Avpr2 (arginine vasopressin receptor 2) - Rat Genome Database

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Gene: Avpr2 (arginine vasopressin receptor 2) Mus musculus
Analyze
Symbol: Avpr2
Name: arginine vasopressin receptor 2
RGD ID: 10222
MGI Page MGI
Description: Predicted to enable peptide binding activity and vasopressin receptor activity. Acts upstream of or within I-kappaB kinase/NF-kappaB signaling and response to cytokine. Predicted to be located in cytoplasmic vesicle; perinuclear region of cytoplasm; and plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including central nervous system; forelimb bud; heart; and sensory organ. Used to study nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in nephrogenic diabetes insipidus and nephrogenic syndrome of inappropriate antidiuresis. Orthologous to human AVPR2 (arginine vasopressin receptor 2).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADHR; antidiuretic hormone receptor; AVPR V2; DI; DI1; DIR; MGC124213; MGC124214; MGC124215; MGC129321; ND; ND1; nephrogenic diabetes insipidus; renal-type arginine vasopressin receptor; V; V2R; vasopressin V2 receptor; VPV2R
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X72,935,371 - 72,938,034 (+)NCBIGRCm39mm39
GRCm39 EnsemblX72,935,708 - 72,939,108 (+)Ensembl
GRCm38X73,891,765 - 73,894,428 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX73,892,102 - 73,895,502 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X71,137,441 - 71,139,766 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X70,144,822 - 70,147,147 (+)NCBImm8
CeleraX65,144,532 - 65,146,857 (+)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:6393185   PMID:8088815   PMID:8449515   PMID:8833156   PMID:10322631   PMID:10322639   PMID:10349636   PMID:10395695   PMID:11042159   PMID:11076861   PMID:11104789   PMID:11217851  
PMID:11923476   PMID:11955056   PMID:12477932   PMID:15319430   PMID:15528444   PMID:15561968   PMID:15705776   PMID:15784697   PMID:16141072   PMID:16141073   PMID:16400024   PMID:16602821  
PMID:17429055   PMID:17475820   PMID:17626156   PMID:17630342   PMID:17715188   PMID:18172001   PMID:18715941   PMID:19367412   PMID:19440390   PMID:19477942   PMID:19641130   PMID:19828675  
PMID:19855135   PMID:20139300   PMID:21267068   PMID:21677750   PMID:21873635   PMID:21879339   PMID:21903675   PMID:22205228   PMID:23011808   PMID:24628417   PMID:24952961   PMID:26238476  
PMID:26903624   PMID:27649563   PMID:28215940   PMID:28630289   PMID:30944256   PMID:32035616   PMID:32931849  


Genomics

Comparative Map Data
Avpr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X72,935,371 - 72,938,034 (+)NCBIGRCm39mm39
GRCm39 EnsemblX72,935,708 - 72,939,108 (+)Ensembl
GRCm38X73,891,765 - 73,894,428 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX73,892,102 - 73,895,502 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X71,137,441 - 71,139,766 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X70,144,822 - 70,147,147 (+)NCBImm8
CeleraX65,144,532 - 65,146,857 (+)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.46NCBI
AVPR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX153,902,531 - 153,907,166 (+)EnsemblGRCh38hg38GRCh38
GRCh38X153,902,625 - 153,907,166 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X153,168,079 - 153,172,620 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,823,564 - 152,825,834 (+)NCBINCBI36hg18NCBI36
Build 34X152,691,216 - 152,693,487NCBI
CeleraX153,401,665 - 153,406,333 (+)NCBI
Cytogenetic MapXq28NCBI
HuRefX141,789,000 - 141,824,020 (+)NCBIHuRef
CHM1_1X153,042,396 - 153,047,068 (+)NCBICHM1_1
Avpr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X151,633,501 - 151,636,000 (+)NCBImRatBN7.2
mRatBN7.2 EnsemblX151,633,522 - 151,635,989 (+)Ensembl
Rnor_6.0X156,889,006 - 156,892,707 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,889,410 - 156,891,213 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,637,074 - 152,640,726 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,821,860 - 159,823,488 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X159,897,295 - 159,898,924 (+)NCBI
Celera1136,256,506 - 136,258,135 (-)NCBICelera
Cytogenetic MapXq37NCBI
Avpr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955580583,480 - 586,456 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955580583,827 - 586,739 (+)NCBIChiLan1.0ChiLan1.0
