Avpr2 (arginine vasopressin receptor 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Avpr2 (arginine vasopressin receptor 2) Rattus norvegicus
Analyze
Symbol: Avpr2
Name: arginine vasopressin receptor 2
RGD ID: 2186
Description: Predicted to enable peptide binding activity and vasopressin receptor activity. Involved in several processes, including negative regulation of urine volume; positive regulation of systemic arterial blood pressure; and telencephalon development. Predicted to be located in endocytic vesicle; endosome; and perinuclear region of cytoplasm. Predicted to be active in plasma membrane. Used to study hypertension. Biomarker of ureteral obstruction. Human ortholog(s) of this gene implicated in X-linked nephrogenic diabetes insipidus; nephrogenic diabetes insipidus; and nephrogenic syndrome of inappropriate antidiuresis. Orthologous to human AVPR2 (arginine vasopressin receptor 2); PARTICIPATES IN vasopressin signaling pathway; vasopressin signaling pathway via receptor type 2; G protein mediated signaling pathway via Galphas family; INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: antidiuretic hormone receptor; AVPR V2; renal-type arginine vasopressin receptor; V2R; vasopressin receptor V2; vasopressin V2 receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Avpr2em4Mcwi   Avpr2em5Mcwi  
Genetic Models: SS-Avpr2em4Mcwi SS-Avpr2em5Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X156,785,009 - 156,787,477 (+)NCBIGRCr8
mRatBN7.2X151,633,501 - 151,636,155 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX151,633,522 - 151,635,989 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX153,775,132 - 153,776,760 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X157,338,348 - 157,339,976 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X155,010,181 - 155,011,809 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X156,889,006 - 156,892,707 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,889,410 - 156,891,213 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,637,074 - 152,640,726 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,821,860 - 159,823,488 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X159,897,295 - 159,898,924 (+)NCBI
Celera1136,256,506 - 136,258,135 (-)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Sustained elevated levels of circulating vasopressin selectively stimulate the proliferation of kidney tubular cells via the activation of V2 receptors. Alonso G, etal., Endocrinology. 2008 Sep 11.
2. Vasopressin receptors. Birnbaumer M, Trends Endocrinol Metab. 2000 Dec;11(10):406-10.
3. Vasopressin Type 2 Receptor V88M Mutation: Molecular Basis of Partial and Complete Nephrogenic Diabetes Insipidus. Bockenhauer D, etal., Nephron Physiol. 2009 Oct 8;114(1):p1-p10.
4. Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption. Boone M and Deen PM, Pflugers Arch. 2008 Sep;456(6):1005-24. Epub 2008 Apr 23.
5. Novel vasopressin type 2 (AVPR2) gene mutations in Brazilian nephrogenic diabetes insipidus patients. Boson WL, etal., Genet Test. 2006 Fall;10(3):157-62.
6. Vasopressin and oxytocin receptor mRNA expression during rat telencephalon development. Chen Q, etal., Neuropeptides. 2000 Jun-Aug;34(3-4):173-80.
7. Molecular genetic study of congenital nephrogenic diabetes insipidus and rescue of mutant vasopressin V2 receptor by chemical chaperones. Cheong HI, etal., Nephrology (Carlton). 2007 Apr;12(2):113-7.
8. Partial nephrogenic diabetes insipidus caused by a novel mutation in the AVPR2 gene. Faerch M, etal., Clin Endocrinol (Oxf). 2008 Mar;68(3):395-403. Epub 2007 Oct 17.
9. Chronic V2 vasopressin receptor stimulation increases basal blood pressure and exacerbates deoxycorticosterone acetate-salt hypertension. Fernandes S, etal., Endocrinology 2002 Jul;143(7):2759-66.
10. Molecular analysis of vasopressin receptors in the rat nephron. Evidence for alternative splicing of the V2 receptor. Firsov D, etal., Pflugers Arch 1994 Nov;429(1):79-89.
