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Gene: Invs (inversin) Rattus norvegicus

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Symbol:

Invs

Name:

inversin

RGD ID:

1563359

Description:

Predicted to be involved in kidney development; negative regulation of canonical Wnt signaling pathway; and protein localization to ciliary inversin compartment. Predicted to act upstream of or within several processes, including left/right pattern formation; pancreas development; and protein phosphorylation. Predicted to be located in ciliary base and ciliary inversin compartment. Predicted to be active in cilium. Human ortholog(s) of this gene implicated in hypertension and nephronophthisis 2. Orthologous to human INVS (inversin); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC313228; RGD1563359; similar to Inv protein - mouse

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	INVS (inversin)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Invs (inversin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Invs (inversin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	INVS (inversin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	INVS (inversin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Invs (inversin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	INVS (inversin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	INVS (inversin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Invs (inversin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Invs (inversin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	INVS (inversin)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	invs (inversin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mlt-4	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	invs	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	67,406,511 - 67,559,355 (+)	NCBI		GRCr8
mRatBN7.2	5	62,610,916 - 62,763,813 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	62,610,968 - 62,763,350 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	64,585,540 - 64,741,444 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	66,404,842 - 66,560,742 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	66,374,304 - 66,530,206 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	64,031,131 - 64,180,830 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	64,053,946 - 64,178,759 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	68,548,486 - 68,697,014 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	64,962,873 - 65,120,158 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	64,830,211 - 64,984,549 (-)	NCBI		Celera
Cytogenetic Map	5	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cholestasis (ISO)

congenital disorder of glycosylation Ii (ISO)

congenital disorder of glycosylation type II (ISO)

congenital myasthenic syndrome 14 (ISO)

cystic kidney disease (ISO)

fundus dystrophy (ISO)

genetic disease (ISO)

hypertension (ISO)

intellectual disability (ISO)

Jaundice (ISO)

kidney disease (ISO)

nephronophthisis (ISO)

nephronophthisis 1 (ISO)

nephronophthisis 2 (ISO,ISS)

optic atrophy (ISO)

polycystic kidney disease (ISO)

tetralogy of Fallot (ISS)

thoracic aortic aneurysm (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

amitrole (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

copper(II) sulfate (ISO)

decabromodiphenyl ether (EXP)

dexamethasone (ISO)

Dibutyl phosphate (ISO)

doxorubicin (ISO)

endosulfan (EXP)

fulvestrant (ISO)

glyphosate (ISO)

indometacin (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methimazole (EXP)

methotrexate (ISO)

methoxychlor (EXP)

paracetamol (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

sodium arsenite (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

triphenyl phosphate (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

animal organ development (ISO)

embryonic heart tube left/right pattern formation (ISO)

epithelial cilium movement involved in determination of left/right asymmetry (ISO)

kidney development (IBA,ISO)

negative regulation of canonical Wnt signaling pathway (IEA,ISO)

pancreas development (ISO)

post-embryonic development (ISO)

protein localization to ciliary inversin compartment (IBA,ISO)

protein phosphorylation (ISO)

Cellular Component

ciliary base (ISO)

ciliary inversin compartment (ISO)

cilium (IBA)

extracellular region (IEA)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Multiple renal cyst development but not situs abnormalities in transgenic RNAi mice against Inv::GFP rescue gene.	Kamijho Y, etal., PLoS One. 2014 Feb 24;9(2):e89652. doi: 10.1371/journal.pone.0089652. eCollection 2014.
3.	Anomalous development of the hepatobiliary system in the Inv mouse.	Mazziotti MV, etal., Hepatology. 1999 Aug;30(2):372-8. doi: 10.1002/hep.510300223.
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination.	Otto EA, etal., Nat Genet. 2003 Aug;34(4):413-20. doi: 10.1038/ng1217.
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Sustained cell proliferation of renal epithelial cells in mice with inv mutation.	Sugiyama N and Yokoyama T, Genes Cells. 2006 Oct;11(10):1213-24. doi: 10.1111/j.1365-2443.2006.01011.x.
9.	Mutations of NPHP2 and NPHP3 in infantile nephronophthisis.	Tory K, etal., Kidney Int. 2009 Apr;75(8):839-47. doi: 10.1038/ki.2008.662. Epub 2009 Jan 28.

