24183704  
PMID:24663672   PMID:25144876   PMID:25231980   PMID:31444392   PMID:32393578   PMID:35475675  


Genomics

Comparative Map Data
Grin3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2564,006,847 - 64,206,408 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl564,009,980 - 64,206,085 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx565,943,276 - 66,142,503 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0567,762,618 - 67,961,860 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0567,731,985 - 67,931,195 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0564,928,620 - 65,073,012 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl564,928,620 - 65,073,012 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0569,420,058 - 69,564,696 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4566,406,451 - 66,602,353 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1566,411,563 - 66,607,247 (-)NCBI
Celera563,404,358 - 63,599,048 (+)NCBICelera
Cytogenetic Map5q22NCBI
GRIN3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389101,569,352 - 101,738,647 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9101,569,352 - 101,738,647 (-)EnsemblGRCh38hg38GRCh38
GRCh379104,331,634 - 104,500,929 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369103,371,456 - 103,540,683 (-)NCBINCBI36Build 36hg18NCBI36
Build 349101,411,189 - 101,580,417NCBI
Celera974,845,889 - 75,014,334 (-)NCBICelera
Cytogenetic Map9q31.1NCBI
HuRef973,932,382 - 74,100,688 (-)NCBIHuRef
CHM1_19104,478,039 - 104,647,164 (-)NCBICHM1_1
T2T-CHM13v2.09113,744,124 - 113,912,649 (-)NCBIT2T-CHM13v2.0
Grin3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39449,661,611 - 49,846,023 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl449,661,611 - 49,845,744 (-)EnsemblGRCm39 Ensembl
GRCm38449,661,611 - 49,846,023 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl449,661,611 - 49,845,744 (-)EnsemblGRCm38mm10GRCm38
MGSCv37449,678,098 - 49,857,953 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera449,693,525 - 49,874,264 (-)NCBICelera
Cytogenetic Map4B1NCBI
cM Map426.72NCBI
Grin3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541924,104,820 - 24,273,113 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541924,105,360 - 24,272,533 (+)NCBIChiLan1.0ChiLan1.0
GRIN3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1937,630,856 - 37,800,076 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0972,773,866 - 72,943,790 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19100,767,715 - 100,936,352 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9100,767,715 - 100,941,323 (-)Ensemblpanpan1.1panPan2
GRIN3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11158,271,808 - 58,421,887 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1158,273,377 - 58,421,761 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1156,716,312 - 56,866,073 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01159,411,203 - 59,557,777 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1159,411,203 - 59,557,626 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11157,917,161 - 58,067,281 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01157,930,109 - 58,080,617 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01158,627,851 - 58,778,332 (-)NCBIUU_Cfam_GSD_1.0
Grin3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947173,173,201 - 173,337,402 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365249,720,767 - 9,885,120 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365249,720,777 - 9,884,984 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIN3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1243,259,495 - 243,415,590 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11243,263,202 - 243,416,739 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21271,873,962 - 272,030,759 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRIN3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11237,700,311 - 37,865,390 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1237,701,039 - 37,867,041 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660354,693,852 - 4,858,752 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grin3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247589,579,752 - 9,756,525 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247589,579,750 - 9,756,396 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Grin3a
1036 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:144
Count of miRNA genes:110
Interacting mature miRNAs:128
Transcripts:ENSRNOT00000007957
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)53518915368564008Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)55979352890450144Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1598814Mcs13Mammary carcinoma susceptibility QTL 130.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)56319089069927503Rat

