Tek (TEK receptor tyrosine kinase) - Rat Genome Database

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Gene: Tek (TEK receptor tyrosine kinase) Heterocephalus glaber
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Symbol: Tek
Name: TEK receptor tyrosine kinase
RGD ID: 18934301
Description: ENCODES a protein that exhibits growth factor binding (ortholog); identical protein binding (ortholog); protein tyrosine kinase activity (ortholog); INVOLVED IN angiogenesis (ortholog); cell surface receptor protein tyrosine kinase signaling pathway (ortholog); cell-cell adhesion (ortholog); PARTICIPATES IN angiopoietin signaling pathway; ASSOCIATED WITH acute kidney tubular necrosis (ortholog); acute myeloid leukemia (ortholog); angiosarcoma (ortholog); FOUND IN actin filament (ortholog); apical plasma membrane (ortholog); basal plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: angiopoietin-1 receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473631,345,774 - 31,473,727 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
cell surface receptor protein tyrosine kinase signaling pathway  (ISO)
cell-cell adhesion  (ISO)
cell-matrix adhesion  (ISO)
endochondral ossification  (ISO)
endothelial cell proliferation  (ISO)
glomerulus vasculature development  (ISO)
heart development  (ISO)
heart trabecula formation  (ISO)
hemopoiesis  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of endothelial cell apoptotic process  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cytokine production involved in immune response  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of focal adhesion assembly  (ISO)
positive regulation of intracellular signal transduction  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of Rac protein signal transduction  (ISO)
positive regulation of Rho protein signal transduction  (ISO)
regulation of angiogenesis  (ISO)
regulation of cell migration  (ISO)
regulation of establishment or maintenance of cell polarity  (ISO)
regulation of non-canonical NF-kappaB signal transduction  (ISO)
response to cAMP  (ISO)
response to estrogen  (ISO)
response to hypoxia  (ISO)
response to peptide hormone  (ISO)
response to retinoic acid  (ISO)
sprouting angiogenesis  (ISO)
substrate adhesion-dependent cell spreading  (ISO)
Tie signaling pathway  (ISO)
vasculogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tek
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473631,345,774 - 31,473,727 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TEK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38927,109,225 - 27,230,174 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl927,109,141 - 27,230,174 (+)EnsemblGRCh38hg38GRCh38
GRCh37927,109,223 - 27,230,172 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36927,099,286 - 27,220,172 (+)NCBINCBI36Build 36hg18NCBI36
Build 34927,099,440 - 27,220,164NCBI
Celera927,037,320 - 27,158,328 (+)NCBICelera
Cytogenetic Map9p21.2NCBI
HuRef927,061,676 - 27,182,725 (+)NCBIHuRef
CHM1_1927,108,925 - 27,229,954 (+)NCBICHM1_1
T2T-CHM13v2.0927,119,797 - 27,240,735 (+)NCBIT2T-CHM13v2.0
Tek
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39494,627,322 - 94,763,213 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl494,627,526 - 94,763,213 (+)EnsemblGRCm39 Ensembl
GRCm38494,739,086 - 94,874,976 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl494,739,289 - 94,874,976 (+)EnsemblGRCm38mm10GRCm38
MGSCv37494,405,991 - 94,541,630 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36494,231,318 - 94,366,957 (+)NCBIMGSCv36mm8
Celera493,148,719 - 93,271,150 (+)NCBICelera
Cytogenetic Map4C5NCBI
cM Map443.34NCBI
Tek
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85114,722,815 - 114,849,535 (+)NCBIGRCr8
mRatBN7.25109,607,077 - 109,733,805 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5109,607,077 - 109,733,804 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5112,185,658 - 112,306,395 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05113,911,456 - 114,031,907 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05113,973,696 - 114,094,435 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05113,725,717 - 113,852,799 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5113,725,717 - 113,852,799 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05117,672,484 - 117,799,345 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45115,047,195 - 115,196,172 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15115,171,316 - 115,174,864 (+)NCBI
Celera5108,234,353 - 108,354,536 (+)NCBICelera
Cytogenetic Map5q33NCBI
Tek
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554727,633,721 - 7,748,386 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554727,633,790 - 7,748,130 (-)NCBIChiLan1.0ChiLan1.0
TEK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21197,313,642 - 97,436,178 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1997,319,581 - 97,442,141 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0926,955,339 - 27,077,809 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1927,561,421 - 27,683,572 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl927,561,421 - 27,683,572 (+)Ensemblpanpan1.1panPan2
TEK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11145,278,375 - 45,377,300 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1145,278,891 - 45,409,093 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1143,955,919 - 44,054,831 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01146,225,355 - 46,324,241 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1146,225,693 - 46,324,239 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11144,881,654 - 44,980,440 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01144,771,574 - 44,870,410 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01145,518,478 - 45,616,970 (+)NCBIUU_Cfam_GSD_1.0
Tek
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947160,136,641 - 160,248,238 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366112,420,172 - 2,531,722 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366112,420,176 - 2,531,726 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TEK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1195,937,432 - 196,051,980 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11195,938,177 - 196,052,294 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21218,224,152 - 218,293,514 (-)NCBISscrofa10.2Sscrofa10.2susScr3


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_004838368   ⟹   XP_004838425
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473631,345,774 - 31,473,727 (+)NCBI
RefSeq Acc Id: XM_021252944   ⟹   XP_021108603
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473631,345,774 - 31,473,727 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004838425 (Get FASTA)   NCBI Sequence Viewer  
  XP_021108603 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000024432
  ENSHGLP00000024433
RefSeq Acc Id: XP_021108603   ⟸   XM_021252944
- Peptide Label: isoform X1
RefSeq Acc Id: XP_004838425   ⟸   XM_004838368
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000017418 ENTREZGENE
Ensembl Transcript ENSHGLT00000024653 ENTREZGENE
  ENSHGLT00000024654 ENTREZGENE
NCBI Gene Tek ENTREZGENE