Tek (TEK receptor tyrosine kinase) - Rat Genome Database

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Gene: Tek (TEK receptor tyrosine kinase) Rattus norvegicus
Symbol: Tek
Name: TEK receptor tyrosine kinase
RGD ID: 620980
Description: Enables growth factor binding activity. Involved in several processes, including endochondral ossification; response to cAMP; and response to estrogen. Predicted to be located in several cellular components, including basolateral plasma membrane; centriolar satellite; and microvillus. Predicted to be part of receptor complex. Predicted to colocalize with actin filament and stress fiber. Biomarker of several diseases, including acute kidney tubular necrosis; brain ischemia; gastric ulcer; goiter; and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in arteriovenous malformation; multiple cutaneous and mucosal venous malformations; and renal Wilms' tumor. Orthologous to human TEK (TEK receptor tyrosine kinase); PARTICIPATES IN angiopoietin signaling pathway; rheumatoid arthritis pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.
Type: protein-coding
Previously known as: angiopoietin-1 receptor; endothelial-specific receptor tyrosine kinase; TEK tyrosine kinase, endothelial; Tie-2; Tie2; tyrosine kinases that contain immunoglobulin-like loops and epidermal growth factor-similar domains 2
RGD Orthologs
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.25109,607,077 - 109,733,805 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5109,607,077 - 109,733,804 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5112,185,658 - 112,306,395 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05113,911,456 - 114,031,907 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05113,973,696 - 114,094,435 (+)NCBIRnor_WKY
Rnor_6.05113,725,717 - 113,852,799 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5113,725,717 - 113,852,799 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05117,672,484 - 117,799,345 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45115,047,195 - 115,196,172 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15115,171,316 - 115,174,864 (+)NCBI
Celera5108,234,353 - 108,354,536 (+)NCBICelera
Cytogenetic Map5q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
baicalin  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
capsaicin  (EXP,ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
crizotinib  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
enalapril  (EXP)
fulvestrant  (ISO)
furan  (EXP)
furosemide  (EXP)
gefitinib  (ISO)
Genipin  (ISO)
gentamycin  (EXP)
glucose  (ISO)
indoles  (EXP)
indometacin  (ISO)
Lasiocarpine  (ISO)
lenalidomide  (ISO)
lipopolysaccharide  (ISO)
malathion  (ISO)
mancozeb  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
Morroniside  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
naproxen  (EXP)
nicotinic acid  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PD123319  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phosgene  (ISO)
ponatinib  (ISO)
progesterone  (ISO)
propranolol  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
streptozocin  (EXP)
sulindac  (ISO)
sumatriptan  (EXP)
tamoxifen  (ISO)
taurine  (ISO)
tetrachloromethane  (EXP)
thalidomide  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IBA,ISO)
cell-cell adhesion  (ISO)
cell-matrix adhesion  (ISO)
endochondral ossification  (IEP)
endothelial cell proliferation  (IBA,ISO)
glomerulus vasculature development  (IMP)
heart development  (ISO)
heart trabecula formation  (ISO)
hemopoiesis  (ISO)
intracellular signal transduction  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of endothelial cell apoptotic process  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of actin cytoskeleton reorganization  (ISO)
positive regulation of angiogenesis  (IMP,ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cytokine production involved in immune response  (ISO)
positive regulation of endothelial cell migration  (IBA,ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of focal adhesion assembly  (ISO)
positive regulation of intracellular signal transduction  (ISO)
positive regulation of kinase activity  (IBA)
positive regulation of MAPK cascade  (IBA)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase activity  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (IBA,ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein kinase B signaling  (IBA,ISO)
positive regulation of protein phosphorylation  (ISO)
protein autophosphorylation  (ISO)
regulation of angiogenesis  (ISO)
regulation of cell migration  (ISO)
regulation of establishment or maintenance of cell polarity  (ISO)
regulation of NIK/NF-kappaB signaling  (ISO)
response to cAMP  (IEP)
response to estrogen  (IDA)
response to hypoxia  (IDA)
response to organic substance  (IEP)
response to peptide hormone  (IEP)
response to retinoic acid  (ISO)
sprouting angiogenesis  (ISO)
substrate adhesion-dependent cell spreading  (ISO)
Tie signaling pathway  (ISO,TAS)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA,ISO)
vasculogenesis  (ISO,TAS)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Differential expression of Tie-2 receptors and angiopoietins in response to in vivo hypoxia in rats. Abdulmalek K, etal., Am J Physiol Lung Cell Mol Physiol 2001 Sep;281(3):L582-90.
