Tnfsf15 (TNF superfamily member 15) - Rat Genome Database

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Gene: Tnfsf15 (TNF superfamily member 15) Rattus norvegicus
Analyze
Symbol: Tnfsf15
Name: TNF superfamily member 15
RGD ID: 628735
Description: Enables death receptor binding activity. Involved in positive regulation of cytokine production. Predicted to be located in plasma membrane. Orthologous to human TNFSF15 (TNF superfamily member 15); PARTICIPATES IN cytokine mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: TNF ligand-related molecule 1; Tnlg1b; tumor necrosis factor (ligand) superfamily, member 15; tumor necrosis factor ligand 1b; tumor necrosis factor ligand superfamily member 15; tumor necrosis factor superfamily member 15; vascular endothelial cell growth inhibitor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8582,150,376 - 82,171,743 (-)NCBIGRCr8
mRatBN7.2577,134,885 - 77,156,171 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl577,139,878 - 77,156,228 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx579,536,800 - 79,552,843 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0581,353,990 - 81,370,033 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0581,329,474 - 81,345,517 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0579,553,935 - 79,569,974 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl579,553,742 - 79,570,073 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0583,660,720 - 83,677,388 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4580,700,180 - 80,716,158 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1580,705,292 - 80,721,271 (-)NCBI
Celera576,073,295 - 76,089,313 (-)NCBICelera
Cytogenetic Map5q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
22-Hydroxycholesterol  (ISO)
25-hydroxycholesterol  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
6-propyl-2-thiouracil  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dorsomorphin  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
GW 3965  (ISO)
GW 4064  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
lucanthone  (ISO)
malathion  (ISO)
manganese(II) chloride  (EXP)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
Nonylphenol  (ISO)
o-anisidine  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP)
PD 0325901  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
propanal  (ISO)
raloxifene  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
testosterone  (EXP,ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
triadimefon  (ISO)
trichloroethene  (EXP)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Migone TS, etal., Immunity 2002 Mar;16(3):479-92.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:20572782   PMID:26125742   PMID:26646413  


Genomics

Comparative Map Data
Tnfsf15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8582,150,376 - 82,171,743 (-)NCBIGRCr8
mRatBN7.2577,134,885 - 77,156,171 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl577,139,878 - 77,156,228 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx579,536,800 - 79,552,843 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0581,353,990 - 81,370,033 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0581,329,474 - 81,345,517 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0579,553,935 - 79,569,974 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl579,553,742 - 79,570,073 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0583,660,720 - 83,677,388 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4580,700,180 - 80,716,158 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1580,705,292 - 80,721,271 (-)NCBI
Celera576,073,295 - 76,089,313 (-)NCBICelera
Cytogenetic Map5q24NCBI
TNFSF15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389114,784,635 - 114,806,039 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9114,784,652 - 114,806,039 (-)EnsemblGRCh38hg38GRCh38
GRCh379117,546,915 - 117,568,319 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369116,591,421 - 116,608,229 (-)NCBINCBI36Build 36hg18NCBI36
Build 349114,631,165 - 114,647,962NCBI
Celera988,199,259 - 88,215,833 (-)NCBICelera
Cytogenetic Map9q32NCBI
HuRef987,151,524 - 87,173,014 (-)NCBIHuRef
CHM1_19117,693,586 - 117,715,078 (-)NCBICHM1_1
T2T-CHM13v2.09126,977,075 - 126,998,476 (-)NCBIT2T-CHM13v2.0
Tnfsf15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39463,642,837 - 63,663,296 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl463,642,840 - 63,663,350 (-)EnsemblGRCm39 Ensembl
GRCm38463,724,600 - 63,745,059 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl463,727,084 - 63,745,113 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl463,724,603 - 63,745,113 (-)EnsemblGRCm38mm10GRCm38
MGSCv37463,385,637 - 63,406,147 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36463,213,445 - 63,231,448 (-)NCBIMGSCv36mm8
Celera462,385,254 - 62,405,702 (-)NCBICelera
Cytogenetic Map4C1NCBI
cM Map434.06NCBI
Tnfsf15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541912,863,615 - 12,879,517 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541912,863,617 - 12,884,498 (+)NCBIChiLan1.0ChiLan1.0
TNFSF15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21124,571,103 - 24,593,502 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1924,573,463 - 24,595,862 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0985,881,800 - 85,904,191 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19114,243,664 - 114,265,139 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9114,249,472 - 114,265,441 (-)Ensemblpanpan1.1panPan2
TNFSF15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11168,887,858 - 68,909,406 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1168,893,084 - 68,909,602 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1167,291,777 - 67,310,991 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01170,013,909 - 70,033,147 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11168,528,248 - 68,547,440 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01168,569,008 - 68,588,222 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01169,300,208 - 69,319,429 (-)NCBIUU_Cfam_GSD_1.0
Tnfsf15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947184,185,757 - 184,207,492 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364873,959,224 - 3,975,959 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364873,959,224 - 3,975,959 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNFSF15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1255,328,719 - 255,349,539 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11255,328,731 - 255,349,508 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21286,440,650 - 286,461,441 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TNFSF15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11224,784,185 - 24,801,809 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1224,785,046 - 24,800,692 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603518,025,960 - 18,047,188 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnfsf15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476020,386,113 - 20,403,716 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476020,386,025 - 20,408,919 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tnfsf15
82 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:32
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000011845
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
1598845Mcs14Mammary carcinoma susceptibility QTL 140.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)57636977680813390Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)55979352890450144Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)568984307104251008Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 2 12 1 19 1 6 6 30 31 22 11 6
Below cutoff 1 41 27 22 22 2 4 22 4 18 2

