Avpr1a (arginine vasopressin receptor 1A) - Rat Genome Database

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Gene: Avpr1a (arginine vasopressin receptor 1A) Rattus norvegicus
Symbol: Avpr1a
Name: arginine vasopressin receptor 1A
RGD ID: 2185
Description: Enables V1A vasopressin receptor binding activity; peptide hormone binding activity; and vasopressin receptor activity. Involved in several processes, including copulation; positive regulation of secretion; and regulation of blood circulation. Located in cytoplasmic vesicle and plasma membrane. Used to study acute kidney failure; brain edema; and myocardial infarction. Biomarker of hypertension and renovascular hypertension. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human AVPR1A (arginine vasopressin receptor 1A); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; vasopressin signaling pathway; vasopressin signaling pathway via receptor type 1; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: antidiuretic hormone receptor 1a; arginine vasopressin receptor V1a; AVPR; MGC108538; V1a; V1aR; vascular/hepatic-type arginine vasopressin receptor; Vasopressin receptor V1a; vasopressin V1a receptor
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SS.LEW-(D7Rat73-D7Rat128)/Ayd   LEW.SS-(D7Rat73-D7Rat128)/Ayd  
Candidate Gene For: Lnnr1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2758,114,306 - 58,118,230 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl758,114,284 - 58,122,215 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx759,986,073 - 59,990,009 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0762,188,888 - 62,192,822 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0761,966,702 - 61,970,636 (+)NCBIRnor_WKY
Rnor_6.0767,341,366 - 67,345,290 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl767,341,080 - 67,345,308 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0767,528,358 - 67,532,282 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4762,225,537 - 62,229,461 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1762,246,266 - 62,250,191 (+)NCBI
Celera755,286,966 - 55,290,890 (+)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(RS)-coclaurine  (ISO)
(RS)-norcoclaurine  (ISO)
(S)-coclaurine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
argipressin  (ISO)
arsenite(3-)  (ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
caffeine  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
carbachol  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
coumarin  (EXP)
Cuprizon  (EXP)
cycloheximide  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
etoposide  (ISO)
fenthion  (ISO)
flutamide  (EXP)
furan  (EXP)
GW 7647  (EXP,ISO)
indole-3-methanol  (EXP)
leflunomide  (EXP)
methotrexate  (ISO)
morphine  (ISO)
Muraglitazar  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nicardipine  (EXP)
nimesulide  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
pioglitazone  (ISO)
pirenzepine  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
ritodrine  (ISO)
rotenone  (EXP)
scopolamine  (EXP)
sevoflurane  (EXP)
sodium arsenate  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topiramate  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
XL147  (ISO)
yohimbine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
calcium-mediated signaling  (IMP)
cellular response to hormone stimulus  (IBA)
cellular response to water deprivation  (IEP)
G protein-coupled receptor signaling pathway  (IBA,IEA,NAS)
grooming behavior  (IMP)
maternal aggressive behavior  (IMP)
maternal behavior  (IMP)
myotube differentiation  (IEP)
negative regulation of female receptivity  (IMP)
negative regulation of transmission of nerve impulse  (IMP)
penile erection  (IMP)
positive regulation of blood pressure  (IMP)
positive regulation of cell growth  (IMP)
positive regulation of cell population proliferation  (IMP,ISO)
positive regulation of cellular pH reduction  (IMP)
positive regulation of cytosolic calcium ion concentration  (IMP)
positive regulation of glutamate secretion  (IMP)
positive regulation of glycogen catabolic process  (NAS)
positive regulation of heart rate  (IMP)
positive regulation of prostaglandin biosynthetic process  (IMP)
positive regulation of renal sodium excretion  (IMP)
positive regulation of systemic arterial blood pressure  (IMP)
positive regulation of urine volume  (NAS)
positive regulation of vasoconstriction  (IBA,IMP)
regulation of blood pressure  (ISO)
regulation of corticotropin secretion  (NAS)
regulation of secretion  (IEA)
regulation of systemic arterial blood pressure by vasopressin  (IBA,ISO)
response to corticosterone  (IEP)
response to inorganic substance  (IMP)
response to organic substance  (IMP)
social behavior  (IDA,IEP)
sperm ejaculation  (IMP)
telencephalon development  (IEP)

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. V1a vasopressin receptor expression is modulated during myogenic differentiation. Alvisi M, etal., Differentiation. 2008 Apr;76(4):371-80. Epub 2007 Nov 16.
2. Food competition and social experience effects on V1a receptor binding in the forebrain of male Long-Evans hooded rats. Askew A, etal., Horm Behav. 2006 Mar;49(3):328-36. Epub 2005 Sep 9.
