Pcsk9 (proprotein convertase subtilisin/kexin type 9) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Pcsk9 (proprotein convertase subtilisin/kexin type 9) Rattus norvegicus
Analyze
Symbol: Pcsk9
Name: proprotein convertase subtilisin/kexin type 9
RGD ID: 728909
Description: Predicted to enable several functions, including lipoprotein particle binding activity; lipoprotein particle receptor binding activity; and serine-type endopeptidase activity. Involved in several processes, including cellular response to insulin stimulus; cholesterol homeostasis; and protein autoprocessing. Located in extracellular space. Human ortholog(s) of this gene implicated in familial hypercholesterolemia and hypobetalipoproteinemia. Orthologous to human PCSK9 (proprotein convertase subtilisin/kexin type 9); INTERACTS WITH 1,2-dimethylhydrazine; 1-(3-(trifluoromethyl)phenyl)piperazine; 1-benzylpiperazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: NARC-1; Narc1; neural apoptosis regulated convertase 1; neural apoptosis-regulated convertase 1; PC9; proprotein convertase 9; proprotein convertase PC9; subtilisin/kexin-like protease PC9
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85126,440,102 - 126,462,507 (-)NCBIGRCr8
mRatBN7.25121,211,278 - 121,233,688 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5121,211,278 - 121,233,688 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5123,824,322 - 123,846,721 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05125,547,373 - 125,569,772 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05125,598,631 - 125,621,028 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05126,031,368 - 126,053,726 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5126,031,368 - 126,053,726 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05129,878,797 - 129,900,625 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45127,501,476 - 127,524,289 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15127,507,768 - 127,529,490 (-)NCBI
Celera5119,960,965 - 119,983,199 (-)NCBICelera
Cytogenetic Map5q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-isolariciresinol  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-(3-(trifluoromethyl)phenyl)piperazine  (EXP)
1-benzylpiperazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetaldehyde  (ISO)
acetamide  (EXP)
acetohydrazide  (ISO)
Actein  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
belinostat  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
caffeine  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroethene  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
ezetimibe  (ISO)
fenofibrate  (ISO)
flusilazole  (EXP)
fluvastatin  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
Ganoderic acid A  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
glafenine  (EXP)
glucose  (ISO)
glutathione  (EXP)
glyphosate  (ISO)
herbicide  (ISO)
hydrazine  (ISO)
indometacin  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
letrozole  (EXP)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
Nutlin-3  (ISO)
O-methyleugenol  (ISO)
orphenadrine  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
spironolactone  (EXP)
sulindac sulfide  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
Yessotoxin  (ISO)
zaragozic acid A  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Abifadel M, etal., Nat Genet. 2003 Jun;34(2):154-6.
2. Proapoptotic effects of NARC 1 (= PCSK9), the gene encoding a novel serine proteinase. Bingham B, etal., Cytometry A. 2006 Nov 1;69(11):1123-31.
3. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. Cohen JC, etal., N Engl J Med. 2006 Mar 23;354(12):1264-72.
4. Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c. Costet P, etal., J Biol Chem. 2006 Mar 10;281(10):6211-8. Epub 2006 Jan 6.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Expression and localization of PCSK9 in rat hepatic cells. Grozdanov PN, etal., Biochem Cell Biol. 2006 Feb;84(1):80-92.
7. Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. Hao CL, etal., J Food Biochem. 2019 Mar;43(3):e12769. doi: 10.1111/jfbc.12769. Epub 2019 Jan 13.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Functional characterization of Narc 1, a novel proteinase related to proteinase K. Naureckiene S, etal., Arch Biochem Biophys. 2003 Dec 1;420(1):55-67.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk. Paez-Pereda M, etal., Proc Natl Acad Sci U S A 2003 Feb 4;100(3):1034-9.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. Seidah NG, etal., Proc Natl Acad Sci U S A 2003 Feb 4;100(3):928-33.
16. Mechanisms of disease: genetic causes of familial hypercholesterolemia. Soutar AK and Naoumova RP, Nat Clin Pract Cardiovasc Med. 2007 Apr;4(4):214-25.
17. Evidence for effect of mutant PCSK9 on apolipoprotein B secretion as the cause of unusually severe dominant hypercholesterolaemia. Sun XM, etal., Hum Mol Genet. 2005 May 1;14(9):1161-9. Epub 2005 Mar 16.
18. A mutation in PCSK9 causing autosomal-dominant hypercholesterolemia in a Utah pedigree. Timms KM, etal., Hum Genet. 2004 Mar;114(4):349-53. Epub 2004 Jan 15.
19. The c.43_44insCTG variation in PCSK9 is associated with low plasma LDL-cholesterol in a Caucasian population. Yue P, etal., Hum Mutat. 2006 May;27(5):460-6.
Additional References at PubMed
PMID:10964518   PMID:12477932   PMID:15178557   PMID:15741654   PMID:15805190   PMID:16893422   PMID:16912035   PMID:17080197   PMID:17170371   PMID:17242417   PMID:17328821   PMID:17452316  
PMID:17461796   PMID:18039658   PMID:18054320   PMID:18054775   PMID:18197702   PMID:18799458   PMID:19008317   PMID:21763412   PMID:22081141   PMID:22481440   PMID:22493497   PMID:22580899  
PMID:22658674   PMID:22848640   PMID:23580231   PMID:24006456   PMID:24166456   PMID:24533584   PMID:24619822   PMID:24755036   PMID:26481479   PMID:26691006   PMID:26978583   PMID:28232185  
PMID:28913715   PMID:29938676   PMID:30483910   PMID:31748600   PMID:32100557   PMID:32396274   PMID:32750454   PMID:33169229   PMID:33307067   PMID:33581194   PMID:33609572   PMID:34576046  
PMID:35276836   PMID:35378805   PMID:35460665   PMID:35742954   PMID:36342620   PMID:37844755   PMID:38154546  


