RGD Reference Report - Effects of resveratrol on biomarkers of oxidative stress and on the activity of delta aminolevulinic acid dehydratase in liver and kidney of streptozotocin-induced diabetic rats.

General

Effects of resveratrol on biomarkers of oxidative stress and on the activity of delta aminolevulinic acid dehydratase in liver and kidney of streptozotocin-induced diabetic rats.
Authors:	Schmatz, Roberta Perreira, Luciane Belmonte Stefanello, Naiara Mazzanti, Cinthia Spanevello, Roselia Gutierres, Jessié Bagatini, Margarete Martins, Caroline Curry Abdalla, Fátima Husein Daci da Silva Serres, Jonas Zanini, Daniela Vieira, Juliano Marchi Cardoso, Andréia Machado Schetinger, Maria Rosa Morsch, Vera Maria
Citation:	Schmatz R, etal., Biochimie. 2012 Feb;94(2):374-83. doi: 10.1016/j.biochi.2011.08.005. Epub 2011 Aug 16.
RGD ID:	12904702
Pubmed:	PMID:21864646 (View Abstract at PubMed)
DOI:	DOI:10.1016/j.biochi.2011.08.005 (Journal Full-text)
The present study investigated the effects of resveratrol (RV), a polyphenol with potent antioxidant properties, on oxidative stress parameters in liver and kidney, as well as on serum biochemical parameters of streptozotocin (STZ)-induced diabetic rats. Animals were divided into six groups (n = 8): control/saline; control/RV 10 mg/kg; control/RV 20 mg/kg; diabetic/saline; diabetic/RV10 mg/kg; diabetic/RV 20 mg/kg. After 30 days of treatment with resveratrol the animals were sacrificed and the liver, kidney and serum were used for experimental determinations. Results showed that TBARS levels were significantly increased in the diabetic/saline group and the administration of resveratrol prevented this increase in the diabetic/RV10 and diabetic/RV20 groups (P < 0.05). The activities of catalase (CAT), superoxide dismutase (SOD) and aminolevulinic acid dehydratase (d-ALA-D) and the levels of non protein thiols (NPSH) and vitamin C presented a significant decrease in the diabetic/saline group when compared with the control/saline group (P < 0.05). The treatment with resveratrol was able to prevent these decrease improving the antioxidant defense of the diabetic/RV10 and diabetic/RV20 groups (P < 0.05). In addition, the elevation in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and γ-glutamiltransferase (γ-GT) activities as well as in levels of urea, creatinine, cholesterol and triglycerides observed in the diabetic/saline group were reverted to levels close to normal by the administration of resveratrol in the diabetic/RV10 and diabetic/RV20 groups (P < 0.05). These findings suggest that resveratrol could have a protector effect against hepatic and renal damage induced by oxidative stress in the diabetic state, which was evidenced by the capacity of this polyphenol to modulate the antioxidant defense and to decrease the lipid peroxidation in these tissues.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Experimental Diabetes Mellitus	treatment	ISO	Alad (Rattus norvegicus)	12904702; 12904702		RGD
Experimental Diabetes Mellitus	treatment	IDA		12904702		RGD

Objects Annotated

Genes (Rattus norvegicus)

Alad (aminolevulinate dehydratase)

Genes (Mus musculus)

Alad (aminolevulinate, delta-, dehydratase)

Genes (Homo sapiens)

ALAD (aminolevulinate dehydratase)

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Effects of resveratrol on biomarkers of oxidative stress and on the activity of delta aminolevulinic acid dehydratase in liver and kidney of streptozotocin-induced diabetic rats.