Txn1 (thioredoxin 1) - Rat Genome Database

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Gene: Txn1 (thioredoxin 1) Rattus norvegicus
Symbol: Txn1
Name: thioredoxin 1
RGD ID: 621157
Description: Enables enzyme binding activity. Involved in several processes, including cellular response to hyperoxia; response to dexamethasone; and response to thyroxine. Located in axon; dendrite; and neuronal cell body. Biomarker of fatty liver disease and glaucoma. Orthologous to human TXN (thioredoxin); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH (R)-lipoic acid; (R,R,R)-alpha-tocopherol; (S)-nicotine.
Type: protein-coding
Previously known as: thioredoxin; trx; Txn
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2572,712,334 - 72,724,564 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl572,711,933 - 72,724,629 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx574,603,651 - 74,615,881 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0576,425,269 - 76,437,499 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0576,397,400 - 76,409,630 (-)NCBIRnor_WKY
Rnor_6.0575,049,735 - 75,057,731 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl575,049,747 - 75,057,752 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0579,201,386 - 79,209,384 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4575,921,365 - 75,933,595 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1575,926,428 - 75,938,789 (-)NCBI
Celera571,558,162 - 71,570,393 (-)NCBICelera
RH 3.4 Map5494.0RGD
Cytogenetic Map5q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(-)-quinic acid  (ISO)
(-)-selegiline  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-nicotine  (EXP,ISO)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-methylumbelliferyl acetate  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,8-Diacetoxy-4-methylcoumarin  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8-Br-cAMP  (EXP)
8-bromo-3',5'-cyclic GMP  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
antimonite  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atenolol  (ISO)
atrazine  (EXP,ISO)
auranofin  (ISO)
benfotiamine  (ISO)
benzbromarone  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[d]isothiazol-3-one  (ISO)
benzoic acid  (ISO)
benzyl cinnamate  (ISO)
beta-D-glucosamine  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
brilliant green  (ISO)
Brodifacoum  (EXP)
bromobenzene  (EXP)
bucladesine  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
cerium trichloride  (ISO)
chenodeoxycholic acid  (ISO)
chloroacetaldehyde  (ISO)
chloroform  (EXP)
chlorogenic acid  (ISO)
chlorpromazine  (EXP)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
cyproconazole  (ISO)
cytochalasin D  (ISO)
D-glucose  (EXP,ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
diethyl maleate  (ISO)
dimethylarsinic acid  (EXP,ISO)
dioxygen  (ISO)
diphenylcyclopropenone  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dipyridamole  (EXP)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
emodin  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
finasteride  (EXP)
fipronil  (EXP)
fluorescein 5-isothiocyanate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fumaraldehyde  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gamma-linolenic acid  (ISO)
Ganoderic acid A  (ISO)
genistein  (ISO)
glucose  (EXP,ISO)
herbicide  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxycitronellal  (ISO)
ifosfamide  (ISO)
imidazopyrazole  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
iron(III) nitrilotriacetate  (EXP)
isobutanol  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
KT 5823  (EXP)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (EXP)
L-ethionine  (EXP)
linalool  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
lutein  (EXP)
luteolin  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
maneb  (ISO)
manumycin A  (ISO)
mechlorethamine  (ISO)
medroxyprogesterone acetate  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
methamphetamine  (ISO)
methidathion  (ISO)
methyl non-2-ynoate  (ISO)
methylarsonic acid  (ISO)
methylene blue  (ISO)
methyllycaconitine  (EXP)
methylmercury chloride  (ISO)
metronidazole  (ISO)
microcystin RR  (ISO)
monosodium L-glutamate  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-acetylsphingosine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
naloxone  (EXP)
nefazodone  (EXP)
neomycin  (ISO)
nicotine  (EXP,ISO)
nimesulide  (EXP)
nitrogen dioxide  (EXP)
Nonidet P-40  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
Osajin  (ISO)
ouabain  (ISO)
ozone  (EXP,ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perillyl aldehyde  (ISO)
phenethyl isothiocyanate  (EXP,ISO)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (ISO)
phosphatidylethanolamine  (ISO)
pirinixic acid  (EXP)
poly(I:C)  (EXP)
Pomiferin  (ISO)
potassium dichromate  (EXP)
propiconazole  (ISO)
puerarin  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
ribavirin  (ISO)
Rosavin  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
salicylic acid  (ISO)
SB 431542  (ISO)
selenium atom  (EXP)
sildenafil citrate  (EXP)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium chromate  (ISO)
sodium dodecyl sulfate  (ISO)
sodium selenide  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
superoxide  (EXP)
tacrolimus hydrate  (EXP)
tamoxifen  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thioacetamide  (EXP)
toluene 2,4-diisocyanate  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IDA)
cytoplasm  (ISO)
cytosol  (IEA,ISO)
dendrite  (IDA)
extracellular region  (IEA,ISO)
neuronal cell body  (IDA)
nucleoplasm  (IEA,ISO)
nucleus  (ISO)


References - curated
# Reference Title Reference Citation
1. Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system. Aon-Bertolino ML, etal., Biochim Biophys Acta. 2011 Jan;1810(1):93-110. Epub 2010 Jul 8.
