RGD Reference Report - Molecular cloning and expression of a rat V1a arginine vasopressin receptor. - Rat Genome Database

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Molecular cloning and expression of a rat V1a arginine vasopressin receptor.

Authors: Morel, A  O'Carroll, AM  Brownstein, MJ  Lolait, SJ 
Citation: Morel A, etal., Nature 1992 Apr 9;356(6369):523-6.
RGD ID: 1298691
Pubmed: PMID:1560825   (View Abstract at PubMed)
DOI: DOI:10.1038/356523a0   (Journal Full-text)

The neurohypophyseal hormone arginine vasopressin has diverse actions, including the inhibition of diuresis, contraction of smooth muscle, stimulation of liver glycogenolysis and modulation of adrenocorticotropic hormone release from the pituitary. Arginine vasopressin receptors are G protein-coupled and have been divided into at least three types; the V1a (vascular/hepatic) and V1b (anterior pituitary) receptors which act through phosphatidylinositol hydrolysis to mobilize intracellular Ca2+, and the V2 (kidney) receptor which is coupled to adenylate cyclase. We report here the cloning of a complementary DNA encoding the hepatic V1a arginine vasopressin receptor. The liver cDNA encodes a protein with seven putative transmembrane domains, which binds arginine vasopressin and related compounds with affinities similar to the native rat V1a receptor. The messenger RNA corresponding to the cDNA is distributed in rat tissues known to contain V1a receptors.

Gene Ontology Annotations    

Cellular Component
membrane  (NAS)

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Avpr1a  (arginine vasopressin receptor 1A)

Additional Information