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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of EPB41L4B mRNA] | CTD | PMID:31150632 | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | EPB41L4B (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of EPB41L4B mRNA | CTD | PMID:22079256 | (1->4)-beta-D-glucan | multiple interactions | ISO | Epb41l4b (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of EPB41L4B mRNA | CTD | PMID:36331819 | 1,1-dichloroethene | decreases expression | ISO | Epb41l4b (Mus musculus) | 6480464 | vinylidene chloride results in decreased expression of EPB41L4B mRNA | CTD | PMID:26682919 | 1,2-dichloroethane | decreases expression | ISO | Epb41l4b (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of EPB41L4B mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | multiple interactions | ISO | Epb41l4b (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of EPB41L4B mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | decreases expression | ISO | Epb41l4b (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of EPB41L4B mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | multiple interactions | ISO | Epb41l4b (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EPB41L4B mRNA | CTD | PMID:17942748 | 17beta-estradiol | multiple interactions | ISO | EPB41L4B (Homo sapiens) | 6480464 | [Estradiol co-treated with Progesterone] results in increased expression of EPB41L4B mRNA and [Estradiol co-treated with TGFB1 protein] results in decreased expression of EPB41L4B mRNA | CTD | PMID:20660070 and PMID:30165855 | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of EPB41L4B mRNA | CTD | PMID:32145629 | 17beta-hydroxy-5alpha-androstan-3-one | increases expression | ISO | EPB41L4B (Homo sapiens) | 6480464 | Dihydrotestosterone results in increased expression of EPB41L4B mRNA | CTD | PMID:29581250 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:27291303 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | EPB41L4B (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EPB41L4B mRNA | CTD | PMID:20106945 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of EPB41L4B mRNA | CTD | PMID:32109520 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Epb41l4b (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of EPB41L4B mRNA | CTD | PMID:19770486 and PMID:32553695 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Epb41l4b (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EPB41L4B mRNA | CTD | PMID:17942748 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Epb41l4b (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of EPB41L4B mRNA | CTD | PMID:20188158 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | EPB41L4B (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EPB41L4B mRNA | CTD | PMID:28628672 | 4-hydroxyphenyl retinamide | increases expression | ISO | Epb41l4b (Mus musculus) | 6480464 | Fenretinide results in increased expression of EPB41L4B mRNA | CTD | PMID:28973697 | 7,12-dimethyltetraphene | decreases expression | ISO | Epb41l4b (Mus musculus) | 6480464 | 9 more ... | CTD | PMID:32553695 | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of EPB41L4B mRNA | CTD | PMID:31881176 | aflatoxin B1 | affects expression | ISO | EPB41L4B (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of EPB41L4B protein | CTD | PMID:20106945 | Aflatoxin B2 alpha | decreases methylation | ISO | EPB41L4B (Homo sapiens) | 6480464 | aflatoxin B2 results in decreased methylation of EPB41L4B 3' UTR | CTD | PMID:30157460 | aristolochic acid A | decreases expression | ISO | EPB41L4B (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of EPB41L4B mRNA | CTD | PMID:33212167 | arsenous acid | increases expression | ISO | EPB41L4B (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of EPB41L4B mRNA | CTD | PMID:22521957 | benzo[a]pyrene | decreases expression | ISO | Epb41l4b (Mus musculus) | 6480464 | Benzo(a)pyrene metabolite results in decreased expression of EPB41L4B mRNA | CTD | PMID:32553695 | benzo[a]pyrene | decreases expression | ISO | EPB41L4B (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of EPB41L4B mRNA | CTD | PMID:32234424 | benzo[a]pyrene | increases methylation | ISO | EPB41L4B (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of EPB41L4B promoter | CTD | PMID:27901495 | benzo[e]pyrene | increases methylation | ISO | EPB41L4B (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of