Additional References at PubMed

PMID:9192865	PMID:9771707	PMID:10549278	PMID:18371931	PMID:20169535	PMID:29395339	PMID:35106541

Genomics

Comparative Map Data

Invs
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	67,406,511 - 67,559,355 (+)	NCBI		GRCr8
mRatBN7.2	5	62,610,916 - 62,763,813 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	62,610,968 - 62,763,350 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	64,585,540 - 64,741,444 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	66,404,842 - 66,560,742 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	66,374,304 - 66,530,206 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	64,031,131 - 64,180,830 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	64,053,946 - 64,178,759 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	68,548,486 - 68,697,014 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	64,962,873 - 65,120,158 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	64,830,211 - 64,984,549 (-)	NCBI		Celera
Cytogenetic Map	5	q22	NCBI

INVS
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	100,099,243 - 100,302,175 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	100,099,243 - 100,302,175 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	102,861,525 - 103,064,457 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	101,901,332 - 102,103,247 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	9	73,374,912 - 73,576,755 (+)	NCBI		Celera
Cytogenetic Map	9	q31.1	NCBI
HuRef	9	72,460,680 - 72,662,467 (+)	NCBI		HuRef
CHM1_1	9	103,007,943 - 103,209,867 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	112,270,863 - 112,473,811 (+)	NCBI		T2T-CHM13v2.0

Invs
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	48,279,707 - 48,431,956 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	48,279,760 - 48,431,954 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	48,279,707 - 48,431,956 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	48,279,760 - 48,431,954 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	48,292,674 - 48,444,825 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	48,300,923 - 48,453,762 (+)	NCBI		MGSCv36	mm8
Celera	4	48,301,442 - 48,455,346 (+)	NCBI		Celera
Cytogenetic Map	4	B1	NCBI
cM Map	4	26.11	NCBI

Invs
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955419	25,444,582 - 25,581,201 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955419	25,445,404 - 25,584,244 (-)	NCBI	ChiLan1.0	ChiLan1.0

INVS
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	39,150,375 - 39,362,210 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	39,155,507 - 39,364,581 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	71,185,345 - 71,395,015 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	99,302,077 - 99,509,731 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	99,329,528 - 99,508,260 (+)	Ensembl	panpan1.1		panPan2

INVS
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	57,040,005 - 57,196,465 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	57,040,070 - 57,195,281 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	55,486,857 - 55,638,992 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	58,161,098 - 58,317,346 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	58,161,184 - 58,364,961 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	56,668,538 - 56,820,593 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	56,693,389 - 56,845,533 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	57,392,943 - 57,545,213 (+)	NCBI		UU_Cfam_GSD_1.0

Invs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	171,923,221 - 172,130,603 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936524	8,476,574 - 8,611,620 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936524	8,470,958 - 8,612,835 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

INVS
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	241,897,764 - 242,059,050 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	241,897,685 - 242,058,293 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	270,324,717 - 270,407,975 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

