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Gene: Avpr2 (arginine vasopressin receptor 2) Rattus norvegicus
Symbol: Avpr2
Name: arginine vasopressin receptor 2
Description: Predicted to have peptide binding activity and vasopressin receptor activity. Involved in several processes, including negative regulation of renal sodium excretion; negative regulation of urine volume; and positive regulation of systemic arterial blood pressure. Predicted to localize to cytoplasmic vesicle; integral component of plasma membrane; and perinuclear region of cytoplasm. Used to study hypertension. Biomarker of ureteral obstruction. Human ortholog(s) of this gene implicated in nephrogenic diabetes insipidus. Orthologous to human AVPR2 (arginine vasopressin receptor 2); PARTICIPATES IN vasopressin signaling pathway; vasopressin signaling pathway via receptor type 2; G protein mediated signaling pathway via Galphas family; INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; bis(2-ethylhexyl) phthalate.
Type: protein-coding
Also known as: antidiuretic hormone receptor; AVPR V2; renal-type arginine vasopressin receptor; V2R; vasopressin receptor V2; vasopressin V2 receptor
Homo sapiens (human) : AVPR2 (arginine vasopressin receptor 2)  HGNC  Alliance
Mus musculus (house mouse) : Avpr2 (arginine vasopressin receptor 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Avpr2 (arginine vasopressin receptor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : AVPR2 (arginine vasopressin receptor 2)
Canis lupus familiaris (dog) : AVPR2 (arginine vasopressin receptor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Avpr2 (arginine vasopressin receptor 2)
Sus scrofa (pig) : AVPR2 (arginine vasopressin receptor 2)
Chlorocebus sabaeus (African green monkey) : AVPR2 (arginine vasopressin receptor 2)
Heterocephalus glaber (naked mole-rat) : Avpr2 (arginine vasopressin receptor 2)
more info ...
Allele / Splice: Avpr2em4Mcwi   Avpr2em5Mcwi  
Genetic Models: SS-Avpr2em4Mcwi SS-Avpr2em5Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0X156,889,006 - 156,892,707 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,889,410 - 156,891,213 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,637,074 - 152,640,726 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,821,860 - 159,823,488 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X159,897,295 - 159,898,924 (+)NCBI
Celera1136,256,506 - 136,258,135 (-)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Avpr2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2186
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-09-01
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.