Mup4l4 (major urinary protein 4 like 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Mup4l4 (major urinary protein 4 like 4) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Mup4l4 (Ensembl: Mup18)
Name: major urinary protein 4 like 4 (Ensembl:major urinary protein 18)
RGD ID: 708501
Description: Predicted to enable pheromone binding activity and small molecule binding activity.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alpha-2u globulin PGCL3; LOC259244
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8579,704,451 - 79,707,807 (-)NCBIGRCr8
mRatBN7.2574,909,468 - 74,912,890 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl574,842,319 - 75,061,474 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx576,809,410 - 76,812,766 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0578,631,043 - 78,634,399 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0578,603,220 - 78,606,576 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0577,245,206 - 77,248,563 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl577,245,143 - 77,492,013 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0581,374,724 - 81,378,081 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4578,163,491 - 78,166,847 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1578,168,603 - 78,171,960 (-)NCBI
Celera573,712,675 - 73,716,031 (-)NCBICelera
Cytogenetic Map5q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Molecular evidence of complex tissue- and sex-specific mRNA expression of the rat alpha(2u)-globulin multigene family. Saito K, etal., Biochem Biophys Res Commun 2000 Jun 7;272(2):337-44.

Genomics

Variants

.
Variants in Mup4l4
20 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:45
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000052243
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)55979352890450144Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)568984307104251008Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 8 15 23 38 48 26 7 26 6 73 32 14 7 20 22

Sequence


Ensembl Acc Id: ENSRNOT00000012293   ⟹   ENSRNOP00000012293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl577,245,143 - 77,492,013 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000044186   ⟹   ENSRNOP00000083579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl574,842,319 - 75,061,474 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000046857   ⟹   ENSRNOP00000047327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl577,245,143 - 77,408,323 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000052175   ⟹   ENSRNOP00000076684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl574,909,626 - 74,912,890 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000052243   ⟹   ENSRNOP00000044277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl574,909,534 - 74,912,890 (-)Ensembl
Rnor_6.0 Ensembl577,245,206 - 77,248,563 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000059374   ⟹   ENSRNOP00000088275
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl574,961,235 - 74,964,589 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000075881   ⟹   ENSRNOP00000092009
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl574,961,146 - 74,990,036 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000089382   ⟹   ENSRNOP00000068776
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl574,909,534 - 74,990,082 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098961   ⟹   ENSRNOP00000092495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl574,842,319 - 74,964,589 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111463   ⟹   ENSRNOP00000078218
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl574,961,143 - 74,990,036 (-)Ensembl
RefSeq Acc Id: NM_147212   ⟹   NP_671745
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8579,704,451 - 79,707,807 (-)NCBI
mRatBN7.2574,909,534 - 74,912,890 (-)NCBI
Rnor_6.0577,245,206 - 77,248,563 (-)NCBI
Rnor_5.0581,374,724 - 81,378,081 (-)NCBI
RGSC_v3.4578,163,491 - 78,166,847 (-)RGD
Celera573,712,675 - 73,716,031 (-)RGD
Sequence:
RefSeq Acc Id: NP_671745   ⟸   NM_147212
- Peptide Label: precursor
- UniProtKB: Q9JJI3 (UniProtKB/TrEMBL),   F7EMS3 (UniProtKB/TrEMBL),   A0A0G2JTN2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012293   ⟸   ENSRNOT00000012293
Ensembl Acc Id: ENSRNOP00000047327   ⟸   ENSRNOT00000046857
Ensembl Acc Id: ENSRNOP00000044277   ⟸   ENSRNOT00000052243
Ensembl Acc Id: ENSRNOP00000078218   ⟸   ENSRNOT00000111463
Ensembl Acc Id: ENSRNOP00000083579   ⟸   ENSRNOT00000044186
Ensembl Acc Id: ENSRNOP00000088275   ⟸   ENSRNOT00000059374
Ensembl Acc Id: ENSRNOP00000068776   ⟸   ENSRNOT00000089382
Ensembl Acc Id: ENSRNOP00000092495   ⟸   ENSRNOT00000098961
Ensembl Acc Id: ENSRNOP00000092009   ⟸   ENSRNOT00000075881
Ensembl Acc Id: ENSRNOP00000076684   ⟸   ENSRNOT00000052175
Protein Domains
Lipocalin/cytosolic fatty-acid binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7ET54-F1-model_v2 AlphaFold F7ET54 1-181 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693774
Promoter ID:EPDNEW_R4299
Type:initiation region
Name:LOC259244_2
Description:alpha-2u globulin PGCL3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4303  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0577,248,583 - 77,248,643EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708501 AgrOrtholog
BioCyc Gene G2FUF-41129 BioCyc
Ensembl Genes ENSRNOG00000009273 Ensembl
  ENSRNOG00000062459 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000063113 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044186.6 UniProtKB/TrEMBL
  ENSRNOT00000052175.6 UniProtKB/TrEMBL
  ENSRNOT00000052243.6 UniProtKB/TrEMBL
  ENSRNOT00000075881.2 UniProtKB/TrEMBL
  ENSRNOT00000089382.2 UniProtKB/TrEMBL
  ENSRNOT00000111463.1 UniProtKB/TrEMBL
  ENSRNOT00000112271.1 UniProtKB/TrEMBL
  ENSRNOT00000112696.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.128.20 UniProtKB/TrEMBL
InterPro Calycin UniProtKB/TrEMBL
  Lipocalin UniProtKB/TrEMBL
  Lipocalin_CS UniProtKB/TrEMBL
  Lipocln_cytosolic_FA_bd UniProtKB/TrEMBL
  Maj_urinary UniProtKB/TrEMBL
KEGG Report rno:259244 UniProtKB/TrEMBL
NCBI Gene 259244 ENTREZGENE
PANTHER MAJOR URINARY PROTEIN 1-RELATED UniProtKB/TrEMBL
  PTHR11430 UniProtKB/TrEMBL
Pfam Lipocalin UniProtKB/TrEMBL
PhenoGen Mup4l4 PhenoGen
PRINTS LIPOCALIN UniProtKB/TrEMBL
  MAJORURINARY UniProtKB/TrEMBL
PROSITE LIPOCALIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009273 RatGTEx
  ENSRNOG00000062459 RatGTEx
  ENSRNOG00000063113 RatGTEx
Superfamily-SCOP Calycin UniProtKB/TrEMBL
UniProt A0A096MK41_RAT UniProtKB/TrEMBL
  A0A0G2JTN2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y2J8_RAT UniProtKB/TrEMBL
  A0A8I5YBU2_RAT UniProtKB/TrEMBL
  A0A8I6A5C6_RAT UniProtKB/TrEMBL
  A0A8I6AMI2_RAT UniProtKB/TrEMBL
  F7EMS3 ENTREZGENE, UniProtKB/TrEMBL
  Q9JJI3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Mup4l4  major urinary protein 4 like 4  LOC259244  alpha-2u globulin PGCL3  Symbol and Name Changed 1299863 APPROVED
2005-10-12 LOC259244        Symbol and Name status set to provisional 70820 PROVISIONAL