INVS
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	39,138,586 - 39,333,758 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	39,139,505 - 39,333,661 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666035	3,219,006 - 3,418,780 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Invs
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624825	702,347 - 866,353 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624825	701,335 - 866,598 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Invs
687 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	263
Count of miRNA genes:	163
Interacting mature miRNAs:	210
Transcripts:	ENSRNOT00000011622
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578776	Stresp18	Stress response QTL 18	2.9		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	5	27955440	72955440	Rat
1298067	Scl15	Serum cholesterol level QTL 15	4.8	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	33215665	78215665	Rat
1300115	Hrtrt7	Heart rate QTL 7	2.76		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	5	47869062	90099692	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	40128307	148607290	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	1	131345958	Rat
1358353	Srcrtb2	Stress Responsive Cort Basal QTL 2	3.48	0.003	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	18873947	74251464	Rat
634305	Mamtr1	Mammary tumor resistance QTL 1		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	12789751	113558310	Rat
61386	Bp49	Blood pressure QTL 49	16.6		cerebrum integrity trait (VT:0010549)	brain infarction volume (CMO:0001013)	5	60293434	98603051	Rat
1331801	Rf33	Renal function QTL 33	4.149		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	43726656	129132602	Rat
1598807	Glom12	Glomerulus QTL 12	2.7		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	5	33215665	78215665	Rat
1302786	Kidm8	Kidney mass QTL 8	28.15		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	5	33215665	78215665	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	60293434	161481680	Rat
6903292	Stl28	Serum triglyceride level QTL 28	2.6	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	5	28515489	73515489	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
1578767	Stresp17	Stress response QTL 17	4.3	0.01	blood aldosterone amount (VT:0005346)	plasma aldosterone level (CMO:0000551)	5	27955440	72955440	Rat
7411561	Bw134	Body weight QTL 134	24	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	49463600	94463600	Rat
1641922	Alcrsp8	Alcohol response QTL 8			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	5	35189153	68564008	Rat
2303615	Vencon7	Ventilatory control QTL 7		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	5	50983895	95983895	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	50328551	141643988	Rat
1641912	Alcrsp18	Alcohol response QTL 18			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	35189153	141643988	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
6903306	Scl35	Serum cholesterol QTL 35	2.6	0.0073	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	28515489	73515489	Rat
1576317	Eutr2	Estrogen induced uterine response QTL 2		0.01	uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	34730116	104251008	Rat
7394712	Emca13	Estrogen-induced mammary cancer QTL 13			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	9823266	99753708	Rat
1331773	Scl26	Serum cholesterol level QTL 26	3.065		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	43726656	86724018	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55805606	132207589	Rat
1331771	Rf35	Renal function QTL 35	4.36965		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	729470	86724018	Rat
61359	Eaex	Experimental allergic encephalomyelitis QTL x	3		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	5	55715622	100715622	Rat
8662454	Vetf3	Vascular elastic tissue fragility QTL 3	27.4		artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	5	2282226	69540447	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	31663789	131345958	Rat
61426	Scl2	Serum cholesterol level QTL 2	7.3	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	59793399	143070159	Rat
9589025	Epfw7	Epididymal fat weight QTL 7	20.66	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	5	49463600	94463600	Rat
2303574	Gluco42	Glucose level QTL 42	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	53496719	98496719	Rat
1331756	Rf34	Renal function QTL 34	4.16275		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	1	90450412	Rat
8552954	Pigfal14	Plasma insulin-like growth factor 1 level QTL 14	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	21226744	66226744	Rat
2316954	Rf57	Renal function QTL 57	0		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	5	59793528	90450144	Rat
1358895	Bp254	Blood pressure QTL 254	3.6	0.0003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	58829236	128034027	Rat
2316959	Gluco59	Glucose level QTL 59	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	34944474	113558310	Rat
1600358	Mamtr5	Mammary tumor resistance QTL 5			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	18873947	63873947	Rat
2316957	Pur21	Proteinuria QTL 21	6.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	5	59793528	113558156	Rat

Markers in Region

BB360193

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	62,759,629 - 62,759,739 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	64,176,647 - 64,176,756	NCBI	Rnor6.0
Rnor_5.0	5	68,692,831 - 68,692,940	UniSTS	Rnor5.0
RGSC_v3.4	5	65,115,975 - 65,116,084	UniSTS	RGSC3.4
Celera	5	64,834,285 - 64,834,394	UniSTS
Cytogenetic Map	5	q22	UniSTS

AU048338

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	62,734,760 - 62,734,893 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	64,151,804 - 64,151,936	NCBI	Rnor6.0
Rnor_5.0	5	68,667,988 - 68,668,120	UniSTS	Rnor5.0
RGSC_v3.4	5	65,091,353 - 65,091,485	UniSTS	RGSC3.4
Celera	5	64,859,116 - 64,859,248	UniSTS
Cytogenetic Map	5	q22	UniSTS

