Hcrtr1 (hypocretin receptor 1) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Hcrtr1 (hypocretin receptor 1) Rattus norvegicus
Symbol: Hcrtr1
Name: hypocretin receptor 1
RGD ID: 2787
Description: Enables orexin receptor activity and peptide hormone binding activity. Involved in neuropeptide signaling pathway. Predicted to be located in plasma membrane. Orthologous to human HCRTR1 (hypocretin receptor 1); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1; orexin/hypocretin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Hctr1; hypocretin (orexin) receptor 1; hypocretin receptor type 1; orexin receptor type 1; orexin/Hypocretin receptor type 1; ox-1-R; ox1-R; ox1r
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.25142,477,214 - 142,486,674 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5142,477,214 - 142,486,674 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5145,177,816 - 145,187,460 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05146,947,628 - 146,957,270 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05146,945,402 - 146,954,867 (-)NCBIRnor_WKY
Rnor_6.05148,346,029 - 148,355,404 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5148,346,031 - 148,355,406 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05152,064,507 - 152,073,882 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45149,160,739 - 149,170,736 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15149,170,777 - 149,180,775 (-)NCBI
Celera5140,944,936 - 140,954,306 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
plasma membrane  (ISO,ISS)

Molecular Function


References - curated
# Reference Title Reference Citation
1. Orexin receptor-1 (OX-R1) immunoreactivity in chemically identified neurons of the hypothalamus: focus on orexin targets involved in control of food and water intake. Backberg M, etal., Eur J Neurosci 2002 Jan;15(2):315-28.
2. Localization of orexins and their receptors in the rat olfactory system: possible modulation of olfactory perception by a neuropeptide synthetized centrally or locally. Caillol M, etal., Brain Res 2003 Jan 17;960(1-2):48-61.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness. Sakurai T Nat Rev Neurosci. 2007 Mar;8(3):171-81. Epub 2007 Feb 14.
9. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Sakurai T, etal., Cell 1998 Feb 20;92(4):573-85.
10. Evidence implicating a role for orexin-1 receptor modulation of paradoxical sleep in the rat. Smith MI, etal., Neurosci Lett 2003 May 8;341(3):256-8.
11. Orexin-1 receptor immunoreactivity in chemically identified target neurons in the rat hypothalamus. Suzuki R, etal., Neurosci Lett 2002 May 10;324(1):5-8.
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
13. The SK-N-MC cell line expresses an orexin binding site different from recombinant orexin 1-type receptor. Wieland HA, etal., Eur J Biochem 2002 Feb;269(4):1128-35.
14. Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins. Zhu Y, etal., J Pharmacol Sci. 2003 Jul;92(3):259-66.
Additional References at PubMed
PMID:11283317   PMID:11340621   PMID:12639903   PMID:12639939   PMID:12816759   PMID:14764632   PMID:15350698   PMID:15453542   PMID:15870901   PMID:15893599   PMID:15976062   PMID:16157481  
PMID:16763079   PMID:16815564   PMID:16930690   PMID:17276508   PMID:17292491   PMID:17585016   PMID:17638707   PMID:17982683   PMID:18223663   PMID:19033203   PMID:19118115   PMID:19207823  
PMID:19261974   PMID:19271123   PMID:19328827   PMID:19409203   PMID:19427365   PMID:19656173   PMID:19699765   PMID:19741128   PMID:19889100   PMID:20062799   PMID:20177882   PMID:20667500  
PMID:20728473   PMID:21089218   PMID:21418915   PMID:21596094   PMID:21957165   PMID:22028875   PMID:22186370   PMID:22356621   PMID:22450910   PMID:22569505   PMID:22588980   PMID:23744436  
PMID:23978908   PMID:24637063   PMID:24807827   PMID:25036612   PMID:25223979   PMID:25239810   PMID:25371350   PMID:25446454   PMID:25817882   PMID:25899624   PMID:25948277   PMID:26059340  
PMID:26096126   PMID:26277341   PMID:26287582   PMID:26943473   PMID:26950369   PMID:26987804   PMID:27575948   PMID:27771284   PMID:27837432   PMID:28549933   PMID:28667055   PMID:28866050  
PMID:28888954   PMID:28889006   PMID:29258865   PMID:29269074   PMID:30144975   PMID:30336854   PMID:30406600   PMID:30458283   PMID:31002819   PMID:31213116   PMID:32044404   PMID:32061874  
PMID:32207079   PMID:32474210   PMID:32668268   PMID:32745488   PMID:33212156   PMID:34718063   PMID:34730554   PMID:35338110   PMID:36284025   PMID:36470538   PMID:36539163  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.25142,477,214 - 142,486,674 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5142,477,214 - 142,486,674 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5145,177,816 - 145,187,460 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05146,947,628 - 146,957,270 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05146,945,402 - 146,954,867 (-)NCBIRnor_WKY
Rnor_6.05148,346,029 - 148,355,404 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5148,346,031 - 148,355,406 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05152,064,507 - 152,073,882 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45149,160,739 - 149,170,736 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15149,170,777 - 149,180,775 (-)NCBI
Celera5140,944,936 - 140,954,306 (-)NCBICelera
Cytogenetic Map5q36NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38131,617,689 - 31,634,492 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl131,617,686 - 31,632,518 (+)EnsemblGRCh38hg38GRCh38
GRCh37132,083,290 - 32,093,214 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36131,857,228 - 31,865,301 (+)NCBINCBI36Build 36hg18NCBI36
Build 34131,753,733 - 31,761,807NCBI
Celera130,352,534 - 30,362,141 (+)NCBICelera
Cytogenetic Map1p35.2NCBI
HuRef130,200,818 - 30,210,425 (+)NCBIHuRef
CHM1_1132,199,098 - 32,208,715 (+)NCBICHM1_1
T2T-CHM13v2.0131,475,343 - 31,490,165 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm394130,024,010 - 130,033,389 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4130,024,010 - 130,033,152 (-)EnsemblGRCm39 Ensembl
GRCm384130,130,217 - 130,139,594 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4130,130,217 - 130,139,359 (-)EnsemblGRCm38mm10GRCm38
MGSCv374129,807,461 - 129,816,406 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364129,632,521 - 129,641,466 (-)NCBIMGSCv36mm8
Celera4128,464,692 - 128,473,445 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495545210,026,464 - 10,036,186 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545210,026,464 - 10,036,267 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11194,323,439 - 194,333,994 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0130,901,772 - 30,913,633 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1131,918,650 - 31,928,290 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl131,919,980 - 31,928,290 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1269,484,776 - 69,493,956 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl269,480,199 - 69,494,005 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha266,064,201 - 66,072,739 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0270,050,261 - 70,058,799 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl270,045,316 - 70,057,436 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1266,886,002 - 66,894,539 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0267,882,448 - 67,890,972 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0268,881,857 - 68,890,396 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440505848,908,833 - 48,920,670 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647414,735,638 - 14,742,854 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493647414,735,654 - 14,744,112 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl688,139,498 - 88,154,848 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1688,139,623 - 88,149,531 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2681,853,666 - 81,864,501 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.120101,241,742 - 101,252,841 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20101,243,586 - 101,251,349 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603315,439,702 - 15,447,823 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462476414,862,397 - 14,869,739 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476414,861,672 - 14,872,728 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Hcrtr1
56 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:81
Count of miRNA genes:63
Interacting mature miRNAs:73
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5129132428143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Low 1 2 1 43 14 9
Below cutoff 2 18 17 5 15 5 6 9 17 20 26 9 6


