Alad (aminolevulinate dehydratase) - Rat Genome Database

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Gene: Alad (aminolevulinate dehydratase) Rattus norvegicus
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Symbol: Alad
Name: aminolevulinate dehydratase
RGD ID: 2083
Description: Enables porphobilinogen synthase activity and proteasome core complex binding activity. Involved in several processes, including cellular response to lead ion; response to herbicide; and response to vitamin B1. Located in extracellular space. Used to study anemia and hemochromatosis. Biomarker of acute kidney failure; hypothyroidism; liver cirrhosis; status epilepticus; and visual epilepsy. Human ortholog(s) of this gene implicated in porphyria cutanea tarda and sickle cell anemia. Orthologous to human ALAD (aminolevulinate dehydratase); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; heme biosynthetic pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ALADH; ALADR; aminolevulinate, delta-, dehydratase; aminolevulinatedelta-dehydratase; delta - aminolevulinic acid dehydratase; delta-aminolevulinic acid dehydratase; porphobilinogen synthase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8580,977,562 - 80,987,901 (-)NCBIGRCr8
mRatBN7.2575,961,993 - 75,972,334 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl575,961,993 - 75,972,474 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx578,361,344 - 78,371,685 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0580,178,441 - 80,188,782 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0580,153,956 - 80,164,297 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0578,368,867 - 78,379,206 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl578,368,867 - 78,379,346 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0582,488,238 - 82,498,577 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4579,505,645 - 79,515,983 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1579,510,757 - 79,521,096 (-)NCBI
Celera574,903,347 - 74,913,685 (-)NCBICelera
Cytogenetic Map5q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP,ISO)
(+)-schisandrin B  (EXP)
(R)-lipoic acid  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-methoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5,5-diethylbarbituric acid  (ISO)
5-aminolevulinic acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acephate  (ISO)
acetamide  (EXP)
aconitine  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
amphetamine  (ISO)
arsane  (EXP)
arsenic acid  (EXP)
arsenic atom  (EXP)
arsenite ion  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
beta-carotene  (ISO)
bilirubin IXalpha  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
bromobenzene  (EXP,ISO)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
carbon monoxide  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
chitosan  (EXP)
chlorpyrifos  (ISO)
cisplatin  (EXP,ISO)
citronellal  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyldithiocarbamic acid  (EXP)
diethylstilbestrol  (ISO)
dimercaprol  (ISO)
disodium selenite  (ISO)
disulfiram  (EXP)
dorsomorphin  (ISO)
ebselen  (EXP,ISO)
elemental selenium  (EXP)
enflurane  (ISO)
estrone  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenthion  (ISO)
ferulic acid  (EXP)
fluphenazine  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gallic acid  (EXP)
gamma-Oryzanol (TN)  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glutathione  (EXP)
glycerol  (EXP)
glycidyl methacrylate  (ISO)
hexachlorobenzene  (EXP)
hexestrol  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
isoflurane  (ISO)
L-1,4-dithiothreitol  (EXP,ISO)
L-selenocysteine  (EXP)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (EXP,ISO)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
lithium carbonate  (EXP)
lycopene  (EXP,ISO)
Maleic hydrazide  (ISO)
melphalan  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
mestranol  (ISO)
methamidophos  (ISO)
methidathion  (ISO)
methylseleninic acid  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
naphthalenes  (EXP)
nicotine  (ISO)
nitrofen  (EXP)
nitroprusside  (ISO)
ochratoxin A  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentetrazol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
picrotoxin  (ISO)
pirinixic acid  (ISO)
porphobilinogen  (EXP)
potassium cyanide  (ISO)
progesterone  (ISO)
quinolone  (ISO)
raloxifene  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 431542  (ISO)
selenium atom  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
Soman  (EXP)
streptozocin  (ISO)
styrene  (ISO)
succimer  (EXP,ISO)
sucrose  (ISO)
tamoxifen  (ISO)
taurine  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
topotecan  (EXP,ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
ubiquinones  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP)
zearalenone  (ISO)
zinc acetate  (EXP)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP,ISO)
zinc protoporphyrin  (ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,ISO)
extracellular space  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Antagonistic effects of zinc and aluminum on lead inhibition of delta-aminolevulinic acid dehydratase. Abdulla M, etal., Arch Environ Health. 1979 Nov-Dec;34(6):464-9.