EPB41L4B intron | CTD | PMID:30157460 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of EPB41L4B mRNA | CTD | PMID:25181051 and PMID:34947998 | bisphenol A | decreases expression | ISO | Epb41l4b (Mus musculus) | 6480464 | bisphenol A results in decreased expression of EPB41L4B mRNA | CTD | PMID:33221593 | bisphenol A | multiple interactions | ISO | EPB41L4B (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of EPB41L4B gene and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EPB41L4B mRNA | CTD | PMID:28628672 and PMID:31601247 | cadmium atom | multiple interactions | ISO | EPB41L4B (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of EPB41L4B mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | ISO | EPB41L4B (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of EPB41L4B mRNA | CTD | PMID:35301059 | caffeine | affects phosphorylation | ISO | EPB41L4B (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of EPB41L4B protein | CTD | PMID:35688186 | calcitriol | increases expression | ISO | EPB41L4B (Homo sapiens) | 6480464 | Calcitriol results in increased expression of EPB41L4B mRNA | CTD | PMID:26485663 | carbon nanotube | decreases expression | ISO | Epb41l4b (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | casticin | decreases expression | ISO | Epb41l4b (Mus musculus) | 6480464 | casticin results in decreased expression of EPB41L4B mRNA | CTD | PMID:28444820 | CGP 52608 | multiple interactions | ISO | EPB41L4B (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to EPB41L4B gene] | CTD | PMID:28238834 | copper atom | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of EPB41L4B mRNA | CTD | PMID:26033743 | copper(0) | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of EPB41L4B mRNA | CTD | PMID:26033743 | copper(II) sulfate | decreases expression | ISO | EPB41L4B (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of EPB41L4B mRNA | CTD | PMID:19549813 | crocidolite asbestos | decreases expression | ISO | Epb41l4b (Mus musculus) | 6480464 | Asbestos and Crocidolite results in decreased expression of EPB41L4B mRNA | CTD | PMID:29279043 | dexamethasone | multiple interactions | ISO | EPB41L4B (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EPB41L4B mRNA | CTD | PMID:28628672 | diarsenic trioxide | increases expression | ISO | EPB41L4B (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of EPB41L4B mRNA | CTD | PMID:22521957 | dioxygen | multiple interactions | ISO | Epb41l4b (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of EPB41L4B mRNA | CTD | PMID:30529165 | dorsomorphin | multiple interactions | ISO | EPB41L4B (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | elemental selenium | decreases expression | ISO | EPB41L4B (Homo sapiens) | 6480464 | Selenium results in decreased expression of EPB41L4B mRNA | CTD | PMID:19244175 | entinostat | multiple interactions | ISO | EPB41L4B (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPB41L4B mRNA | CTD | PMID:27188386 | entinostat | increases expression | ISO | EPB41L4B (Homo sapiens) | 6480464 | entinostat results in increased expression of EPB41L4B mRNA | CTD | PMID:26272509 | epoxiconazole | increases expression | ISO | Epb41l4b (Mus musculus) | 6480464 | epoxiconazole results in increased expression of EPB41L4B mRNA | CTD | PMID:35436446 | ethanol | affects splicing | ISO | Epb41l4b (Mus musculus) | 6480464 | Ethanol affects the splicing of EPB41L4B mRNA | CTD | PMID:30319688 | ethanol | increases expression | ISO | Epb41l4b (Mus musculus) | 6480464 | Ethanol results in increased expression of EPB41L4B mRNA | CTD | PMID:30319688 | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of EPB41L4B mRNA | CTD | PMID:24136188 | folic acid | multiple interactions | ISO | Epb41l4b (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of EPB41L4B mRNA | CTD | PMID:22206623 | fulvestrant | multiple interactions | ISO | EPB41L4B (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of EPB41L4B gene | CTD | PMID:31601247 | glyphosate | affects methylation | EXP | | 6480464 | glyphosate affects the methylation of EPB41L4B gene | CTD | PMID:35440735 | indometacin | multiple interactions | ISO | EPB41L4B (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EPB41L4B mRNA | CTD | PMID:28628672 | indometacin | increases expression | ISO | EPB41L4B (Homo sapiens) | 6480464 | Indomethacin results in increased expression of EPB41L4B mRNA | CTD | PMID:24737281 | lead(0) | affects expression | ISO | EPB41L4B (Homo sapiens) | 6480464 | Lead affects the expression of EPB41L4B mRNA | CTD | PMID:28903495 | leflunomide | increases expression | ISO | EPB41L4B (Homo sapiens) | 6480464 | leflunomide results in increased expression of EPB41L4B mRNA | CTD | PMID:28988120 | maneb | multiple interactions | ISO | Epb41l4b (Mus musculus) | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of EPB41L4B mRNA | CTD | PMID:36117858 | methapyrilene | increases methylation | ISO | EPB41L4B (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of EPB41L4B intron | CTD | PMID:30157460 | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of EPB41L4B gene | CTD | PMID:35440735 | methyl methanesulfonate | decreases expression | ISO | EPB41L4B (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of EPB41L4B mRNA | CTD | PMID:23649840 | nefazodone | decreases expression | EXP | | 6480464 | nefazodone results in decreased expression of EPB41L4B mRNA | CTD | PMID:24136188 | nickel atom | decreases expression | ISO | EPB41L4B (Homo sapiens) | 6480464 | Nickel results in decreased expression of EPB41L4B mRNA | CTD | PMID:24768652 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of EPB41L4B mRNA | CTD | PMID:25729387 | paracetamol | decreases expression | ISO | EPB41L4B (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of EPB41L4B mRNA | CTD | PMID:21420995 and PMID:29067470 | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of EPB41L4B mRNA | CTD | PMID:32680482 | paraquat | multiple interactions | ISO | Epb41l4b (Mus musculus) | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of EPB41L4B mRNA | CTD | PMID:36117858 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Epb41l4b (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of EPB41L4B mRNA and [perfluorooctane sulfonic acid co-treated with Pectins] results in decreased expression of EPB41L4B mRNA | CTD | PMID:36331819 | phenylephrine | increases expression | EXP | | 6480464 | Phenylephrine results in increased expression of EPB41L4B mRNA | CTD | PMID:18158353 | potassium chromate | multiple interactions | ISO | EPB41L4B (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of EPB41L4B mRNA | CTD | PMID:22079256 | potassium chromate | decreases expression | ISO | EPB41L4B (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of EPB41L4B mRNA | CTD | PMID:22079256 | progesterone | multiple interactions | ISO | EPB41L4B (Homo sapiens) | 6480464 | [Estradiol co-treated with Progesterone] results in increased expression of EPB41L4B mRNA | CTD | PMID:20660070 | progesterone | decreases expression | ISO | Epb41l4b (Mus musculus) | 6480464 | Progesterone results in decreased expression of EPB41L4B mRNA | CTD | PMID:22238285 | SB 431542 | multiple interactions | ISO | EPB41L4B (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | selenium atom | decreases expression | ISO | EPB41L4B (Homo sapiens) | 6480464 | Selenium results in decreased expression of EPB41L4B mRNA | CTD | PMID:19244175 | testosterone | increases expression | ISO | Epb41l4b (Mus musculus) | 6480464 | Testosterone deficiency results in increased expression of EPB41L4B mRNA | CTD | PMID:33848595 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of EPB41L4B mRNA | CTD | PMID:31150632 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of EPB41L4B mRNA] | CTD | PMID:31150632 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of EPB41L4B mRNA | CTD | PMID:25729387 | tremolite asbestos | decreases expression | ISO | Epb41l4b (Mus musculus) | 6480464 | tremolite results in decreased expression of EPB41L4B mRNA | CTD | PMID:29279043 | trichostatin A | increases expression | ISO | EPB41L4B (Homo sapiens) | 6480464 | trichostatin A results in increased expression of EPB41L4B mRNA | CTD | PMID:24935251 | valproic acid | decreases methylation | ISO | EPB41L4B (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of EPB41L4B gene | CTD | PMID:29154799 | valproic acid | affects expression | ISO | Epb41l4b (Mus musculus) | 6480464 | Valproic Acid affects the expression of EPB41L4B mRNA | CTD | PMID:17292431 | valproic acid | increases expression | ISO | EPB41L4B (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of EPB41L4B mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | ISO | EPB41L4B (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPB41L4B mRNA | CTD | PMID:27188386 | |