3. Effects of novel vasopressin receptor antagonists on renal function and cardiac hypertrophy in rats with experimental congestive heart failure. Bishara B, etal., J Pharmacol Exp Ther. 2008 Aug;326(2):414-22. Epub 2008 May 8.
4. Vasopressin and oxytocin receptor mRNA expression during rat telencephalon development. Chen Q, etal., Neuropeptides. 2000 Jun-Aug;34(3-4):173-80.
5. Activation of ventrolateral medulla neurons by arginine vasopressin via V1A receptors produces inhibition on respiratory-related hypoglossal nerve discharge in the rat. Chuang CW, etal., Chin J Physiol. 2005 Sep 30;48(3):144-54.
6. Interaction of AT1 receptors and V1a receptors-mediated effects in the central cardiovascular control during the post-infarct state. Cudnoch-Jedrzejewska A, etal., Regul Pept. 2007 Aug 16;142(3):86-94. Epub 2007 Feb 15.
7. Enhanced involvement of brain vasopressin V1 receptors in cardiovascular responses to stress in rats with myocardial infarction. Dobruch J, etal., Stress. 2005 Dec;8(4):273-84.
8. Dissociation of the anxiolytic-like effects of Avpr1a and Avpr1b receptor antagonists in the dorsal and ventral hippocampus. Engin E and Treit D, Neuropeptides. 2008 Aug;42(4):411-21. Epub 2008 May 27.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Vasopressin V1a, V1b and V2 receptors mRNA in the kidney and heart of the renin transgenic TGR(mRen2)27 and Sprague Dawley rats. Gozdz A, etal., J Physiol Pharmacol 2002 Sep;53(3):349-57.
12. Oxytocin-induced contractions within rat and rabbit ejaculatory tissues are mediated by vasopressin V(1A) receptors and not oxytocin receptors. Gupta J, etal., Br J Pharmacol. 2008 Sep;155(1):118-26. Epub 2008 Jun 16.
13. Association of novel promoter single nucleotide polymorphisms in vasopressin V1a receptor gene with essential hypertension in nonobese Japanese. Hasan KN, etal., J Hum Hypertens. 2007 Oct;21(10):825-7. Epub 2007 Jul 26.
14. Charged residues of the conserved DRY triplet of the vasopressin V1a receptor provide molecular determinants for cell surface delivery and internalization. Hawtin SR Mol Pharmacol. 2005 Oct;68(4):1172-82. Epub 2005 Jul 27.
15. Science review: Vasopressin and the cardiovascular system part 1--receptor physiology. Holmes CL, etal., Crit Care. 2003 Dec;7(6):427-34. Epub 2003 Jun 26.
16. The vasopressin receptors colocalize with vasopressin in the magnocellular neurons of the rat supraoptic nucleus and are modulated by water balance. Hurbin A, etal., Endocrinology 2002 Feb;143(2):456-66.
17. Altered expression of angiotensin AT1a and vasopressin V1a receptors and nitric oxide synthase mRNA in the brain of rats with renovascular hypertension. Jackiewicz E, etal., J Physiol Pharmacol. 2004 Dec;55(4):725-37.
18. Protective effect of the V1a receptor antagonist SR49059 on brain edema formation following middle cerebral artery occlusion in the rat. Kleindienst A, etal., Acta Neurochir Suppl. 2006;96:303-6.
19. Viral vector-mediated gene transfer of the vole V1a vasopressin receptor in the rat septum: improved social discrimination and active social behaviour. Landgraf R, etal., Eur J Neurosci. 2003 Jul;18(2):403-11.
20. Differential effects of peroxynitrite on the function of arginine vasopressin V(1a) receptors and alpha(1)-adrenoceptors in vivo. Lewis SJ, etal., Vascul Pharmacol. 2007 Jan;46(1):24-34. Epub 2006 Jun 17.
21. Presence of functional vasopressin receptors in spinal ventral horn neurons of young rats: a morphological and electrophysiological study. Liu X, etal., Eur J Neurosci 2003 May;17(9):1833-46.
22. Maternal separation interferes with developmental changes in brain vasopressin and oxytocin receptor binding in male rats. Lukas M, etal., Neuropharmacology. 2009 Jun 26.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Effects of the V1a vasopressin agonist F-180 on portal hypertension-related bleeding in portal hypertensive rats. Morales J, etal., Hepatology. 2003 Dec;38(6):1378-83.
25. Molecular cloning and expression of a rat V1a arginine vasopressin receptor. Morel A, etal., Nature 1992 Apr 9;356(6369):523-6.
