Alad (aminolevulinate, delta-, dehydratase) - Rat Genome Database

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Gene: Alad (aminolevulinate, delta-, dehydratase) Mus musculus
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Symbol: Alad
Name: aminolevulinate, delta-, dehydratase
RGD ID: 10133
MGI Page MGI
Description: Enables porphobilinogen synthase activity. Involved in heme A biosynthetic process; heme B biosynthetic process; and heme O biosynthetic process. Acts upstream of or within cellular response to interleukin-4 and heme biosynthetic process. Is active in cytosol. Is expressed in several structures, including liver; lung; metanephros; spleen; and yolk sac. Human ortholog(s) of this gene implicated in porphyria cutanea tarda and sickle cell anemia. Orthologous to human ALAD (aminolevulinate dehydratase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ALADH; delta-aminolevulinate dehydratase; delta-aminolevulinic acid dehydratase; Lv; porphobilinogen synthase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39462,422,762 - 62,438,300 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl462,427,406 - 62,438,155 (-)EnsemblGRCm39 Ensembl
GRCm38462,505,984 - 62,520,063 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl462,509,169 - 62,519,918 (-)EnsemblGRCm38mm10GRCm38
MGSCv37462,170,204 - 62,181,097 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36461,995,531 - 62,006,424 (-)NCBIMGSCv36mm8
Celera461,179,310 - 61,187,276 (-)NCBICelera
Cytogenetic Map4B3NCBI
cM Map433.17NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP,ISO)
(+)-schisandrin B  (ISO)
(R)-lipoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
1,4-dithiothreitol  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrabromodibenzodioxine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
2-methoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5,5-diethylbarbituric acid  (EXP)
5-aminolevulinic acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acephate  (ISO)
acetamide  (ISO)
aconitine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (ISO)
amphetamine  (EXP)
arsane  (ISO)
arsenic acid  (ISO)
arsenic atom  (ISO)
arsenite ion  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-carotene  (EXP)
bilirubin IXalpha  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (ISO)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
carbon monoxide  (ISO)
carbon nanotube  (EXP)
carmustine  (ISO)
chitosan  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
citronellal  (EXP)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (EXP,ISO)
diethyldithiocarbamic acid  (ISO)
diethylstilbestrol  (ISO)
dimercaprol  (ISO)
disodium selenite  (EXP)
disulfiram  (ISO)
dorsomorphin  (ISO)
ebselen  (EXP,ISO)
elemental selenium  (ISO)
enflurane  (EXP)
estrone  (ISO)
ethanol  (EXP)
etoposide  (ISO)
fenthion  (EXP)
ferulic acid  (ISO)
fluphenazine  (ISO)
folic acid  (EXP)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gallic acid  (ISO)
gamma-Oryzanol (TN)  (EXP)
genistein  (ISO)
gentamycin  (ISO)
glutathione  (ISO)
glycerol  (ISO)
glycidyl methacrylate  (ISO)
hexachlorobenzene  (ISO)
hexestrol  (ISO)
hydrogen cyanide  (EXP)
hydrogen peroxide  (ISO)
inulin  (EXP)
isoflurane  (EXP)
L-1,4-dithiothreitol  (EXP,ISO)
L-selenocysteine  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
lithium carbonate  (ISO)
lycopene  (EXP,ISO)
Maleic hydrazide  (ISO)
melphalan  (ISO)
mercury atom  (EXP,ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
mestranol  (ISO)
methamidophos  (ISO)
methidathion  (EXP)
methylseleninic acid  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
naphthalenes  (ISO)
nicotine  (ISO)
nitrofen  (ISO)
nitroprusside  (EXP)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentetrazol  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
picrotoxin  (EXP)
pirinixic acid  (EXP)
porphobilinogen  (ISO)
potassium cyanide  (EXP)
progesterone  (ISO)
quinolone  (EXP)
raloxifene  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-methioninate  (EXP)
S-adenosyl-L-methionine  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