AVPR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X153,346,391 - 153,348,840 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX153,346,466 - 153,348,840 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X143,458,693 - 143,461,945 (+)NCBIMhudiblu_PPA_v0panPan3
AVPR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X121,751,606 - 121,754,771 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX121,752,027 - 121,754,771 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX107,081,538 - 107,083,529 (+)NCBI
ROS_Cfam_1.0X124,893,080 - 124,896,066 (+)NCBI
UMICH_Zoey_3.1X120,663,338 - 120,665,329 (+)NCBI
UNSW_CanFamBas_1.0X123,178,772 - 123,180,761 (+)NCBI
UU_Cfam_GSD_1.0X122,940,089 - 122,942,080 (+)NCBI
Avpr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,050,498 - 119,053,229 (+)NCBI
SpeTri2.0NW_004936809789,337 - 790,986 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AVPR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX124,638,523 - 124,644,630 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X124,638,433 - 124,640,969 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X142,203,013 - 142,205,697 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AVPR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X128,328,728 - 128,331,482 (+)NCBI
ChlSab1.1 EnsemblX128,329,449 - 128,331,019 (+)Ensembl
Vero_WHO_p1.0NW_02366606566,199,401 - 66,202,350 (+)NCBI
Avpr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624946541,317 - 543,397 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7360056151324042Mouse
13208567Bmiq12_mbody mass index QTL 12 (mouse)X3600000078000000Mouse
4141565Pbwg21_mpostnatal body weight growth 21 (mouse)Not determinedX4006835474068454Mouse
1301009Pbwg7_mpostnatal body weight growth 7 (mouse)Not determinedX4006835474068454Mouse
1300794Spha2_msperm head anomaly 2 (mouse)Not determinedX4083262187216531Mouse
4142200Rtwq1_mreduced testis weight QTL 1 (mouse)Not determined4243170076431843Mouse
1301278Bdln1_mbody length 1 (mouse)Not determinedX4265674676656858Mouse
1300702Fcsa4_mfemoral cross-sectional area 4 (mouse)Not determinedX4698383880983961Mouse
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined48090244130864007Mouse
25314311Syncl3_msynaptonemal complex length 3 (mouse)X5290000090700000Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X55000000150000000Mouse
10412108Desp5_mdespair 5 (mouse)Not determinedX5567874589678745Mouse
13464140Hdlq108_mHDL QTL 108 (mouse)X5872835492728354Mouse
25314316Mlh1fc3_mMLH1 foci count 3 (mouse)X6230000090800000Mouse
25314318Sccor2_msynaptonemal complex length to mean MLH1 count ratio 2 (mouse)X7150000097500000Mouse
1357730Hstx1_mhybrid sterility, X chromosome 1 (mouse)Not determinedX7241024678557206Mouse
4141665Mhysq2_mmale hybrid sterility QTL 2 (mouse)Not determined72410246140302463Mouse
12879918Shm4_msperm head morphology 4 (mouse)X73028444103019114Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1408
Count of miRNA genes:581
Interacting mature miRNAs:711
Transcripts:ENSMUST00000033765, ENSMUST00000101470, ENSMUST00000114395, ENSMUST00000131088
Prediction methods:Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001276298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001276299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006527756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017318365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF133093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ006691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ310753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ627045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK042836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL672002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC104728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC104729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC104731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC105662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC107005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ411230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ411231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000033765   ⟹   ENSMUSP00000033765
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX72,935,708 - 72,938,034 (+)Ensembl
GRCm38.p6 EnsemblX73,892,102 - 73,894,428 (+)Ensembl
RefSeq Acc Id: ENSMUST00000101470   ⟹   ENSMUSP00000099011
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX72,935,716 - 72,939,108 (+)Ensembl
