Mtap (methylthioadenosine phosphorylase) - Rat Genome Database

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Gene: Mtap (methylthioadenosine phosphorylase) Rattus norvegicus
Analyze
Symbol: Mtap
Name: methylthioadenosine phosphorylase
RGD ID: 1310114
Description: Enables S-methyl-5-thioadenosine phosphorylase activity. Involved in response to testosterone. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in biliary tract benign neoplasm and diaphyseal medullary stenosis with malignant fibrous histiocytoma. Orthologous to human MTAP (methylthioadenosine phosphorylase); PARTICIPATES IN methionine cycle/metabolic pathway; glycine N-methyltransferase deficiency pathway; homocystinuria pathway; INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5'-methylthioadenosine phosphorylase; Cc1-6; LOC298227; S-methyl-5'-thioadenosine phosphorylase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85108,990,270 - 109,036,494 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5108,988,830 - 109,055,214 (+)EnsemblGRCr8
mRatBN7.25103,874,460 - 103,920,684 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5103,873,020 - 103,939,406 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5106,308,258 - 106,354,482 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05108,037,874 - 108,084,086 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05108,118,643 - 108,164,834 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05107,711,077 - 107,777,530 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5107,711,077 - 107,777,530 (+)Ensemblrn6Rnor6.0
Rnor_5.05111,679,661 - 111,746,208 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45108,788,725 - 108,861,905 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5102,587,860 - 102,654,739 (+)NCBICelera
RGSC_v3.15108,793,950 - 108,867,131 (+)NCBI
Cytogenetic Map5q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
alpha-pinene  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dichloroacetic acid  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furfural  (ISO)
gentamycin  (EXP)
inulin  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
manganese(II) chloride  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Occurrence of 5'-deoxy-5'-methylthioadenosine phosphorylase in the mammalian CNS: distribution and kinetic studies on the rat brain enzyme. Abbruzzese A, etal., J Neurochem. 1983 Feb;40(2):487-92.
2. Aminooxy analogues of spermidine as inhibitors of spermine synthase and substrates of hepatic polyamine acetylating activity. Eloranta TO, etal., J Biochem. 1990 Oct;108(4):593-8.
3. Demonstration of 5'-methylthioadenosine phosphorylase activity in various rat tissues. Some properties of the enzyme from rat lung. Garbers DL Biochim Biophys Acta. 1978 Mar 14;523(1):82-93.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Homozygous deletion of the MTAP gene in invasive adenocarcinoma of the pancreas and in periampullary cancer: a potential new target for therapy. Hustinx SR, etal., Cancer Biol Ther. 2005 Jan;4(1):83-6. Epub 2005 Jan 15.
7. Homozygous deletions of methylthioadenosine phosphorylase in human biliary tract cancers. Karikari CA, etal., Mol Cancer Ther. 2005 Dec;4(12):1860-6.
8. S-adenosylmethionine in liver health, injury, and cancer. Lu SC and Mato JM, Physiol Rev. 2012 Oct;92(4):1515-42. doi: 10.1152/physrev.00047.2011.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. The stimulatory effect of testosterone propionate and 17 beta-estradiol on 5'-methylthioadenosine phosphorylase activity in rat target tissues. Nicolette JA, etal., Biochim Biophys Acta. 1980 Jan 17;627(2):190-8.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Androgenic regulation of 5'-deoxy-5'-methylthioadenosine concentrations and methylthioadenosine phosphorylase activity in relation to polyamine metabolism of rat prostate. Seidenfeld J, etal., Biochem Biophys Res Commun. 1980 Aug 29;95(4):1861-8.
18. Loss of methylthioadenosine phosphorylase and elevated ornithine decarboxylase is common in pancreatic cancer. Subhi AL, etal., Clin Cancer Res. 2004 Nov 1;10(21):7290-6.
Additional References at PubMed
PMID:19001417   PMID:19056867   PMID:22952318   PMID:23376485   PMID:27748820  


