Oxtr (oxytocin receptor) - Rat Genome Database

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Gene: Oxtr (oxytocin receptor) Rattus norvegicus
Analyze
Symbol: Oxtr
Name: oxytocin receptor
RGD ID: 3239
Description: Enables oxytocin receptor activity and peptide hormone binding activity. Involved in several processes, including ERK1 and ERK2 cascade; positive regulation of synaptic transmission; and regulation of secretion. Located in adherens junction; apical plasma membrane; and microvillus. Used to study gastric ulcer. Biomarker of hypertension. Orthologous to human OXTR (oxytocin receptor); PARTICIPATES IN G protein mediated signaling pathway via Galphai family; G protein mediated signaling pathway via Galphaq family; oxytocin signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: OT-R; OTR; OTR1; oxcytocin receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Oxtrm1Mcwi  
Genetic Models: BN-Oxtrm1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24145,598,549 - 145,614,674 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl4144,403,358 - 144,416,116 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04144,399,326 - 144,417,598 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04207,701,360 - 207,717,840 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44148,314,089 - 148,326,797 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14148,558,929 - 148,571,638 (-)NCBI
Celera4134,168,869 - 134,184,999 (-)NCBICelera
Cytogenetic Map4q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
1. Arthur P, etal., J Physiol. 2008 Dec 15;586(Pt 24):6063-76. Epub 2008 Oct 20.
2. Asad M, etal., Life Sci. 2001 Nov 21;70(1):17-24.
3. Bale TL, etal., J Neurosci. 2001 Apr 1;21(7):2546-52.
4. Bealer SL, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Jul;291(1):R53-8.
5. Breton JD, etal., Mol Pain. 2008 May 29;4:19.
6. Chen Q, etal., Neuropeptides. 2000 Jun-Aug;34(3-4):173-80.
7. ChruĊ›cicka B, etal., ACS Chem Neurosci. 2019 Jul 17;10(7):3225-3240. doi: 10.1021/acschemneuro.8b00665. Epub 2019 May 8.
8. Clement P, etal., Br J Pharmacol. 2008 Jul;154(5):1150-9. Epub 2008 May 12.
9. Fang X, etal., Am J Reprod Immunol. 2000 Aug;44(2):65-72.
10. Feng M, etal., Am J Physiol Endocrinol Metab. 2009 Mar 3.
11. Figueira RJ, etal., Behav Neurosci. 2008 Jun;122(3):618-28.
12. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. GOA data from the GO Consortium
14. Hoare S, etal., J Biol Chem. 1999 Oct 1;274(40):28682-9.
15. Holmes CL, etal., Crit Care. 2003 Dec;7(6):427-34. Epub 2003 Jun 26.
16. Huber D, etal., Science. 2005 Apr 8;308(5719):245-8.
17. Jankowski M, etal., Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):13074-9. Epub 2004 Aug 17.
18. Jarrett TM, etal., Neuropeptides. 2006 Jun;40(3):161-7. Epub 2006 May 4.
19. Jeng YJ, etal., Neuropeptides 1996 Dec;30(6):557-65.
20. Johns JM, etal., Int J Dev Neurosci. 2004 Aug-Oct;22(5-6):321-8.
21. Kasahara Y, etal., Endocrinology. 2013 Nov;154(11):4305-15. doi: 10.1210/en.2012-2206. Epub 2013 Sep 3.
22. Kennett JE, etal., Endocrinology. 2008 Dec 23.
23. Khazipov R, etal., Prog Brain Res. 2008;170:243-57.
24. Lancel M, etal., Regul Pept. 2003 Jul 15;114(2-3):145-52.
25. Larrazolo-Lopez A, etal., Neuroscience. 2008 Mar 27;152(3):585-93. Epub 2008 Jan 25.
26. Lee PR, etal., Brain Res. 2007 Jul 2;1156:152-67. Epub 2007 Apr 22.
27. Lukas M, etal., Neuropharmacology. 2009 Jun 26.
28. Magalhaes J, etal., Reprod Sci. 2009 Jan 22.
29. Martins AS, etal., Hypertension. 2005 Oct;46(4):1004-9. Epub 2005 Sep 12.
30. McCafferty GP, etal., Am J Physiol Regul Integr Comp Physiol. 2007 Jul;293(1):R299-305. Epub 2007 Mar 29.
31. MGD data from the GO Consortium
32. Mitchell JA, etal., Biol Reprod. 2003 Aug;69(2):556-62. Epub 2003 Apr 16.
33. Morel G, etal., Cell Tissue Res. 2001 Jun;304(3):377-82.
34. Murata T, etal., J Endocrinol. 2000 Jul;166(1):45-52.
35. Murata T, etal., J Vet Med Sci. 2003 Jun;65(6):707-12.
36. NCBI rat LocusLink and RefSeq merged data July 26, 2002
37. Onaka T, etal., Eur J Neurosci. 2003 Dec;18(11):3018-26.
38. Patisaul HB, etal., Brain Res. 2003 Jul 18;978(1-2):185-93.
39. Pipeline to import KEGG annotations from KEGG into RGD
40. Pournajafi-Nazarloo H, etal., Peptides. 2007 Jun;28(6):1170-7. Epub 2007 May 6.
41. RGD automated data pipeline
42. RGD automated import pipeline for gene-chemical interactions
43. Rozen F, etal., Proc Natl Acad Sci U S A 1995 Jan 3;92(1):200-4.
44. Strakova Z and Soloff MS, Am J Physiol. 1997 May;272(5 Pt 1):E870-6.
45. Strakova Z, etal., Am J Physiol. 1998 Apr;274(4 Pt 1):E634-41.
46. Theodosis DT, etal., Mol Cell Neurosci. 2006 Apr;31(4):785-94. Epub 2006 Feb 20.
47. Thompson MR, etal., Neuroscience. 2007 May 11;146(2):509-14. Epub 2007 Mar 23.
48. Verty AN, etal., Neuropharmacology. 2004 Sep;47(4):593-603.
49. Wang D, etal., Cardiovasc Res. 2003 Jan;57(1):186-94.
50. Welch MG, etal., J Comp Neurol. 2009 Jan 10;512(2):256-70.
51. Widmer H, etal., J Physiol. 2003 Apr 1;548(Pt 1):233-44. Epub 2003 Feb 14.
52. Wu CL, etal., Naunyn Schmiedebergs Arch Pharmacol. 2003 Apr;367(4):406-13. Epub 2003 Feb 26.
53. Zaninetti M and Raggenbass M, Eur J Neurosci. 2000 Nov;12(11):3975-84.
54. Zingg HH and Laporte SA, Trends Endocrinol Metab. 2003 Jul;14(5):222-7.
Additional References at PubMed
PMID:12486173   PMID:12517588   PMID:12834434   PMID:14614214   PMID:16033890   PMID:17170070   PMID:17504438   PMID:17628000   PMID:18006631   PMID:18552879   PMID:19057146   PMID:19258669  
PMID:19309416   PMID:19429063   PMID:19807846   PMID:20224888   PMID:20671291   PMID:21750583   PMID:21820489   PMID:21858088   PMID:22044052   PMID:22178314   PMID:22286791   PMID:22824810  
PMID:23102456   PMID:23219972   PMID:23474276   PMID:23500836   PMID:24055336   PMID:24834854   PMID:24877632   PMID:25011012   PMID:25152590   PMID:25486578   PMID:25565097   PMID:25637830  
PMID:25740340   PMID:26122287   PMID:26590611   PMID:26630388   PMID:27132494   PMID:27235738   PMID:27389643   PMID:28575174   PMID:28739524   PMID:29118105   PMID:30071278   PMID:30898126  
PMID:32705167   PMID:32726160   PMID:33077706  