Soman  (ISO)
streptozocin  (EXP)
styrene  (ISO)
succimer  (EXP,ISO)
sucrose  (EXP)
tamoxifen  (EXP)
taurine  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triptonide  (EXP)
troglitazone  (EXP)
ubiquinones  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
zearalenone  (EXP)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc dichloride  (EXP,ISO)
zinc protoporphyrin  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to interleukin-4  (IDA)
cellular response to lead ion  (ISO)
heme A biosynthetic process  (IDA,IMP)
heme B biosynthetic process  (IDA,IMP)
heme biosynthetic process  (IBA,IDA,ISO)
heme O biosynthetic process  (IDA,IMP)
negative regulation of proteasomal protein catabolic process  (ISO)
porphyrin-containing compound biosynthetic process  (IEA)
protein homooligomerization  (ISO)
response to activity  (ISO)
response to aluminum ion  (ISO)
response to amino acid  (ISO)
response to arsenic-containing substance  (ISO)
response to cadmium ion  (ISO)
response to cobalt ion  (ISO)
response to ethanol  (ISO)
response to fatty acid  (ISO)
response to glucocorticoid  (ISO)
response to herbicide  (ISO)
response to hormone  (ISO)
response to hypoxia  (ISO)
response to inorganic substance  (ISO)
response to ionizing radiation  (ISO)
response to iron ion  (ISO)
response to lead ion  (ISO)
response to lipopolysaccharide  (ISO)
response to mercury ion  (ISO)
response to metal ion  (ISO)
response to methylmercury  (ISO)
response to nutrient  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to oxidative stress  (ISO)
response to platinum ion  (ISO)
response to selenium ion  (ISO)
response to toxic substance  (ISO)
response to vitamin  (ISO)
response to vitamin B1  (ISO)
response to vitamin E  (ISO)
response to xenobiotic stimulus  (ISO)
response to zinc ion  (ISO)
tetrapyrrole biosynthetic process  (IEA)

Cellular Component
cytosol  (IBA,IDA)
extracellular space  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Biosynthesis of heme in mammals. Ajioka RS, etal., Biochim Biophys Acta. 2006 Jul;1763(7):723-36. Epub 2006 Jun 3.
2. Increased erythrocyte uroporphyrinogen-l-synthetase, delta-aminolevulinic acid dehydratase and protoporphyrin in hemolytic anemias. Anderson KE, etal., Am J Med. 1977 Sep;63(3):359-64.
3. Involvement of striatal lipid peroxidation and inhibition of calcium influx into brain slices in neurobehavioral alterations in a rat model of short-term oral exposure to manganese. Avila DS, etal., Neurotoxicology. 2008 Nov;29(6):1062-8. Epub 2008 Aug 20.
4. Acute diphenyl diselenide treatment reduces hyperglycemia but does not change delta-aminolevulinate dehydratase activity in alloxan-induced diabetes in rats. Barbosa NB, etal., Biol Pharm Bull. 2008 Dec;31(12):2200-4.
5. Synthesis, delivery and regulation of eukaryotic heme and Fe-S cluster cofactors. Barupala DP, etal., Arch Biochem Biophys. 2016 Feb 15;592:60-75. doi: 10.1016/j.abb.2016.01.010. Epub 2016 Jan 16.
6. Hepatic heme synthesis in a new model of experimental hemochromatosis: studies in rats fed finely divided elemental iron. Bonkovsky HL, etal., Hepatology. 1987 Nov-Dec;7(6):1195-203.
7. Diphenyl diselenide protects against glycerol-induced renal damage in rats. Brandao R, etal., J Appl Toxicol. 2009 Oct;29(7):612-8.
8. Effect of vitamin D3 on behavioural and biochemical parameters in diabetes type 1-induced rats. Calgaroto NS, etal., Cell Biochem Funct. 2014 Aug;32(6):502-10. doi: 10.1002/cbf.3044. Epub 2014 Jun 19.
9. Delta aminolevulinate dehydratase (ALA-D) activity in human and experimental diabetes mellitus. Fernández-Cuartero B, etal., Int J Biochem Cell Biol. 1999 Mar-Apr;31(3-4):479-88. doi: 10.1016/s1357-2725(98)00145-9.
10. Delta-aminolevulinate dehydratase activity in red blood cells of rats infected with Trypanosoma evansi. França RT, etal., Parasitology. 2011 Sep;138(10):1272-7. doi: 10.1017/S0031182011000989.
11. Oral supplementation of gossypin during lead exposure protects alteration in heme synthesis pathway and brain oxidative stress in rats. Gautam P and Flora SJ, Nutrition. 2010 May;26(5):563-70. Epub 2009 Jul 31.
