Gene: Hcrtr1 (hypocretin receptor 1) Rattus norvegicus
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Symbol:
Hcrtr1
Name:
hypocretin receptor 1
RGD ID:
2787
Description:
Enables orexin receptor activity and peptide hormone binding activity. Involved in neuropeptide signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human HCRTR1 (hypocretin receptor 1); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1; orexin/hypocretin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
Hctr1; hypocretin (orexin) receptor 1; hypocretin receptor type 1; orexin receptor type 1; orexin/Hypocretin receptor type 1; ox-1-R; ox1-R; ox1r
RGD Orthologs
Alliance Orthologs
More Info
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More Info
Species
Gene symbol and name
Data Source
Assertion derived from
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Orthologs 1
Homo sapiens (human):
HCRTR1 (hypocretin receptor 1)
HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Hcrtr1 (hypocretin (orexin) receptor 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Hcrtr1 (hypocretin receptor 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
HCRTR1 (hypocretin receptor 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
HCRTR1 (hypocretin receptor 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Hcrtr1 (hypocretin receptor 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
HCRTR1 (hypocretin receptor 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
HCRTR1 (hypocretin receptor 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Hcrtr1 (hypocretin receptor 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
OR52E5 (olfactory receptor family 52 subfamily E member 5)
HGNC
OMA
Alliance orthologs 3
Homo sapiens (human):
HCRTR1 (hypocretin receptor 1)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Hcrtr1 (hypocretin (orexin) receptor 1)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Caenorhabditis elegans (roundworm):
npr-14
Alliance
DIOPT (Hieranoid|OrthoFinder|PhylomeDB|SonicParanoid)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 5 147,761,392 - 147,771,846 (-) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 5 147,760,145 - 147,770,850 (-) Ensembl GRCr8 mRatBN7.2 5 142,477,214 - 142,486,674 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 5 142,477,214 - 142,486,674 (-) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 5 145,177,816 - 145,187,460 (-) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 5 146,947,628 - 146,957,270 (-) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 5 146,945,402 - 146,954,867 (-) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 5 148,346,029 - 148,355,404 (-) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 5 148,346,031 - 148,355,406 (-) Ensembl rn6 Rnor6.0 Rnor_5.0 5 152,064,507 - 152,073,882 (-) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 5 149,160,739 - 149,170,736 (-) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 5 140,944,936 - 140,954,306 (-) NCBI Celera RGSC_v3.1 5 149,170,777 - 149,180,775 (-) NCBI Cytogenetic Map 5 q36 NCBI
JBrowse:
Imported Disease Annotations - CTD
Only show annotations with direct experimental evidence (0 objects hidden)
Hcrtr1 Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO Hcrtr1 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Hcrtr1 Rat 1,2-dimethylhydrazine increases expression ISO Hcrtr1 (Mus musculus) 6480464 1,2-Dimethylhydrazine results in increased expression of HCRTR1 mRNA CTD PMID:22206623 Hcrtr1 Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Hcrtr1 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Hcrtr1 Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Hcrtr1 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Hcrtr1 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO HCRTR1 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in