RGD Reference Report - Immediate prostaglandin E2 synthesis in rat 3Y1 fibroblasts following vasopressin V1a receptor stimulation. - Rat Genome Database

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Immediate prostaglandin E2 synthesis in rat 3Y1 fibroblasts following vasopressin V1a receptor stimulation.

Authors: Nakatani, Y  Chin, Y  Hara, S  Kudo, I 
Citation: Nakatani Y, etal., Biochem Biophys Res Commun. 2007 Mar 16;354(3):676-80. Epub 2007 Jan 17.
RGD ID: 2300349
Pubmed: PMID:17254553   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2007.01.041   (Journal Full-text)

Arginine vasopressin (AVP) induces immediate prostaglandin E(2) (PGE(2)) production in rat 3Y1 fibroblasts. Judging from effects of several inhibitors, cytosolic phospholipase A(2)alpha (cPLA(2)alpha) and cyclooxygenase-1 (COX-1) were mainly involved in this reaction. The antagonist of vasopressin receptor V1a, and not that of V2, inhibited the AVP-induced PGE(2) synthesis, indicating that AVP activates cPLA(2)alpha through V1a receptor. Treatment of 3Y1 cells with AVP resulted in transient activation of p44/42 mitogen-activated protein kinase (MAPK) and cPLA(2)alpha, and phosphatidylinositol 3-kinase (PI3K) inhibitor blocked not only AVP-induced PGE(2) synthesis but also MAPK activation, suggesting that PI3K is involved in the AVP-induced MAPK and cPLA(2)alpha activation, which initiates the production of PGE(2). These results suggest that PGE(2) generated by the stimulation of AVP probably modulates the physiological effects of AVP.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
positive regulation of prostaglandin biosynthetic process  IMP 2300349; 2300349 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Avp  (arginine vasopressin)
Avpr1a  (arginine vasopressin receptor 1A)


Additional Information