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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620980
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tek
Name: TEK receptor tyrosine kinase
Acc ID: CHEBI:49668
Term: gefitinib
Definition: A member of the class of quinazolines that is quinazoline which is substituted by a (3-chloro-4-fluorophenyl)nitrilo group, 3-(morpholin-4-yl)propoxy group and a methoxy group at positions 4,6 and 7, respectively. An EGFR kinase inhibitor used for the treatment of non-small cell lung cancer.
Chemical ID: MESH:C419708
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tekmultiple interactionsISOTek (Mus musculus)6480464CTDgefitinib inhibits the reaction [TGFA protein results in decreased expression of TEK mRNA]PMID:18424623
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