RGD Reference Report - Molecular cloning and expression of a rat V1a arginine vasopressin receptor. - Rat Genome Database

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Molecular cloning and expression of a rat V1a arginine vasopressin receptor.

Authors: Morel, A  O'Carroll, AM  Brownstein, MJ  Lolait, SJ 
Citation: Morel A, etal., Nature 1992 Apr 9;356(6369):523-6.
RGD ID: 1298691
Pubmed: PMID:1560825   (View Abstract at PubMed)
DOI: DOI:10.1038/356523a0   (Journal Full-text)

The neurohypophyseal hormone arginine vasopressin has diverse actions, including the inhibition of diuresis, contraction of smooth muscle, stimulation of liver glycogenolysis and modulation of adrenocorticotropic hormone release from the pituitary. Arginine vasopressin receptors are G protein-coupled and have been divided into at least three types; the V1a (vascular/hepatic) and V1b (anterior pituitary) receptors which act through phosphatidylinositol hydrolysis to mobilize intracellular Ca2+, and the V2 (kidney) receptor which is coupled to adenylate cyclase. We report here the cloning of a complementary DNA encoding the hepatic V1a arginine vasopressin receptor. The liver cDNA encodes a protein with seven putative transmembrane domains, which binds arginine vasopressin and related compounds with affinities similar to the native rat V1a receptor. The messenger RNA corresponding to the cDNA is distributed in rat tissues known to contain V1a receptors.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Avpr1aRatG protein-coupled receptor signaling pathway involved_inNAS PMID:1560825UniProt 
Avpr1aRatpositive regulation of glycogen catabolic process involved_inNAS PMID:1560825UniProt 
Avpr1aRatpositive regulation of urine volume involved_inNAS PMID:1560825UniProt 
Avpr1aRatregulation of corticotropin secretion involved_inNAS PMID:1560825UniProt 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Avpr1aRatmembrane located_inNAS PMID:1560825UniProt 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Avpr1aRatV1A vasopressin receptor binding enablesIDA PMID:1560825UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Avpr1a  (arginine vasopressin receptor 1A)


Additional Information