2. Measurement of the soluble angiopoietin receptor tie-2 in patients with coronary artery disease: development and application of an immunoassay. Chung NA, etal., Eur J Clin Invest. 2003 Jul;33(7):529-35.
3. Tie2 receptor tyrosine kinase, a major mediator of tumor necrosis factor alpha-induced angiogenesis in rheumatoid arthritis. DeBusk LM, etal., Arthritis Rheum. 2003 Sep;48(9):2461-71.
4. Compensatory growth of coronary arterioles in postinfarcted heart: regional differences in DNA synthesis and growth factor/receptor expression patterns. Dedkov EI, etal., Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1686-93. Epub 2006 May 19.
5. Angiopoietin/Tie2 pathway influences smooth muscle hyperplasia in idiopathic pulmonary hypertension. Dewachter L, etal., Am J Respir Crit Care Med. 2006 Nov 1;174(9):1025-33. Epub 2006 Aug 17.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2. Hughes DP, etal., Circ Res. 2003 Apr 4;92(6):630-6. Epub 2003 Feb 27.
8. Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. Jones N, etal., J Biol Chem. 1999 Oct 22;274(43):30896-905.
9. A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and function. Jones N, etal., Mol Cell Biol. 2003 Apr;23(8):2658-68.
10. Angiopoietin-1 promotes neurite outgrowth from dorsal root ganglion cells positive for Tie-2 receptor. Kosacka J, etal., Cell Tissue Res. 2005 Apr;320(1):11-9. Epub 2005 Feb 16.
11. Expression of vascular antigens by bone cells during bone regeneration in a membranous bone distraction system. Lewinson D, etal., Histochem Cell Biol. 2001 Nov;116(5):381-8. Epub 2001 Oct 18.
12. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences Li WZ, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006 Aug;31(4):523-7.
13. Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth. Lin P, etal., J Clin Invest. 1997 Oct 15;100(8):2072-8.
14. Angiotensin II promotes development of the renal microcirculation through AT1 receptors. Madsen K, etal., J Am Soc Nephrol. 2010 Mar;21(3):448-59. doi: 10.1681/ASN.2009010045. Epub 2010 Jan 7.
15. Accumulation of malignant renal stem cells is associated with epigenetic changes in normal renal progenitor genes. Metsuyanim S, etal., Stem Cells. 2008 Jul;26(7):1808-17. doi: 10.1634/stemcells.2007-0322. Epub 2008 May 8.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Changes of mRNA expression of vascular endothelial growth factor, angiopoietins and their receptors during the periovulatory period in eCG/hCG-treated immature female rats. Miyabayashi K, etal., J Exp Zoolog A Comp Exp Biol. 2005 Jul 1;303(7):590-7.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. Immunohistochemical study of VEGF, angiopoietin 2 and their receptors in the neovascularization following microinjection of C6 glioma cells into rat brain. Peoch M, etal., Anticancer Res 2002 Jul-Aug;22(4):2147-51.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. Requirement for the TIE family of receptor tyrosine kinases in adult but not fetal hematopoiesis. Puri MC and Bernstein A, Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12753-8. Epub 2003 Oct 6.
23. Tie-2 is expressed on thyroid follicular cells, is increased in goiter, and is regulated by thyrotropin through cyclic adenosine 3',5'-monophosphate. Ramsden JD, etal., J Clin Endocrinol Metab. 2001 Jun;86(6):2709-16.
24. The role of angiopoietins during angiogenesis in gliomas. Reiss Y, etal., Brain Pathol. 2005 Oct;15(4):311-7.
25. GOA pipeline RGD automated data pipeline
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Comprehensive gene review and curation RGD comprehensive gene curation
29. Downregulation of the endothelial genes Notch1 and ephrinB2 in patients with nodular regenerative hyperplasia. Rothweiler S, etal., Liver Int. 2014 Apr;34(4):594-603. doi: 10.1111/liv.12261. Epub 2013 Jul 21.
30. tie2, a putative protein tyrosine kinase from a new class of cell surface receptor. Runting AS, etal., Growth Factors. 1993;9(2):99-105.