Reference Sequences
RefSeq Acc Id: ENSRNOT00000018674   ⟹   ENSRNOP00000018674
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5142,477,214 - 142,486,674 (-)Ensembl
Rnor_6.0 Ensembl5148,346,031 - 148,355,406 (-)Ensembl
RefSeq Acc Id: NM_013064   ⟹   NP_037196
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.25142,477,214 - 142,486,674 (-)NCBI
Rnor_6.05148,346,029 - 148,355,404 (-)NCBI
Rnor_5.05152,064,507 - 152,073,882 (-)NCBI
RGSC_v3.45149,160,739 - 149,170,736 (-)RGD
Celera5140,944,936 - 140,954,306 (-)RGD
RefSeq Acc Id: XM_039109321   ⟹   XP_038965249
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25142,477,214 - 142,485,538 (-)NCBI
Protein Sequences
Protein RefSeqs NP_037196 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965249 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC40041 (Get FASTA)   NCBI Sequence Viewer  
  EDL80583 (Get FASTA)   NCBI Sequence Viewer  
  P56718 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_037196   ⟸   NM_013064
- UniProtKB: P56718 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018674   ⟸   ENSRNOT00000018674
RefSeq Acc Id: XP_038965249   ⟸   XM_039109321
- Peptide Label: isoform X1
- UniProtKB: P56718 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P56718-F1-model_v2 AlphaFold P56718 1-416 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2787 AgrOrtholog
BIND 128267
BioCyc Gene G2FUF-39763 BioCyc
Ensembl Genes ENSRNOG00000013838 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000018674 ENTREZGENE
  ENSRNOP00000018674.3 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018674 ENTREZGENE
  ENSRNOT00000018674.7 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Orexin_rcpt UniProtKB/Swiss-Prot
  Orexin_rcpt_1 UniProtKB/Swiss-Prot
KEGG Report rno:25593 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Hcrtr1 PhenoGen
  OREXIN1R UniProtKB/Swiss-Prot
  OREXINR UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
TIGR TC234778
UniProt OX1R_RAT UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Hcrtr1  hypocretin receptor 1  Hcrtr1  hypocretin (orexin) receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Hcrtr1  hypocretin (orexin) receptor 1    hypocretin receptor 1  Name updated 1299863 APPROVED
2002-11-06 Hcrtr1  hypocretin receptor 1    Hypocretin (orexin) receptor 1  Name updated 625702 APPROVED
2002-06-10 Hcrtr1  Hypocretin (orexin) receptor 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains C-terminus is amidated and also contains two intramolecular disulphide bonds that connect cysteine residues 625512
gene_drugs Modafinil, an anti-narcoleptic drug, might act through the orexin pathway 625512
gene_function G-protein-coupled receptor 625512
gene_physical_interaction binds the ligands Orexin A and Orexin B 625512
gene_process plays an important role in food intake, sleep/wake cycle and neuroendocrine functions 625512