12. GenMAPP: Gene Map Annotator and Pathway Profiler GenMAPP
13. Experimental hypothyroidism inhibits delta-aminolevulinate dehydratase activity in neonatal rat blood and liver. Gravina FS, etal., Exp Biol Med (Maywood). 2007 Sep;232(8):1021-6.
14. Message amplification phenotyping of an inherited delta-aminolevulinate dehydratase deficiency in a family with acute hepatic porphyria. Ishida N, etal., Biochem Biophys Res Commun. 1990 Oct 15;172(1):237-42.
15. Effect of oral administration of diphenyl diselenide on antioxidant status, and activity of delta aminolevulinic acid dehydratase and isoforms of lactate dehydrogenase, in streptozotocin-induced diabetic rats. Kade IJ, etal., Cell Biol Toxicol. 2009 Aug;25(4):415-24. doi: 10.1007/s10565-008-9095-5. Epub 2008 Jul 31.
16. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
17. Changes in aminolevulinate synthase and aminolevulinate dehydratase activity in cirrhotic liver. Kodama T, etal., Gastroenterology. 1983 Feb;84(2):236-41.
18. Associations of blood pressure and hypertension with lead dose measures and polymorphisms in the vitamin D receptor and delta-aminolevulinic acid dehydratase genes. Lee BK, etal., Environ Health Perspect. 2001 Apr;109(4):383-9.
19. Delta-aminolevulinate dehydratase activity in mice with hereditary anemia. Margolis FL and Russell ES, Science. 1965 Oct 22;150(3695):496-7.
20. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
21. MGDs mouse GO annotations MGD data from the GO Consortium
22. Differential oxidative stress and DNA damage in rat brain regions and blood following chronic arsenic exposure. Mishra D and Flora SJ, Toxicol Ind Health. 2008 May;24(4):247-56.
23. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
27. STZ-induced diabetes in mice and heme pathway enzymes. Effect of allylisopropylacetamide and alpha-tocopherol. Polo CF, etal., Chem Biol Interact. 1995 Apr 14;95(3):327-34.
28. Involvement of oxidative stress in seizures induced by diphenyl diselenide in rat pups. Prigol M, etal., Brain Res. 2007 May 25;1147:226-32. Epub 2007 Feb 4.
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Lipoic acid blocks seizures induced by pilocarpine via increases in delta-aminolevulinic dehydratase and Na+, K+-ATPase activity in rat brain. Santos IM, etal., Pharmacol Biochem Behav. 2010 Mar;95(1):88-91. Epub 2009 Dec 21.
32. Changes in brain biogenic amines and haem biosynthesis and their response to combined administration of succimers and Centella asiatica in lead poisoned rats. Saxena G and Flora SJ, J Pharm Pharmacol. 2006 Apr;58(4):547-59.
33. Effects of resveratrol on biomarkers of oxidative stress and on the activity of delta aminolevulinic acid dehydratase in liver and kidney of streptozotocin-induced diabetic rats. Schmatz R, etal., Biochimie. 2012 Feb;94(2):374-83. doi: 10.1016/j.biochi.2011.08.005. Epub 2011 Aug 16.
34. Study of erythrocyte delta-aminolevulinic acid dehydratase activity in porphyria cutanea tarda. Simon N and Kiss M, Arch Dermatol Res. 1979 Oct;266(2):121-6.
35. [Activity of delta-aminolaevulinic acid (ALAD) in erythrocytes of patients with chronic hepatic porphyria (porphyria cutanea tarda)]. Stankiewicz-Wróblewska J, Pol Arch Med Wewn. 1993 Mar;89(3):212-6.
36. Decrease of hepatic delta-aminolevulinate dehydratase activity in an animal model of fatigue. Tahara T, etal., Biochem Biophys Res Commun. 2006 Dec 28;.
37. Mechanism of hexachlorobenzene-induced porphyria in rats. Effect of phenobarbitone pretreatment. Wainstok de Calmanovici R, etal., Biochem J. 1984 Mar 15;218(3):753-63.
