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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2083
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Alad
Name: aminolevulinate dehydratase
Acc ID: CHEBI:42106
Term: L-1,4-dithiothreitol
Definition: A 1,4-dithiothreitol that has formula C4H10O2S2.
Chemical ID: MESH:D004229
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aladincreases activityEXP 6480464CTDDithiothreitol results in increased activity of ALAD proteinPMID:21360559
Aladmultiple interactionsEXP 6480464CTDcadmium acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; Dithiothreitol inhibits the reaction [2,2'-dithienyl diselenide results in decreased activity of ALAD protein]; Dithiothreitol inhibits the reaction [ebselen results in decreased activity of ALAD protein]; Zinc Acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]PMID:21360559 PMID:22180340 PMID:23933410
Aladincreases activityISOALAD (Homo sapiens)6480464CTDDithiothreitol results in increased activity of ALAD proteinPMID:2061546
Aladmultiple interactionsISOAlad (Mus musculus)6480464CTDDithiothreitol inhibits the reaction [Cadmium Chloride inhibits the reaction [diphenyldiselenide results in decreased activity of ALAD protein]]PMID:20472051
Aladmultiple interactionsISOALAD (Homo sapiens)6480464CTD[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]; Cadmium affects the reaction [[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]]; lead nitrate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; lead nitrate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]; triethyllead acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; triethyllead acetate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]; zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]PMID:2061546 PMID:21910133
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