Genomics

Candidate Gene Status
Oxtr is a candidate Gene for QTL Bp21
Comparative Map Data
Oxtr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24145,598,549 - 145,614,674 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl4144,403,358 - 144,416,116 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04144,399,326 - 144,417,598 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04207,701,360 - 207,717,840 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44148,314,089 - 148,326,797 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14148,558,929 - 148,571,638 (-)NCBI
Celera4134,168,869 - 134,184,999 (-)NCBICelera
Cytogenetic Map4q41NCBI
OXTR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl38,750,381 - 8,769,628 (-)EnsemblGRCh38hg38GRCh38
GRCh3838,750,381 - 8,769,613 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3738,792,067 - 8,811,299 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3638,767,094 - 8,786,300 (-)NCBINCBI36hg18NCBI36
Build 3438,767,093 - 8,786,300NCBI
Celera38,726,881 - 8,746,086 (-)NCBI
Cytogenetic Map3p25.3NCBI
HuRef38,726,158 - 8,745,365 (-)NCBIHuRef
CHM1_138,742,513 - 8,761,719 (-)NCBICHM1_1
Oxtr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396112,450,644 - 112,467,997 (-)NCBIGRCm39mm39
GRCm39 Ensembl6112,450,644 - 112,466,904 (-)Ensembl
GRCm386112,473,683 - 112,491,035 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6112,473,683 - 112,489,943 (-)EnsemblGRCm38mm10GRCm38
MGSCv376112,423,678 - 112,439,802 (-)NCBIGRCm37mm9NCBIm37
MGSCv366112,439,461 - 112,455,585 (-)NCBImm8
Celera6114,311,708 - 114,327,999 (-)NCBICelera
Cytogenetic Map6E3NCBI
Oxtr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955561337,902 - 354,336 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955561340,387 - 354,499 (-)NCBIChiLan1.0ChiLan1.0
OXTR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.138,962,454 - 8,963,730 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v038,701,344 - 8,721,706 (-)NCBIMhudiblu_PPA_v0panPan3
OXTR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1209,358,797 - 9,382,308 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl209,358,916 - 9,378,343 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha209,392,409 - 9,411,729 (+)NCBI
ROS_Cfam_1.0209,388,927 - 9,412,408 (+)NCBI
UMICH_Zoey_3.1209,110,306 - 9,130,001 (+)NCBI
UNSW_CanFamBas_1.0209,455,823 - 9,475,105 (+)NCBI
UU_Cfam_GSD_1.0209,429,314 - 9,449,013 (+)NCBI
Oxtr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494214,650,853 - 14,668,467 (-)NCBI
SpeTri2.0NW_0049366024,241,743 - 4,259,866 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OXTR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1365,134,057 - 65,153,489 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11365,134,055 - 65,155,543 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21372,415,345 - 72,436,029 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OXTR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12244,746,108 - 44,764,501 (-)NCBI
ChlSab1.1 Ensembl2244,742,419 - 44,763,243 (-)Ensembl
Vero_WHO_p1.0NW_023666041121,803,523 - 121,822,069 (+)NCBI
Oxtr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247313,367,645 - 3,384,815 (-)NCBI