RH131507

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	62,762,498 - 62,762,687 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	64,179,516 - 64,179,704	NCBI	Rnor6.0
Rnor_5.0	5	68,695,700 - 68,695,888	UniSTS	Rnor5.0
RGSC_v3.4	5	65,118,844 - 65,119,032	UniSTS	RGSC3.4
Celera	5	64,831,337 - 64,831,525	UniSTS
RH 3.4 Map	5	413.6	UniSTS
Cytogenetic Map	5	q22	UniSTS

AW530466

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	62,763,574 - 62,763,790 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	64,180,592 - 64,180,807	NCBI	Rnor6.0
Rnor_5.0	5	68,696,776 - 68,696,991	UniSTS	Rnor5.0
RGSC_v3.4	5	65,119,920 - 65,120,135	UniSTS	RGSC3.4
Celera	5	64,830,234 - 64,830,449	UniSTS
RH 3.4 Map	5	414.5	UniSTS
Cytogenetic Map	5	q22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107932	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109855	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109856	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109857	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109859	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109860	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063287624	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474056	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000011622 ⟹ ENSRNOP00000011622

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	62,610,968 - 62,763,350 (+)	Ensembl
Rnor_6.0 Ensembl	5	64,053,946 - 64,178,759 (+)	Ensembl

RefSeq Acc Id:

NM_001107932 ⟹ NP_001101402

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	67,406,511 - 67,559,350 (+)	NCBI
mRatBN7.2	5	62,610,968 - 62,763,810 (+)	NCBI
Rnor_6.0	5	64,031,131 - 64,180,830 (+)	NCBI
Rnor_5.0	5	68,548,486 - 68,697,014 (+)	NCBI
RGSC_v3.4	5	64,962,873 - 65,120,158 (+)	RGD
Celera	5	64,830,211 - 64,984,549 (-)	RGD

Sequence:

show sequence

TGCGGCCGGGAGCCTCAGGCTGCTTCTTCAGAGCTCCTGGGCTCTAGGGTCCTGGGGTCTGTTC
CTGTGGGCAAAGTGGCCTGACTTGGCGGGAGGCGCGGCCCAGTGAGGGTTGTACCTCCTAGGGC
GGCCCCGGGACGCCAGTTTTGGAGGCAGGGGTCACTAGGGTTGTGGAGAAAACTATGAACATAT
CAGAGAATGTGCTCTCTACGGGGTCCTCATTAGCATCTCAGGTTCATGCCGCTGCAGTTAATGG
AGATAAAGGTGCCCTTCAGAGACTCATTGTTGGAAACTCTGCTCTTAAAGACAAAGAAGACCAA
TTTGGGAGAACACCACTTATGTATTGTGTGTTGGCAGACAGATTGGACTGTGCAGATGCCCTTC
TAAAAGCAGGGGCAGATGTCAACAAAACCGACCATAGCCGGAGAACAGCCCTCCACCTTGCAGC
CCAAAAGGGAAATTACCGCTTTATGAAACTCTTACTCACTCGCAGAGCAAACTGGATGCAGAAG
GACCTAGAAGAGATGACGCCTCTGCACCTGAGCACTCGGCACAGGAGCCCCAAGTGTCTAGCGC
TCCTGCTGAAGTTTATGGCGCCCGGGGAGGTGGATACACAGGACAAAAACAAGCAAACAGCTCT
GCACTGGAGCGCCTACTACAACAATCCCGAGCATGCGAAGCTGCTCATCAAGCATGACTCCAAC
ATCGGGATTCCTGACGTGGAGGGCAAGATCCCCCTCCACTGGGCAGCCAACCATAAAGACGCGA
GTGCCGTGCACACAGTGAGATGCATCCTGGATGCCGCCCCAACAGAGTCTTTATTGAACTGGCA
AGACTATGAGGGCCGCACACCTCTGCACTTCGCAGTTGCTGATGGAAACCTAACGGTGGTGGAT
GTCTTGACCTCCTATGAAAGCTGCAACATAACGTCTTATGACAACTTATTTCGAACCCCACTTC
ACTGGGCAGCCTTACTAGGCCATGCACAGATTGTCCATCTCCTTCTGGAAAGAAACAAGTCTGG
AACCGTCCCTTCCGACAGCCAAGGGGCAACACCCTTGCACTATGCAGCTCAGAGTAATTTTGCT
GAAACAGTTAAGGTGTTTTTAACGCATCCTTCAGTGAGAGATGATTCTGACTTGGAAGGAAGAA
CATCTTTCATGTGGGCAGCAGGAAAAGGCAGTGACGACGTGCTCAGAACTATGCTCAGTTTAAA
ATCGGACATCGACATCAACATGGCGGACAAATATGGAGGCACAGCTTTACATGCCGCTGCCCTT
TCTGGCCACGTCAGCACCGTGAAGTTGTTATTGGACAATGATGCCCAAGTAGATGCTACTGACG
TCATGAAACACACTCCACTGTTCCGAGCCTGCGAGATGGGACACAGAGACGTGATTCAGACGCT
TATTAAAGGCGGAGCACGAGTCGACCTGGTTGACCAAGATGGACATTCACTTCTACACTGGGCA
GCACTGGGAGGAAACGCTGACGTCTGCCAGATCCTGATAGAAAACAAGATCAACCCAAACGTGC
AGGACTACGCGGGAAGAACCCCACTTCAGTGCGCTGCATATGGAGGGTACATCAACTGCATGGC
TGTGCTCATGGAGAACAATGCAGACCCCAACATCCAAGACAAAGAGGGACGAACAGCTCTGCAC
TGGTCCTGTAACAACGGCTACCTCGATGCCATTAAACTACTGCTGGACTTCGCTGCTTTCCCTA
ACCAGATGGAGAACAATGAGGAGAGGTACACACCCCTTGACTATGCATTGCTTGGTGAGCGCCA
TGAGGTGATCCAGTTCATGCTGGAACACGGTGCCCTGTCCATCGCAGCTATTCAAGACATCGCT
GCCTTCAAAATCCAAGCGGTCTACAAAGGATACAAGGTCAGAAAAGCCTTCCGAGACCGGAAGA
ACCTCCTCATGAAGCACGAACAGCTGAGAAAGGACGCTGCAGCTAAGAAACGGGAGGAGGAAAA
CAAGCGGAAGGAAGCTGAACAGAAAGGACAGCCGGACACAGATCCTCCCAGGCCCCAAGTCCTC
CCCTGTCCACCCAGCCCCCAGAATGAGCCCAGTAGGCAGAGCGCAGCCCCTAGCAAACAGCCAC
CTGCTAGCCACACAGTCCAGAGCCCCGACCCAGAGCAGGGCAGGCCTGCAGGCCAATGTCCAGG
CAGAGCCTCCCACAGGGATTGTTCCTCAGACCTTCAGGGAACAGCCTCCAGAAAGCCGAGTGAA
TCCCCCAGGGAGCACTGCAGAGGCGCCTCTGCCGGCGTGCACCCCAGATCCTGCGAGGATGGTG
ATAGCTACAGGCATCAGGGAACATCCTCTGCGGAGAAGTGCAGAGGTGAGACCAGTGGCGAACA
CCAGCGGTGTGAGCAGGGCCCAAGCAGAGCCAGGCAGCCCGTGTCCACTGGGTCAGCGGGGCCT
GCCGAGAAAGGAGAGGACTCCAGCCCTGCCATTACAAGTGCTTCCCAGCGGGACCGCCCCCGGA
AACCCAGCAAGAGACAGGACGGGGCGCCCAGGTCCAGAGGTGCGTCCCAGAAAAGACGCACCCA
TCAGCTCAGAGACAGGTGCTCCCCCGCTGGGTCCAGCCGGCCTGGCAGTGCTAAGGCGGAAGTT
GCCCGCGCTGATCAGAGTTCTGTCCACCATGACACACCAAGAAACAAGGTGACCCAGGACAAGC
TTGTAGGAGGGGTCTCCTCGGATGTGCCACTCAGCACAGAAGAGCTGGGGTCAGGATGCCAGAA