11. Immunological profile in a family with nephrogenic diabetes insipidus with a novel 11 kb deletion in AVPR2 and ARHGAP4 genes. Fujimoto M, etal., BMC Med Genet. 2008 May 20;9:42.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Vasopressin V1a, V1b and V2 receptors mRNA in the kidney and heart of the renin transgenic TGR(mRen2)27 and Sprague Dawley rats. Gozdz A, etal., J Physiol Pharmacol 2002 Sep;53(3):349-57.
15. A cyclic peptide mimicking the third intracellular loop of the V2 vasopressin receptor inhibits signaling through its interaction with receptor dimer and G protein. Granier S, etal., J Biol Chem 2004 Dec 3;279(49):50904-14. Epub 2004 Sep 27.
16. Science review: Vasopressin and the cardiovascular system part 1--receptor physiology. Holmes CL, etal., Crit Care. 2003 Dec;7(6):427-34. Epub 2003 Jun 26.
17. Angiotensin II regulates V2 receptor and pAQP2 during ureteral obstruction. Jensen AM, etal., Am J Physiol Renal Physiol. 2009 Jan;296(1):F127-34. Epub 2008 Oct 29.
18. Correlation between AVPR2 mutations and urinary AQP2 excretion in patients with nephrogenic diabetes insipidus. Kotnik P, etal., J Pediatr Endocrinol Metab. 2007 Apr;20(4):483-9.
19. Molecular mechanisms of antidiuretic effect of oxytocin. Li C, etal., J Am Soc Nephrol. 2008 Feb;19(2):225-32. Epub 2007 Dec 5.
20. Cloning and characterization of a vasopressin V2 receptor and possible link to nephrogenic diabetes insipidus. Lolait SJ, etal., Nature 1992 May 28;357(6376):336-9.
21. Involvement of the V2 receptor in vasopressin-stimulated translocation of placental leucine aminopeptidase/oxytocinase in renal cells. Masuda S, etal., Eur J Biochem 2003 May;270(9):1988-94.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. Vasopressin increases intracellular NO concentration via Ca(2+) signaling in inner medullary collecting duct. Mori T, etal., Hypertension 2002 Feb;39(2 Pt 2):465-9.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
26. Evidence for the presence of smooth muscle alpha-actin within pericytes of the renal medulla. Park F, etal., Am J Physiol 1997 Nov;273(5 Pt 2):R1742-8.
27. Arginine vasopressin-mediated stimulation of nitric oxide within the rat renal medulla. Park F, etal., Hypertension 1998 Nov;32(5):896-901.
28. Vasopressin and angiotensin receptors of the medial septal area in the control of mean arterial pressure induced by vasopressin. Pavan de Arruda Camargo GM, etal., J Renin Angiotensin Aldosterone Syst. 2008 Sep;9(3):133-8.
29. Sodium excretion in response to vasopressin and selective vasopressin receptor antagonists. Perucca J, etal., J Am Soc Nephrol. 2008 Sep;19(9):1721-31. Epub 2008 Jul 2.
30. Vasopressin induces expression of the Cl-/HCO3- exchanger SLC26A7 in kidney medullary collecting ducts of Brattleboro rats. Petrovic S, etal., Am J Physiol Renal Physiol. 2006 May;290(5):F1194-201. Epub 2005 Dec 13.
31. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
32. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
33. GOA pipeline RGD automated data pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
37. Alterations of renal vasopressin V1A and V2 receptors in spontaneously hypertensive rats. Tahara A, etal., Pharmacology 2003 Feb;67(2):106-12.