26. Immediate prostaglandin E2 synthesis in rat 3Y1 fibroblasts following vasopressin V1a receptor stimulation. Nakatani Y, etal., Biochem Biophys Res Commun. 2007 Mar 16;354(3):676-80. Epub 2007 Jan 17.
27. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
28. Portal hypertension is associated with increased mRNA levels of vasopressor G-protein-coupled receptors in human hepatic arteries. Neef M, etal., Eur J Clin Invest. 2003 Mar;33(3):249-55.
29. Central actions of arginine vasopressin and a V1a receptor antagonist on maternal aggression, maternal behavior, and grooming in lactating rats. Nephew BC and Bridges RS, Pharmacol Biochem Behav. 2008 Nov;91(1):77-83. Epub 2008 Jun 29.
30. Traumatic brain injury results in a concomitant increase in neocortical expression of vasopressin and its V1a receptor. Pascale CL, etal., J Physiol Pharmacol. 2006 Nov;57 Suppl 11:161-7.
31. Vasopressin and angiotensin receptors of the medial septal area in the control of mean arterial pressure induced by vasopressin. Pavan de Arruda Camargo GM, etal., J Renin Angiotensin Aldosterone Syst. 2008 Sep;9(3):133-8.
32. Vasopressin interactions with oxytocin in the control of female sexual behavior. Pedersen CA and Boccia ML, Neuroscience. 2006;139(3):843-51. Epub 2006 Feb 20.
33. Sodium excretion in response to vasopressin and selective vasopressin receptor antagonists. Perucca J, etal., J Am Soc Nephrol. 2008 Sep;19(9):1721-31. Epub 2008 Jul 2.
34. Mineralocorticoid treatment upregulates the hypothalamic vasopressinergic system of spontaneously hypertensive rats. Pietranera L, etal., Neuroendocrinology. 2004;80(2):100-10. Epub 2004 Oct 6.
35. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
36. GOA pipeline RGD automated data pipeline
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. Arginine-vasopressin modulates intracellular pH via V1 and V2 receptors in renal collecting duct cells. Rivarola V, etal., Cell Physiol Biochem. 2007;20(5):549-58.
39. Arginine vasopressin inhibits Kir6.1/SUR2B channel and constricts the mesenteric artery via V1a receptor and protein kinase C. Shi W, etal., Am J Physiol Regul Integr Comp Physiol. 2007 Jul;293(1):R191-9. Epub 2007 Apr 11.
40. Blockade of central vasopressin receptors reduces the cardiovascular response to acute stress in freely moving rats. Stojicic S, etal., Neuropharmacology. 2008 Apr;54(5):824-36. Epub 2008 Jan 18.
41. Arginine vasopressin increases glutamate release and intracellular Ca2+ concentration in hippocampal and cortical astrocytes through two distinct receptors. Syed N, etal., J Neurochem. 2007 Oct;103(1):229-37.
42. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
43. Alterations of renal vasopressin V1A and V2 receptors in spontaneously hypertensive rats. Tahara A, etal., Pharmacology 2003 Feb;67(2):106-12.
44. Binding and signal transduction characteristics of the nonpeptide vasopressin V1A receptor-selective antagonist YM218 in cultured rat mesangial cells. Tahara A, etal., Pharmacology. 2006;78(2):81-90. Epub 2006 Sep 11.
45. Effect of YM218, a nonpeptide vasopressin V(1A) receptor-selective antagonist, on rat mesangial cell hyperplasia and hypertrophy. Tahara A, etal., Vascul Pharmacol. 2007 Jun;46(6):463-9. Epub 2007 Mar 1.
46. Effects of vasopressin on isolated rat adrenal chromaffin cells. Takeda M, etal., Regul Pept 2002 Jun 15;106(1-3):55-65.
47. Enhanced Ca2+ response to AVP in preglomerular vessels from rats with genetic hypertension during different hydration states. Vagnes OB, etal., Am J Physiol Renal Physiol. 2005 Jun;288(6):F1249-56. Epub 2005 Jan 18.
48. Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin. Wigger A, etal., Neuropsychopharmacology 2004 Jan;29(1):1-14.
49. Early, but not late therapy with a vasopressin V1a-antagonist ameliorates the development of renal damage after 5/6 nephrectomy. Windt WA, etal., J Renin Angiotensin Aldosterone Syst. 2006 Dec;7(4):217-24.
50. Increased affiliative response to vasopressin in mice expressing the V1a receptor from a monogamous vole. Young LJ, etal., Nature 1999 Aug 19;400(6746):766-8.
