Mtap (methylthioadenosine phosphorylase)

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Gene: Mtap (methylthioadenosine phosphorylase) Rattus norvegicus

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Symbol:

Mtap

Name:

methylthioadenosine phosphorylase

RGD ID:

1310114

Description:

Exhibits S-methyl-5-thioadenosine phosphorylase activity. Involved in response to testosterone. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in biliary tract benign neoplasm and diaphyseal medullary stenosis with malignant fibrous histiocytoma. Orthologous to human MTAP (methylthioadenosine phosphorylase); PARTICIPATES IN methionine cycle/metabolic pathway; glycine N-methyltransferase deficiency pathway; homocystinuria pathway; INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

5'-methylthioadenosine phosphorylase; Cc1-6; LOC298227; S-methyl-5'-thioadenosine phosphorylase

Orthologs:

Homo sapiens (human) : MTAP (methylthioadenosine phosphorylase) HGNC Alliance
Mus musculus (house mouse) : Mtap (methylthioadenosine phosphorylase) MGI Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mtap (methylthioadenosine phosphorylase)
Pan paniscus (bonobo/pygmy chimpanzee) : MTAP (methylthioadenosine phosphorylase)
Canis lupus familiaris (dog) : MTAP (methylthioadenosine phosphorylase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mtap (methylthioadenosine phosphorylase)
Sus scrofa (pig) : MTAP (methylthioadenosine phosphorylase)
Chlorocebus sabaeus (African green monkey) : MTAP (methylthioadenosine phosphorylase)
Heterocephalus glaber (naked mole-rat) : Mtap (methylthioadenosine phosphorylase)

more info ...

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MTAP (methylthioadenosine phosphorylase)	HGNC	Ensembl, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Mtap (methylthioadenosine phosphorylase)	HGNC	Treefam, NCBI, OMA, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Mtap (methylthioadenosine phosphorylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MTAP (methylthioadenosine phosphorylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MTAP (methylthioadenosine phosphorylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mtap (methylthioadenosine phosphorylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MTAP (methylthioadenosine phosphorylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	MTAP (methylthioadenosine phosphorylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mtap (methylthioadenosine phosphorylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	MTAP (methylthioadenosine phosphorylase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Mus musculus (house mouse):	Mtap (methylthioadenosine phosphorylase)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	mtap (methylthioadenosine phosphorylase)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	CG31115	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Caenorhabditis elegans (roundworm):	B0228.7	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	MEU1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	Mtap	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	5	107,711,077 - 107,777,530 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	107,711,077 - 107,777,530 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	111,679,661 - 111,746,208 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	108,788,725 - 108,861,905 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	5	108,793,950 - 108,867,131 (+)	NCBI
Celera	5	102,587,860 - 102,654,739 (+)	NCBI		Celera
Cytogenetic Map	5	q32	NCBI

JBrowse:

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Disease Annotations

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References - curated

References - uncurated

Genomics

Comparative Map Data

QTLs in Region (Rnor_6.0)

miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences

Protein Sequences

Transcriptome

Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links

Nomenclature History

More on Mtap
	Alliance Gene
	NCBI Gene
	Ensembl Gene
	JBrowse: rn5 rn6
	NCBI Genome Data Viewer

RGD Object Information
RGD ID:	1310114
Created:	2005-01-12
Species:	Rattus norvegicus
Last Modified:	2020-08-20
Status:	ACTIVE

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

RGD Manual Annotations

Imported Annotations - ClinVar

Imported Annotations - CTD

Imported Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)