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GENE - TERM ANNOTATION REPORT

22 Annotations Found.

An association has been curated linking Lepr and obesity in Rattus norvegicus.        

  • The association was inferred from mutant phenotype (IMP)
    		•  
  • The annotation was made from Kanoski SE, etal., Am J Physiol Endocrinol Metab. 2012 Aug 15;303(4):E496-503. doi: 10.1152/ajpendo.00205.2012. Epub 2012 Jun 12.
  • 2 additional annotations were made from Kanoski SE, etal., Am J Physiol Endocrinol Metab. 2012 Aug 15;303(4):E496-503. doi: 10.1152/ajpendo.00205.2012. Epub 2012 Jun 12.
  • 798 RGD objects have been annotated to obesity  (DOID:9970)
  • 100 papers in RGD have been used to annotate Lepr


    • An association has been curated linking Lepr and obesity in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Koga S, etal., Neurosci Lett. 2014 Jun 13;571:11-6. doi: 10.1016/j.neulet.2014.04.028. Epub 2014 Apr 28.
  • The annotation has been inferred from sequence orthology with Lepr (Mus musculus) [(IEP) inferred from expression pattern]
  • 2 additional annotations were made from Koga S, etal., Neurosci Lett. 2014 Jun 13;571:11-6. doi: 10.1016/j.neulet.2014.04.028. Epub 2014 Apr 28.
  • 798 RGD objects have been annotated to obesity  (DOID:9970)
  • 100 papers in RGD have been used to annotate Lepr
  • Curation Notes: protein:increased expression:hippocampus,astrocyte:


    • An association has been curated linking Lepr and obesity in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Popko K, etal., J Physiol Pharmacol. 2007 Nov;58 Suppl 5(Pt 2):551-61.
  • The annotation has been inferred from sequence orthology with LEPR (Homo sapiens) [(IAGP) inferred by association of genotype and phenotype]
  • 5 additional annotations were made from Popko K, etal., J Physiol Pharmacol. 2007 Nov;58 Suppl 5(Pt 2):551-61.
  • 798 RGD objects have been annotated to obesity  (DOID:9970)
  • 100 papers in RGD have been used to annotate Lepr
  • Qualifier: susceptibility
  • Curation Notes: DNA:polymorphism:exon:p.Q223R (human)


    • An association has been curated linking Lepr and obesity in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Karlsson EA, etal., J Nutr. 2010 Sep;140(9):1691-7. Epub 2010 Jun 30.
  • The annotation has been inferred from sequence orthology with Lepr (Mus musculus) [(IEP) inferred from expression pattern]
  • 2 additional annotations were made from Karlsson EA, etal., J Nutr. 2010 Sep;140(9):1691-7. Epub 2010 Jun 30.
  • 798 RGD objects have been annotated to obesity  (DOID:9970)
  • 100 papers in RGD have been used to annotate Lepr
  • Curation Notes: mRNA:decreased expression:lung


    • An association has been curated linking Lepr and obesity in Rattus norvegicus.        

  • The association was inferred by association of genotype and phenotype (IAGP)
    		•  
  • The annotation was made from Iida M, etal., Biochem Biophys Res Commun 1996 Jul 16;224(2):597-604.
  • 2 additional annotations were made from Iida M, etal., Biochem Biophys Res Commun 1996 Jul 16;224(2):597-604.
  • 798 RGD objects have been annotated to obesity  (DOID:9970)
  • 100 papers in RGD have been used to annotate Lepr
  • Curation Notes: DNA:missense mutation:CDS:p.Q269P (rat)


    • An association has been curated linking Lepr and obesity in Rattus norvegicus.        

  • The association was inferred by association of genotype and phenotype (IAGP)
    		•  
  • The annotation was made from Takaya K, etal., Nat Genet. 1996 Oct;14(2):130-1.
  • 2 additional annotations were made from Takaya K, etal., Nat Genet. 1996 Oct;14(2):130-1.
  • 798 RGD objects have been annotated to obesity  (DOID:9970)
  • 100 papers in RGD have been used to annotate Lepr


    • An association has been curated linking Lepr and obesity in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
  • The annotation has been inferred from sequence orthology with LEPR (Homo sapiens) [(IEA) inferred from electronic annotation]
  • 619 additional annotations were made from Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
  • 798 RGD objects have been annotated to obesity  (DOID:9970)
  • 100 papers in RGD have been used to annotate Lepr


