Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2083
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Alad
Name: aminolevulinate dehydratase
Acc ID: CHEBI:27563
Term: arsenic atom
Definition: A pnictogen that has formula As.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aladdecreases activityEXP 6480464CTDArsenic results in decreased activity of ALAD proteinPMID:20587388 PMID:21034764 PMID:22704994
Aladdecreases expressionEXP 6480464CTDArsenic results in decreased expression of ALAD proteinPMID:19966145
Aladmultiple interactionsEXP 6480464CTD[Arsenic co-treated with Cadmium] results in decreased activity of ALAD protein; [Arsenic co-treated with Lead co-treated with Cadmium] results in decreased activity of ALAD protein; [Arsenic co-treated with Lead] results in decreased activity of ALAD protein; [Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of ALAD protein]; Curcumin inhibits the reaction [Arsenic results in decreased activity of ALAD protein]; Selenium inhibits the reaction [Arsenic results in decreased activity of ALAD protein]PMID:20587388 PMID:21034764 PMID:22354675 PMID:22704994
Go Back to source page   Continue to Ontology report