2. Redox regulation of myocardial ERK 1/2 phosphorylation in experimental hyperthyroidism: role of thioredoxin-peroxiredoxin system. Araujo AS, etal., J Cardiovasc Pharmacol. 2010 Nov;56(5):513-7.
3. Redox regulation of resveratrol-mediated switching of death signal into survival signal. Das S, etal., Free Radic Biol Med. 2008 Jan 1;44(1):82-90. Epub 2007 Sep 21.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Severe liver steatosis correlates with nitrosative and oxidative stress in rats. Grattagliano I, etal., Eur J Clin Invest. 2008 Jul;38(7):523-30.
6. Simultaneous expression of glutathione, thioredoxin-1, and their reductases in nerve transected hypoglossal motor neurons of rat. Hama I, etal., Brain Res. 2010 Jan 8;1306:1-7. Epub 2009 Oct 13.
7. Plasma thioredoxin levels in patients with unstable angina. Hokamaki J, etal., Int J Cardiol. 2005 Mar 18;99(2):225-31.
8. Dipyridamole suppresses high glucose-induced osteopontin secretion and mRNA expression in rat aortic smooth muscle cells. Hsieh MS, etal., Circ J. 2010 Jun;74(6):1242-50. Epub 2010 Apr 20.
9. Protective effect of tetraethyl pyrazine against focal cerebral ischemia/reperfusion injury in rats: therapeutic time window and its mechanism. Jia J, etal., Thromb Res. 2009 Mar;123(5):727-30. Epub 2009 Jan 6.
10. Antioxidant defenses in the rat placenta in late gestation: increased labyrinthine expression of superoxide dismutases, glutathione peroxidase 3, and uncoupling protein 2. Jones ML, etal., Biol Reprod. 2010 Aug 1;83(2):254-60. Epub 2010 Apr 14.
11. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
12. Acute exercise and thioredoxin-1 in rat brain, and alpha-lipoic acid and thioredoxin-interacting protein response, in diabetes. Lappalainen Z, etal., Int J Sport Nutr Exerc Metab. 2010 Jun;20(3):206-15.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Nucleolin binds to a subset of selenoprotein mRNAs and regulates their expression. Miniard AC, etal., Nucleic Acids Res. 2010 Aug;38(14):4807-20. Epub 2010 Apr 12.
15. Redox proteins thioredoxin 1 and thioredoxin 2 support retinal ganglion cell survival in experimental glaucoma. Munemasa Y, etal., Gene Ther. 2009 Jan;16(1):17-25. Epub 2008 Aug 14.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Upregulation of redox-regulating protein, thioredoxin, in endomyocardial biopsy samples of patients with myocarditis and cardiomyopathies. Nimata M, etal., Mol Cell Biochem. 2003 Jun;248(1-2):193-6.
18. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
20. GOA pipeline RGD automated data pipeline
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Effects of hyperoxia on cytoplasmic thioredoxin system in alveolar type epithelial cells of premature rats. Shan R, etal., J Huazhong Univ Sci Technolog Med Sci. 2011 Apr;31(2):258-63. Epub 2011 Apr 20.
23. Increased plasma thioredoxin in patients with acute myocardial infarction. Soejima H, etal., Clin Cardiol. 2003 Dec;26(12):583-7.
24. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
25. Expression of thioredoxin is enhanced in atherosclerotic plaques and during neointima formation in rat arteries. Takagi Y, etal., Lab Invest. 1998 Aug;78(8):957-66.
26. Neuroprotective mechanisms of minocycline against sphingomyelinase/ceramide toxicity: Roles of Bcl-2 and thioredoxin. Tang CM, etal., Free Radic Biol Med. 2011 Mar 15;50(6):710-21. Epub 2010 Dec 22.