    • An association has been curated linking Lepr and obesity in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from de Luca C, etal., J Clin Invest. 2005 Dec;115(12):3484-93. Epub 2005 Nov 10.
  • The annotation has been inferred from sequence orthology with Lepr (Mus musculus) [(IMP) inferred from mutant phenotype]
  • 8 additional annotations were made from de Luca C, etal., J Clin Invest. 2005 Dec;115(12):3484-93. Epub 2005 Nov 10.
  • 798 RGD objects have been annotated to obesity  (DOID:9970)
  • 100 papers in RGD have been used to annotate Lepr
  • Qualifier: treatment


    • An association has been curated linking Lepr and obesity in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Rolland V, etal., Obes Res. 1998 Mar;6(2):122-7.
  • The annotation has been inferred from sequence orthology with LEPR (Homo sapiens) [(IAGP) inferred by association of genotype and phenotype]
  • 2 additional annotations were made from Rolland V, etal., Obes Res. 1998 Mar;6(2):122-7.
  • 798 RGD objects have been annotated to obesity  (DOID:9970)
  • 100 papers in RGD have been used to annotate Lepr
  • Qualifier: no_association


    • An association has been curated linking Lepr and obesity in Rattus norvegicus.        

  • The association was inferred from mutant phenotype (IMP)
    		•  
  • The annotation was made from McPherson KC, etal., Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F793-F804. doi: 10.1152/ajprenal.00590.2015. Epub 2016 Jul 27.
  • 75 additional annotations were made from McPherson KC, etal., Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F793-F804. doi: 10.1152/ajprenal.00590.2015. Epub 2016 Jul 27.
  • 798 RGD objects have been annotated to obesity  (DOID:9970)
  • 100 papers in RGD have been used to annotate Lepr


    • An association has been curated linking Lepr and obesity in Rattus norvegicus.        

  • The association was inferred by association of genotype and phenotype (IAGP)
    		•  
  • The annotation was made from Stevenson FT, etal., Obes Res 2001 Aug;9(8):492-9.
  • 27 additional annotations were made from Stevenson FT, etal., Obes Res 2001 Aug;9(8):492-9.
  • 798 RGD objects have been annotated to obesity  (DOID:9970)
  • 100 papers in RGD have been used to annotate Lepr
  • Curation Notes: compared to heterozygous controls +/fa


    • An association has been curated linking Lepr and obesity in Rattus norvegicus.        

  • The association was inferred from mutant phenotype (IMP)
    		•  
  • The annotation was made from McPherson KC, etal., Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F793-F804. doi: 10.1152/ajprenal.00590.2015. Epub 2016 Jul 27.
  • 75 additional annotations were made from McPherson KC, etal., Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F793-F804. doi: 10.1152/ajprenal.00590.2015. Epub 2016 Jul 27.
  • 798 RGD objects have been annotated to obesity  (DOID:9970)
  • 100 papers in RGD have been used to annotate Lepr
  • Qualifier: disease_progression


    • An association has been curated linking Lepr and obesity in Rattus norvegicus.        

  • The association was inferred by association of genotype and phenotype (IAGP)
    		•  
  • The annotation was made from Kim K, etal., Physiol Genomics. 2010 Feb 16.
  • 119 additional annotations were made from Kim K, etal., Physiol Genomics. 2010 Feb 16.
  • 798 RGD objects have been annotated to obesity  (DOID:9970)
  • 100 papers in RGD have been used to annotate Lepr
  • Qualifier: sexual_dimorphism
  • Curation Notes: compared to BN


    • An association has been curated linking Lepr and obesity in Rattus norvegicus.        

  • The association was inferred from mutant phenotype (IMP)
    		•  
  • The annotation was made from Chen Y, etal., Sci China Life Sci. 2017 Feb;60(2):152-157. doi: 10.1007/s11427-016-5049-y. Epub 2016 May 25.
  • 24 additional annotations were made from Chen Y, etal., Sci China Life Sci. 2017 Feb;60(2):152-157. doi: 10.1007/s11427-016-5049-y. Epub 2016 May 25.
  • 798 RGD objects have been annotated to obesity  (DOID:9970)
  • 100 papers in RGD have been used to annotate Lepr


    • An association has been curated linking Lepr and obesity in Rattus norvegicus.        

  • The association was inferred by association of genotype and phenotype (IAGP)
    		•  
  • The annotation was made from Marques BG, etal., Am J Physiol 1998 Dec;275(6 Pt 2):R1898-908.
  • 29 additional annotations were made from Marques BG, etal., Am J Physiol 1998 Dec;275(6 Pt 2):R1898-908.
  • 798 RGD objects have been annotated to obesity  (DOID:9970)
  • 100 papers in RGD have been used to annotate Lepr
  • Curation Notes: compared to age-matched lean +/fa rats


    • An association has been curated linking Lepr and obesity in Rattus norvegicus.        