2. Influence of protein calorie malnutrition and fasting on the activities of delta-aminolevulinic acid dehydratase and porphobilinogen deaminase in rats. Adjarov DG, etal., Exp Toxicol Pathol. 1994 Aug;46(3):199-202.
3. Biosynthesis of heme in mammals. Ajioka RS, etal., Biochim Biophys Acta. 2006 Jul;1763(7):723-36. Epub 2006 Jun 3.
4. Increased erythrocyte uroporphyrinogen-l-synthetase, delta-aminolevulinic acid dehydratase and protoporphyrin in hemolytic anemias. Anderson KE, etal., Am J Med. 1977 Sep;63(3):359-64.
5. Organic and inorganic forms of selenium inhibited differently fish (Rhamdia quelen) and rat (Rattus norvergicus albinus) delta-aminolevulinate dehydratase. Antunes Soares F, etal., Environ Res. 2005 May;98(1):46-54.
6. Effect of astaxanthin on kidney function impairment and oxidative stress induced by mercuric chloride in rats. Augusti PR, etal., Food Chem Toxicol. 2008 Jan;46(1):212-9. Epub 2007 Aug 14.
7. Involvement of striatal lipid peroxidation and inhibition of calcium influx into brain slices in neurobehavioral alterations in a rat model of short-term oral exposure to manganese. Avila DS, etal., Neurotoxicology. 2008 Nov;29(6):1062-8. Epub 2008 Aug 20.
8. Acute diphenyl diselenide treatment reduces hyperglycemia but does not change delta-aminolevulinate dehydratase activity in alloxan-induced diabetes in rats. Barbosa NB, etal., Biol Pharm Bull. 2008 Dec;31(12):2200-4.
9. Delta-aminolevulinic dehydratase is a proteasome interacting protein. Bardag-Gorce F and French SW, Exp Mol Pathol. 2011 Oct;91(2):485-9. doi: 10.1016/j.yexmp.2011.05.003. Epub 2011 May 27.
10. Synthesis, delivery and regulation of eukaryotic heme and Fe-S cluster cofactors. Barupala DP, etal., Arch Biochem Biophys. 2016 Feb 15;592:60-75. doi: 10.1016/j.abb.2016.01.010. Epub 2016 Jan 16.
11. Effect of homeopathic drugs plumbum and opium on experimentally induced lead toxicity in rats. Begum R, etal., Indian J Exp Biol. 1994 Mar;32(3):192-5.
12. Response of arsenic-induced oxidative stress, DNA damage, and metal imbalance to combined administration of DMSA and monoisoamyl-DMSA during chronic arsenic poisoning in rats. Bhadauria S and Flora SJ, Cell Biol Toxicol. 2006 Nov 1;.
13. Nucleotide sequence of rat liver delta-aminolevulinic acid dehydratase cDNA. Bishop TR, etal., Nucleic Acids Res 1986 Dec 22;14(24):10115.
14. Hepatic heme synthesis in a new model of experimental hemochromatosis: studies in rats fed finely divided elemental iron. Bonkovsky HL, etal., Hepatology. 1987 Nov-Dec;7(6):1195-203.
15. Diphenyl diselenide protects against glycerol-induced renal damage in rats. Brandao R, etal., J Appl Toxicol. 2009 Oct;29(7):612-8.
16. Effect of vitamin D3 on behavioural and biochemical parameters in diabetes type 1-induced rats. Calgaroto NS, etal., Cell Biochem Funct. 2014 Aug;32(6):502-10. doi: 10.1002/cbf.3044. Epub 2014 Jun 19.
17. Influence of cereal bran supplement on cadmium effects in growing rats. Callegaro MG, etal., Hum Exp Toxicol. 2010 Jun;29(6):467-76. Epub 2009 Dec 17.
18. Interactions of diorganolead(IV) with 3-(2-thienyl)-2-sulfanylpropenoic acid and/or thiamine: chemical and in vitro and in vivo toxicological results. Casas JS, etal., Inorg Chem. 2010 Mar 1;49(5):2173-81.