GCTTTATGAGGACCTGTGTGCATCTCCGGAGAACAATGTGGCTCACGGCCCCCGACCTGGACAG
AGTGTGAATATCCACCTTCTTCCCGTAGAACAGCGCCTGCTGATAATCCAGAGGGAACGGAGCA
GGAAGGAGCTGTTTCGGAGAAAAAACAAGGCAGCGGCCGTCATCCAGCGAGCTTGGCGAAGCTA
CCAGCTCAGGAAGCACCTCTCTCGGCTTCTGCATTTGAAGCAGCTTGGAGCCAGAGATGTGCTC
AGATGTACTCAACTGTGCGCAGCCCTGCTCCTCCAGGTTTGGAGGAAAGAACTGGAGCTCAAGT
TCCCAAAGTCCATCTCAGTAAGCAGAACATCAAAGAGTCCATCCAAAGGCATGTCGGCCGCAAA
GTCCGCCAGGCACTCAGTGCTCAGGCAGATCTACGGTTGTTCTCAGGAAGGGAAAGTACATCAT
CCCATCAGATCTCCCAAAGTCCCTCCTGTGCTTCATCTCAGTTCAGTGAACAGTTTGCAGTCTA
TACATCTTGACAGCAGTGGAAGATCAAAGAAGTTTTCTTACAATCTGCAACCAGCCAGTCAATC
AAAAAACAAGCCAAAGCTTTGAGCCTGAAGGAAGATCAAAACCAGTGTGGACTTCGGCTCTGTG
AACTCTTAATTAGGACACCGAAGTCCTCATTCCCCAACATATGTGGTCAGAGGCAGCGTTCAGA
TGTTTTCTCCTGGGTACTCCTACCAGCATACTTTTCCATTCCTCTTGGCACGCACTGAAAAGGA
CCAGAGCAGAGTGCGCGGATGGACCGCCGAGCTGTGCGCCTCACCTCAGCCGGCGTGGCTGGAG
AAGAGAACTGCCACGCTCCTCAGTGTAACAGACAACACCTGCACTAAAGGAGCCGTGGGCCGGG
ATTTCTCACAGCTAACCTGCACAGGCCTGGCCTCTTCACCCTAGGAAACCTGGGCCTCAGCGGC
CACCTTCAATTCTTTACTTCCCTGGAACATACTGTGTGACAAACATCACAAGAGACAGTTTAAA
TTTTAGATCGAAATCATGGCTTAGTGTTTGCATTAGAAACCCGGAACTGAGGAGTGCATTCTGG
GGCTTCCTTACAGTTTTCAGTTTCCAAATTGGCCCTGGAAGACGACGCGCTGCAGCTGTGTGCT
CTCCCTGACTGGGGCTTTCACTGCTGAGAGGCACCGATGACAGCACAGCACCAAGAAGTCGGTA
GACAGGTTGACAGCACAATGCGCCAACCAACTCTGGCTTCTCTTCCCCTTTGCATCCTGACCAA
CTTGCAGAAGAAAATAACCTTCCCCAAATGCAATTTCTTTTGTGAAAGTAACCCACATTCTAGC
TTTCTAAGAATACTTGCCTTAAATAAAGTCTAGTGATTATGGACTTTTACAGAGGCAGATAACA
TCAGGTCATTCCTGTGCTAACACTAAAGGACAGGAATTTACGTCATTTAATCACAATGACTTTG
GTATAGTAAATTATATTCAAAATTTTGGAGACAGGTTTATCTAGACAGGATCACAAAGATTCAT
TGGTAAGTGAATGAAGGCACCATAGATCACTGTATGTCTTATAAACATTTAGCTTTTATGAAAT
TCACAATGTTCTACTGCCTGTCCTTGTATCATGTGCTAATCCACGCAAACAGAGTGAGATCACT
AAGAACTCTTAAACCTTATTTTCCCACTTTTGTAAGAAGGAAGCTCACGAACAACTTCTTTAAA
AGTTGAGTTTAATGGCAAATATTTGTTACATCAGTCTCTCTTCAAAATAAAATGAATGTGCATG
AACAATTAATTTCAAACAGGAGGTGCCATGGTGCTTCTTTAATACAGTGCATTCAATATACTAG
GCCCCTGGGGATGGCCACTGATGTACACACTGAAGCAGTAATGTAAGTCTGTAAGCCACTGCTC
CTGAACACTGCCACTCTTCAAAGTCTGCAGAGAAAAACAAAAGGCACTTTAGTTTGAGAACTGA
ACTACCTGACATTTTTCATGGCCTCCATAAAAGTATCCTCCTCCACCACCAGCTGGAGAACATA
CATGGGCTGGACCTACGCCTCCCTGAACACAGTATGCAGCAGACGTGTAGCCTCATCTTCGTGT
GGGTCCTGAACAATGGGAGCAAGGGCTGTCCCAGAAATTGTTGCCTATACATGAAACATGTCCT
CTATAGCTGGGCTCCCTTGTCTGGCCTCAGCGGGAGTGGAGAAACCTATCCTCCCAGAGGACTT
GATGTGCCAGGGTGGAAGGATACCCAGGGGTGTCCCCACCCACTCAGAGGAGAAGGGGATGGGG
GAGGAATTGTGAGAGGGGGTGTAGGTAGGTAGGGTAGTAAGCAGGAAGTAAAAAGTGAGTAAGA
AATAAAAAAGAAATCTTAAAATATAAAACAAACCAATCAACTATTGGGAGTTACTATAGCCAGT
GAAAATGCCTACTCTTTACGAAAATTTGAAATTATAAATGGGCCCTAAGGCTTTGGTATCTGAA
TAATTTTTCCCGAGTAGTGCTGCTGTTTGGAAGGTTCTTTGGACAGAGCCCACTTGTGGTCCAG
GCTCTCTACTTCCTGACTCACTGAGATATAACTCCACCCAGCAAACTCCCACTGCCGCAAATGT
ACCCCAGCCACAGTGTTTACCCCATGACAATAGAGTGCCTGCCCGCTCAAATTGTCAAATACAG
TGAGTCCTTTAAGTTGGAACTGTGATTTGGTTAATGTGACAAGAGAAACAGTATGTGCCCCTAA
GAATAACAAGTTCTTTGCAAATCTGTTCCTTCCTGGACATGCTGGAGACTAATAAAAAATTTTA
TGGACAACCA

