Npffr2 (neuropeptide FF receptor 2) - Rat Genome Database

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Gene: Npffr2 (neuropeptide FF receptor 2) Rattus norvegicus
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Symbol: Npffr2
Name: neuropeptide FF receptor 2
RGD ID: 620168
Description: Predicted to enable G protein-coupled receptor activity and peptide binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and cellular response to hormone stimulus. Predicted to be located in actin cytoskeleton. Predicted to be active in plasma membrane. Orthologous to human NPFFR2 (neuropeptide FF receptor 2); INTERACTS WITH ammonium chloride; bisphenol A; endosulfan.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G protein-coupled receptor 74; G-protein coupled receptor 74; Gpr74; neuropeptide G-protein coupled receptor; Npff2; Npgpr
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21418,513,277 - 18,521,919 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1418,513,277 - 18,521,919 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1418,503,730 - 18,512,373 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01419,822,615 - 19,831,258 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01418,537,009 - 18,545,776 (-)NCBIRnor_WKY
Rnor_6.01420,148,485 - 20,193,577 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1420,148,913 - 20,193,083 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01420,054,945 - 20,099,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41420,041,856 - 20,050,499 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11420,041,855 - 20,050,499 (-)NCBI
Celera1417,879,584 - 17,888,229 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin cytoskeleton  (IEA,ISO)
plasma membrane  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification and characterization of two G protein-coupled receptors for neuropeptide FF. Bonini JA, etal., J Biol Chem 2000 Dec 15;275(50):39324-31.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Quantitative autoradiographic distribution of NPFF1 neuropeptide FF receptor in the rat brain and comparison with NPFF2 receptor by using YVP and [(125I]EYF as selective radioligands. Gouarderes C, etal., Neuroscience 2002;115(2):349-61.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14696013   PMID:28825666  


Genomics

Comparative Map Data
Npffr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21418,513,277 - 18,521,919 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1418,513,277 - 18,521,919 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1418,503,730 - 18,512,373 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01419,822,615 - 19,831,258 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01418,537,009 - 18,545,776 (-)NCBIRnor_WKY
Rnor_6.01420,148,485 - 20,193,577 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1420,148,913 - 20,193,083 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01420,054,945 - 20,099,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41420,041,856 - 20,050,499 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11420,041,855 - 20,050,499 (-)NCBI
Celera1417,879,584 - 17,888,229 (-)NCBICelera
Cytogenetic Map14p22NCBI
NPFFR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38472,032,000 - 72,148,305 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl472,031,902 - 72,148,305 (+)EnsemblGRCh38hg38GRCh38
GRCh37472,897,717 - 73,014,022 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36473,116,385 - 73,232,642 (+)NCBINCBI36Build 36hg18NCBI36
Build 34473,270,125 - 73,378,813NCBI
Celera470,253,879 - 70,369,821 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef468,702,459 - 68,818,720 (+)NCBIHuRef
CHM1_1472,933,070 - 73,049,409 (+)NCBICHM1_1
T2T-CHM13v2.0475,374,029 - 75,490,284 (+)NCBIT2T-CHM13v2.0
Npffr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39589,674,701 - 89,731,773 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl589,675,288 - 89,731,599 (+)EnsemblGRCm39 Ensembl
GRCm38589,526,840 - 89,583,914 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl589,527,429 - 89,583,740 (+)EnsemblGRCm38mm10GRCm38
MGSCv37589,956,454 - 90,012,765 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36590,602,628 - 90,658,939 (+)NCBIMGSCv36mm8
Celera587,701,454 - 87,717,464 (+)NCBICelera
Cytogenetic Map5E1NCBI
Npffr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554471,112,854 - 1,205,322 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554471,112,856 - 1,205,051 (-)NCBIChiLan1.0ChiLan1.0
NPFFR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1458,393,065 - 58,412,577 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl458,393,065 - 58,508,526 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0452,073,462 - 52,189,443 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NPFFR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11361,140,285 - 61,164,966 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1361,148,828 - 61,164,811 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1360,874,074 - 60,899,431 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01361,950,541 - 61,973,894 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1361,958,652 - 61,973,971 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11361,558,985 - 61,584,534 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01361,050,028 - 61,073,505 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01362,198,644 - 62,224,209 (+)NCBIUU_Cfam_GSD_1.0
Npffr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528514,540,862 - 14,612,269 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365982,992,780 - 3,003,355 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365982,993,845 - 3,063,891 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPFFR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl868,572,578 - 68,643,756 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1868,572,164 - 68,643,394 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2872,528,102 - 72,559,432 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NPFFR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1720,552,443 - 20,664,818 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl720,646,369 - 20,664,578 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660842,149,982 - 2,168,443 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npffr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248903,562,775 - 3,581,448 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Npffr2
180 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:29
Count of miRNA genes:28
Interacting mature miRNAs:29
Transcripts:ENSRNOT00000004153
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141757341219726296Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 15 2 1 3
Below cutoff 1 8 22 16 16 16 2 2 45 18 17 9 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000004153   ⟹   ENSRNOP00000004153
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1418,513,277 - 18,521,919 (-)Ensembl
Rnor_6.0 Ensembl1420,148,913 - 20,193,083 (-)Ensembl
RefSeq Acc Id: NM_023980   ⟹   NP_076470
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21418,513,277 - 18,521,919 (-)NCBI
Rnor_6.01420,148,963 - 20,157,598 (-)NCBI
Rnor_5.01420,054,945 - 20,099,540 (-)NCBI
RGSC_v3.41420,041,856 - 20,050,499 (-)RGD
Celera1417,879,584 - 17,888,229 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001399325 (Get FASTA)   NCBI Sequence Viewer  
  NP_076470 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG41399 (Get FASTA)   NCBI Sequence Viewer  
  EDL88540 (Get FASTA)   NCBI Sequence Viewer  
  Q9EQD2 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_076470   ⟸   NM_023980
- UniProtKB: Q9EQD2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004153   ⟸   ENSRNOT00000004153

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EQD2-F1-model_v2 AlphaFold Q9EQD2 1-417 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620168 AgrOrtholog
BioCyc Gene G2FUF-16173 BioCyc
Ensembl Genes ENSRNOG00000003067 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000004153 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004153 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  NPFF_rcpt UniProtKB/Swiss-Prot
  NPFF_rcpt_2 UniProtKB/Swiss-Prot
KEGG Report rno:78964 UniProtKB/Swiss-Prot
NCBI Gene 78964 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Npffr2 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  NPFFRECEPTOR UniProtKB/Swiss-Prot
  NPFFRECEPTR2 UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
UniProt NPFF2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Npffr2  neuropeptide FF receptor 2  Gpr74  G protein-coupled receptor 74  Symbol and Name updated 1299863 APPROVED
2004-09-10 Gpr74  G protein-coupled receptor 74  Npgpr  neuropeptide FF receptor 2  Symbol and Name updated 1299863 APPROVED
2002-08-07 Npgpr  neuropeptide FF receptor 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in dorsal horn of the spinal cord, the lateral hypothalamus, the spinal trigeminal nuclei, and the thalamic nuclei 633416