19. Fluoride-induced changes in haem biosynthesis pathway, neurological variables and tissue histopathology of rats. Chouhan S, etal., J Appl Toxicol. 2010 Jan;30(1):63-73.
20. Chronic exposure to arsenic in tap water reduces acetylcholine-induced relaxation in the aorta and increases oxidative stress in female rats. Cifuentes F, etal., Int J Toxicol. 2009 Nov-Dec;28(6):534-41.
21. Chronic treatment with fluphenazine alters parameters of oxidative stress in liver and kidney of rats. Corte CL, etal., Basic Clin Pharmacol Toxicol. 2009 Jul;105(1):51-7. Epub 2009 Apr 16.
22. 131I induced hematological alterations in rat blood: protection by zinc. Dani V, etal., Biol Trace Elem Res. 2007 Winter;120(1-3):219-26.
23. Delta aminolevulinate dehydratase (ALA-D) activity in human and experimental diabetes mellitus. Fernández-Cuartero B, etal., Int J Biochem Cell Biol. 1999 Mar-Apr;31(3-4):479-88. doi: 10.1016/s1357-2725(98)00145-9.
24. Essential metal status, prooxidant/antioxidant effects of MiADMSA in male rats: age-related effects. Flora SJ, etal., Biol Trace Elem Res. 2007 Winter;120(1-3):235-47.
25. Delta-aminolevulinate dehydratase activity in red blood cells of rats infected with Trypanosoma evansi. França RT, etal., Parasitology. 2011 Sep;138(10):1272-7. doi: 10.1017/S0031182011000989.
26. The regulation of porphobilinogen oxygenase and porphobilinogen deaminase activities in rat bone marrow under conditions of erythropoietic stress. Frydman RB, etal., Biochim Biophys Acta. 1986 Apr 22;870(3):520-9.
27. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
28. Oral supplementation of gossypin during lead exposure protects alteration in heme synthesis pathway and brain oxidative stress in rats. Gautam P and Flora SJ, Nutrition. 2010 May;26(5):563-70. Epub 2009 Jul 31.
29. GenMAPP: Gene Map Annotator and Pathway Profiler GenMAPP
30. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
31. Experimental hypothyroidism inhibits delta-aminolevulinate dehydratase activity in neonatal rat blood and liver. Gravina FS, etal., Exp Biol Med (Maywood). 2007 Sep;232(8):1021-6.
32. Regulation of porphyrin synthesis and photodynamic therapy in heavy metal intoxication. Grinblat B, etal., J Environ Pathol Toxicol Oncol. 2006;25(1-2):145-58.
33. Effect of simultaneous low level exposure of Pb and Cd on delta-ALAD and acetylcholinesterase activity in rats. Gupta S, etal., Indian J Exp Biol. 1994 Nov;32(11):819-21.
34. Protective effect of binaphthyl diselenide, a synthetic organoselenium compound, on 2-nitropropane-induced hepatotoxicity in rats. Ibrahim M, etal., Cell Biochem Funct. 2010 Jun;28(4):258-65.
35. Message amplification phenotyping of an inherited delta-aminolevulinate dehydratase deficiency in a family with acute hepatic porphyria. Ishida N, etal., Biochem Biophys Res Commun. 1990 Oct 15;172(1):237-42.
36. Effect of cis-platinum on kidney cytochrome P-450 and heme metabolism: evidence for the regulatory role of the pituitary hormones. Jollie DR and Maines MD, Arch Biochem Biophys. 1985 Jul;240(1):51-9.
37. Effect of oral administration of diphenyl diselenide on antioxidant status, and activity of delta aminolevulinic acid dehydratase and isoforms of lactate dehydrogenase, in streptozotocin-induced diabetic rats. Kade IJ, etal., Cell Biol Toxicol. 2009 Aug;25(4):415-24. doi: 10.1007/s10565-008-9095-5. Epub 2008 Jul 31.
38. Development of iron deficiency decreases zinc requirement of rats. Kaganda J, etal., J Nutr Sci Vitaminol (Tokyo). 2003 Aug;49(4):234-40.