hide sequence

RefSeq Acc Id:

XM_039109855 ⟹ XP_038965783

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	67,406,530 - 67,559,355 (+)	NCBI
mRatBN7.2	5	62,610,916 - 62,763,813 (+)	NCBI

RefSeq Acc Id:

XM_039109856 ⟹ XP_038965784

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	67,406,530 - 67,559,355 (+)	NCBI
mRatBN7.2	5	62,610,923 - 62,763,813 (+)	NCBI

RefSeq Acc Id:

XM_039109857 ⟹ XP_038965785

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	67,406,530 - 67,559,355 (+)	NCBI
mRatBN7.2	5	62,610,930 - 62,763,813 (+)	NCBI

RefSeq Acc Id:

XM_039109859 ⟹ XP_038965787

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	67,406,530 - 67,549,444 (+)	NCBI
mRatBN7.2	5	62,610,930 - 62,753,904 (+)	NCBI

RefSeq Acc Id:

XM_039109860 ⟹ XP_038965788

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	67,406,530 - 67,549,484 (+)	NCBI
mRatBN7.2	5	62,610,930 - 62,753,926 (+)	NCBI

RefSeq Acc Id:

XM_063287624 ⟹ XP_063143694

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	67,406,530 - 67,526,706 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101402	(Get FASTA)	NCBI Sequence Viewer
	XP_038965783	(Get FASTA)	NCBI Sequence Viewer
	XP_038965784	(Get FASTA)	NCBI Sequence Viewer
	XP_038965785	(Get FASTA)	NCBI Sequence Viewer
	XP_038965787	(Get FASTA)	NCBI Sequence Viewer
	XP_038965788	(Get FASTA)	NCBI Sequence Viewer
	XP_063143694	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL78193	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000011622
	ENSRNOP00000011622.8
	ENSRNOP00000107064

