Elp1 (elongator acetyltransferase complex subunit 1) - Rat Genome Database

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Gene: Elp1 (elongator acetyltransferase complex subunit 1) Rattus norvegicus
Analyze
Symbol: Elp1
Name: elongator acetyltransferase complex subunit 1
RGD ID: 620072
Description: Enables ATP binding activity and protein kinase activity. Predicted to be involved in tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation. Predicted to be located in cytoplasm. Predicted to be part of elongator holoenzyme complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Riley-Day syndrome; asthma; kyphosis; medulloblastoma; and scoliosis. Orthologous to human ELP1 (elongator acetyltransferase complex subunit 1); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: elongator complex protein 1; elongator complex protein 1-like; ikappaB kinase complex-associated protein; Ikbkap; IKK complex-associated protein; inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein; LOC102555189
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8576,248,545 - 76,300,985 (-)NCBIGRCr8
mRatBN7.2571,453,338 - 71,505,833 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl571,456,310 - 71,505,762 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx573,340,793 - 73,393,272 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0575,172,255 - 75,224,700 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0575,144,331 - 75,196,776 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0573,503,406 - 73,552,798 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl573,503,407 - 73,552,798 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0577,661,315 - 77,710,707 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4574,657,287 - 74,707,435 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1574,662,400 - 74,712,548 (-)NCBI
Celera570,310,353 - 70,359,709 (-)NCBICelera
Cytogenetic Map5q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO,ISS)
cytosol  (IBA,IEA,ISO)
elongator holoenzyme complex  (IBA,IEA,ISO,ISS)
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Familial dysautonomia is caused by mutations of the IKAP gene. Anderson SL, etal., Am J Hum Genet. 2001 Mar;68(3):753-8. Epub 2001 Jan 22.
2. Orthopaedic manifestations of familial dysautonomia. A review of one hundred and thirty-six patients. Bar-On E, etal., J Bone Joint Surg Am. 2000 Nov;82-A(11):1563-70.
3. Genomic organization and chromosomal localization of the mouse IKBKAP gene. Coli R, etal., Gene 2001 Nov 14;279(1):81-9.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Norepinephrine increases I kappa B alpha expression in astrocytes. Gavrilyuk V, etal., J Biol Chem 2002 Aug 16;277(33):29662-8.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Measurement of IKK activity in primary rat T cells: rapid activation and inactivation. Kupfer R and Scheinman RI, J Immunol Methods. 2002 Aug 1;266(1-2):155-64.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. The role of the IKAP gene polymorphisms in atopic diseases in the middle European population. Schuller M, etal., J Hum Genet. 2003;48(6):300-4. Epub 2003 May 28.
15. Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia. Slaugenhaupt SA, etal., Am J Hum Genet. 2001 Mar;68(3):598-605. Epub 2001 Jan 22.
16. Amino-acid substitutions in the IKAP gene product significantly increase risk for bronchial asthma in children. Takeoka S, etal., J Hum Genet. 2001;46(2):57-63.
Additional References at PubMed
PMID:11714725   PMID:11818576   PMID:20184874   PMID:22854966   PMID:30053369  


Genomics

Comparative Map Data
Elp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8576,248,545 - 76,300,985 (-)NCBIGRCr8
mRatBN7.2571,453,338 - 71,505,833 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl571,456,310 - 71,505,762 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx573,340,793 - 73,393,272 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0575,172,255 - 75,224,700 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0575,144,331 - 75,196,776 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0573,503,406 - 73,552,798 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl573,503,407 - 73,552,798 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0577,661,315 - 77,710,707 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4574,657,287 - 74,707,435 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1574,662,400 - 74,712,548 (-)NCBI
Celera570,310,353 - 70,359,709 (-)NCBICelera
Cytogenetic Map5q24NCBI
ELP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389108,867,517 - 108,934,124 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9108,866,898 - 108,934,328 (-)EnsemblGRCh38hg38GRCh38
GRCh379111,629,797 - 111,696,404 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369110,669,621 - 110,736,217 (-)NCBINCBI36Build 36hg18NCBI36
Build 349108,709,355 - 108,775,951NCBI
Celera982,129,095 - 82,195,809 (-)NCBICelera
Cytogenetic Map9q31.3NCBI
HuRef981,229,552 - 81,296,258 (-)NCBIHuRef
CHM1_19111,776,416 - 111,843,122 (-)NCBICHM1_1
T2T-CHM13v2.09121,036,644 - 121,103,197 (-)NCBIT2T-CHM13v2.0
Elp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39456,746,547 - 56,802,565 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl456,749,680 - 56,802,331 (-)EnsemblGRCm39 Ensembl
GRCm38456,746,547 - 56,802,569 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl456,749,680 - 56,802,331 (-)EnsemblGRCm38mm10GRCm38
MGSCv37456,762,552 - 56,815,203 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36456,844,828 - 56,896,313 (-)NCBIMGSCv36mm8
Celera456,657,583 - 56,710,224 (-)NCBICelera
Cytogenetic Map4B3NCBI
cM Map431.66NCBI
Elp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541918,038,507 - 18,095,894 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541918,035,197 - 18,097,681 (+)NCBIChiLan1.0ChiLan1.0
ELP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21130,475,862 - 30,540,680 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1930,478,226 - 30,543,043 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0980,020,131 - 80,085,076 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19108,194,008 - 108,258,500 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9108,194,011 - 108,258,500 (-)Ensemblpanpan1.1panPan2
ELP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11164,035,667 - 64,094,402 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1164,037,506 - 64,093,819 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1162,437,897 - 62,496,433 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01165,169,787 - 65,228,593 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1165,170,724 - 65,228,543 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11163,690,982 - 63,749,074 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01163,709,775 - 63,768,691 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01164,402,753 - 64,461,318 (-)NCBIUU_Cfam_GSD_1.0
Elp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947179,284,678 - 179,342,148 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365593,924,185 - 3,983,028 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365593,924,185 - 3,981,907 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ELP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1249,905,351 - 249,981,641 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11249,905,550 - 249,980,570 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21280,435,992 - 280,511,016 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ELP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11230,620,685 - 30,687,583 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1230,620,278 - 30,687,405 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603511,996,706 - 12,063,562 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Elp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247582,575,671 - 2,646,313 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247582,575,516 - 2,646,313 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Elp1
236 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:403
Count of miRNA genes:229
Interacting mature miRNAs:260
Transcripts:ENSRNOT00000022836
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)55979352890450144Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)568984307104251008Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat

Markers in Region
Ikbkap  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2571,476,656 - 71,476,834 (+)MAPPERmRatBN7.2
Rnor_6.0573,523,769 - 73,523,946NCBIRnor6.0
Rnor_5.0577,681,678 - 77,681,855UniSTSRnor5.0
RGSC_v3.4574,678,406 - 74,678,583UniSTSRGSC3.4
Celera570,330,715 - 70,330,892UniSTS
Cytogenetic Map5q24UniSTS
AI501954  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2571,456,384 - 71,456,564 (+)MAPPERmRatBN7.2
Rnor_6.0573,503,495 - 73,503,674NCBIRnor6.0
Rnor_5.0577,661,404 - 77,661,583UniSTSRnor5.0
RGSC_v3.4574,657,376 - 74,657,555UniSTSRGSC3.4
Celera570,310,442 - 70,310,621UniSTS
RH 3.4 Map5482.2UniSTS
Cytogenetic Map5q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 38 46 30 19 30 8 11 74 33 36 11 8
Low 2 5 11 11 11 2 5
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000022836   ⟹   ENSRNOP00000022836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl571,456,310 - 71,505,762 (-)Ensembl
Rnor_6.0 Ensembl573,503,407 - 73,552,798 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000083131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl573,803,066 - 73,805,951 (-)Ensembl
RefSeq Acc Id: NM_080899   ⟹   NP_543175
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8576,248,545 - 76,300,985 (-)NCBI
mRatBN7.2571,453,338 - 71,505,779 (-)NCBI
Rnor_6.0573,503,406 - 73,552,798 (-)NCBI
Rnor_5.0577,661,315 - 77,710,707 (-)NCBI
RGSC_v3.4574,657,287 - 74,707,435 (-)RGD
Celera570,310,353 - 70,359,709 (-)RGD
Sequence:
RefSeq Acc Id: XM_039109191   ⟹   XP_038965119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8576,252,965 - 76,300,964 (-)NCBI
mRatBN7.2571,457,766 - 71,505,833 (-)NCBI
Protein Sequences
Protein RefSeqs NP_543175 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965119 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL40926 (Get FASTA)   NCBI Sequence Viewer  
  EDL91690 (Get FASTA)   NCBI Sequence Viewer  
  EDL91691 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022836
  ENSRNOP00000022836.5
GenBank Protein Q8VHU4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_543175   ⟸   NM_080899
- UniProtKB: Q8VHU4 (UniProtKB/Swiss-Prot),   F1LP76 (UniProtKB/TrEMBL),   A6KDR5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022836   ⟸   ENSRNOT00000022836
RefSeq Acc Id: XP_038965119   ⟸   XM_039109191
- Peptide Label: isoform X1
- UniProtKB: Q8VHU4 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VHU4-F1-model_v2 AlphaFold Q8VHU4 1-1331 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693752
Promoter ID:EPDNEW_R4277
Type:initiation region
Name:Elp1_1
Description:elongator complex protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0573,552,881 - 73,552,941EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620072 AgrOrtholog
BioCyc Gene G2FUF-41220 BioCyc
Ensembl Genes ENSRNOG00000016725 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000051572 Ensembl
Ensembl Transcript ENSRNOT00000022836 ENTREZGENE
  ENSRNOT00000022836.6 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Elp1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:140934 UniProtKB/Swiss-Prot
NCBI Gene 140934 ENTREZGENE
PANTHER ELONGATOR COMPLEX PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12747 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IKI3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Elp1 PhenoGen
PIRSF IKAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016725 RatGTEx
  ENSRNOG00000051572 RatGTEx
Superfamily-SCOP DPP6 N-terminal domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6KDR5 ENTREZGENE, UniProtKB/TrEMBL
  ELP1_RAT UniProtKB/Swiss-Prot
  F1LP76 ENTREZGENE, UniProtKB/TrEMBL
  Q8VHU4 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Elp1  elongator acetyltransferase complex subunit 1  LOC102555189  elongator complex protein 1-like  Data merged from RGD:7611240 737654 PROVISIONAL
2020-10-12 Elp1  elongator acetyltransferase complex subunit 1  Elp1  elongator complex protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-05-16 Elp1  elongator complex protein 1  Ikbkap  inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-18 LOC102555189  elongator complex protein 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2009-02-26 Ikbkap  inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein  Ikbkap  inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Ikbkap  inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Ikbkap  inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression detected in the frontal cortex of the normal rat 625572
gene_product member of the heat shock protein family 625572
gene_regulation protein kinase A and beta-antagonist prevent neurotransmitter NE (norepinephrine)-induced activation 625572