Markers in Region
D5Rat140  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2564,168,599 - 64,168,813 (+)MAPPERmRatBN7.2
mRatBN7.2564,168,538 - 64,168,813 (+)MAPPERmRatBN7.2
Rnor_6.0565,089,516 - 65,089,791NCBIRnor6.0
Rnor_6.0565,089,575 - 65,089,791NCBIRnor6.0
Rnor_5.0569,578,856 - 69,579,072UniSTSRnor5.0
Rnor_5.0569,578,797 - 69,579,072UniSTSRnor5.0
RGSC_v3.4566,564,857 - 66,565,073UniSTSRGSC3.4
RGSC_v3.4566,564,798 - 66,565,073RGDRGSC3.4
RGSC_v3.4566,564,799 - 66,565,073UniSTSRGSC3.4
RGSC_v3.1566,569,911 - 66,570,186RGD
Celera563,440,142 - 63,440,422UniSTS
Celera563,440,142 - 63,440,364UniSTS
SHRSP x BN Map538.7199RGD
SHRSP x BN Map538.7199UniSTS
AW530893  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2564,026,970 - 64,027,396 (+)MAPPERmRatBN7.2
Rnor_6.0564,945,651 - 64,946,076NCBIRnor6.0
Rnor_5.0569,437,089 - 69,437,514UniSTSRnor5.0
RGSC_v3.4566,423,442 - 66,423,867UniSTSRGSC3.4
Celera563,581,627 - 63,582,052UniSTS
RH 3.4 Map5434.7UniSTS
Cytogenetic Map5q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 38
Low 10 4 5 26 10 30 1 4
Below cutoff 1 24 10 2 9 2 4 6 6 10 9 10 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007957   ⟹   ENSRNOP00000007957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl564,009,980 - 64,206,085 (-)Ensembl
Rnor_6.0 Ensembl564,928,620 - 65,073,012 (-)Ensembl
RefSeq Acc Id: NM_001198583   ⟹   NP_001185512
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2564,009,980 - 64,206,085 (-)NCBI
Rnor_6.0564,928,620 - 65,073,012 (-)NCBI
Rnor_5.0569,420,058 - 69,564,696 (-)NCBI
Celera563,404,358 - 63,599,048 (+)NCBI
Sequence:
RefSeq Acc Id: NM_138546   ⟹   NP_612555
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2564,009,980 - 64,206,085 (-)NCBI
Rnor_6.0564,928,620 - 65,073,012 (-)NCBI
Rnor_5.0569,420,058 - 69,564,696 (-)NCBI
Celera563,404,358 - 63,599,048 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109241   ⟹   XP_038965169
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2564,006,847 - 64,206,408 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001185512   ⟸   NM_001198583
- Peptide Label: isoform 2 precursor
- UniProtKB: A6KJD4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_612555   ⟸   NM_138546
- Peptide Label: isoform 1 precursor
- UniProtKB: Q63268 (UniProtKB/Swiss-Prot),   Q62800 (UniProtKB/Swiss-Prot),   O09155 (UniProtKB/Swiss-Prot),   O09098 (UniProtKB/Swiss-Prot),   Q9Z2H0 (UniProtKB/Swiss-Prot),   Q9R1M7 (UniProtKB/Swiss-Prot),   A6KJD3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007957   ⟸   ENSRNOT00000007957
RefSeq Acc Id: XP_038965169   ⟸   XM_039109241
- Peptide Label: isoform X1
Protein Domains
Ionotropic glutamate receptor C-terminal   Ionotropic glutamate receptor L-glutamate and

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R1M7-F1-model_v2 AlphaFold Q9R1M7 1-1135 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621704 AgrOrtholog
BioCyc Gene G2FUF-41323 BioCyc
Ensembl Genes ENSRNOG00000005723 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007957 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.2300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Periplasmic binding protein-like II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glu/Gly-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iono_rcpt_met UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ionotropic_Glu_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iontro_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:191573 UniProtKB/Swiss-Prot
NCBI Gene 191573 ENTREZGENE
PANTHER GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IONOTROPIC GLUTAMATE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grin3a PhenoGen
PRINTS NMDARECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005723 RatGTEx
SMART Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PBPe UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Periplasmic binding protein-like II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A096MIS4_RAT UniProtKB/TrEMBL
  A6KJD3 ENTREZGENE, UniProtKB/TrEMBL
  A6KJD4 ENTREZGENE, UniProtKB/TrEMBL
  NMD3A_RAT UniProtKB/Swiss-Prot
  O09098 ENTREZGENE
  O09155 ENTREZGENE
  Q62800 ENTREZGENE
  Q63268 ENTREZGENE
  Q9R1M7 ENTREZGENE
  Q9Z2H0 ENTREZGENE
UniProt Secondary O09098 UniProtKB/Swiss-Prot
  O09155 UniProtKB/Swiss-Prot
  Q62800 UniProtKB/Swiss-Prot
  Q63268 UniProtKB/Swiss-Prot
  Q9Z2H0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Grin3a  glutamate ionotropic receptor NMDA type subunit 3A  Grin3a  glutamate receptor, ionotropic, N-methyl-D-aspartate 3A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Grin3a  glutamate receptor, ionotropic, N-methyl-D-aspartate 3A      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Grin3a  glutamate receptor, ionotropic, N-methyl-D-aspartate 3A      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the spinal cord, brainstem, hypothalamus, thalamus, CA1 field of the hippocampus, and amygdala 632839