RefSeq Acc Id:

NP_001101402 ⟸ NM_001107932

- UniProtKB:

D4A4A8 (UniProtKB/TrEMBL), A6KJF5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNISENVLSTGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCA
DALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPK
CLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANH
KDASAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNLTVVDVLTSYESCNITSYDNLFR
TPLHWAALLGHAQIVHLLLERNKSGTVPSDSQGATPLHYAAQSNFAETVKVFLTHPSVRDDSDL
EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLDNDAQVD
ATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKIN
PNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFA
AFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFR
DRKNLLMKHEQLRKDAAAKKREEENKRKEAEQKGQPDTDPPRPQVLPCPPSPQNEPSRQSAAPS
KQPPASHTVQSPDPEQGRPAGQCPGRASHRDCSSDLQGTASRKPSESPREHCRGASAGVHPRSC
EDGDSYRHQGTSSAEKCRGETSGEHQRCEQGPSRARQPVSTGSAGPAEKGEDSSPAITSASQRD
RPRKPSKRQDGAPRSRGASQKRRTHQLRDRCSPAGSSRPGSAKAEVARADQSSVHHDTPRNKVT
QDKLVGGVSSDVPLSTEELGSGCQKLYEDLCASPENNVAHGPRPGQSVNIHLLPVEQRLLIIQR
ERSRKELFRRKNKAAAVIQRAWRSYQLRKHLSRLLHLKQLGARDVLRCTQLCAALLLQVWRKEL
ELKFPKSISVSRTSKSPSKGMSAAKSARHSVLRQIYGCSQEGKVHHPIRSPKVPPVLHLSSVNS
LQSIHLDSSGRSKKFSYNLQPASQSKNKPKL

hide sequence

Ensembl Acc Id:

ENSRNOP00000011622 ⟸ ENSRNOT00000011622

RefSeq Acc Id:	XP_038965783 ⟸ XM_039109855
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038965784 ⟸ XM_039109856
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038965785 ⟸ XM_039109857
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038965788 ⟸ XM_039109860
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038965787 ⟸ XM_039109859
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_063143694 ⟸ XM_063287624
- Peptide Label:	isoform X5

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A4A8-F1-model_v2	AlphaFold	D4A4A8	1-1003	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1563359	AgrOrtholog
BioCyc Gene	G2FUF-41358	BioCyc
Ensembl Genes	ENSRNOG00000008632	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000011622	ENTREZGENE
	ENSRNOT00000011622.8	UniProtKB/TrEMBL
	ENSRNOT00000161508	ENTREZGENE
Gene3D-CATH	1.25.40.20	UniProtKB/TrEMBL
InterPro	Ankyrin_rpt	UniProtKB/TrEMBL
	Ankyrin_rpt-contain_sf	UniProtKB/TrEMBL
	IQ_motif_EF-hand-BS	UniProtKB/TrEMBL
KEGG Report	rno:313228	UniProtKB/TrEMBL
NCBI Gene	313228	ENTREZGENE
PANTHER	ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED	UniProtKB/TrEMBL
	ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 35	UniProtKB/TrEMBL
Pfam	Ank	UniProtKB/TrEMBL
	Ank_2	UniProtKB/TrEMBL
	PF00612	UniProtKB/TrEMBL
PhenoGen	Invs	PhenoGen
PROSITE	ANK_REP_REGION	UniProtKB/TrEMBL
	ANK_REPEAT	UniProtKB/TrEMBL
	PS50096	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000008632	RatGTEx
SMART	ANK	UniProtKB/TrEMBL
	SM00015	UniProtKB/TrEMBL
Superfamily-SCOP	ANK	UniProtKB/TrEMBL
UniProt	A6KJF5	ENTREZGENE, UniProtKB/TrEMBL
	D4A4A8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-07	Invs	inversin	RGD1563359_predicted	similar to Inv protein - mouse (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1563359_predicted	similar to Inv protein - mouse (predicted)	LOC313228	similar to Inv protein - mouse	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC313228	similar to Inv protein - mouse			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - MGI

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