Additional References at PubMed
PMID:9322919   PMID:10395695   PMID:14675036   PMID:14757828   PMID:15213068   PMID:15723124   PMID:16014025   PMID:17190913   PMID:17213462   PMID:17553938   PMID:17626156   PMID:17762181  
PMID:18701631   PMID:19281786   PMID:19285506   PMID:19587140   PMID:19625993   PMID:19641130   PMID:19796672   PMID:21123493   PMID:21679749   PMID:22493236   PMID:22628529   PMID:22700868  
PMID:23246465   PMID:23488898   PMID:24089411   PMID:26248278   PMID:26335823   PMID:26924211   PMID:30944256   PMID:31691500   PMID:32165443   PMID:33000260  


Genomics

Comparative Map Data
Avpr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X156,785,009 - 156,787,477 (+)NCBIGRCr8
mRatBN7.2X151,633,501 - 151,636,155 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX151,633,522 - 151,635,989 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX153,775,132 - 153,776,760 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X157,338,348 - 157,339,976 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X155,010,181 - 155,011,809 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X156,889,006 - 156,892,707 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,889,410 - 156,891,213 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,637,074 - 152,640,726 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,821,860 - 159,823,488 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X159,897,295 - 159,898,924 (+)NCBI
Celera1136,256,506 - 136,258,135 (-)NCBICelera
Cytogenetic MapXq37NCBI
AVPR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X153,902,625 - 153,907,166 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX153,902,531 - 153,907,166 (+)EnsemblGRCh38hg38GRCh38
GRCh37X153,168,079 - 153,172,620 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,823,564 - 152,825,834 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X152,691,216 - 152,693,487NCBI
CeleraX153,401,665 - 153,406,333 (+)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX141,789,000 - 141,824,020 (+)NCBIHuRef
CHM1_1X153,042,396 - 153,047,068 (+)NCBICHM1_1
T2T-CHM13v2.0X152,176,300 - 152,180,878 (+)NCBIT2T-CHM13v2.0
Avpr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X72,935,371 - 72,938,034 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX72,935,708 - 72,939,108 (+)EnsemblGRCm39 Ensembl
GRCm38X73,891,765 - 73,894,428 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX73,892,102 - 73,895,502 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X71,137,441 - 71,139,766 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X70,144,822 - 70,147,147 (+)NCBIMGSCv36mm8
CeleraX65,144,532 - 65,146,857 (+)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.46NCBI
Avpr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955580583,480 - 586,456 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955580583,827 - 586,739 (+)NCBIChiLan1.0ChiLan1.0
AVPR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X153,949,469 - 153,951,487 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X153,953,075 - 153,955,605 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X143,458,693 - 143,461,945 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X153,346,391 - 153,348,840 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX153,346,466 - 153,348,840 (+)Ensemblpanpan1.1panPan2
AVPR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X121,751,606 - 121,754,771 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX121,752,027 - 121,754,771 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX107,081,538 - 107,083,529 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X124,893,080 - 124,896,066 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX124,892,719 - 124,896,066 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X120,663,338 - 120,665,329 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X123,178,772 - 123,180,761 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X122,940,089 - 122,942,080 (+)NCBIUU_Cfam_GSD_1.0
Avpr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,050,498 - 119,053,229 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936809788,286 - 790,954 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936809789,337 - 790,986 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AVPR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX124,638,523 - 124,640,966 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X124,638,433 - 124,640,969 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X142,203,013 - 142,205,697 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AVPR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X128,328,728 - 128,331,482 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX128,329,449 - 128,331,019 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606566,199,401 - 66,202,350 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Avpr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624946541,362 - 543,492 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624946541,317 - 543,397 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:32
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000056342
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat

Markers in Region
RH127646  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,635,683 - 151,635,868 (-)MAPPERmRatBN7.2
Rnor_6.0X156,889,138 - 156,889,322NCBIRnor6.0
Rnor_5.01152,637,206 - 152,637,390UniSTSRnor5.0
RGSC_v3.4X159,823,576 - 159,823,760UniSTSRGSC3.4
Celera1136,256,234 - 136,256,418UniSTS
Cytogenetic MapXq37UniSTS
REN88106  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,634,689 - 151,634,951 (-)MAPPERmRatBN7.2
Rnor_6.0X156,890,055 - 156,890,316NCBIRnor6.0
Rnor_5.01152,638,123 - 152,638,384UniSTSRnor5.0
RGSC_v3.4X159,822,582 - 159,822,843UniSTSRGSC3.4
Celera1136,257,151 - 136,257,412UniSTS
Cytogenetic MapXq37UniSTS


Genetic Models
This gene Avpr2 is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 6 19
Low 2 1 8 13 2 2 11 16 11 11 2
Below cutoff 1 9 12 10 10 6 8 17 6

Sequence


RefSeq Acc Id: ENSRNOT00000082899   ⟹   ENSRNOP00000068561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX156,889,559 - 156,891,213 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091495   ⟹   ENSRNOP00000071931
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,633,522 - 151,635,989 (+)Ensembl
Rnor_6.0 EnsemblX156,889,410 - 156,891,038 (-)Ensembl
RefSeq Acc Id: NM_019136   ⟹   NP_062009
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X156,785,139 - 156,787,477 (+)NCBI
mRatBN7.2X151,633,817 - 151,636,155 (+)NCBI
Rnor_6.0X156,889,410 - 156,891,038 (-)NCBI
Rnor_5.01152,637,074 - 152,640,726 (-)NCBI
RGSC_v3.4X159,821,860 - 159,823,488 (+)RGD
Celera1136,256,506 - 136,258,135 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063279818   ⟹   XP_063135888
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X156,785,009 - 156,787,322 (+)NCBI
RefSeq Acc Id: NP_062009   ⟸   NM_019136
- UniProtKB: Q53ZC4 (UniProtKB/Swiss-Prot),   Q00788 (UniProtKB/Swiss-Prot),   A6KRU6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068561   ⟸   ENSRNOT00000082899
RefSeq Acc Id: ENSRNOP00000071931   ⟸   ENSRNOT00000091495
RefSeq Acc Id: XP_063135888   ⟸   XM_063279818
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q00788-F1-model_v2 AlphaFold Q00788 1-371 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2186 AgrOrtholog
BioCyc Gene G2FUF-657 BioCyc
Ensembl Genes ENSRNOG00000059862 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055024972 UniProtKB/Swiss-Prot
  ENSRNOG00060006538 UniProtKB/Swiss-Prot
  ENSRNOG00065014794 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000091495 ENTREZGENE
  ENSRNOT00000091495.2 UniProtKB/Swiss-Prot
  ENSRNOT00055043038 UniProtKB/Swiss-Prot
  ENSRNOT00060010704 UniProtKB/Swiss-Prot
  ENSRNOT00065024453 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vasoprsn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vprsn_rcpt_V2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25108 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25108 ENTREZGENE
PANTHER NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VASOPRESSIN V2 RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Avpr2 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VASOPRESSINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VASOPRSNV2R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000059862 RatGTEx
  ENSRNOG00055024972 RatGTEx
  ENSRNOG00060006538 RatGTEx
  ENSRNOG00065014794 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6KRU6 ENTREZGENE, UniProtKB/TrEMBL
  Q00788 ENTREZGENE
  Q53ZC4 ENTREZGENE
  V2R_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q53ZC4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Avpr2  arginine vasopressin receptor 2  Avpr2  arginine vasopressin receptor 2  Symbol and Name status set to approved 70586 APPROVED
2001-07-23 Avpr2  arginine vasopressin receptor 2  Avpr2  Vasopressin receptor V2  Name updated 67952 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease chronic stimulation of vasopressin V2 receptor raises basal blood pressure and leads to DOCA-salt hypertension, organ damage, and mortality 1298694
gene_drugs 1-desamino-8-D-argnine vasopressin (dDAVP), an agonist to the receptor, results in significant rise in renal medullary interstitial NO 628575
gene_expression predominantly in the kidney distal convoluted tubule and collecting ducts and in fetal lung tissue 61489
gene_process couples to G-protein thus stimulating adenylate cyclase 61489
gene_process involved in concentrating urine and maintaining water homeostasis  
gene_process may promote the arginine vassopressin(Avp)-mediated blood flow into renal medulla by increasing renall medullary interstitial nitric oxide (NO) 628575
gene_transcript contains three exons and two introns, 2.1 kb 61489
gene_transcript consists of two alternatively spliced forms, long (V2L) form encodes the adenylyl cyclase-coupled receptor and short form lacks putative seventh transmembrane domain 1298557