Position Markers
AU047790  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24145,614,933 - 145,615,073 (+)MAPPERmRatBN7.2
Rnor_6.04144,416,461 - 144,416,600NCBIRnor6.0
Rnor_5.04207,716,718 - 207,716,857UniSTSRnor5.0
RGSC_v3.44148,327,172 - 148,327,311UniSTSRGSC3.4
Celera4134,185,259 - 134,185,398UniSTS
Cytogenetic Map4q42UniSTS
PMC170950P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24145,613,871 - 145,614,261 (+)MAPPERmRatBN7.2
Rnor_6.04144,415,399 - 144,415,788NCBIRnor6.0
Rnor_5.04207,715,656 - 207,716,045UniSTSRnor5.0
RGSC_v3.44148,326,110 - 148,326,499UniSTSRGSC3.4
Celera4134,184,197 - 134,184,586UniSTS
Cytogenetic Map4q42UniSTS
Oxtr  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24145,613,875 - 145,614,537 (+)MAPPERmRatBN7.2
Rnor_6.04144,415,403 - 144,416,064NCBIRnor6.0
Rnor_5.04207,715,660 - 207,716,321UniSTSRnor5.0
RGSC_v3.44148,326,114 - 148,326,775UniSTSRGSC3.4
Celera4134,184,201 - 134,184,862UniSTS
Cytogenetic Map4q42UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)43043231145254791Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)47850904182171018Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)423850384169318094Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)436615599145611886Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)443414605155469929Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)443414792146942075Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)443414792146942075Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)446898276145611886Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)449906054145611886Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)455324953148360954Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)458640017154427984Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)458640017154427984Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)458640017154427984Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)463537179157286626Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)481959983152055009Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)484475257178931073Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486312589146942261Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)486312589147702403Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486438317168047091Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494893247168046938Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105277348150277348Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4105682594150682594Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4105971071168047091Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106347236151347236Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4108876717169215811Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109636356154636356Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109636356154636356Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110702761155702761Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110702761155702761Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4112807675157807675Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4115372758150038284Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4116726724157291438Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4117926139162926139Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4119705414146087100Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4120318422146087100Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4120400597146942261Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4123111827168111827Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123478354168478354Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4123587009168587009Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4124442168169442168Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4125884464168047091Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4128602727173602727Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131532269168047091Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131532269168047091Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4131834282176834282Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4131864442176864442Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132455408168047091Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4134917642179917642Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4136351734174694858Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4136351734174694858Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4136351734180689124Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4136908430182878540Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)4137171018182171018Rat


Genetic Models
This gene Oxtr is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:51
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000007724
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 1 14 8 6 6 35 21 12 3 6
Below cutoff 1 12 4 3 7 3 2 2 29 14 19 3 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007724   ⟹   ENSRNOP00000007724
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4144,403,358 - 144,416,116 (-)Ensembl
RefSeq Acc Id: NM_012871   ⟹   NP_037003
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24145,598,549 - 145,614,674 (-)NCBI
Rnor_6.04144,399,326 - 144,416,201 (-)NCBI
Rnor_5.04207,701,360 - 207,717,840 (-)NCBI
RGSC_v3.44148,314,089 - 148,326,797 (-)RGD
Celera4134,168,869 - 134,184,999 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037003   ⟸   NM_012871
- UniProtKB: P70536 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007724   ⟸   ENSRNOT00000007724

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3239 AgrOrtholog
Ensembl Genes ENSRNOG00000005806 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000007724 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007724 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Oxytocn_rcpt UniProtKB/Swiss-Prot
  Vasoprsn_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:25342 UniProtKB/Swiss-Prot
NCBI Gene 25342 ENTREZGENE
PANTHER PTHR24241:SF89 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Oxtr PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  OXYTOCINR UniProtKB/Swiss-Prot
  VASOPRESSINR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
UniProt OXYR_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q53ZC5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Oxtr  oxytocin receptor    oxcytocin receptor  Name updated 1299863 APPROVED
2002-06-10 Oxtr  oxcytocin receptor      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression protein expressed in heart chambers 631223
gene_other mapped to the vicinity of the Bp21 QTL region and proposed to be a candidate gene for blood pressure regulation 631223
gene_process may be involved in cardiovascular functions and hypertension 631223
gene_process stimulates prostaglandin release in uterine endometrium 729203
gene_transcript gene contains multiple interleukin-response elements and four STAT3 binding motifs 69917