Genomics

Comparative Map Data
Mtap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85108,990,270 - 109,036,494 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5108,988,830 - 109,055,214 (+)EnsemblGRCr8
mRatBN7.25103,874,460 - 103,920,684 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5103,873,020 - 103,939,406 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5106,308,258 - 106,354,482 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05108,037,874 - 108,084,086 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05108,118,643 - 108,164,834 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05107,711,077 - 107,777,530 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5107,711,077 - 107,777,530 (+)Ensemblrn6Rnor6.0
Rnor_5.05111,679,661 - 111,746,208 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45108,788,725 - 108,861,905 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5102,587,860 - 102,654,739 (+)NCBICelera
RGSC_v3.15108,793,950 - 108,867,131 (+)NCBI
Cytogenetic Map5q32NCBI
MTAP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38921,802,636 - 21,941,115 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl921,802,636 - 21,937,651 (+)Ensemblhg38GRCh38
GRCh37921,802,635 - 21,941,114 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36921,792,635 - 21,855,970 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34921,792,634 - 21,855,967NCBI
Celera921,740,998 - 21,804,334 (+)NCBICelera
Cytogenetic Map9p21.3NCBI
HuRef921,765,963 - 21,829,332 (+)NCBIHuRef
CHM1_1921,802,515 - 21,865,858 (+)NCBICHM1_1
T2T-CHM13v2.0921,816,863 - 21,955,417 (+)NCBIT2T-CHM13v2.0
Mtap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39489,055,607 - 89,099,327 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl489,055,359 - 89,099,318 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38489,137,370 - 89,181,090 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl489,137,122 - 89,181,081 (+)Ensemblmm10GRCm38
MGSCv37488,783,274 - 88,826,994 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36488,608,657 - 88,652,314 (+)NCBIMGSCv36mm8
Celera487,620,095 - 87,663,899 (+)NCBICelera
Cytogenetic Map4C4NCBI
cM Map442.15NCBI
Mtap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547212,390,032 - 12,439,206 (-)Ensembl
ChiLan1.0NW_00495547212,391,399 - 12,439,221 (-)NCBIChiLan1.0ChiLan1.0
MTAP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211102,620,519 - 102,756,196 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19102,623,086 - 102,762,138 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0921,637,543 - 21,769,698 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1922,253,357 - 22,316,883 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl922,266,376 - 22,382,218 (+)EnsemblpanPan2panpan1.1
MTAP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11141,148,389 - 41,200,635 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1141,148,404 - 41,264,504 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1139,820,541 - 39,872,745 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01142,090,758 - 42,142,952 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1142,090,124 - 42,142,944 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11140,760,953 - 40,813,082 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01140,648,752 - 40,701,001 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01141,262,101 - 41,314,256 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mtap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947155,762,052 - 155,800,008 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366523,431,171 - 3,472,071 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366523,431,588 - 3,468,770 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTAP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1200,882,956 - 200,934,445 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11200,882,954 - 200,934,389 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21224,075,795 - 224,126,822 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103241896
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11584,196,548 - 84,198,357 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1257,997,427 - 58,050,241 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604157,778,455 - 57,780,270 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mtap
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473625,778,240 - 25,826,530 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473625,778,191 - 25,826,945 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Mtap
151 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:89
Interacting mature miRNAs:94
Transcripts:ENSRNOT00000029486
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
1582212Livw2Liver weight QTL 23.50.0004liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)599016066119085810Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)599753548113061097Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)590067849128034027Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584132602129132602Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)568984307104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)590067849128034027Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
18 12 73 185 91 90 59 143 59 6 432 250 12 170 97 106 31 20 20

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001394049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000029486   ⟹   ENSRNOP00000031214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5108,988,830 - 109,055,214 (+)Ensembl
mRatBN7.2 Ensembl5103,873,020 - 103,939,406 (+)Ensembl
Rnor_6.0 Ensembl5107,711,077 - 107,777,530 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090739   ⟹   ENSRNOP00000073330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5108,990,270 - 109,036,494 (+)Ensembl
mRatBN7.2 Ensembl5103,874,507 - 103,917,591 (+)Ensembl
Rnor_6.0 Ensembl5107,712,579 - 107,758,686 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096850   ⟹   ENSRNOP00000082661
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5103,873,732 - 103,914,803 (+)Ensembl
RefSeq Acc Id: NM_001394049   ⟹   NP_001380978
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85108,990,270 - 109,036,494 (+)NCBI
mRatBN7.25103,874,460 - 103,920,684 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001380978 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000031214.2
  ENSRNOP00000073330
  ENSRNOP00000073330.1
  ENSRNOP00000082661.1
Ensembl Acc Id: ENSRNOP00000073330   ⟸   ENSRNOT00000090739
Ensembl Acc Id: ENSRNOP00000031214   ⟸   ENSRNOT00000029486
Ensembl Acc Id: ENSRNOP00000082661   ⟸   ENSRNOT00000096850
RefSeq Acc Id: NP_001380978   ⟸   NM_001394049
- UniProtKB: A0A0G2K583 (UniProtKB/TrEMBL),   A6JRF0 (UniProtKB/TrEMBL)
Protein Domains
Nucleoside phosphorylase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TP15-F1-model_v2 AlphaFold Q7TP15 1-391 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693835
Promoter ID:EPDNEW_R4356
Type:initiation region
Name:Mtap_1
Description:methylthioadenosine phosphorylase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05107,712,599 - 107,712,659EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310114 AgrOrtholog
BioCyc Gene G2FUF-40781 BioCyc
BioCyc Pathway PWY-6756 [S-methyl-5'-thioadenosine degradation II] BioCyc
BioCyc Pathway Image PWY-6756 BioCyc
Ensembl Genes ENSRNOG00000006615 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029486.4 UniProtKB/TrEMBL
  ENSRNOT00000090739 ENTREZGENE
  ENSRNOT00000090739.2 UniProtKB/TrEMBL
  ENSRNOT00000096850.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1580 UniProtKB/TrEMBL
InterPro MTAP UniProtKB/TrEMBL
  Nucleoside_phosphorylase UniProtKB/TrEMBL
  Nucleoside_phosphorylase_sf UniProtKB/TrEMBL
  Purine_phosphorylase-2_CS UniProtKB/TrEMBL
NCBI Gene 298227 ENTREZGENE
PANTHER PTHR42679 UniProtKB/TrEMBL
  S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE UniProtKB/TrEMBL
Pfam PNP_UDP_1 UniProtKB/TrEMBL
PhenoGen Mtap PhenoGen
PROSITE PNP_MTAP_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006615 RatGTEx
Superfamily-SCOP SSF53167 UniProtKB/TrEMBL
UniProt A0A0G2K583 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZXI1_RAT UniProtKB/TrEMBL
  A6JRF0 ENTREZGENE, UniProtKB/TrEMBL
  Q7TP15_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Mtap  methylthioadenosine phosphorylase   Mtap_predicted  methylthioadenosine phosphorylase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Mtap_predicted  methylthioadenosine phosphorylase (predicted)      Symbol and Name status set to approved 70820 APPROVED