Avpr2 (arginine vasopressin receptor 2)

Gene: Avpr2 (arginine vasopressin receptor 2) Ictidomys tridecemlineatus

Analyze

Symbol:

Avpr2

Name:

arginine vasopressin receptor 2

RGD ID:

12466987

Description:

ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); peptide binding (inferred); signaling receptor activity (inferred); INVOLVED IN negative regulation of urine volume (ortholog); positive regulation of blood pressure (ortholog); positive regulation of cell population proliferation (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; vasopressin signaling pathway; vasopressin signaling pathway via receptor type 2; ASSOCIATED WITH adrenoleukodystrophy (ortholog); autistic disorder (ortholog); Barth syndrome (ortholog); FOUND IN endocytic vesicle (inferred); endosome (inferred); membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

vasopressin V2 receptor

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	119,050,498 - 119,053,229 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936809	788,286 - 790,954 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936809	789,337 - 790,986 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adrenoleukodystrophy (ISO)

autistic disorder (ISO)

Barth syndrome (ISO)

cardiomyopathy (ISO)

cerebral creatine deficiency syndrome 1 (ISO)

congenital adrenal hyperplasia (ISO)

congestive heart failure (ISO)

dyskeratosis congenita (ISO)

Emery-Dreifuss muscular dystrophy (ISO)

favism (ISO)

genetic disease (ISO)

Growth Disorders (ISO)

hypertension (ISO)

immunodeficiency 33 (ISO)

nephrogenic diabetes insipidus (ISO)

nephrogenic syndrome of inappropriate antidiuresis (ISO)

Oliguria (ISO)

paraplegia (ISO)

periventricular nodular heterotopia (ISO)

severe congenital encephalopathy due to MECP2 mutation (ISO)

Splenomegaly (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

ureteral obstruction (ISO)

X-linked monogenic disease (ISO)

X-linked nephrogenic diabetes insipidus (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to hormone stimulus (IEA)

G protein-coupled receptor signaling pathway (IEA)

negative regulation of cell population proliferation (IEA)

negative regulation of urine volume (ISO)

positive regulation of blood pressure (ISO)

positive regulation of cell population proliferation (ISO)

positive regulation of gene expression (ISO)

positive regulation of intracellular signal transduction (IEA)

positive regulation of systemic arterial blood pressure (ISO)

positive regulation of vasoconstriction (IEA)

regulation of systemic arterial blood pressure by vasopressin (IEA)

response to cytokine (IEA,ISO)

telencephalon development (ISO)

Cellular Component

endocytic vesicle (IEA)

endosome (IEA)

membrane (IEA)

perinuclear region of cytoplasm (IEA)

plasma membrane (IEA)

Molecular Function

G protein-coupled receptor activity (IEA)

peptide binding (IEA)

protein binding (ISO)

signaling receptor activity (IEA)

vasopressin receptor activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

G protein mediated signaling pathway via Galphas family (ISO)

vasopressin signaling pathway (ISO)

vasopressin signaling pathway via receptor type 2 (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Avpr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	119,050,498 - 119,053,229 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936809	788,286 - 790,954 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936809	789,337 - 790,986 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AVPR2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	153,902,625 - 153,907,166 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	153,902,531 - 153,907,166 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	153,168,079 - 153,172,620 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	152,823,564 - 152,825,834 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	152,691,216 - 152,693,487	NCBI
Celera	X	153,401,665 - 153,406,333 (+)	NCBI		Celera
Cytogenetic Map	X	q28	NCBI
HuRef	X	141,789,000 - 141,824,020 (+)	NCBI		HuRef
CHM1_1	X	153,042,396 - 153,047,068 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	152,176,300 - 152,180,878 (+)	NCBI		T2T-CHM13v2.0

Avpr2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	72,935,371 - 72,938,034 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	72,935,708 - 72,939,108 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	73,891,765 - 73,894,428 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	73,892,102 - 73,895,502 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	71,137,441 - 71,139,766 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	70,144,822 - 70,147,147 (+)	NCBI		MGSCv36	mm8
Celera	X	65,144,532 - 65,146,857 (+)	NCBI		Celera
Cytogenetic Map	X	A7.3	NCBI
cM Map	X	37.46	NCBI

Avpr2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	156,785,009 - 156,787,477 (+)	NCBI		GRCr8
mRatBN7.2	X	151,633,501 - 151,636,155 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	151,633,522 - 151,635,989 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	153,775,132 - 153,776,760 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	157,338,348 - 157,339,976 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	155,010,181 - 155,011,809 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	156,889,006 - 156,892,707 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	156,889,410 - 156,891,213 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	152,637,074 - 152,640,726 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	159,821,860 - 159,823,488 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	159,897,295 - 159,898,924 (+)	NCBI
Celera	1	136,256,506 - 136,258,135 (-)	NCBI		Celera
Cytogenetic Map	X	q37	NCBI

Avpr2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955580	583,480 - 586,456 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955580	583,827 - 586,739 (+)	NCBI	ChiLan1.0	ChiLan1.0

AVPR2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	153,949,469 - 153,951,487 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	153,953,075 - 153,955,605 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	143,458,693 - 143,461,945 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	153,346,391 - 153,348,840 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	153,346,466 - 153,348,840 (+)	Ensembl	panpan1.1		panPan2

AVPR2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	121,751,606 - 121,754,771 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	121,752,027 - 121,754,771 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	107,081,538 - 107,083,529 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	124,893,080 - 124,896,066 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	124,892,719 - 124,896,066 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	120,663,338 - 120,665,329 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	123,178,772 - 123,180,761 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	122,940,089 - 122,942,080 (+)	NCBI		UU_Cfam_GSD_1.0

