RGD Reference Report - Blockade of central vasopressin receptors reduces the cardiovascular response to acute stress in freely moving rats. - Rat Genome Database

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Blockade of central vasopressin receptors reduces the cardiovascular response to acute stress in freely moving rats.

Authors: Stojicic, S  Milutinovic-Smiljanic, S  Sarenac, O  Milosavljevic, S  Paton, JF  Murphy, D  Japundzic-Zigon, N 
Citation: Stojicic S, etal., Neuropharmacology. 2008 Apr;54(5):824-36. Epub 2008 Jan 18.
RGD ID: 2300339
Pubmed: PMID:18339407   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neuropharm.2007.12.013   (Journal Full-text)

To investigate the contribution of central vasopressin receptors to blood pressure (BP) and heart rate (HR) response to stress we injected non-peptide selective V(1a) (SR49059), V(1b) (SSR149415), V(2) (SR121463) receptor antagonists, diazepam or vehicle in the lateral cerebral ventricle of conscious freely moving rats stressed by blowing air on their heads for 2 min. Cardiovascular effects of stress were evaluated by analyzing maximum increase of BP and HR (MAX), latency of maximum response (LAT), integral under BP and HR curve (integral), duration of their recovery and spectral parameters of BP and HR indicative of increased sympathetic outflow (LF(BP) and LF/HF(HR)). Moreover, the increase of serum corticosterone was measured. Exposure to air-jet stress induced simultaneous increase in BP and HR followed by gradual decline during recovery while LF(BP) oscillation remained increased as well as serum corticosterone level. Rats pre-treated with vasopressin receptor antagonists were not sedated while diazepam induced sedation that persisted during exposure to stress. V(1a), V(1b) and V(2) receptor antagonists applied separately did not modify basal values of cardiovascular parameters but prevented the increase in integral(BP). In addition, V(1b) and V(2) receptor antagonists reduced BP(MAX) whereas V(1a), V(1b) antagonist and diazepam reduced HR(MAX) induced by exposure to air-jet stress. All drugs shortened the recovery period, prevented the increase of LF(BP) without affecting the increase in serum corticosterone levels. Results indicate that vasopressin receptors located within the central nervous system mediate, in part, the cardiovascular response to air-jet stress without affecting either the neuroendocrine component or inducing sedation. They support the view that the V(1b) receptor antagonist may be of potential therapeutic value in reducing arterial pressure induced by stress-related disorders.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
positive regulation of blood pressure  IMP 2300339 RGD 
positive regulation of heart rate  IMP 2300339 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Avpr1a  (arginine vasopressin receptor 1A)


Additional Information