increased expression of HCRTR1 mRNA CTD PMID:21296121 Hcrtr1 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of HCRTR1 mRNA CTD PMID:32109520 Hcrtr1 Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO Hcrtr1 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Hcrtr1 Rat 4,4'-sulfonyldiphenol increases expression ISO Hcrtr1 (Mus musculus) 6480464 bisphenol S results in increased expression of HCRTR1 mRNA CTD PMID:30951980 Hcrtr1 Rat 4,4'-sulfonyldiphenol decreases methylation ISO Hcrtr1 (Mus musculus) 6480464 bisphenol S results in decreased methylation of HCRTR1 exon CTD PMID:33297965 Hcrtr1 Rat 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of HCRTR1 mRNA CTD PMID:24780913 Hcrtr1 Rat acrylamide increases expression ISO Hcrtr1 (Mus musculus) 6480464 Acrylamide results in increased expression of HCRTR1 mRNA CTD PMID:30807115 Hcrtr1 Rat aflatoxin B1 increases methylation ISO HCRTR1 (Homo sapiens) 6480464 Aflatoxin B1 results in increased methylation of HCRTR1 gene CTD PMID:27153756 Hcrtr1 Rat ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of HCRTR1 mRNA CTD PMID:16483693 Hcrtr1 Rat amphetamine multiple interactions EXP 6480464 [1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea binds to and results in decreased activity of HCRTR1 protein] inhibits the reaction more ... CTD PMID:19737591 Hcrtr1 Rat arsane affects methylation ISO HCRTR1 (Homo sapiens) 6480464 Arsenic affects the methylation of HCRTR1 gene CTD PMID:25304211 Hcrtr1 Rat arsenic atom affects methylation ISO HCRTR1 (Homo sapiens) 6480464 Arsenic affects the methylation of HCRTR1 gene CTD PMID:25304211 Hcrtr1 Rat arsenous acid decreases expression ISO HCRTR1 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of HCRTR1 mRNA CTD PMID:15761015 Hcrtr1 Rat benzo[a]pyrene affects methylation ISO HCRTR1 (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of HCRTR1 promoter CTD PMID:27901495 Hcrtr1 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of HCRTR1 mRNA CTD PMID:30816183|PMID:32528016 Hcrtr1 Rat bisphenol A decreases expression ISO Hcrtr1 (Mus musculus) 6480464 bisphenol A results in decreased expression of HCRTR1 mRNA CTD PMID:32156529 Hcrtr1 Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of HCRTR1 mRNA CTD PMID:34947998 Hcrtr1 Rat bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of HCRTR1 gene CTD PMID:28505145 Hcrtr1 Rat bisphenol F decreases expression ISO Hcrtr1 (Mus musculus) 6480464 bisphenol F results in decreased expression of HCRTR1 mRNA CTD PMID:36706583 Hcrtr1 Rat cadmium atom multiple interactions ISO HCRTR1 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HCRTR1 more ... CTD PMID:35301059 Hcrtr1 Rat cadmium dichloride multiple interactions ISO HCRTR1 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HCRTR1 more ... CTD PMID:35301059 Hcrtr1 Rat cannabidiol multiple interactions ISO HCRTR1 (Homo sapiens) 6480464 Cannabidiol binds to and results in decreased activity of HCRTR1 protein CTD PMID:34439801 Hcrtr1 Rat cetrorelix decreases expression EXP 6480464 cetrorelix results in decreased expression of HCRTR1 mRNA CTD PMID:17638707 Hcrtr1 Rat chlorpyrifos increases expression ISO Hcrtr1 (Mus musculus) 6480464 Chlorpyrifos results in increased expression of HCRTR1 mRNA CTD PMID:34289071 Hcrtr1 Rat choline multiple interactions ISO Hcrtr1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation more ... CTD PMID:20938992 Hcrtr1 Rat Cuprizon increases expression EXP 6480464 Cuprizone results in increased expression of HCRTR1 mRNA CTD PMID:27523638 Hcrtr1 Rat diarsenic trioxide decreases expression ISO HCRTR1 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of HCRTR1 mRNA CTD PMID:15761015 Hcrtr1 Rat dioxygen multiple interactions EXP 6480464 [Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in increased expression more ... CTD PMID:33729688 Hcrtr1 Rat dopamine multiple interactions