31. Increased expression of angiopoietin-2 and Tie2 receptor in a rat model of myocardial ischaemia/reperfusion. Shyu KG, etal., Clin Sci (Lond). 2003 Sep;105(3):287-94.
32. Induction of pulmonary hypertension by an angiopoietin 1/TIE2/serotonin pathway. Sullivan CC, etal., Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12331-6. Epub 2003 Sep 25.
33. Selective role of a distinct tyrosine residue on Tie2 in heart development and early hematopoiesis. Tachibana K, etal., Mol Cell Biol. 2005 Jun;25(11):4693-702.
34. Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. Vikkula M, etal., Cell. 1996 Dec 27;87(7):1181-90.
35. Ischemic acute renal failure induces the expression of a wide range of nephrogenic proteins. Villanueva S, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Apr;290(4):R861-70. Epub 2005 Nov 10.
36. A cyclosporine-sensitive psoriasis-like disease produced in Tie2 transgenic mice. Voskas D, etal., Am J Pathol. 2005 Mar;166(3):843-55.
37. DITPA stimulates bFGF, VEGF, angiopoietin, and Tie-2 and facilitates coronary arteriolar growth. Wang X, etal., Am J Physiol Heart Circ Physiol. 2003 Feb;284(2):H613-8. Epub 2002 Oct 31.
38. Expression of Tie-2 and angiopoietin-1 and -2 in early phase of ulcer healing. Wen CY, etal., J Gastroenterol. 2003;38(5):431-5.
39. Tie2 receptor expression is stimulated by hypoxia and proinflammatory cytokines in human endothelial cells. Willam C, etal., Circ Res 2000 Sep 1;87(5):370-7.
40. Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2. Witzenbichler B, etal., J Biol Chem. 1998 Jul 17;273(29):18514-21.
41. Regulation of angiopoietin and Tie-2 receptor expression in non-reproductive tissues by estrogen. Ye F, etal., Steroids 2002 Mar;67(3-4):305-10.
42. Nitric oxide regulates Angiopoietin1/Tie2 expression after stroke. Zacharek A, etal., Neurosci Lett. 2006 Aug 14;404(1-2):28-32. Epub 2006 Jun 9.
43. Correlation of VEGF and angiopoietin expression with disruption of blood-brain barrier and angiogenesis after focal cerebral ischemia. Zhang ZG, etal., J Cereb Blood Flow Metab 2002 Apr;22(4):379-92.
Additional References at PubMed
PMID:7596437   PMID:7958865   PMID:8980223   PMID:9683559   PMID:9846489   PMID:11375937   PMID:11513602   PMID:11822892   PMID:12816861   PMID:14665640   PMID:14966366   PMID:15260986  
PMID:15284220   PMID:15548727   PMID:15845622   PMID:15985432   PMID:18073453   PMID:18285514   PMID:18425119   PMID:18425120   PMID:18439490   PMID:18586890   PMID:18751736   PMID:18929864  
PMID:18947490   PMID:19223473   PMID:19409199   PMID:19424712   PMID:19615361   PMID:19689429   PMID:19712575   PMID:19786610   PMID:20060382   PMID:20969813   PMID:21701128   PMID:22577112  
PMID:22869617   PMID:23049737   PMID:25446117   PMID:26666854   PMID:26887441   PMID:27439004   PMID:30527680  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.25109,607,077 - 109,733,805 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5109,607,077 - 109,733,804 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5112,185,658 - 112,306,395 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05113,911,456 - 114,031,907 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05113,973,696 - 114,094,435 (+)NCBIRnor_WKY
Rnor_6.05113,725,717 - 113,852,799 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5113,725,717 - 113,852,799 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05117,672,484 - 117,799,345 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45115,047,195 - 115,196,172 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15115,171,316 - 115,174,864 (+)NCBI
Celera5108,234,353 - 108,354,536 (+)NCBICelera
Cytogenetic Map5q33NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38927,109,141 - 27,230,178 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl927,109,141 - 27,230,174 (+)EnsemblGRCh38hg38GRCh38
GRCh37927,109,139 - 27,230,176 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36927,099,286 - 27,220,172 (+)NCBINCBI36Build 36hg18NCBI36
Build 34927,099,440 - 27,220,164NCBI
Celera927,037,320 - 27,158,328 (+)NCBICelera
Cytogenetic Map9p21.2NCBI
HuRef927,061,676 - 27,182,725 (+)NCBIHuRef
CHM1_1927,108,925 - 27,229,954 (+)NCBICHM1_1
T2T-CHM13v2.0927,119,713 - 27,240,739 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39494,627,322 - 94,763,213 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl494,627,526 - 94,763,213 (+)EnsemblGRCm39 Ensembl