Sequence


Ensembl Acc Id: ENSRNOT00000011845   ⟹   ENSRNOP00000011845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl577,139,878 - 77,156,228 (-)Ensembl
Rnor_6.0 Ensembl579,553,742 - 79,570,073 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100755   ⟹   ENSRNOP00000090865
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl577,139,878 - 77,156,196 (-)Ensembl
RefSeq Acc Id: NM_145765   ⟹   NP_665708
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8582,150,376 - 82,171,658 (-)NCBI
mRatBN7.2577,134,885 - 77,156,171 (-)NCBI
Rnor_6.0579,553,935 - 79,569,974 (-)NCBI
Rnor_5.0583,660,720 - 83,677,388 (-)NCBI
RGSC_v3.4580,700,180 - 80,716,158 (-)RGD
Celera576,073,295 - 76,089,313 (-)RGD
Sequence:
RefSeq Acc Id: XM_063287176   ⟹   XP_063143246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8582,152,474 - 82,171,743 (-)NCBI
Protein Sequences
Protein RefSeqs NP_665708 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143246 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAM77368 (Get FASTA)   NCBI Sequence Viewer  
  CTQ86171 (Get FASTA)   NCBI Sequence Viewer  
  EDM10514 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000011845.3
  ENSRNOP00000090865.1
GenBank Protein Q8K3Y7 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_665708   ⟸   NM_145765
- UniProtKB: Q8K3Y7 (UniProtKB/Swiss-Prot),   A6J7Z3 (UniProtKB/TrEMBL),   A0A0H2UHG9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011845   ⟸   ENSRNOT00000011845
Ensembl Acc Id: ENSRNOP00000090865   ⟸   ENSRNOT00000100755
RefSeq Acc Id: XP_063143246   ⟸   XM_063287176
- Peptide Label: isoform X1
- UniProtKB: A0A0H2UHG9 (UniProtKB/TrEMBL)
Protein Domains
THD   TNF family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K3Y7-F1-model_v2 AlphaFold Q8K3Y7 1-252 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693804
Promoter ID:EPDNEW_R4328
Type:single initiation site
Name:Tnfsf15_1
Description:TNF superfamily member 15
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0579,570,003 - 79,570,063EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628735 AgrOrtholog
BioCyc Gene G2FUF-41054 BioCyc
Ensembl Genes ENSRNOG00000008930 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011845.4 UniProtKB/TrEMBL
  ENSRNOT00000100755.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro TNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tumour_necrosis_fac-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:252878 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 252878 ENTREZGENE
PANTHER PTHR11471:SF24 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TUMOR NECROSIS FACTOR FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tnfsf15 PhenoGen
PRINTS TNECROSISFCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TNF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008930 RatGTEx
SMART TNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49842 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHG9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AB10_RAT UniProtKB/TrEMBL
  A6J7Z3 ENTREZGENE, UniProtKB/TrEMBL
  Q8K3Y7 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-21 Tnfsf15  TNF superfamily member 15  Tnfsf15  tumor necrosis factor superfamily member 15  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-25 Tnfsf15  tumor necrosis factor superfamily member 15  Tnfsf15  tumor necrosis factor (ligand) superfamily, member 15  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Tnfsf15  tumor necrosis factor (ligand) superfamily, member 15      Symbol and Name status set to approved 625702 APPROVED
2003-02-27 Tnfsf15  tumor necrosis factor (ligand) superfamily, member 15      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process induces NF-kB activation and apoptosis in DR3-expressing cell lines 634236
gene_protein 251 amino acids 634236