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Gene: Grhpr (glyoxylate and hydroxypyruvate reductase) Rattus norvegicus
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Symbol: Grhpr
Name: glyoxylate and hydroxypyruvate reductase
Description: Exhibits carboxylic acid binding activity; coenzyme binding activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in dicarboxylic acid metabolic process. Localizes to the cytosol. Human ortholog(s) of this gene implicated in primary hyperoxaluria. Orthologous to human GRHPR (glyoxylate and hydroxypyruvate reductase); PARTICIPATES IN Leigh disease pathway; primary hyperoxaluria type 2 pathway; pyruvate decarboxylase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: glyoxylate reductase/hydroxypyruvate reductase; LOC298085; LOC680021; similar to glyoxylate reductase/hydroxypyruvate reductase
Orthologs:
Homo sapiens (human) : GRHPR (glyoxylate and hydroxypyruvate reductase)  HGNC  Alliance
Mus musculus (house mouse) : Grhpr (glyoxylate reductase/hydroxypyruvate reductase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grhpr (glyoxylate and hydroxypyruvate reductase)
Pan paniscus (bonobo/pygmy chimpanzee) : GRHPR (glyoxylate and hydroxypyruvate reductase)
Canis lupus familiaris (dog) : GRHPR (glyoxylate and hydroxypyruvate reductase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grhpr (glyoxylate and hydroxypyruvate reductase)
Sus scrofa (pig) : GRHPR (glyoxylate and hydroxypyruvate reductase)
Chlorocebus sabaeus (green monkey) : GRHPR (glyoxylate and hydroxypyruvate reductase)
Heterocephalus glaber (naked mole-rat) : Grhpr (glyoxylate and hydroxypyruvate reductase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0560,528,981 - 60,538,410 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl560,528,997 - 60,538,375 (+)Ensembl
Rnor_5.0565,037,813 - 65,047,242 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4561,536,652 - 61,545,982 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1561,502,910 - 61,546,124 (+)NCBI
Celera557,802,736 - 57,812,175 (+)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Grhpr
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1308851
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.