EXP 6480464 [1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea binds to and results in decreased activity of HCRTR1 protein] inhibits the reaction more ... CTD PMID:19737591 Hcrtr1 Rat doxorubicin decreases expression ISO HCRTR1 (Homo sapiens) 6480464 Doxorubicin results in decreased expression of HCRTR1 mRNA CTD PMID:16404146 Hcrtr1 Rat fentanyl decreases expression EXP 6480464 Fentanyl results in decreased expression of HCRTR1 mRNA CTD PMID:36032789 Hcrtr1 Rat fenvalerate increases expression EXP 6480464 fenvalerate results in increased expression of HCRTR1 mRNA CTD PMID:30307764 Hcrtr1 Rat folic acid multiple interactions ISO Hcrtr1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation more ... CTD PMID:20938992 Hcrtr1 Rat fonofos increases methylation ISO HCRTR1 (Homo sapiens) 6480464 Fonofos results in increased methylation of HCRTR1 promoter CTD PMID:22847954 Hcrtr1 Rat glyphosate decreases expression EXP 6480464 Glyphosate results in decreased expression of HCRTR1 mRNA CTD PMID:38314887 Hcrtr1 Rat L-methionine multiple interactions ISO Hcrtr1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation more ... CTD PMID:20938992 Hcrtr1 Rat methoxychlor affects methylation EXP 6480464 Methoxychlor affects the methylation of HCRTR1 gene CTD PMID:35440735 Hcrtr1 Rat milnacipran increases expression ISO Hcrtr1 (Mus musculus) 6480464 milnacipran results in increased expression of HCRTR1 mRNA CTD PMID:21157932 Hcrtr1 Rat mono(2-ethylhexyl) phthalate increases expression ISO Hcrtr1 (Mus musculus) 6480464 mono-(2-ethylhexyl)phthalate results in increased expression of HCRTR1 mRNA CTD PMID:36189433 Hcrtr1 Rat morphine increases expression EXP 6480464 Morphine results in increased expression of HCRTR1 mRNA; Morphine results in increased expression of HCRTR1 more ... CTD PMID:32319158 Hcrtr1 Rat parathion increases methylation ISO HCRTR1 (Homo sapiens) 6480464 Parathion results in increased methylation of HCRTR1 promoter CTD PMID:22847954 Hcrtr1 Rat paroxetine increases expression ISO Hcrtr1 (Mus musculus) 6480464 Paroxetine results in increased expression of HCRTR1 mRNA CTD PMID:21157932 Hcrtr1 Rat PCB138 multiple interactions ISO Hcrtr1 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Hcrtr1 Rat pentobarbital decreases expression EXP 6480464 Pentobarbital results in decreased expression of HCRTR1 mRNA CTD PMID:17638707 Hcrtr1 Rat perfluorooctane-1-sulfonic acid affects expression EXP 6480464 perfluorooctane sulfonic acid affects the expression of HCRTR1 mRNA CTD PMID:20136073 Hcrtr1 Rat pirinixic acid multiple interactions ISO HCRTR1 (Homo sapiens) 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in more ... CTD PMID:19710929 Hcrtr1 Rat resveratrol multiple interactions ISO HCRTR1 (Homo sapiens) 6480464 [Plant Extracts co-treated with Resveratrol] results in decreased expression of HCRTR1 mRNA CTD PMID:23557933 Hcrtr1 Rat sodium arsenite decreases expression ISO Hcrtr1 (Mus musculus) 6480464 sodium arsenite results in decreased expression of HCRTR1 mRNA CTD PMID:37682722 Hcrtr1 Rat terbufos increases methylation ISO HCRTR1 (Homo sapiens) 6480464 terbufos results in increased methylation of HCRTR1 promoter CTD PMID:22847954 Hcrtr1 Rat titanium dioxide decreases methylation ISO Hcrtr1 (Mus musculus) 6480464 titanium dioxide results in decreased methylation of HCRTR1 gene; titanium dioxide results in decreased methylation more ... CTD PMID:35295148 Hcrtr1 Rat titanium dioxide increases methylation ISO Hcrtr1 (Mus musculus) 6480464 titanium dioxide results in increased methylation of HCRTR1 promoter CTD PMID:35295148 Hcrtr1 Rat trichloroethene decreases expression EXP 6480464 Trichloroethylene results in decreased expression of HCRTR1 mRNA CTD PMID:33387578 Hcrtr1 Rat vinclozolin increases methylation EXP 6480464 vinclozolin results in increased methylation of HCRTR1 gene CTD PMID:31079544