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Gene: Tek (TEK receptor tyrosine kinase) Rattus norvegicus
Symbol: Tek
Name: TEK receptor tyrosine kinase
RGD ID: 620980
Description: Exhibits growth factor binding activity. Involved in several processes, including endochondral ossification; response to cAMP; and response to estrogen. Predicted to colocalize with actin filament and stress fiber. Biomarker of several diseases, including acute kidney tubular necrosis; brain ischemia; gastric ulcer; goiter; and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in arteriovenous malformation and multiple cutaneous and mucosal venous malformations. Orthologous to human TEK (TEK receptor tyrosine kinase); PARTICIPATES IN angiopoietin signaling pathway; rheumatoid arthritis pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.
Type: protein-coding
Also known as: angiopoietin-1 receptor; endothelial-specific receptor tyrosine kinase; TEK tyrosine kinase, endothelial; Tie-2; Tie2; tyrosine kinases that contain immunoglobulin-like loops and epidermal growth factor-similar domains 2
Homo sapiens (human) : TEK (TEK receptor tyrosine kinase)  HGNC  Alliance
Mus musculus (house mouse) : Tek (TEK receptor tyrosine kinase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tek (TEK receptor tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : TEK (TEK receptor tyrosine kinase)
Canis lupus familiaris (dog) : TEK (TEK receptor tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tek (TEK receptor tyrosine kinase)
Sus scrofa (pig) : TEK (TEK receptor tyrosine kinase)
Chlorocebus sabaeus (African green monkey) : TEK (TEK receptor tyrosine kinase)
Heterocephalus glaber (naked mole-rat) : Tek (TEK receptor tyrosine kinase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05113,725,717 - 113,852,799 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5113,725,717 - 113,852,799 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05117,672,484 - 117,799,345 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45115,047,195 - 115,196,172 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15115,171,316 - 115,174,864 (+)NCBI
Celera5108,234,353 - 108,354,536 (+)NCBICelera
Cytogenetic Map5q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Tek
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620980
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.