GRCm38.p6 EnsemblX73,892,110 - 73,895,502 (+)Ensembl
RefSeq Acc Id: ENSMUST00000114395   ⟹   ENSMUSP00000110037
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX72,935,720 - 72,937,803 (+)Ensembl
GRCm38.p6 EnsemblX73,892,114 - 73,894,197 (+)Ensembl
RefSeq Acc Id: ENSMUST00000131088
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX72,935,709 - 72,937,027 (+)Ensembl
GRCm38.p6 EnsemblX73,892,103 - 73,893,421 (+)Ensembl
RefSeq Acc Id: NM_001276298   ⟹   NP_001263227
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X72,935,708 - 72,938,034 (+)NCBI
GRCm38X73,892,102 - 73,894,428 (+)NCBI
CeleraX65,144,532 - 65,146,858 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001276299   ⟹   NP_001263228
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X72,935,708 - 72,938,034 (+)NCBI
GRCm38X73,892,102 - 73,894,428 (+)NCBI
CeleraX65,144,532 - 65,146,858 (+)NCBI
Sequence:
RefSeq Acc Id: NM_019404   ⟹   NP_062277
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X72,935,708 - 72,938,034 (+)NCBI
GRCm38X73,892,102 - 73,894,428 (+)NCBI
MGSCv37X71,137,441 - 71,139,766 (+)RGD
CeleraX65,144,532 - 65,146,858 (+)NCBI
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006527756   ⟹   XP_006527819
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X72,935,371 - 72,938,034 (+)NCBI
GRCm38X73,891,765 - 73,894,428 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017318365   ⟹   XP_017173854
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X72,935,371 - 72,938,034 (+)NCBI
GRCm38X73,891,765 - 73,894,428 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_062277   ⟸   NM_019404
- Peptide Label: isoform a
- UniProtKB: O88721 (UniProtKB/Swiss-Prot),   Q3SWS1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001263227   ⟸   NM_001276298
- Peptide Label: isoform b
- UniProtKB: Q3SWS4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001263228   ⟸   NM_001276299
- Peptide Label: isoform c
- UniProtKB: Q3KNZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006527819   ⟸   XM_006527756
- Peptide Label: isoform X1
- UniProtKB: O88721 (UniProtKB/Swiss-Prot),   Q3SWS1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017173854   ⟸   XM_017318365
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000033765   ⟸   ENSMUST00000033765
RefSeq Acc Id: ENSMUSP00000099011   ⟸   ENSMUST00000101470
RefSeq Acc Id: ENSMUSP00000110037   ⟸   ENSMUST00000114395
Protein Domains
G_PROTEIN_RECEP_F1_2

Promoters
RGD ID:6845434
Promoter ID:MM_KWN:60745
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Spleen
Transcripts:ENSMUST00000114395,   OTTMUST00000042869,   OTTMUST00000044424,   UC009TMX.1,   UC009TMZ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X71,136,361 - 71,137,617 (+)MPROMDB
RGD ID:6849278
Promoter ID:MM_XEF:7868
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   Lung
Transcripts:NM_000054,   NM_001003177,   NM_001146151,   NM_001168791,   NM_019136,   NM_174246,   NM_214232,   NR_027419
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X71,137,964 - 71,138,464 (+)MPROMDB
RGD ID:13680750
Promoter ID:EPDNEW_M24524
Type:single initiation site
Name:Avpr2_1
Description:Mus musculus arginine vasopressin receptor 2 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X73,892,060 - 73,892,120EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88123 AgrOrtholog
Ensembl Genes ENSMUSG00000031390 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000033765 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000099011 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000110037 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000033765 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000101470 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000114395 ENTREZGENE, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vasoprsn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vprsn_rcpt_V2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12000 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:88123 ENTREZGENE
NCBI Gene 12000 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Avpr2 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VASOPRESSINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VASOPRSNV2R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt O88721 ENTREZGENE
  Q3KNZ4 ENTREZGENE, UniProtKB/TrEMBL
  Q3SWS1 ENTREZGENE, UniProtKB/TrEMBL
  Q3SWS4 ENTREZGENE, UniProtKB/TrEMBL
  Q684Q3_MOUSE UniProtKB/TrEMBL
  V2R_MOUSE UniProtKB/Swiss-Prot