27. Mammalian thioredoxin reductase 1: roles in redox homoeostasis and characterization of cellular targets. Turanov AA, etal., Biochem J. 2010 Sep 1;430(2):285-93.
28. Effects of dietary selenium on post-ischemic expression of antioxidant mRNA. Venardos K, etal., Mol Cell Biochem. 2005 Feb;270(1-2):131-8.
29. Elevated thioredoxin after angioplasty in peripheral arterial disease. Wahlgren CM and Pekkari K, Eur J Vasc Endovasc Surg. 2005 Mar;29(3):281-6.
30. Vitamin D(3)-up-regulated protein-1 is a stress-responsive gene that regulates cardiomyocyte viability through interaction with thioredoxin. Wang Y, etal., J Biol Chem 2002 Jul 19;277(29):26496-500.
31. [The change of thioredoxin system in myocardial tissue of type 2 diabetic rats undergoing myocardial injury]. Zhao XQ, etal., Sheng Li Xue Bao. 2010 Jun 25;62(3):261-8.
32. Therapeutic time window and mechanism of tetramethylpyrazine on transient focal cerebral ischemia/reperfusion injury in rats. Zhu XL, etal., Neurosci Lett. 2009 Jan 2;449(1):24-7. Epub 2008 Sep 6.
Additional References at PubMed
PMID:1332947   PMID:2176490   PMID:2734107   PMID:9108029   PMID:9369469   PMID:11118054   PMID:11213470   PMID:13679060   PMID:14651853   PMID:15123525   PMID:15128745   PMID:15489334  
PMID:15723974   PMID:16408020   PMID:17023680   PMID:17130129   PMID:17182577   PMID:17256724   PMID:17260951   PMID:17360810   PMID:17606900   PMID:18555775   PMID:18614015   PMID:19032234  
PMID:19056867   PMID:19074570   PMID:19940280   PMID:20238036   PMID:20458337   PMID:20558743   PMID:20709139   PMID:21586560   PMID:22165200   PMID:22342837   PMID:22492997   PMID:22658674  
PMID:22681889   PMID:22732447   PMID:22871113   PMID:23376485   PMID:23533145   PMID:23846223   PMID:24925443   PMID:25055978   PMID:25451293   PMID:25541364   PMID:25735211   PMID:25957836  
PMID:26327811   PMID:26346161   PMID:26846911   PMID:26975474   PMID:27052476   PMID:27894668   PMID:28659344   PMID:28939765   PMID:29036266   PMID:29328386   PMID:31276937   PMID:31547465  
PMID:31785355   PMID:31904090   PMID:33161477   PMID:33450132   PMID:34132424   PMID:35072836  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2572,712,334 - 72,724,564 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl572,711,933 - 72,724,629 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx574,603,651 - 74,615,881 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0576,425,269 - 76,437,499 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0576,397,400 - 76,409,630 (-)NCBIRnor_WKY
Rnor_6.0575,049,735 - 75,057,731 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl575,049,747 - 75,057,752 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0579,201,386 - 79,209,384 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4575,921,365 - 75,933,595 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1575,926,428 - 75,938,789 (-)NCBI
Celera571,558,162 - 71,570,393 (-)NCBICelera
RH 3.4 Map5494.0RGD
Cytogenetic Map5q24NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh389110,243,810 - 110,256,507 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl9110,243,810 - 110,256,507 (-)EnsemblGRCh38hg38GRCh38
GRCh379113,006,090 - 113,018,787 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369112,046,131 - 112,058,599 (-)NCBINCBI36Build 36hg18NCBI36
Build 349110,085,864 - 110,098,333NCBI
Celera983,507,936 - 83,520,398 (-)NCBICelera
Cytogenetic Map9q31.3NCBI
HuRef982,607,811 - 82,620,710 (-)NCBIHuRef
CHM1_19113,152,543 - 113,165,343 (-)NCBICHM1_1
T2T-CHM13v2.09122,413,340 - 122,426,045 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39457,943,373 - 57,956,411 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl457,943,373 - 57,956,411 (-)EnsemblGRCm39 Ensembl
GRCm38457,943,373 - 57,956,411 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl457,943,373 - 57,956,411 (-)EnsemblGRCm38mm10GRCm38
MGSCv37457,956,245 - 57,969,283 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36458,037,427 - 58,050,345 (-)NCBIMGSCv36mm8
Celera457,856,035 - 57,868,968 (-)NCBICelera
Cytogenetic Map4B3NCBI