Additional References at PubMed
PMID:1192808   PMID:1379092   PMID:2037292   PMID:2212703   PMID:2922298   PMID:3100390   PMID:3502704   PMID:4959158   PMID:4981581   PMID:5111568   PMID:5358144   PMID:5393940  
PMID:5424503   PMID:7508415   PMID:7774911   PMID:8088814   PMID:8692689   PMID:8838309   PMID:8889548   PMID:9521876   PMID:9798653   PMID:10337627   PMID:10338499   PMID:10349636  
PMID:10512203   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11591653   PMID:12477932   PMID:14050799   PMID:14610273   PMID:14681479   PMID:15489334   PMID:15597075   PMID:15782199  
PMID:15840001   PMID:15923635   PMID:16141072   PMID:16141073   PMID:17374603   PMID:17476283   PMID:17936691   PMID:18799693   PMID:19423573   PMID:20508144   PMID:21267068   PMID:21640720  
PMID:21677750   PMID:21873635   PMID:22496890   PMID:23056320   PMID:23604909   PMID:26287972   PMID:27650074   PMID:30550785   PMID:32325033  


Genomics

Comparative Map Data
Alad
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39462,422,762 - 62,438,300 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl462,427,406 - 62,438,155 (-)EnsemblGRCm39 Ensembl
GRCm38462,505,984 - 62,520,063 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl462,509,169 - 62,519,918 (-)EnsemblGRCm38mm10GRCm38
MGSCv37462,170,204 - 62,181,097 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36461,995,531 - 62,006,424 (-)NCBIMGSCv36mm8
Celera461,179,310 - 61,187,276 (-)NCBICelera
Cytogenetic Map4B3NCBI
cM Map433.17NCBI
ALAD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389113,386,312 - 113,401,284 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9113,386,312 - 113,401,290 (-)EnsemblGRCh38hg38GRCh38
GRCh379116,148,592 - 116,163,564 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369115,188,413 - 115,203,391 (-)NCBINCBI36Build 36hg18NCBI36
Build 349113,228,146 - 113,243,124NCBI
Celera986,796,194 - 86,811,219 (-)NCBICelera
Cytogenetic Map9q32NCBI
HuRef985,755,612 - 85,770,551 (-)NCBIHuRef
CHM1_19116,295,230 - 116,310,254 (-)NCBICHM1_1
T2T-CHM13v2.09125,585,129 - 125,600,114 (-)NCBIT2T-CHM13v2.0
Alad
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8580,977,562 - 80,987,901 (-)NCBIGRCr8
mRatBN7.2575,961,993 - 75,972,334 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl575,961,993 - 75,972,474 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx578,361,344 - 78,371,685 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0580,178,441 - 80,188,782 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0580,153,956 - 80,164,297 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0578,368,867 - 78,379,206 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl578,368,867 - 78,379,346 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0582,488,238 - 82,498,577 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4579,505,645 - 79,515,983 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1579,510,757 - 79,521,096 (-)NCBI
Celera574,903,347 - 74,913,685 (-)NCBICelera
Cytogenetic Map5q24NCBI
Alad
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541914,093,010 - 14,104,545 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541914,093,010 - 14,104,376 (+)NCBIChiLan1.0ChiLan1.0
ALAD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21125,972,297 - 25,987,310 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1925,974,656 - 25,991,945 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0984,488,339 - 84,503,360 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19112,859,171 - 112,873,784 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9112,859,171 - 112,873,784 (-)Ensemblpanpan1.1panPan2
ALAD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11167,736,643 - 67,752,399 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1167,741,390 - 67,752,321 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1166,141,416 - 66,157,086 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01168,860,894 - 68,876,553 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1168,861,709 - 68,876,497 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11167,378,968 - 67,394,637 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01167,409,910 - 67,425,556 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01168,146,847 - 68,162,517 (-)NCBIUU_Cfam_GSD_1.0
Alad
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947183,026,318 - 183,040,122 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936559226,424 - 241,684 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936559226,481 - 237,258 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALAD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1254,012,850 - 254,027,508 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11254,015,426 - 254,027,584 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ALAD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11226,173,063 - 26,185,456 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1226,173,096 - 26,189,845 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603516,615,859 - 16,628,288 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alad