AVPR2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	124,638,523 - 124,640,966 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	124,638,433 - 124,640,969 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	142,203,013 - 142,205,697 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AVPR2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	128,328,728 - 128,331,482 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	128,329,449 - 128,331,019 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666065	66,199,401 - 66,202,350 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Avpr2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624946	541,362 - 543,492 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624946	541,317 - 543,397 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021720423	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000614	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000008339 ⟹ ENSSTOP00000007473

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936809	788,286 - 790,954 (+)	Ensembl

RefSeq Acc Id:

XM_021720423 ⟹ XP_021576098

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	X	119,050,498 - 119,053,229 (+)	NCBI
SpeTri2.0	NW_004936809	789,337 - 790,986 (+)	NCBI

Sequence:

show sequence

GAAATTTCCTTGGCCTGAGATCCCTACATGGCACCCTTTCTAACTTGGCCTCTCCTCCCACCCT
TGCCCAGCTGTGCCTGGGCCCCTCTCTCCACTTAGCCCGCCAAGCAACGGCAGCCGGGAGGAGT
CATTGGACACCAGGGACCCATTGCTGGCCCGGGCAGAACTGGCCCTACTTTCCACAGTCTTTGT
GGCTGTGGCCTTGAGCAATGGCTTGGTACTGGGGGCCCTAGTACGACGTGGCCGGCGCGGCCGC
TGGGCACCCATGCACGTCTTCATTGGCCACTTGTGCCTAGCAGACCTGGCTGTGGCTCTATTTC
AAGTGCTGCCCCAGCTGGCCTGGGATGCCACCGACCGCTTCCGTGGGCCTGATGCCCTGTGTCG
GGCCGTCAAGTACCTGCAGATGGTGGGCATGTATGCTTCCTCCTACATGATCCTGGCCATGACG
CTAGACCGCCACCGCGCCATCTGCCGCCCCATGCTGGCATACCGCCATGGAGGTGGGGCTCGCT
GGAACCGGCCAGTGCTGGTGGCCTGGGCCTTCTCGCTTCTTCTCAGCCTGCCTCAGCTATTCAT
CTTTGCCCAGCGTGATGTGGGAGATGGCAGCGGGGTCTTCGACTGCTGGGCCCGCTTTGCAGAG
CCCTGGGGCCTTCGTGCCTATGTCACCTGGATTGCCCTGATGGTGTTTGTGGCACCTGCCCTGG
GTATTGCTGCTTGCCAGGTTCTCATCTTCCGGGAGATTCATGCCAGTCTGGTGCCAGGGCCATC
AGAAAGGGCTGGGGGGCGCCACAGAAGGCACCGGACAGGCAGTCCCAGAGAGGGAGCCCGGGTG
TCAGCAGCCATGGCCAAGACTGTGAGGATGACACTGGTGATTGTGATCGTCTACGTGTTATGCT
GGGCACCCTTCTTCCTTGTGCAGCTGTGGGCAGCATGGGACCCAGAGGCACCTCTGGAAGGGCC
CCCCTTCGTGCTGCTCATGTTGCTGGCCAGCCTCAACAGCTGTACCAACCCCTGGATCTATGCT
TCCTTCAGCAGCAGCGTCTCCTCAGAGCTGCGCAGCTTGCTCTGCTGTGCTCGGGTACAGGCCC
CACCCAGCCTGGGGCCCCAAGACGAGTCCTGTGCCACTGCCAGCTCCTCCCTGGCCAAGGATAC
TTTCTCCTGAGGAGCCAGTGGGCACTTTCCTTCCAAAAGCTCCATGAAGCTTAGCCGCCTCTGG
GGCTGGCTCCTCTAGGACTCACTGTATACAAAGAGGCTTTCAGGCTCCAAGACTGTGAGAGTCC
CTTACGTTAGCTCCTTGTTCCAGGCATGGGGAGAGACTAGATAGGGCAGAGGATCCCAGGGCCT
GGGAGTGGCAGGTGACCTGTGCCCTGGAGAGTGCCCTCCAGGTAACACAGAGGTCCCAAGGAGC
CAAAGAGGAAGGAGCAGGGTGGGGCCAGTGTACCTTCCTGTCTGTATCTCTCTAGTCCTTCCCT
AA

hide sequence

Protein Sequences


Protein RefSeqs	XP_021576098	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000007473.2
GenBank Protein	KAG3273206	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_021576098 ⟸ XM_021720423

- UniProtKB:

I3MBG2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MHVFIGHLCLADLAVALFQVLPQLAWDATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDR
HRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGDGSGVFDCWARFAEPWG
LRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGPSERAGGRHRRHRTGSPREGARVSAA
MAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPLEGPPFVLLMLLASLNSCTNPWIYASFS
SSVSSELRSLLCCARVQAPPSLGPQDESCATASSSLAKDTFS

hide sequence

RefSeq Acc Id:

ENSSTOP00000007473 ⟸ ENSSTOT00000008339

Protein Domains

G-protein coupled receptors family 1 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000008352	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000008339.3	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
	Vasoprsn_rcpt	UniProtKB/TrEMBL
	Vprsn_rcpt_V2	UniProtKB/TrEMBL
NCBI Gene	Avpr2	ENTREZGENE
PANTHER	NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR	UniProtKB/TrEMBL
	VASOPRESSIN V2 RECEPTOR	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PRINTS	GPCRRHODOPSN	UniProtKB/TrEMBL
	VASOPRESSINR	UniProtKB/TrEMBL
	VASOPRSNV2R	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	I3MBG2	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB