Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Sec61b | Rat | (1->4)-beta-D-glucan | multiple interactions | ISO | Sec61b (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SEC61B mRNA | CTD | PMID:36331819 | Sec61b | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Sec61b (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SEC61B mRNA | CTD | PMID:22206623 | Sec61b | Rat | 17alpha-ethynylestradiol | increases expression | ISO | Sec61b (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of SEC61B mRNA | CTD | PMID:17942748 | Sec61b | Rat | 17alpha-ethynylestradiol | affects expression | EXP | | 6480464 | Ethinyl Estradiol affects the expression of SEC61B mRNA | CTD | PMID:26865667 | Sec61b | Rat | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of SEC61B mRNA | CTD | PMID:32145629 | Sec61b | Rat | 17beta-hydroxy-5alpha-androstan-3-one | increases expression | ISO | SEC61B (Homo sapiens) | 6480464 | Dihydrotestosterone results in increased expression of SEC61B mRNA | CTD | PMID:29581250 | Sec61b | Rat | 2,2',4,4'-Tetrabromodiphenyl ether | affects expression | ISO | Sec61b (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:30294300 | Sec61b | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Sec61b (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SEC61B mRNA | CTD | PMID:19770486 | Sec61b | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of SEC61B mRNA | CTD | PMID:34747641 | Sec61b | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Sec61b (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SEC61B mRNA | CTD | PMID:21570461 and PMID:24680724 | Sec61b | Rat | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | affects expression | ISO | Sec61b (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:38648751 | Sec61b | Rat | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of SEC61B mRNA | CTD | PMID:21346803 | Sec61b | Rat | 2-hydroxypropanoic acid | decreases expression | ISO | SEC61B (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of SEC61B mRNA | CTD | PMID:30851411 | Sec61b | Rat | all-trans-retinoic acid | increases expression | ISO | SEC61B (Homo sapiens) | 6480464 | Tretinoin results in increased expression of SEC61B mRNA | CTD | PMID:17218384 | Sec61b | Rat | alpha-Zearalanol | multiple interactions | EXP | | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of SEC61B mRNA | CTD | PMID:35163327 | Sec61b | Rat | amphetamine | increases expression | EXP | | 6480464 | Amphetamine results in increased expression of SEC61B mRNA | CTD | PMID:30779732 | Sec61b | Rat | benzatropine | increases expression | ISO | SEC61B (Homo sapiens) | 6480464 | Benztropine results in increased expression of SEC61B protein | CTD | PMID:34122009 | Sec61b | Rat | beta-lapachone | increases expression | ISO | SEC61B (Homo sapiens) | 6480464 | beta-lapachone results in increased expression of SEC61B mRNA | CTD | PMID:38218311 | Sec61b | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of SEC61B mRNA | CTD | PMID:25181051 and PMID:32145629 | Sec61b | Rat | bisphenol A | decreases expression | ISO | SEC61B (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of SEC61B protein | CTD | PMID:34186270 | Sec61b | Rat | bisphenol A | increases expression | ISO | Sec61b (Mus musculus) | 6480464 | bisphenol A results in increased expression of SEC61B mRNA | CTD | PMID:33221593 and PMID:38074096 | Sec61b | Rat | bisphenol A | increases expression | ISO | SEC61B (Homo sapiens) | 6480464 | bisphenol A results in increased expression of SEC61B protein | CTD | PMID:33376534 | Sec61b | Rat | Bisphenol B | increases expression | ISO | SEC61B (Homo sapiens) | 6480464 | bisphenol B results in increased expression of SEC61B protein | CTD | PMID:34186270 | Sec61b | Rat | bisphenol F | increases expression | ISO | SEC61B (Homo sapiens) | 6480464 | bisphenol F results in increased expression of SEC61B protein | CTD | PMID:34186270 | Sec61b | Rat | bisphenol F | increases expression | ISO | Sec61b (Mus musculus) | 6480464 | bisphenol F results in increased expression of SEC61B mRNA | CTD | PMID:35387338 | Sec61b | Rat | cadmium atom | multiple interactions | ISO | SEC61B (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SEC61B mRNA | CTD | PMID:35301059 | Sec61b | Rat | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of SEC61B mRNA | CTD | PMID:33453195 | Sec61b | Rat | cadmium dichloride | multiple interactions | ISO | SEC61B (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SEC61B mRNA | CTD | PMID:35301059 | Sec61b | Rat | cadmium dichloride | increases expression | ISO | SEC61B (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of SEC61B mRNA | CTD | PMID:38568856 | Sec61b | Rat | caffeine | affects phosphorylation | ISO | SEC61B (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of SEC61B protein | CTD | PMID:35688186 | Sec61b | Rat | cannabidiol | increases expression | ISO | SEC61B (Homo sapiens) | 6480464 | Cannabidiol results in increased expression of SEC61B protein | CTD | PMID:34122009 | Sec61b | Rat | carbon nanotube | increases expression | ISO | Sec61b (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | Sec61b | Rat | chloropicrin | increases expression | ISO | SEC61B (Homo sapiens) | 6480464 | chloropicrin results in increased expression of SEC61B mRNA | CTD | PMID:26352163 | Sec61b | Rat | chlorpyrifos | increases expression | ISO | Sec61b (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of SEC61B mRNA | CTD | PMID:37019170 | Sec61b | Rat | chrysene | decreases expression | ISO | Sec61b (Mus musculus) | 6480464 | chrysene results in decreased expression of SEC61B mRNA | CTD | PMID:26377693 | Sec61b | Rat | cisplatin | decreases expression | ISO | SEC61B (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of SEC61B mRNA | CTD | PMID:27392435 and PMID:27594783 | Sec61b | Rat | clobetasol | increases expression | ISO | Sec61b (Mus musculus) | 6480464 | Clobetasol results in increased expression of SEC61B mRNA | CTD | PMID:27462272 | Sec61b | Rat | clofibrate | multiple interactions | ISO | Sec61b (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of SEC61B mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SEC61B mRNA] | CTD | PMID:17585979 | Sec61b | Rat | clofibrate | decreases expression | ISO | Sec61b (Mus musculus) | 6480464 | Clofibrate results in decreased expression of SEC61B mRNA | CTD | PMID:17585979 | Sec61b | Rat | clozapine | increases expression | ISO | SEC61B (Homo sapiens) | 6480464 | Clozapine results in increased expression of SEC61B protein | CTD | PMID:34122009 | Sec61b | Rat | copper atom | multiple interactions | ISO | SEC61B (Homo sapiens) | 6480464 | [Disulfiram binds to Copper] which results in decreased expression of SEC61B mRNA | CTD | PMID:24690739 | Sec61b | Rat | copper atom | decreases expression | EXP | | 6480464 | Copper results in decreased expression of SEC61B mRNA | CTD | PMID:30556269 | Sec61b | Rat | copper(0) | multiple interactions | ISO | SEC61B (Homo sapiens) | 6480464 | [Disulfiram binds to Copper] which results in decreased expression of SEC61B mRNA | CTD | PMID:24690739 | Sec61b | Rat | copper(0) | decreases expression | EXP | | 6480464 | Copper results in decreased expression of SEC61B mRNA | CTD | PMID:30556269 | Sec61b | Rat | copper(II) chloride | increases expression | ISO | SEC61B (Homo sapiens) | 6480464 | cupric chloride results in increased expression of SEC61B mRNA | CTD | PMID:38568856 | Sec61b | Rat | cyclosporin A | increases expression | ISO | Sec61b (Mus musculus) | 6480464 | Cyclosporine results in increased expression of SEC61B mRNA | CTD | PMID:19770486 and PMID:25270620 | Sec61b | Rat | cyclosporin A | increases expression | ISO | SEC61B (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of SEC61B mRNA | CTD | PMID:20106945 and PMID:25562108 | Sec61b | Rat | cyproconazole | increases expression | ISO | Sec61b (Mus musculus) | 6480464 | cyproconazole results in increased expression of SEC61B mRNA | CTD | PMID:22334560 | Sec61b | Rat | deoxynivalenol | decreases phosphorylation | ISO | Sec61b (Mus musculus) | 6480464 | deoxynivalenol results in decreased phosphorylation of SEC61B protein | CTD | PMID:23352502 | Sec61b | Rat | disulfiram | multiple interactions | ISO | SEC61B (Homo sapiens) | 6480464 | [Disulfiram binds to Copper] which results in decreased expression of SEC61B mRNA | CTD | PMID:24690739 | Sec61b | Rat | dorsomorphin | multiple interactions | ISO | SEC61B (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEC61B mRNA | CTD | PMID:27188386 | Sec61b | Rat | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of SEC61B mRNA | CTD | PMID:29391264 and PMID:31464424 | Sec61b | Rat | enzyme inhibitor | multiple interactions | ISO | SEC61B (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SEC61B protein | CTD | PMID:23301498 | Sec61b | Rat | epoxiconazole | increases expression | ISO | Sec61b (Mus musculus) | 6480464 | epoxiconazole results in increased expression of SEC61B mRNA | CTD | PMID:22334560 | Sec61b | Rat | folic acid | multiple interactions | ISO | Sec61b (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SEC61B mRNA | CTD | PMID:22206623 | Sec61b | Rat | FR900359 | decreases phosphorylation | ISO | SEC61B (Homo sapiens) | 6480464 | FR900359 results in decreased phosphorylation of SEC61B protein | CTD | PMID:37730182 | Sec61b | Rat | furan | increases methylation | EXP | | 6480464 | furan results in increased methylation of SEC61B gene | CTD | PMID:22079235 | Sec61b | Rat | genistein | increases expression | ISO | SEC61B (Homo sapiens) | 6480464 | Genistein results in increased expression of SEC61B mRNA | CTD | PMID:26865667 | Sec61b | Rat | glafenine | increases expression | EXP | | 6480464 | Glafenine results in increased expression of SEC61B mRNA | CTD | PMID:24136188 | Sec61b | Rat | inulin | multiple interactions | ISO | Sec61b (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of SEC61B mRNA | CTD | PMID:36331819 | Sec61b | Rat | ivermectin | decreases expression | ISO | SEC61B (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of SEC61B protein | CTD | PMID:32959892 | Sec61b | Rat | nickel sulfate | increases expression | ISO | SEC61B (Homo sapiens) | 6480464 | nickel sulfate results in increased expression of SEC61B mRNA | CTD | PMID:18651567 | Sec61b | Rat | paracetamol | multiple interactions | ISO | Sec61b (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of SEC61B mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SEC61B mRNA] | CTD | PMID:17585979 | Sec61b | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of SEC61B mRNA | CTD | PMID:33387578 | Sec61b | Rat | paracetamol | affects expression | ISO | Sec61b (Mus musculus) | 6480464 | Acetaminophen affects the expression of SEC61B mRNA | CTD | PMID:17562736 | Sec61b | Rat | parathion | decreases expression | ISO | Sec61b (Mus musculus) | 6480464 | Parathion results in decreased expression of SEC61B mRNA | CTD | PMID:34813904 | Sec61b | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Sec61b (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SEC61B mRNA and [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of SEC61B mRNA | CTD | PMID:36331819 | Sec61b | Rat | perfluorooctanoic acid | multiple interactions | EXP | | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of SEC61B mRNA | CTD | PMID:35163327 | Sec61b | Rat | propiconazole | increases expression | ISO | Sec61b (Mus musculus) | 6480464 | propiconazole results in increased expression of SEC61B mRNA | CTD | PMID:21278054 and PMID:22334560 | Sec61b | Rat | rac-lactic acid | decreases expression | ISO | SEC61B (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of SEC61B mRNA | CTD | PMID:30851411 | Sec61b | Rat | rotenone | decreases expression | EXP | | 6480464 | Rotenone results in decreased expression of SEC61B mRNA | CTD | PMID:28374803 | Sec61b | Rat | SB 431542 | multiple interactions | ISO | SEC61B (Homo sapiens) | 6480464 | [LDN 193189 co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 and PMID:37664457 | Sec61b | Rat | sodium arsenite | increases expression | ISO | SEC61B (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of SEC61B mRNA | CTD | PMID:38568856 | Sec61b | Rat | sodium arsenite | increases expression | ISO | Sec61b (Mus musculus) | 6480464 | sodium arsenite results in increased expression of SEC61B mRNA | CTD | PMID:37682722 | Sec61b | Rat | sunitinib | increases expression | ISO | SEC61B (Homo sapiens) | 6480464 | Sunitinib results in increased expression of SEC61B mRNA | CTD | PMID:31533062 | Sec61b | Rat | tetrachloroethene | decreases expression | ISO | Sec61b (Mus musculus) | 6480464 | Tetrachloroethylene results in decreased expression of SEC61B mRNA | CTD | PMID:28973375 | Sec61b | Rat | thapsigargin | increases expression | ISO | SEC61B (Homo sapiens) | 6480464 | Thapsigargin results in increased expression of SEC61B mRNA | CTD | PMID:22378314 | Sec61b | Rat | thiram | increases expression | ISO | SEC61B (Homo sapiens) | 6480464 | Thiram results in increased expression of SEC61B mRNA | CTD | PMID:38568856 | Sec61b | Rat | titanium dioxide | increases expression | ISO | Sec61b (Mus musculus) | 6480464 | titanium dioxide results in increased expression of SEC61B mRNA | CTD | PMID:23557971 | Sec61b | Rat | triphenyl phosphate | affects expression | ISO | SEC61B (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of SEC61B mRNA | CTD | PMID:37042841 | Sec61b | Rat | tungsten | increases expression | ISO | Sec61b (Mus musculus) | 6480464 | Tungsten results in increased expression of SEC61B mRNA | CTD | PMID:30912803 | Sec61b | Rat | tunicamycin | increases expression | ISO | SEC61B (Homo sapiens) | 6480464 | Tunicamycin results in increased expression of SEC61B mRNA | CTD | PMID:22378314 and PMID:29453283 | Sec61b | Rat | valproic acid | decreases methylation | ISO | SEC61B (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of SEC61B gene | CTD | PMID:29154799 | Sec61b | Rat | valproic acid | increases expression | ISO | SEC61B (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of SEC61B mRNA | CTD | PMID:23179753 and PMID:26272509 | Sec61b | Rat | valproic acid | multiple interactions | ISO | SEC61B (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEC61B mRNA | CTD | PMID:27188386 | |