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476021,698,587 - 21,711,822 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476021,698,689 - 21,709,907 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Alad
479 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:612
Count of miRNA genes:345
Interacting mature miRNAs:387
Transcripts:ENSMUST00000030090, ENSMUST00000107444, ENSMUST00000137448
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
4142318Lyr2_mlymphoma resistance 2 (mouse)Not determined1401045763283678Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
4141911W6q15_mweight 6 weeks QTL 15 (mouse)Not determined1789261688982216Mouse
39128211Lwq22_mliver weight QTL 22 (mouse)41789261688982216Mouse
1357453Kidq4_mkidney weight QTL 4 (mouse)Not determined41789261688982216Mouse
1301586Stheal3_msoft tissue heal 3 (mouse)Not determined42865844262658566Mouse
1357877Synch1_msynechia 1 (mouse)Not determined42870992562710107Mouse
1301990Arvm1_mautoimmune renal vasculitis 1 (mouse)Not determined42933264663332776Mouse
1301792Hdlq10_mHDL QTL 10 (mouse)Not determined43585970769859853Mouse
1300977Mopkd1_mmodifier of polycystic kidney disease progression 1 (mouse)Not determined43655083970550967Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000128993793Mouse
1302116Bbaa1_mB.burgdorferi-associated arthritis 1 (mouse)Not determined43825093072251078Mouse
10412178Habiir2_mhyperoxic acute lung injury imprinted region 2 (mouse)Not determined43945212663283678Mouse
1301786Bpq3_mblood pressure QTL 3 (mouse)Not determined44240224076402381Mouse
27226724Tibw2_mtibia width 2, proximal, 10 week (mouse)443000000108357197Mouse
1301941Mmtg1_mmodifier of mammary tumor growth 1 (mouse)Not determined44565844283099157Mouse
1558948Ath8_matherosclerosis 8 (mouse)Not determined445658442105156995Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
12879977Bod2_mbone length and organs 2 (mouse)44628353180283678Mouse
10043880Adip23_madiposity 23 (mouse)Not determined44628353180283678Mouse
1300966Pabr2_mplasma apolipoprotein B (human) regulator 2 (mouse)Not determined446332646105801860Mouse
10449022Aanq1_maristolochic acid nephrotoxicity QTL 1 (mouse)44660382680603826Mouse
11532714Sluc43_msusceptibility to lung cancer 43 (mouse)446642108123127211Mouse
11532688Mh_mmodifier of hemostasis (mouse)44830477582304775Mouse
25314308Mlh1fc1_mMLH1 foci count 1 (mouse)44850000076918237Mouse
1301995Lprm1_mlymphoproliferation modifier 1 (mouse)Not determined45010026284100408Mouse
1301213Lgth3_mbody length 3 (mouse)Not determined45010026284100408Mouse
13207572Spir2_mStreptococcus pneumoniae infection resistance 2 (mouse)45068279588510637Mouse
1301033Abbp2_mA/J and C57BL/6 blood pressure 2 (mouse)Not determined45355083993763305Mouse
4141900Skts-fp1_mskin tumor susceptibility in FVB and PWK 1 (mouse)Not determined453550839124055180Mouse
26884434Zlq1_mzygomatic length QTL 1, 5 week (mouse)453700000103257197Mouse
13524838Hbasrq1a_mhabituation of the acoustic startle response QTL 1a (mouse)45447158988471589Mouse
13524841Hbasrq1_mhabituation of the acoustic startle response QTL 1 (mouse)45447158988471589Mouse
27095905Scvln3_msacral vertebrae length 2, 5 week (mouse)455600000128993793Mouse
27095934Ulnl2_mulna length 2, 5 week (mouse)45770000094788237Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
10043964Obq26_mobesity QTL 26 (mouse)Not determined45904725193047251Mouse
1357507Synch2_msynechia 2 (mouse)Not determined46014527794145424Mouse
1301190Cd4ts2_mCD4 T cell subset 2 (mouse)Not determined46014527794145424Mouse
1357443Lhyp_mlung hyperpermeability (mouse)Not determined46045401166764818Mouse
25394561Skmw53_mskeletal muscle weight 53, TA (mouse)46213829369838031Mouse
1558962Cms1_mresistance to Coccidioides immitis 1 (mouse)Not determined46242740662438155Mouse


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001276446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001421131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF003353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF004855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK032908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL732594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC055930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY208737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB524263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L08247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L08248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L08249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U89407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X13752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000030090   ⟹   ENSMUSP00000030090