GRCm38494,739,086 - 94,874,976 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl494,739,289 - 94,874,976 (+)EnsemblGRCm38mm10GRCm38
MGSCv37494,405,991 - 94,541,630 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36494,231,318 - 94,366,957 (+)NCBIMGSCv36mm8
Celera493,148,719 - 93,271,150 (+)NCBICelera
Cytogenetic Map4C5NCBI
cM Map443.34NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554727,633,721 - 7,748,386 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554727,633,790 - 7,748,130 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1997,319,587 - 97,442,141 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0926,955,339 - 27,077,809 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1927,561,421 - 27,683,572 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl927,561,421 - 27,683,572 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11145,278,375 - 45,377,300 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1145,278,891 - 45,409,093 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1143,955,919 - 44,054,831 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01146,225,355 - 46,324,241 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1146,225,693 - 46,324,239 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11144,881,654 - 44,980,440 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01144,771,574 - 44,870,410 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01145,518,478 - 45,616,970 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404947160,136,641 - 160,248,238 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366112,420,172 - 2,531,722 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366112,420,176 - 2,531,726 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1195,937,432 - 196,051,980 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11195,938,177 - 196,052,294 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21218,224,152 - 218,293,514 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_00462473631,345,774 - 31,473,727 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Tek
542 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:103
Count of miRNA genes:92
Interacting mature miRNAs:94
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584132602129132602Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)590067849128034027Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)590067849128034027Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
1582212Livw2Liver weight QTL 23.50.0004liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)599016066119085810Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)599753548113061097Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25109,719,127 - 109,719,390 (+)MAPPERmRatBN7.2
Rnor_6.05113,838,123 - 113,838,385NCBIRnor6.0
Rnor_5.05117,784,669 - 117,784,931UniSTSRnor5.0
RGSC_v3.45115,181,496 - 115,181,758UniSTSRGSC3.4
Celera5108,339,861 - 108,340,123UniSTS
Cytogenetic Map5q33UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25109,721,675 - 109,721,780 (+)MAPPERmRatBN7.2
Rnor_6.05113,840,671 - 113,840,775NCBIRnor6.0
Rnor_5.05117,787,217 - 117,787,321UniSTSRnor5.0
RGSC_v3.45115,184,044 - 115,184,148UniSTSRGSC3.4
Celera5108,342,409 - 108,342,513UniSTS
Cytogenetic Map5q33UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25109,733,610 - 109,733,790 (+)MAPPERmRatBN7.2
Rnor_6.05113,852,606 - 113,852,785NCBIRnor6.0
Rnor_5.05117,799,152 - 117,799,331UniSTSRnor5.0
RGSC_v3.45115,195,979 - 115,196,158UniSTSRGSC3.4
Celera5108,354,343 - 108,354,522UniSTS
RH 3.4 Map5779.4UniSTS
Cytogenetic Map5q33UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25109,732,963 - 109,733,181 (+)MAPPERmRatBN7.2
Rnor_6.05113,851,959 - 113,852,176NCBIRnor6.0
Rnor_5.05117,798,505 - 117,798,722UniSTSRnor5.0
RGSC_v3.45115,195,332 - 115,195,549UniSTSRGSC3.4
Celera5108,353,696 - 108,353,913UniSTS
RH 3.4 Map5782.8UniSTS
Cytogenetic Map5q33UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25109,666,343 - 109,666,463 (+)MAPPERmRatBN7.2
Rnor_6.05113,784,732 - 113,784,851NCBIRnor6.0
Rnor_5.05117,731,278 - 117,731,397UniSTSRnor5.0
RGSC_v3.45115,108,168 - 115,108,287UniSTSRGSC3.4
Celera5108,293,629 - 108,293,748UniSTS
RH 3.4 Map5781.8UniSTS
Cytogenetic Map5q33UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 43 24 14 13 14 6 6 59 35 28 11 6