Genomics

Comparative Map Data
Pcsk9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85126,440,102 - 126,462,507 (-)NCBIGRCr8
mRatBN7.25121,211,278 - 121,233,688 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5121,211,278 - 121,233,688 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5123,824,322 - 123,846,721 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05125,547,373 - 125,569,772 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05125,598,631 - 125,621,028 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05126,031,368 - 126,053,726 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5126,031,368 - 126,053,726 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05129,878,797 - 129,900,625 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45127,501,476 - 127,524,289 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15127,507,768 - 127,529,490 (-)NCBI
Celera5119,960,965 - 119,983,199 (-)NCBICelera
Cytogenetic Map5q34NCBI
PCSK9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38155,039,548 - 55,064,852 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl155,039,445 - 55,064,852 (+)EnsemblGRCh38hg38GRCh38
GRCh37155,505,221 - 55,530,525 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36155,277,808 - 55,303,111 (+)NCBINCBI36Build 36hg18NCBI36
Build 34155,217,240 - 55,242,544NCBI
Celera153,792,769 - 53,818,130 (+)NCBICelera
Cytogenetic Map1p32.3NCBI
HuRef153,618,200 - 53,643,557 (+)NCBIHuRef
CHM1_1155,621,314 - 55,646,685 (+)NCBICHM1_1
T2T-CHM13v2.0154,913,987 - 54,945,736 (+)NCBIT2T-CHM13v2.0
Pcsk9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394106,299,531 - 106,321,522 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4106,299,526 - 106,321,526 (-)EnsemblGRCm39 Ensembl
GRCm384106,442,334 - 106,464,325 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4106,442,329 - 106,464,329 (-)EnsemblGRCm38mm10GRCm38
MGSCv374106,114,939 - 106,136,930 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364105,940,274 - 105,974,961 (-)NCBIMGSCv36mm8
Celera4104,803,009 - 104,824,874 (-)NCBICelera
Cytogenetic Map4C7NCBI
cM Map449.67NCBI
Pcsk9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554644,425,435 - 4,439,842 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554644,424,583 - 4,439,805 (-)NCBIChiLan1.0ChiLan1.0
PCSK9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21171,754,941 - 171,787,297 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11170,895,635 - 170,927,961 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0154,323,036 - 54,355,397 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1155,911,016 - 55,943,404 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl155,911,016 - 55,936,456 (+)Ensemblpanpan1.1panPan2
PCSK9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1554,197,211 - 54,210,724 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha554,264,679 - 54,280,339 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0554,383,361 - 54,399,016 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1554,380,525 - 54,396,181 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0554,270,491 - 54,282,704 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0554,658,929 - 54,672,888 (-)NCBIUU_Cfam_GSD_1.0
Pcsk9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505869,116,048 - 69,144,955 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365226,272,507 - 6,299,917 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365226,271,339 - 6,300,202 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCSK9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6157,388,372 - 157,409,551 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16157,388,370 - 157,409,620 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26145,451,983 - 145,473,336 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PCSK9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12077,893,574 - 77,921,076 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2077,893,590 - 77,918,613 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603339,376,139 - 39,401,572 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pcsk9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248624,879,561 - 4,895,776 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248624,873,457 - 4,895,836 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pcsk9
60 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:250
Count of miRNA genes:169
Interacting mature miRNAs:195
Transcripts:ENSRNOT00000008535
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
7794739Bp372Blood pressure QTL 3720.0058arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5117913688125222967Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1582230Bw78Body weight QTL 783.20.0016epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)5119085612128034027Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)590067849128034027Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584132602129132602Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)590067849128034027Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat

Markers in Region
RH131239  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25121,211,277 - 121,211,487 (+)MAPPERmRatBN7.2
Rnor_6.05126,031,368 - 126,031,577NCBIRnor6.0
Rnor_5.05129,878,797 - 129,879,006UniSTSRnor5.0
RGSC_v3.45127,501,476 - 127,501,685UniSTSRGSC3.4
Celera5119,960,965 - 119,961,174UniSTS
RH 3.4 Map5805.1UniSTS
Cytogenetic Map5q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 8 22 107 85 84 59 25 59 4 185 65 89 44 58 25

Sequence


Ensembl Acc Id: ENSRNOT00000008535   ⟹   ENSRNOP00000008536
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5121,211,278 - 121,233,688 (-)Ensembl
Rnor_6.0 Ensembl5126,031,368 - 126,053,726 (-)Ensembl
RefSeq Acc Id: NM_199253   ⟹   NP_954862
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85126,440,102 - 126,462,507 (-)NCBI
mRatBN7.25121,211,278 - 121,233,688 (-)NCBI
Rnor_6.05126,031,368 - 126,053,726 (-)NCBI
Rnor_5.05129,878,797 - 129,900,625 (-)NCBI
RGSC_v3.45127,501,476 - 127,524,289 (-)RGD
Celera5119,960,965 - 119,983,199 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_954862 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI33064 (Get FASTA)   NCBI Sequence Viewer  
  AAW31850 (Get FASTA)   NCBI Sequence Viewer  
  CAC60363 (Get FASTA)   NCBI Sequence Viewer  
  EDL90477 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008536.5
  ENSRNOP00055045498
  ENSRNOP00060028195
  ENSRNOP00065030917
GenBank Protein P59996 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_954862   ⟸   NM_199253
- Peptide Label: precursor
- UniProtKB: Q5I6U6 (UniProtKB/Swiss-Prot),   P59996 (UniProtKB/Swiss-Prot),   A6JYM6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008536   ⟸   ENSRNOT00000008535
Protein Domains
Inhibitor I9   Peptidase S8   Peptidase S8/S53   Proprotein convertase subtilisin/kexin type 9 C-

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P59996-F1-model_v2 AlphaFold P59996 1-691 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693877
Promoter ID:EPDNEW_R4402
Type:multiple initiation site
Name:Pcsk9_1
Description:proprotein convertase subtilisin/kexin type 9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05126,053,691 - 126,053,751EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:728909 AgrOrtholog
BioCyc Gene G2FUF-40453 BioCyc
Ensembl Genes ENSRNOG00000006280 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055031814 UniProtKB/Swiss-Prot
  ENSRNOG00060019885 UniProtKB/Swiss-Prot
  ENSRNOG00065022391 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008535.6 UniProtKB/Swiss-Prot
  ENSRNOT00055055053 UniProtKB/Swiss-Prot
  ENSRNOT00060034363 UniProtKB/Swiss-Prot
  ENSRNOT00065038186 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.80 UniProtKB/Swiss-Prot
  3.40.50.200 UniProtKB/Swiss-Prot
  Peptidase S8 propeptide/proteinase inhibitor I9 UniProtKB/TrEMBL
  Peptidase S8/S53 domain UniProtKB/TrEMBL
  Proprotein convertase subtilisin/kexin type 9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PCSK9_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PCSK9_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PCSK9_C3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PCSK9_ProteinaseK-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8/S53_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8/S53_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_subtilisin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_subtilisin-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S8pro/Inhibitor_I9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S8pro/Inhibitor_I9_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:298296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 298296 ENTREZGENE
PANTHER PEPTIDASE S8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Inhibitor_I9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PCSK9_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PCSK9_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PCSK9_C3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PCSK9 RGD
PhenoGen Pcsk9 PhenoGen
PRINTS SUBTILISIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SUBTILASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006280 RatGTEx
  ENSRNOG00055031814 RatGTEx
  ENSRNOG00060019885 RatGTEx
  ENSRNOG00065022391 RatGTEx
Superfamily-SCOP Protease propeptides/inhibitors UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52743 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JYM6 ENTREZGENE, UniProtKB/TrEMBL
  P59996 ENTREZGENE, UniProtKB/Swiss-Prot
  Q5I6U6 ENTREZGENE
UniProt Secondary Q5I6U6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-11 Pcsk9  proprotein convertase subtilisin/kexin type 9  Narc1  neural apoptosis-regulated convertase 1  Data merged from RGD:727848 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression increased mRNA expression is detected during liver regeneration, mRNA is detected in post-natal and adult kidney 629544
gene_expression mRNA detected in postnatal and adult kidney 629544
gene_process may play roles in hepatic growth and proliferation and in renal development, mouse homolog has subtilase activity and induces cortical neurogenesis 629544
gene_regulation liver mRNA expression increases after partial hepatectomy 629544