Avpr2 (arginine vasopressin receptor 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Avpr2 (arginine vasopressin receptor 2) Rattus norvegicus
Analyze
Symbol: Avpr2
Name: arginine vasopressin receptor 2
RGD ID: 2186
Description: Predicted to have peptide binding activity and vasopressin receptor activity. Involved in several processes, including negative regulation of renal sodium excretion; negative regulation of urine volume; and positive regulation of systemic arterial blood pressure. Predicted to localize to cytoplasmic vesicle; integral component of plasma membrane; and perinuclear region of cytoplasm. Used to study hypertension. Biomarker of ureteral obstruction. Human ortholog(s) of this gene implicated in nephrogenic diabetes insipidus and nephrogenic syndrome of inappropriate antidiuresis. Orthologous to human AVPR2 (arginine vasopressin receptor 2); PARTICIPATES IN vasopressin signaling pathway; vasopressin signaling pathway via receptor type 2; G protein mediated signaling pathway via Galphas family; INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: antidiuretic hormone receptor; AVPR V2; renal-type arginine vasopressin receptor; V2R; vasopressin receptor V2; vasopressin V2 receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Avpr2em4Mcwi   Avpr2em5Mcwi  
Genetic Models: SS-Avpr2em4Mcwi SS-Avpr2em5Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X151,633,501 - 151,636,000 (+)NCBI
Rnor_6.0 EnsemblX156,889,410 - 156,891,213 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X156,889,006 - 156,892,707 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01152,637,074 - 152,640,726 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,821,860 - 159,823,488 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X159,897,295 - 159,898,924 (+)NCBI
Celera1136,256,506 - 136,258,135 (-)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Alonso G, etal., Endocrinology. 2008 Sep 11.
2. Birnbaumer M, Trends Endocrinol Metab. 2000 Dec;11(10):406-10.
3. Bockenhauer D, etal., Nephron Physiol. 2009 Oct 8;114(1):p1-p10.
4. Boone M and Deen PM, Pflugers Arch. 2008 Sep;456(6):1005-24. Epub 2008 Apr 23.
5. Boson WL, etal., Genet Test. 2006 Fall;10(3):157-62.
6. Chen Q, etal., Neuropeptides. 2000 Jun-Aug;34(3-4):173-80.
7. Cheong HI, etal., Nephrology (Carlton). 2007 Apr;12(2):113-7.
8. Faerch M, etal., Clin Endocrinol (Oxf). 2008 Mar;68(3):395-403. Epub 2007 Oct 17.
9. Fernandes S, etal., Endocrinology 2002 Jul;143(7):2759-66.
10. Firsov D, etal., Pflugers Arch 1994 Nov;429(1):79-89.
11. Fujimoto M, etal., BMC Med Genet. 2008 May 20;9:42.
12. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. GOA data from the GO Consortium