Low 3 33 27 6 27 2 5 15 13 2
Below cutoff


Reference Sequences
RefSeq Acc Id: ENSRNOT00000032248   ⟹   ENSRNOP00000036086
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5109,607,077 - 109,733,804 (+)Ensembl
Rnor_6.0 Ensembl5113,725,717 - 113,852,799 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114153   ⟹   ENSRNOP00000083602
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5109,647,237 - 109,733,804 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114201   ⟹   ENSRNOP00000083432
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5109,607,077 - 109,733,804 (+)Ensembl
RefSeq Acc Id: NM_001105737   ⟹   NP_001099207
Rat AssemblyChrPosition (strand)Source
mRatBN7.25109,607,077 - 109,733,804 (+)NCBI
Rnor_6.05113,725,717 - 113,852,799 (+)NCBI
Rnor_5.05117,672,484 - 117,799,345 (+)NCBI
RGSC_v3.45115,047,195 - 115,196,172 (+)RGD
Celera5108,234,353 - 108,354,536 (+)RGD
RefSeq Acc Id: XM_039110892   ⟹   XP_038966820
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25109,658,813 - 109,733,805 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001099207 (Get FASTA)   NCBI Sequence Viewer  
  XP_038966820 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL97760 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001099207   ⟸   NM_001105737
- UniProtKB: D3ZCD0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000036086   ⟸   ENSRNOT00000032248
RefSeq Acc Id: XP_038966820   ⟸   XM_039110892
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000083602   ⟸   ENSRNOT00000114153
RefSeq Acc Id: ENSRNOP00000083432   ⟸   ENSRNOT00000114201
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZCD0-F1-model_v2 AlphaFold D3ZCD0 1-1120 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693842
Promoter ID:EPDNEW_R4366
Type:initiation region
Description:TEK receptor tyrosine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.05113,725,905 - 113,725,965EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620980 AgrOrtholog
BioCyc Gene G2FUF-40701 BioCyc
Ensembl Genes ENSRNOG00000008587 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000036086 ENTREZGENE
  ENSRNOP00000036086.3 UniProtKB/TrEMBL
  ENSRNOP00000083432.1 UniProtKB/TrEMBL
  ENSRNOP00000083602.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000032248 ENTREZGENE
  ENSRNOT00000032248.4 UniProtKB/TrEMBL
  ENSRNOT00000114153.1 UniProtKB/TrEMBL
  ENSRNOT00000114201.1 UniProtKB/TrEMBL
  Tie2 ligand-binding domain superfamily UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro EGF_3 UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  LE_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr-Pkinase UniProtKB/TrEMBL
  Tyr_kin_Tie2_Ig-like_dom-1_N UniProtKB/TrEMBL
  Tyr_Pkinase_cat_dom UniProtKB/TrEMBL
  Tyr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:89804 UniProtKB/TrEMBL
Pfam fn3 UniProtKB/TrEMBL
  Ig_Tie2_1 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PhenoGen Tek PhenoGen
  EGF_3 UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
UniProt A0A8I5ZW61_RAT UniProtKB/TrEMBL
  A0A8I6G914_RAT UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Tek  TEK receptor tyrosine kinase  Tek  TEK tyrosine kinase, endothelial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Tek  TEK tyrosine kinase, endothelial  Tek  endothelial-specific receptor tyrosine kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Tek  endothelial-specific receptor tyrosine kinase      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Tek  endothelial-specific receptor tyrosine kinase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed by endothelial cells 628494
gene_function receptor for Angiopoietin (Ang)-1 and Ang-2 628494
gene_physical_interaction binding of Ang-1 causes autophosphorylation and activation, but Ang-2 binding antagonizes this effect 628494
gene_process mediates the maturation of blood vessels during embryonic development 628494
gene_process plays a role in angiogenesis and stabilization of vascular integrity 628494
gene_regulation induced by hypoxia and inflammatory cytokines 724763
gene_regulation hypoxia reduces mRNA, protein, and phosphorylation levels in the lung, liver, cerebellum, and heart but not in the kidney and diaphragm 628494
gene_regulation inhibitory effect of hypoxia on the gene expression acts through the reduction of angiopoietin-1 and upregulation of angiopoietin-2 and -3 628494