  • The association was inferred by association of genotype and phenotype (IAGP)
    		•  
  • The annotation was made from Schauer A, etal., ESC Heart Fail. 2020 Oct;7(5):2123-2134. doi: 10.1002/ehf2.12915. Epub 2020 Jul 25.
  • 39 additional annotations were made from Schauer A, etal., ESC Heart Fail. 2020 Oct;7(5):2123-2134. doi: 10.1002/ehf2.12915. Epub 2020 Jul 25.
  • 798 RGD objects have been annotated to obesity  (DOID:9970)
  • 100 papers in RGD have been used to annotate Lepr
  • Curation Notes: DNA:mutations:cds: : (rat)


    • An association has been curated linking Lepr and obesity in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from RGD automated import pipeline for CTD gene-to-disease annotations
  • The annotation has been inferred from sequence orthology with LEPR (Homo sapiens) [(EXP) inferred from experiment]
  • 798 RGD objects have been annotated to obesity  (DOID:9970)
  • 100 papers in RGD have been used to annotate Lepr
  • Curation Notes: CTD Direct Evidence: marker/mechanism
  • Original References(s): PMID:3519326 PMID:17065336 PMID:17229951 PMID:19913045 PMID:20567778 PMID:22276206 PMID:23563609 PMID:24263156 PMID:25222487 PMID:29743445 PMID:30689673 PMID:30993381 PMID:35235096 PMID:35472412


    • An association has been curated linking Lepr and obesity in Rattus norvegicus.        

  • The association was inferred by association of genotype and phenotype (IAGP)
    		•  
  • The annotation was made from Dower K, etal., PLoS One. 2017 Jul 26;12(7):e0181861. doi: 10.1371/journal.pone.0181861. eCollection 2017.
  • 42 additional annotations were made from Dower K, etal., PLoS One. 2017 Jul 26;12(7):e0181861. doi: 10.1371/journal.pone.0181861. eCollection 2017.
  • 798 RGD objects have been annotated to obesity  (DOID:9970)
  • 100 papers in RGD have been used to annotate Lepr
  • Curation Notes: DNA:mutations:cds: : (rat)


    • An association has been curated linking Lepr and obesity in Rattus norvegicus.        

  • The association was inferred by association of genotype and phenotype (IAGP)
    		•  
  • The annotation was made from Abdellatif M, etal., Sci Transl Med. 2021 Feb 10;13(580):eabd7064. doi: 10.1126/scitranslmed.abd7064.
  • 35 additional annotations were made from Abdellatif M, etal., Sci Transl Med. 2021 Feb 10;13(580):eabd7064. doi: 10.1126/scitranslmed.abd7064.
  • 798 RGD objects have been annotated to obesity  (DOID:9970)
  • 100 papers in RGD have been used to annotate Lepr
  • Qualifier: treatment


    • An association has been curated linking Lepr and obesity in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
  • The annotation has been inferred from sequence orthology with LEPR (Homo sapiens) [(IAGP) inferred by association of genotype and phenotype]
  • 798 RGD objects have been annotated to obesity  (DOID:9970)
  • 100 papers in RGD have been used to annotate Lepr
  • Curation Notes: ClinVar Annotator: match by term: Monogenic Non-Syndromic Obesity | ClinVar Annotator: match by term: Obesity | ClinVar Annotator: match by term: Obesity disorder
  • Original References(s): PMID:11354636 PMID:11380591 PMID:11443193 PMID:12006639 PMID:17785359 PMID:18490929 PMID:21393862 PMID:21744741 PMID:22331430 PMID:25741868 PMID:26467025 PMID:28492532 PMID:8666155


    • An association has been curated linking Lepr and obesity in Rattus norvegicus.        

  • The association was inferred from sequence or structural similarity (ISS)
    		•  
  • The annotation was made from RGD automated import pipeline for MGI gene-to-disease annotations
  • The annotation has been inferred from sequence or structural similarity with Lepr (Mus musculus) [(IAGP) inferred by association of genotype and phenotype]
  • 798 RGD objects have been annotated to obesity  (DOID:9970)
  • 100 papers in RGD have been used to annotate Lepr
  • Curation Notes: OMIM:601665


    • An association has been curated linking Lepr and obesity in Rattus norvegicus.        

  • The association was inferred by association of genotype and phenotype (IAGP)
    		•  
  • The annotation was made from Tofovic SP, etal., Ren Fail. 2000;22(4):387-406. doi: 10.1081/jdi-100100882.
  • 74 additional annotations were made from Tofovic SP, etal., Ren Fail. 2000;22(4):387-406. doi: 10.1081/jdi-100100882.
  • 798 RGD objects have been annotated to obesity  (DOID:9970)
  • 100 papers in RGD have been used to annotate Lepr
  • Curation Notes: DNA:mutations::cds: : (rat)


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