39. Effects of voluntary resistance exercise on heme biosynthesis in rats given glucocorticoid-injections. Kang HS, etal., Biosci Biotechnol Biochem. 2002 Dec;66(12):2710-4.
40. Changes in aminolevulinate synthase and aminolevulinate dehydratase activity in cirrhotic liver. Kodama T, etal., Gastroenterology. 1983 Feb;84(2):236-41.
41. Associations of blood pressure and hypertension with lead dose measures and polymorphisms in the vitamin D receptor and delta-aminolevulinic acid dehydratase genes. Lee BK, etal., Environ Health Perspect. 2001 Apr;109(4):383-9.
42. Probing the active site of rat porphobilinogen synthase using newly developed inhibitors. Li N, etal., Bioorg Chem. 2009 Feb;37(1):33-40. Epub 2008 Dec 17.
43. Enzymes of heme metabolism in the kidney: regulation by trace metals which do not form heme complexes. Maines MD and Kappas A, J Exp Med. 1977 Nov 1;146(5):1286-93.
44. Evidence for the catabolism of polychlorinated biphenyl-induced cytochrome P-448 by microsomal heme oxygenase, and the inhibition of delta-aminolevulinate dehydratase by polychlorinated biphenyls. Maines MD J Exp Med. 1976 Dec 1;144(6):1509-19.
45. Delta-aminolevulinate dehydratase activity in mice with hereditary anemia. Margolis FL and Russell ES, Science. 1965 Oct 22;150(3695):496-7.
46. Voluntary resistance exercise improves blood hemoglobin concentration in severely iron-deficient rats. Matsuo T, etal., J Nutr Sci Vitaminol (Tokyo). 2002 Apr;48(2):161-4.
47. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
48. Differential oxidative stress and DNA damage in rat brain regions and blood following chronic arsenic exposure. Mishra D and Flora SJ, Toxicol Ind Health. 2008 May;24(4):247-56.
49. Effect of zinc or S-adenosyl-l-methionine on long term administration of low doses of lead to rats. Munoz JJ, etal., Pharmacol Toxicol. 1993 Oct;73(4):189-91.
50. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
51. Bilirubin is highly effective in preventing in vivo delta-aminolevulinic acid-induced oxidative cell damage. Noriega GO, etal., Biochim Biophys Acta 2003 Jul 14;1638(2):173-8.
52. Paraquat-generated oxidative stress in rat liver induces heme oxygenase-1 and aminolevulinic acid synthase. Noriega GO, etal., Free Radic Res. 2002 Jun;36(6):633-9.
53. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
54. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
55. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
56. STZ-induced diabetes in mice and heme pathway enzymes. Effect of allylisopropylacetamide and alpha-tocopherol. Polo CF, etal., Chem Biol Interact. 1995 Apr 14;95(3):327-34.
57. Involvement of oxidative stress in seizures induced by diphenyl diselenide in rat pups. Prigol M, etal., Brain Res. 2007 May 25;1147:226-32. Epub 2007 Feb 4.
58. In vivo protection by melatonin against delta-aminolevulinic acid-induced oxidative damage and its antioxidant effect on the activity of haem enzymes. Princ FG, etal., J Pineal Res. 1998 Jan;24(1):1-8.
59. Vitamin-E reduces the oxidative damage on delta-aminolevulinic dehydratase induced by lead intoxication in rat erythrocytes. Rendon-Ramirez A, etal., Toxicol In Vitro. 2007 Sep;21(6):1121-6. Epub 2007 May 8.
60. GOA pipeline RGD automated data pipeline
61. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
62. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
63. Comprehensive gene review and curation RGD comprehensive gene curation
64. Lipoic acid blocks seizures induced by pilocarpine via increases in delta-aminolevulinic dehydratase and Na+, K+-ATPase activity in rat brain. Santos IM, etal., Pharmacol Biochem Behav. 2010 Mar;95(1):88-91. Epub 2009 Dec 21.
65. Changes in brain biogenic amines and haem biosynthesis and their response to combined administration of succimers and Centella asiatica in lead poisoned rats. Saxena G and Flora SJ, J Pharm Pharmacol. 2006 Apr;58(4):547-59.