cM Map431.87NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1929,152,695 - 29,165,262 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0981,399,056 - 81,411,607 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19109,565,557 - 109,578,311 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9109,565,557 - 109,578,311 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1X82,986,288 - 82,986,753 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX69,064,524 - 69,064,989 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X84,637,255 - 84,637,720 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X82,113,902 - 82,114,367 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X83,808,036 - 83,808,501 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X83,636,876 - 83,637,341 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404947180,444,054 - 180,454,833 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365592,811,782 - 2,822,528 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365592,811,786 - 2,822,528 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1251,263,175 - 251,277,988 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11251,264,180 - 251,278,000 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21282,027,082 - 282,035,642 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1qNCBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11229,296,166 - 29,308,979 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603513,456,569 - 13,469,439 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247581,318,529 - 1,329,011 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247581,318,108 - 1,329,011 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Txn1
31 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:110
Count of miRNA genes:87
Interacting mature miRNAs:95
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)55979352890450144Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)568984307104251008Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2572,720,241 - 72,720,334 (+)MAPPERmRatBN7.2
Rnor_6.0575,057,643 - 75,057,735NCBIRnor6.0
Rnor_5.0579,209,294 - 79,209,386UniSTSRnor5.0
RGSC_v3.4575,929,273 - 75,929,365UniSTSRGSC3.4
Celera571,566,069 - 71,566,161UniSTS
Cytogenetic Map5q24UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2572,712,236 - 72,712,336 (+)MAPPERmRatBN7.2
Rnor_6.0575,049,638 - 75,049,737NCBIRnor6.0
Rnor_5.0579,201,289 - 79,201,388UniSTSRnor5.0
RGSC_v3.4575,921,268 - 75,921,367UniSTSRGSC3.4
Celera571,558,065 - 71,558,164UniSTS
RH 3.4 Map5494.0UniSTS
Cytogenetic Map5q24UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2572,726,259 - 72,726,452 (+)MAPPERmRatBN7.2
Rnor_6.0575,064,192 - 75,064,384NCBIRnor6.0
Rnor_5.0579,215,618 - 79,215,810UniSTSRnor5.0
RGSC_v3.4575,935,240 - 75,935,432UniSTSRGSC3.4
Celera571,572,084 - 71,572,276UniSTS
RH 3.4 Map5495.8UniSTS
Cytogenetic Map5q24UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1 8 8 8 3 1 4
Medium 2 43 49 33 19 33 8 11 74 32 40 7 8
Below cutoff


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016447   ⟹   ENSRNOP00000016447
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl572,711,933 - 72,724,629 (-)Ensembl
Rnor_6.0 Ensembl575,049,747 - 75,057,752 (-)Ensembl
RefSeq Acc Id: NM_053800   ⟹   NP_446252
Rat AssemblyChrPosition (strand)Source
mRatBN7.2572,712,334 - 72,724,564 (-)NCBI
Rnor_6.0575,049,735 - 75,057,731 (-)NCBI
Rnor_5.0579,201,386 - 79,209,384 (-)NCBI
RGSC_v3.4575,921,365 - 75,933,595 (-)RGD
Celera571,558,162 - 71,570,393 (-)RGD
Protein Sequences
Protein RefSeqs NP_446252 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG49923 (Get FASTA)   NCBI Sequence Viewer  
  AAH58454 (Get FASTA)   NCBI Sequence Viewer  
  EDL91664 (Get FASTA)   NCBI Sequence Viewer  
  P11232 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_446252   ⟸   NM_053800
- UniProtKB: P11232 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016447   ⟸   ENSRNOT00000016447
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11232-F1-model_v2 AlphaFold P11232 1-105 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621157 AgrOrtholog
BioCyc Gene G2FUF-41194 BioCyc
Ensembl Genes ENSRNOG00000012081 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000016447 ENTREZGENE
  ENSRNOP00000016447.6 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016447 ENTREZGENE
  ENSRNOT00000016447.7 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Thioredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116484 UniProtKB/Swiss-Prot
Pfam Thioredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Txn1 PhenoGen
PIRSF Thioredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOREDOXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIO_RAT UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Txn1  thioredoxin 1  Txn  thioredoxin  Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation regulated by vitamin D(3)-up-regulated protein-1 727213