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Gene: Oxtr (oxytocin receptor) Rattus norvegicus
Symbol: Oxtr
Name: oxytocin receptor
Description: Exhibits oxytocin receptor activity and peptide hormone binding activity. Involved in several processes, including ERK1 and ERK2 cascade; estrous cycle; and positive regulation of cell communication. Localizes to adherens junction; apical plasma membrane; and microvillus. Used to study gastric ulcer. Biomarker of hypertension. Orthologous to human OXTR (oxytocin receptor); PARTICIPATES IN G protein mediated signaling pathway via Galphai family; G protein mediated signaling pathway via Galphaq family; oxytocin signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: OT-R; OTR; OTR1; oxcytocin receptor
Homo sapiens (human) : OXTR (oxytocin receptor)  HGNC  Alliance
Mus musculus (house mouse) : Oxtr (oxytocin receptor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Oxtr (oxytocin receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : OXTR (oxytocin receptor)
Canis lupus familiaris (dog) : OXTR (oxytocin receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Oxtr (oxytocin receptor)
Sus scrofa (pig) : OXTR (oxytocin receptor)
Chlorocebus sabaeus (African green monkey) : OXTR (oxytocin receptor)
Heterocephalus glaber (naked mole-rat) : Oxtr (oxytocin receptor)
more info ...
Allele / Splice: Oxtrm1Mcwi  
Genetic Models: BN-Oxtrm1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04144,399,326 - 144,417,598 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4144,403,358 - 144,416,116 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04207,701,360 - 207,717,840 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44148,314,089 - 148,326,797 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14148,558,929 - 148,571,638 (-)NCBI
Celera4134,168,869 - 134,184,999 (-)NCBICelera
Cytogenetic Map4q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Oxtr
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3239
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.