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl462,427,406 - 62,438,155 (-)Ensembl
GRCm38.p6 Ensembl462,509,169 - 62,519,918 (-)Ensembl
RefSeq Acc Id: ENSMUST00000107444   ⟹   ENSMUSP00000103068
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl462,427,406 - 62,438,131 (-)Ensembl
GRCm38.p6 Ensembl462,509,169 - 62,519,894 (-)Ensembl
RefSeq Acc Id: ENSMUST00000137448
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl462,427,406 - 62,438,118 (-)Ensembl
GRCm38.p6 Ensembl462,509,169 - 62,519,881 (-)Ensembl
RefSeq Acc Id: NM_001276446   ⟹   NP_001263375
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39462,422,762 - 62,438,146 (-)NCBI
GRCm38462,505,984 - 62,519,909 (-)NCBI
Celera461,176,124 - 61,187,276 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001421131   ⟹   NP_001408060
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39462,422,762 - 62,434,953 (-)NCBI
RefSeq Acc Id: NM_008525   ⟹   NP_032551
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39462,422,762 - 62,438,300 (-)NCBI
GRCm38462,505,984 - 62,520,063 (-)NCBI
MGSCv37462,170,204 - 62,181,097 (-)RGD
Celera461,176,124 - 61,187,276 (-)NCBI
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032551   ⟸   NM_008525
- UniProtKB: Q3THV6 (UniProtKB/Swiss-Prot),   P10518 (UniProtKB/Swiss-Prot),   Q9DD05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001263375   ⟸   NM_001276446
- UniProtKB: Q3THV6 (UniProtKB/Swiss-Prot),   P10518 (UniProtKB/Swiss-Prot),   Q9DD05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000103068   ⟸   ENSMUST00000107444
RefSeq Acc Id: ENSMUSP00000030090   ⟸   ENSMUST00000030090
RefSeq Acc Id: NP_001408060   ⟸   NM_001421131
- UniProtKB: Q3THV6 (UniProtKB/Swiss-Prot),   P10518 (UniProtKB/Swiss-Prot),   Q9DD05 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10518-F1-model_v2 AlphaFold P10518 1-330 view protein structure

Promoters
RGD ID:6848779
Promoter ID:MM_TRO:6837
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung,   Spleen
Transcripts:MTR003062.4.985.4
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36462,171,289 - 62,171,789 (-)MPROMDB
RGD ID:6847781
Promoter ID:MM_ACW:34665
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung,   Spleen
Transcripts:ALAD.CSEP07,   ALAD.DSEP07,   ALAD.JSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36462,177,264 - 62,177,764 (-)MPROMDB
RGD ID:6834853
Promoter ID:MM_KWN:37961
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000030090,   ENSMUST00000107444,   OTTMUST00000020468
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36462,180,526 - 62,181,387 (-)MPROMDB
RGD ID:6883606
Promoter ID:EPDNEW_M5254
Type:initiation region
Name:Alad_2
Description:Mus musculus aminolevulinate, delta-, dehydratase , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M5255  EPDNEW_M5256  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38462,516,692 - 62,516,752EPDNEW
RGD ID:6883608
Promoter ID:EPDNEW_M5255
Type:initiation region
Name:Alad_1
Description:Mus musculus aminolevulinate, delta-, dehydratase , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M5254  EPDNEW_M5256  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38462,519,896 - 62,519,956EPDNEW
RGD ID:6883610
Promoter ID:EPDNEW_M5256
Type:initiation region
Name:Alad_3
Description:Mus musculus aminolevulinate, delta-, dehydratase , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M5254  EPDNEW_M5255  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38462,520,073 - 62,520,133EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96853 AgrOrtholog
Ensembl Genes ENSMUSG00000028393 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000030090 ENTREZGENE
  ENSMUST00000030090.4 UniProtKB/Swiss-Prot
  ENSMUST00000107444 ENTREZGENE
  ENSMUST00000107444.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.20.20.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ALAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALAD_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldolase_TIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17025 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96853 ENTREZGENE
NCBI Gene 17025 ENTREZGENE
PANTHER DELTA-AMINOLEVULINIC ACID DEHYDRATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11458 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ALAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Alad PhenoGen
PIRSF Porphbilin_synth UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS DALDHYDRTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE D_ALA_DEHYDRATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ALAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Aldolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt HEM2_MOUSE UniProtKB/Swiss-Prot
  O89061_MOUSE UniProtKB/TrEMBL
  P10518 ENTREZGENE
  Q3THV6 ENTREZGENE
  Q8VCZ1_MOUSE UniProtKB/TrEMBL
  Q9DD05 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q3THV6 UniProtKB/Swiss-Prot