66. Effects of resveratrol on biomarkers of oxidative stress and on the activity of delta aminolevulinic acid dehydratase in liver and kidney of streptozotocin-induced diabetic rats. Schmatz R, etal., Biochimie. 2012 Feb;94(2):374-83. doi: 10.1016/j.biochi.2011.08.005. Epub 2011 Aug 16.
67. Effects of leaves extract of Ocimum sanctum L. on arsenic-induced toxicity in Wistar albino rats. Sharmila Banu G, etal., Food Chem Toxicol. 2009 Feb;47(2):490-5. Epub 2008 Dec 13.
68. Study of erythrocyte delta-aminolevulinic acid dehydratase activity in porphyria cutanea tarda. Simon N and Kiss M, Arch Dermatol Res. 1979 Oct;266(2):121-6.
69. delta-Aminolevulinic acid dehydratase in rat liver: studies on the effects of ethanol, acetaldehyde, and B6 vitamers. Solomon LR and Crouch JY, J Lab Clin Med. 1990 Aug;116(2):228-36.
70. [Activity of delta-aminolaevulinic acid (ALAD) in erythrocytes of patients with chronic hepatic porphyria (porphyria cutanea tarda)]. Stankiewicz-Wróblewska J, Pol Arch Med Wewn. 1993 Mar;89(3):212-6.
71. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
72. Decrease of hepatic delta-aminolevulinate dehydratase activity in an animal model of fatigue. Tahara T, etal., Biochem Biophys Res Commun. 2006 Dec 28;.
73. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
74. Erythrocyte aminolevulinic acid dehydratase inhibition by cis-platin. Trevisan A, etal., Toxicol Lett. 2004 Sep 10;152(2):105-10.
75. Sub-chronic exposure to methylmercury at low levels decreases butyrylcholinesterase activity in rats. Valentini J, etal., Basic Clin Pharmacol Toxicol. 2010 Feb;106(2):95-9. Epub 2009 Oct 27.
76. Lead induced disorders in hematopoietic and drug metabolizing enzyme system and their protection by ascorbic acid supplementation. Vij AG, etal., Biomed Environ Sci. 1998 Mar;11(1):7-14.
77. Mechanism of hexachlorobenzene-induced porphyria in rats. Effect of phenobarbitone pretreatment. Wainstok de Calmanovici R, etal., Biochem J. 1984 Mar 15;218(3):753-63.
78. Hepatoprotective effect of 3-alkynyl selenophene on acute liver injury induced by D-galactosamine and lipopolysaccharide. Wilhelm EA, etal., Exp Mol Pathol. 2009 Aug;87(1):20-6. Epub 2009 Apr 1.
79. Alteration of mitochondrial structure and heme biosynthetic parameters in liver and kidney cells by bismuth. Woods JS and Fowler BA, Toxicol Appl Pharmacol. 1987 Sep 15;90(2):274-83.
80. Renal heme metabolism in hereditary tyrosinemia: use of succinylacetone in rat renal tubules. Wyss PA, etal., Biochim Biophys Acta. 1991 Dec 9;1070(2):300-4.
81. Aminolevulinic acid dehydratase activity in the blood of rats exposed to tin and zinc. Zareba G and Chmielnicka J, Ecotoxicol Environ Saf. 1985 Feb;9(1):40-6.