51. Vasopressin-induced cytoplasmic and nuclear calcium signaling in cultured cortical astrocytes. Zhao L and Brinton RD, Brain Res 2002 Jul 5;943(1):117-31.
Additional References at PubMed
PMID:7650021   PMID:7774575   PMID:8257445   PMID:8511367   PMID:8670090   PMID:8793116   PMID:9105680   PMID:9322919   PMID:11466323   PMID:11520055   PMID:12399435   PMID:12477932  
PMID:12486173   PMID:12923165   PMID:12971956   PMID:14552875   PMID:14757828   PMID:15075196   PMID:15089968   PMID:15189327   PMID:15239592   PMID:15241560   PMID:15489334   PMID:16398053  
PMID:16873404   PMID:17213462   PMID:17970727   PMID:18701631   PMID:19258664   PMID:19577256   PMID:19587140   PMID:19625993   PMID:20042688   PMID:21123759   PMID:21228111   PMID:21415155  
PMID:21652017   PMID:22019732   PMID:22033278   PMID:22352691   PMID:23219972   PMID:23246465   PMID:23441636   PMID:24641084   PMID:25169016   PMID:26248278   PMID:26354848   PMID:26613552  
PMID:26909846   PMID:26935049   PMID:26969105   PMID:27389643   PMID:27810519   PMID:29524562   PMID:30071278   PMID:32415179   PMID:33264070   PMID:34445168   PMID:35661787  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2758,114,306 - 58,118,230 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl758,114,284 - 58,122,215 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx759,986,073 - 59,990,009 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0762,188,888 - 62,192,822 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0761,966,702 - 61,970,636 (+)NCBIRnor_WKY
Rnor_6.0767,341,366 - 67,345,290 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl767,341,080 - 67,345,308 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0767,528,358 - 67,532,282 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4762,225,537 - 62,229,461 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1762,246,266 - 62,250,191 (+)NCBI
Celera755,286,966 - 55,290,890 (+)NCBICelera
Cytogenetic Map7q22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381263,142,759 - 63,151,201 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1263,142,759 - 63,151,201 (-)EnsemblGRCh38hg38GRCh38
GRCh371263,536,539 - 63,544,981 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361261,826,483 - 61,832,857 (-)NCBINCBI36Build 36hg18NCBI36
Build 341261,826,482 - 61,832,857NCBI
Celera1263,208,681 - 63,215,055 (-)NCBICelera
Cytogenetic Map12q14.2NCBI
HuRef1260,587,763 - 60,597,814 (-)NCBIHuRef
CHM1_11263,504,292 - 63,514,344 (-)NCBICHM1_1
T2T-CHM13v2.01263,121,411 - 63,129,851 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3910122,284,404 - 122,289,358 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10122,284,404 - 122,289,357 (+)EnsemblGRCm39 Ensembl
GRCm3810122,448,499 - 122,453,453 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10122,448,499 - 122,453,452 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710121,885,555 - 121,890,509 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610121,851,559 - 121,856,513 (+)NCBIMGSCv36mm8
Celera10124,830,307 - 124,835,265 (+)NCBICelera
Cytogenetic Map10D2NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495545810,245,111 - 10,253,209 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545810,245,325 - 10,253,209 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11226,065,882 - 26,075,972 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1226,065,882 - 26,075,972 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01225,793,633 - 25,803,026 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1106,266,217 - 6,269,662 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl106,265,998 - 6,269,662 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha106,196,083 - 6,199,528 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0106,304,782 - 6,308,218 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl106,304,563 - 6,308,218 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1106,244,666 - 6,248,110 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0106,496,014 - 6,499,452 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0106,633,959 - 6,637,404 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494552,314,128 - 52,323,553 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365451,786,571 - 1,794,709 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365451,788,995 - 1,795,842 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl527,824,992 - 27,832,703 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1527,824,991 - 27,832,794 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2530,773,944 - 30,779,983 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11159,074,699 - 59,079,710 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1159,071,202 - 59,079,596 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037186,727,383 - 186,736,923 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248024,894,235 - 4,900,276 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248024,893,172 - 4,900,177 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Avpr1a