14. Gozdz A, etal., J Physiol Pharmacol 2002 Sep;53(3):349-57.
15. Granier S, etal., J Biol Chem 2004 Dec 3;279(49):50904-14. Epub 2004 Sep 27.
16. Holmes CL, etal., Crit Care. 2003 Dec;7(6):427-34. Epub 2003 Jun 26.
17. Jensen AM, etal., Am J Physiol Renal Physiol. 2009 Jan;296(1):F127-34. Epub 2008 Oct 29.
18. Kotnik P, etal., J Pediatr Endocrinol Metab. 2007 Apr;20(4):483-9.
19. Li C, etal., J Am Soc Nephrol. 2008 Feb;19(2):225-32. Epub 2007 Dec 5.
20. Lolait SJ, etal., Nature 1992 May 28;357(6376):336-9.
21. Masuda S, etal., Eur J Biochem 2003 May;270(9):1988-94.
22. MGD data from the GO Consortium
23. Mori T, etal., Hypertension 2002 Feb;39(2 Pt 2):465-9.
24. NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. OMIM Disease Annotation Pipeline
26. Park F, etal., Am J Physiol 1997 Nov;273(5 Pt 2):R1742-8.
27. Park F, etal., Hypertension 1998 Nov;32(5):896-901.
28. Pavan de Arruda Camargo GM, etal., J Renin Angiotensin Aldosterone Syst. 2008 Sep;9(3):133-8.
29. Perucca J, etal., J Am Soc Nephrol. 2008 Sep;19(9):1721-31. Epub 2008 Jul 2.
30. Petrovic S, etal., Am J Physiol Renal Physiol. 2006 May;290(5):F1194-201. Epub 2005 Dec 13.
31. Pipeline to import KEGG annotations from KEGG into RGD
32. Pipeline to import SMPDB annotations from SMPDB into RGD
33. RGD automated data pipeline
34. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. RGD automated import pipeline for gene-chemical interactions
36. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
37. Tahara A, etal., Pharmacology 2003 Feb;67(2):106-12.
Additional References at PubMed
PMID:9322919   PMID:10395695   PMID:14675036   PMID:14757828   PMID:15213068   PMID:15723124   PMID:16014025   PMID:17190913   PMID:17213462   PMID:17553938   PMID:17626156   PMID:17762181  
PMID:18701631   PMID:19281786   PMID:19285506   PMID:19587140   PMID:19625993   PMID:19641130   PMID:19796672   PMID:21123493   PMID:21679749   PMID:22493236   PMID:22628529   PMID:22700868  
PMID:23246465   PMID:23488898   PMID:24089411   PMID:26248278   PMID:26335823   PMID:26924211   PMID:30944256   PMID:31691500   PMID:32165443   PMID:33000260  


Genomics

Comparative Map Data
Avpr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X151,633,501 - 151,636,000 (+)NCBI
Rnor_6.0 EnsemblX156,889,410 - 156,891,213 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X156,889,006 - 156,892,707 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01152,637,074 - 152,640,726 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,821,860 - 159,823,488 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X159,897,295 - 159,898,924 (+)NCBI
Celera1136,256,506 - 136,258,135 (-)NCBICelera
Cytogenetic MapXq37NCBI
AVPR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX153,902,531 - 153,907,166 (+)EnsemblGRCh38hg38GRCh38
GRCh38X153,902,625 - 153,907,166 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X153,168,079 - 153,172,620 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,823,564 - 152,825,834 (+)NCBINCBI36hg18NCBI36
Build 34X152,691,216 - 152,693,487NCBI
CeleraX153,401,665 - 153,406,333 (+)NCBI
Cytogenetic MapXq28NCBI
HuRefX141,789,000 - 141,824,020 (+)NCBIHuRef
CHM1_1X153,042,396 - 153,047,068 (+)NCBICHM1_1
Avpr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X72,935,371 - 72,938,034 (+)NCBIGRCm39mm39
GRCm39 EnsemblX72,935,708 - 72,939,108 (+)Ensembl
GRCm38X73,891,765 - 73,894,428 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX73,892,102 - 73,895,502 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X71,137,441 - 71,139,766 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X70,144,822 - 70,147,147 (+)NCBImm8
CeleraX65,144,532 - 65,146,857 (+)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.46NCBI
Avpr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955580583,480 - 586,456 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955580583,827 - 586,739 (+)NCBIChiLan1.0ChiLan1.0
AVPR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X153,346,391 - 153,348,840 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX153,346,466 - 153,348,840 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X143,458,693 - 143,461,945 (+)NCBIMhudiblu_PPA_v0panPan3
AVPR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X121,751,606 - 121,754,771 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX121,752,027 - 121,754,771 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX107,081,538 - 107,083,529 (+)NCBI
ROS_Cfam_1.0X124,893,080 - 124,896,066 (+)NCBI
UMICH_Zoey_3.1X120,663,338 - 120,665,329 (+)NCBI
UNSW_CanFamBas_1.0X123,178,772 - 123,180,761 (+)NCBI
UU_Cfam_GSD_1.0X122,940,089 - 122,942,080 (+)NCBI
Avpr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,050,498 - 119,053,229 (+)NCBI
SpeTri2.0NW_004936809789,337 - 790,986 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AVPR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX124,638,523 - 124,644,630 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X124,638,433 - 124,640,969 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X142,203,013 - 142,205,697 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AVPR2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X128,328,728 - 128,331,482 (+)NCBI
ChlSab1.1 EnsemblX128,329,449 - 128,331,019 (+)Ensembl
Vero_WHO_p1.0NW_02366606566,199,401 - 66,202,350 (+)NCBI
Avpr2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624946541,317 - 543,397 (+)NCBI

Position Markers
RH127646  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,635,683 - 151,635,868 (-)MAPPER
Rnor_6.0X156,889,138 - 156,889,322NCBIRnor6.0
Rnor_5.01152,637,206 - 152,637,390UniSTSRnor5.0
RGSC_v3.4X159,823,576 - 159,823,760UniSTSRGSC3.4
Celera1136,256,234 - 136,256,418UniSTS
Cytogenetic MapXq37UniSTS
REN88106  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,634,689 - 151,634,951 (-)MAPPER
Rnor_6.0X156,890,055 - 156,890,316NCBIRnor6.0
Rnor_5.01152,638,123 - 152,638,384UniSTSRnor5.0
RGSC_v3.4X159,822,582 - 159,822,843UniSTSRGSC3.4
Celera1136,257,151 - 136,257,412UniSTS
Cytogenetic MapXq37UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X44320616158345622Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X118715462159970021Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X134627816159970021Rat


Genetic Models
This gene Avpr2 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:32
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000056342
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 6 19
Low 2 1 8 13 2 2 11 16 11 11 2
Below cutoff 1 9 12 10 10 6 8 17 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000082899   ⟹   ENSRNOP00000068561
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX156,889,559 - 156,891,213 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091495   ⟹   ENSRNOP00000071931
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX156,889,410 - 156,891,038 (-)Ensembl
RefSeq Acc Id: NM_019136   ⟹   NP_062009
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X151,633,968 - 151,635,596 (+)NCBI
Rnor_6.0X156,889,410 - 156,891,038 (-)NCBI
Rnor_5.01152,637,074 - 152,640,726 (-)NCBI
RGSC_v3.4X159,821,860 - 159,823,488 (+)RGD
Celera1136,256,506 - 136,258,135 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006229549   ⟹   XP_006229611
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X156,889,006 - 156,892,707 (-)NCBI
Rnor_5.01152,637,074 - 152,640,726 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099492   ⟹   XP_038955420
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X151,633,501 - 151,636,000 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_062009   ⟸   NM_019136
- UniProtKB: Q00788 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006229611   ⟸   XM_006229549
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000068561   ⟸   ENSRNOT00000082899
RefSeq Acc Id: ENSRNOP00000071931   ⟸   ENSRNOT00000091495
RefSeq Acc Id: XP_038955420   ⟸   XM_039099492
- Peptide Label: isoform X1
Protein Domains
G_PROTEIN_RECEP_F1_2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2186 AgrOrtholog
Ensembl Genes ENSRNOG00000059862 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000068561 UniProtKB/TrEMBL
  ENSRNOP00000071931 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000082899 UniProtKB/TrEMBL
  ENSRNOT00000091495 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vasoprsn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vprsn_rcpt_V2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25108 UniProtKB/Swiss-Prot
NCBI Gene 25108 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Avpr2 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VASOPRESSINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VASOPRSNV2R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JT42_RAT UniProtKB/TrEMBL
  Q00788 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q53ZC4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Avpr2  arginine vasopressin receptor 2      Symbol and Name status set to approved 70586 APPROVED
2001-07-23 Avpr2  Vasopressin receptor V2      Name withdrawn 67952 WITHDRAWN
2001-07-23 Avpr2  arginine vasopressin receptor 2      Name updated 67952 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease chronic stimulation of vasopressin V2 receptor raises basal blood pressure and leads to DOCA-salt hypertension, organ damage, and mortality 1298694
gene_drugs 1-desamino-8-D-argnine vasopressin (dDAVP), an agonist to the receptor, results in significant rise in renal medullary interstitial NO 628575
gene_expression predominantly in the kidney distal convoluted tubule and collecting ducts and in fetal lung tissue 61489
gene_process couples to G-protein thus stimulating adenylate cyclase 61489
gene_process involved in concentrating urine and maintaining water homeostasis  
gene_process may promote the arginine vassopressin(Avp)-mediated blood flow into renal medulla by increasing renall medullary interstitial nitric oxide (NO) 628575
gene_transcript contains three exons and two introns, 2.1 kb 61489
gene_transcript consists of two alternatively spliced forms, long (V2L) form encodes the adenylyl cyclase-coupled receptor and short form lacks putative seventh transmembrane domain 1298557