Additional References at PubMed
PMID:3502704   PMID:4959158   PMID:4981581   PMID:8175643   PMID:9798653   PMID:11032836   PMID:11591653   PMID:14050799   PMID:15489334   PMID:21630459   PMID:22871113   PMID:23376485  
PMID:23533145  


Genomics

Comparative Map Data
Alad
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8580,977,562 - 80,987,901 (-)NCBIGRCr8
mRatBN7.2575,961,993 - 75,972,334 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl575,961,993 - 75,972,474 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx578,361,344 - 78,371,685 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0580,178,441 - 80,188,782 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0580,153,956 - 80,164,297 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0578,368,867 - 78,379,206 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl578,368,867 - 78,379,346 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0582,488,238 - 82,498,577 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4579,505,645 - 79,515,983 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1579,510,757 - 79,521,096 (-)NCBI
Celera574,903,347 - 74,913,685 (-)NCBICelera
Cytogenetic Map5q24NCBI
ALAD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389113,386,312 - 113,401,284 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9113,386,312 - 113,401,290 (-)EnsemblGRCh38hg38GRCh38
GRCh379116,148,592 - 116,163,564 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369115,188,413 - 115,203,391 (-)NCBINCBI36Build 36hg18NCBI36
Build 349113,228,146 - 113,243,124NCBI
Celera986,796,194 - 86,811,219 (-)NCBICelera
Cytogenetic Map9q32NCBI
HuRef985,755,612 - 85,770,551 (-)NCBIHuRef
CHM1_19116,295,230 - 116,310,254 (-)NCBICHM1_1
T2T-CHM13v2.09125,585,129 - 125,600,114 (-)NCBIT2T-CHM13v2.0
Alad
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39462,422,762 - 62,438,300 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl462,427,406 - 62,438,155 (-)EnsemblGRCm39 Ensembl
GRCm38462,505,984 - 62,520,063 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl462,509,169 - 62,519,918 (-)EnsemblGRCm38mm10GRCm38
MGSCv37462,170,204 - 62,181,097 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36461,995,531 - 62,006,424 (-)NCBIMGSCv36mm8
Celera461,179,310 - 61,187,276 (-)NCBICelera
Cytogenetic Map4B3NCBI
cM Map433.17NCBI
Alad
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541914,093,010 - 14,104,545 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541914,093,010 - 14,104,376 (+)NCBIChiLan1.0ChiLan1.0
ALAD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21125,972,297 - 25,987,310 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1925,974,656 - 25,991,945 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0984,488,339 - 84,503,360 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19112,859,171 - 112,873,784 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9112,859,171 - 112,873,784 (-)Ensemblpanpan1.1panPan2
ALAD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11167,736,643 - 67,752,399 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1167,741,390 - 67,752,321 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1166,141,416 - 66,157,086 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01168,860,894 - 68,876,553 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1168,861,709 - 68,876,497 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11167,378,968 - 67,394,637 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01167,409,910 - 67,425,556 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01168,146,847 - 68,162,517 (-)NCBIUU_Cfam_GSD_1.0
Alad
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947183,026,318 - 183,040,122 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936559226,424 - 241,684 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936559226,481 - 237,258 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALAD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1254,012,850 - 254,027,508 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11254,015,426 - 254,027,584 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ALAD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11226,173,063 - 26,185,456 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1226,173,096 - 26,189,845 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603516,615,859 - 16,628,288 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alad
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476021,698,587 - 21,711,822 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476021,698,689 - 21,709,907 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Alad
30 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:46
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000020625
Prediction methods:Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)55979352890450144Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)568984307104251008Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 40 57 41 19 41 1 4 72 35 41 11 1
Low 3 7 7 2 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001429324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC099453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000020625   ⟹   ENSRNOP00000020625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl575,961,993 - 75,972,474 (-)Ensembl
Rnor_6.0 Ensembl578,368,867 - 78,379,346 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000075916   ⟹   ENSRNOP00000068140
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl575,961,993 - 75,972,310 (-)Ensembl
Rnor_6.0 Ensembl578,368,869 - 78,376,032 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076837   ⟹   ENSRNOP00000068497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl575,966,853 - 75,971,761 (-)Ensembl
Rnor_6.0 Ensembl578,373,723 - 78,378,633 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077013
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl575,961,993 - 75,966,933 (-)Ensembl
Rnor_6.0 Ensembl578,368,867 - 78,370,698 (-)Ensembl
RefSeq Acc Id: NM_012899   ⟹   NP_037031
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8580,977,563 - 80,987,901 (-)NCBI
mRatBN7.2575,961,994 - 75,972,334 (-)NCBI
Rnor_6.0578,368,868 - 78,379,206 (-)NCBI
Rnor_5.0582,488,238 - 82,498,577 (-)NCBI
RGSC_v3.4579,505,645 - 79,515,983 (-)RGD
Celera574,903,347 - 74,913,685 (-)RGD
Sequence:
RefSeq Acc Id: XM_006238234   ⟹   XP_006238296
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8580,977,562 - 80,984,769 (-)NCBI
mRatBN7.2575,961,993 - 75,969,202 (-)NCBI
Rnor_6.0578,368,867 - 78,376,616 (-)NCBI
Rnor_5.0582,488,238 - 82,498,577 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238235   ⟹   XP_006238297
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8580,977,562 - 80,987,323 (-)NCBI
mRatBN7.2575,961,993 - 75,971,701 (-)NCBI
Rnor_6.0578,368,867 - 78,378,578 (-)NCBI
Rnor_5.0582,488,238 - 82,498,577 (-)NCBI
Sequence:
RefSeq Acc Id: NP_037031   ⟸   NM_012899
- UniProtKB: P06214 (UniProtKB/Swiss-Prot),   A0A8I6AS85 (UniProtKB/TrEMBL),   A6J7V5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238297   ⟸   XM_006238235
- Peptide Label: isoform X1
- UniProtKB: P06214 (UniProtKB/Swiss-Prot),   A0A8I6AS85 (UniProtKB/TrEMBL),   A6J7V5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238296   ⟸   XM_006238234
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000068140   ⟸   ENSRNOT00000075916
RefSeq Acc Id: ENSRNOP00000020625   ⟸   ENSRNOT00000020625
RefSeq Acc Id: ENSRNOP00000068497   ⟸   ENSRNOT00000076837

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P06214-F1-model_v2 AlphaFold P06214 1-330 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693794
Promoter ID:EPDNEW_R4317
Type:initiation region
Name:Alad_1
Description:aminolevulinate dehydratase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0578,379,151 - 78,379,211EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2083 AgrOrtholog
BioCyc Gene G2FUF-41090 BioCyc
BioCyc Pathway PWY-5189 [tetrapyrrole biosynthesis II (from glycine)] BioCyc
BioCyc Pathway Image PWY-5189 BioCyc
Ensembl Genes ENSRNOG00000015206 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055018142 UniProtKB/Swiss-Prot
  ENSRNOG00060010276 UniProtKB/Swiss-Prot
  ENSRNOG00065016023 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020625 ENTREZGENE
  ENSRNOT00000020625.7 UniProtKB/Swiss-Prot
  ENSRNOT00000075916.2 UniProtKB/TrEMBL
  ENSRNOT00000076837.2 UniProtKB/TrEMBL
  ENSRNOT00000077013.2 UniProtKB/TrEMBL
  ENSRNOT00055030768 UniProtKB/Swiss-Prot
  ENSRNOT00060017404 UniProtKB/Swiss-Prot
  ENSRNOT00065026678 UniProtKB/Swiss-Prot
Gene3D-CATH 3.20.20.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598340 IMAGE-MGC_LOAD
InterPro ALAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALAD_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldolase_TIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25374 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72551 IMAGE-MGC_LOAD
NCBI Gene 25374 ENTREZGENE
PANTHER DELTA-AMINOLEVULINIC ACID DEHYDRATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11458 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ALAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Alad PhenoGen
PIRSF Porphbilin_synth UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS DALDHYDRTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE D_ALA_DEHYDRATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015206 RatGTEx
  ENSRNOG00055018142 RatGTEx
  ENSRNOG00060010276 RatGTEx
  ENSRNOG00065016023 RatGTEx
SMART ALAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Aldolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC216883
UniProt A0A096MKF7_RAT UniProtKB/TrEMBL
  A0A8I6AS85 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R0C7 ENTREZGENE, UniProtKB/TrEMBL
  A6J7V5 ENTREZGENE, UniProtKB/TrEMBL
  A6J7V7_RAT UniProtKB/TrEMBL
  HEM2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-28 Alad  aminolevulinate dehydratase  Alad  aminolevulinate, delta-, dehydratase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-06-29 Alad  Delta - aminolevulinic acid dehydratase      Name withdrawn 67952 WITHDRAWN
2001-06-29 Alad  aminolevulinate,delta-,dehydratase      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function catalyzes the conversion of 5-aminolevulinate to porphobilinogen 632180
gene_process plays a role in heme biosynthesis 632180
gene_protein protein precursor contains 587 amino acids 632181