6 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:32
Interacting mature miRNAs:32
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
61435Cia4Collagen induced arthritis QTL 45.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)75811322462004598Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2758,113,224 - 58,113,450 (-)MAPPERmRatBN7.2
Rnor_6.0767,346,146 - 67,346,371NCBIRnor6.0
Rnor_5.0767,533,138 - 67,533,363UniSTSRnor5.0
RGSC_v3.4762,224,456 - 62,224,681UniSTSRGSC3.4
Celera755,285,893 - 55,286,110UniSTS
Cytogenetic Map7q21UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2758,114,346 - 58,114,729 (-)MAPPERmRatBN7.2
Rnor_6.0767,344,867 - 67,345,249NCBIRnor6.0
Rnor_5.0767,531,859 - 67,532,241UniSTSRnor5.0
RGSC_v3.4762,225,578 - 62,225,960UniSTSRGSC3.4
Celera755,287,007 - 55,287,389UniSTS
Cytogenetic Map7q21UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2758,113,212 - 58,113,629 (-)MAPPERmRatBN7.2
Rnor_6.0767,345,967 - 67,346,383NCBIRnor6.0
Rnor_5.0767,532,959 - 67,533,375UniSTSRnor5.0
RGSC_v3.4762,224,444 - 62,224,860UniSTSRGSC3.4
Celera755,285,881 - 55,286,289UniSTS
Cytogenetic Map7q21UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2758,117,961 - 58,118,152 (-)MAPPERmRatBN7.2
Rnor_6.0767,341,444 - 67,341,634NCBIRnor6.0
Rnor_5.0767,528,436 - 67,528,626UniSTSRnor5.0
RGSC_v3.4762,229,193 - 62,229,383UniSTSRGSC3.4
Celera755,290,622 - 55,290,812UniSTS
Cytogenetic Map7q21UniSTS

Related Rat Strains
The following Strains have been annotated to Avpr1a


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 21 21 21 3
Low 2 33 16 4 15 4 8 11 60 35 36 11 8
Below cutoff 1 10 14 10 4 10 8 2


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005829   ⟹   ENSRNOP00000005829
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl758,114,284 - 58,122,215 (+)Ensembl
Rnor_6.0 Ensembl767,341,080 - 67,345,308 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000087045   ⟹   ENSRNOP00000069469
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl758,114,284 - 58,118,400 (+)Ensembl
Rnor_6.0 Ensembl767,341,366 - 67,345,295 (-)Ensembl
RefSeq Acc Id: NM_053019   ⟹   NP_444178
RefSeq Status: REVIEWED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2758,114,306 - 58,118,230 (+)NCBI
Rnor_6.0767,341,366 - 67,345,290 (-)NCBI
Rnor_5.0767,528,358 - 67,532,282 (-)NCBI
RGSC_v3.4762,225,537 - 62,229,461 (+)RGD
Celera755,286,966 - 55,290,890 (+)RGD
Reference Sequences
RefSeq Acc Id: NP_444178   ⟸   NM_053019
- UniProtKB: Q9QW18 (UniProtKB/Swiss-Prot),   P30560 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069469   ⟸   ENSRNOT00000087045
RefSeq Acc Id: ENSRNOP00000005829   ⟸   ENSRNOT00000005829
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30560-F1-model_v2 AlphaFold P30560 1-424 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695245
Promoter ID:EPDNEW_R5763
Type:initiation region
Description:arginine vasopressin receptor 1A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0767,345,290 - 67,345,350EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2185 AgrOrtholog
BioCyc Gene G2FUF-33855 BioCyc
Ensembl Genes ENSRNOG00000004400 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000005829 ENTREZGENE
  ENSRNOP00000005829.3 UniProtKB/Swiss-Prot
  ENSRNOP00000069469.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005829 ENTREZGENE
  ENSRNOT00000005829.6 UniProtKB/Swiss-Prot
  ENSRNOT00000087045.2 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DUF1856 UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vasoprsn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vprs_V1A_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25107 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF1856 UniProtKB/Swiss-Prot
PhenoGen Avpr1a PhenoGen
  VASOPRSNV1AR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DUF1856 UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  V1AR_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q5M8D1 UniProtKB/Swiss-Prot
  Q62874 UniProtKB/Swiss-Prot
  Q9QW18 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Avpr1a  arginine vasopressin receptor 1A      Symbol and Name status set to approved 629479 APPROVED
2002-06-10 Avpr1a  arginine vasopressin receptor 1A      Symbol and Name status set to provisional 70585 PROVISIONAL
2001-06-29 Avpr1a  Vasopressin receptor V1a      Name withdrawn 67952 WITHDRAWN
2001-06-29 Avpr1a  arginine vasopressin receptor 1A      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes to cytoplasmic vesicles with vasopressin 70387
gene_function receptor for arginine vasopressin 70387
gene_process mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis 70387
gene_process induces cytoplasmic and nuclear calcium signaling in cultured cortical astrocytes 1298585