Avpr1b (arginine vasopressin receptor 1B) - Rat Genome Database

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Gene: Avpr1b (arginine vasopressin receptor 1B) Rattus norvegicus
Analyze
Symbol: Avpr1b
Name: arginine vasopressin receptor 1B
RGD ID: 6502812
Description: Enables identical protein binding activity; peptide hormone binding activity; and vasopressin receptor activity. Involved in several processes, including adenylate cyclase-modulating G protein-coupled receptor signaling pathway; positive regulation of cellular pH reduction; and positive regulation of glutamate secretion. Located in dendrite. Used to study anxiety disorder and depressive disorder. Biomarker of alcohol dependence; PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; G protein mediated signaling pathway via Galphas family; vasopressin signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: antidiuretic hormone receptor 1b; AVPR V1b; AVPR V3; LOC100909648; V1bR; vasopressin V1b receptor; vasopressin V1b receptor-like; vasopressin V3 receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81345,598,116 - 45,611,680 (+)NCBIGRCr8
mRatBN7.21343,046,531 - 43,059,046 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1343,046,267 - 43,057,792 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01348,390,434 - 48,400,583 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1348,390,417 - 48,400,632 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1348,367,307 - 48,378,831 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01353,465,718 - 53,475,867 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Effect of vasopressin V1b receptor antagonist, SSR149415, on anxiety-like behavior and Lewis lung carcinoma metastasis in mice. Amikishieva AV, etal., Exp Oncol. 2011 Sep;33(3):126-9.
2. Evidence that vasopressin V1b receptors mediate the transition to excessive drinking in ethanol-dependent rats. Edwards S, etal., Addict Biol. 2012 Jan;17(1):76-85. doi: 10.1111/j.1369-1600.2010.00291.x. Epub 2011 Feb 11.
3. ASD and Genetic Associations with Receptors for Oxytocin and Vasopressin-AVPR1A, AVPR1B, and OXTR. Francis SM, etal., Front Neurosci. 2016 Nov 22;10:516. doi: 10.3389/fnins.2016.00516. eCollection 2016.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Vasopressin V1a, V1b and V2 receptors mRNA in the kidney and heart of the renin transgenic TGR(mRen2)27 and Sprague Dawley rats. Gozdz A, etal., J Physiol Pharmacol 2002 Sep;53(3):349-57.
7. Immunohistochemical localization of the vasopressin V1b receptor in the rat brain and pituitary gland: anatomical support for its involvement in the central effects of vasopressin. Hernando F, etal., Endocrinology 2001 Apr;142(4):1659-68.
8. Science review: Vasopressin and the cardiovascular system part 1--receptor physiology. Holmes CL, etal., Crit Care. 2003 Dec;7(6):427-34. Epub 2003 Jun 26.
9. The vasopressin receptors colocalize with vasopressin in the magnocellular neurons of the rat supraoptic nucleus and are modulated by water balance. Hurbin A, etal., Endocrinology 2002 Feb;143(2):456-66.
10. Antidepressant and anxiolytic profiles of newly synthesized arginine vasopressin V1B receptor antagonists: TASP0233278 and TASP0390325. Iijima M, etal., Br J Pharmacol. 2014 Jul;171(14):3511-25. doi: 10.1111/bph.12699.
11. Association between OPCRIT dimensions and polymorphisms of HPA axis genes in bipolar disorder. Leszczyńska-Rodziewicz A, etal., J Affect Disord. 2013 Nov;151(2):744-7. doi: 10.1016/j.jad.2013.08.012. Epub 2013 Aug 23.
12. No association between polymorphisms and haplotypes of the AVPR1b, CRHR1 and NR3C1 genes and depression with melancholic features in the course of bipolar disorder. Leszczyńska-Rodziewicz A, etal., Psychiatry Res. 2013 May 15;207(1-2):140-2. doi: 10.1016/j.psychres.2012.09.025. Epub 2012 Oct 12.
13. Extrapituitary expression of the rat V1b vasopressin receptor gene. Lolait SJ, etal., Proc Natl Acad Sci U S A 1995 Jul 18;92(15):6783-7.
14. A cellular and molecular basis for the selective desmopressin-induced ACTH release in Cushing disease patients: key role of AVPR1b receptor and potential therapeutic implications. Luque RM, etal., J Clin Endocrinol Metab. 2013 Oct;98(10):4160-9. doi: 10.1210/jc.2013-1992. Epub 2013 Jul 24.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Differential coupling of the vasopressin V1b receptor through compartmentalization within the plasma membrane. Orcel H, etal., Mol Pharmacol. 2009 Mar;75(3):637-47. Epub 2008 Dec 1.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. Reduced vasopressin receptors activation mediates the anti-depressant effects of fluoxetine and venlafaxine in bulbectomy model of depression. Poretti MB, etal., Psychopharmacology (Berl). 2016 Mar;233(6):1077-86. doi: 10.1007/s00213-015-4187-4. Epub 2015 Dec 23.
20. GOA pipeline RGD automated data pipeline
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Arginine-vasopressin modulates intracellular pH via V1 and V2 receptors in renal collecting duct cells. Rivarola V, etal., Cell Physiol Biochem. 2007;20(5):549-58.
23. Contribution of molecular analysis to the typification of the non-functioning pituitary adenomas. Sanchez-Tejada L, etal., PLoS One. 2017 Jul 10;12(7):e0180039. doi: 10.1371/journal.pone.0180039. eCollection 2017.
24. Arginine vasopressin increases glutamate release and intracellular Ca2+ concentration in hippocampal and cortical astrocytes through two distinct receptors. Syed N, etal., J Neurochem. 2007 Oct;103(1):229-37.
25. Epistatic interaction between CRHR1 and AVPR1b variants as a predictor of major depressive disorder. Szczepankiewicz A, etal., Psychiatr Genet. 2013 Dec;23(6):239-46. doi: 10.1097/YPG.0000000000000007.
26. Effects of vasopressin on isolated rat adrenal chromaffin cells. Takeda M, etal., Regul Pept 2002 Jun 15;106(1-3):55-65.
27. Transcriptional regulation of the pituitary vasopressin V1b receptor involves a GAGA-binding protein. Volpi S, etal., J Biol Chem 2002 Aug 2;277(31):27829-38.
28. Vasopressin V1b receptor knockout reduces aggressive behavior in male mice. Wersinger SR, etal., Mol Psychiatry 2002;7(9):975-84.
29. Salt-loading increases vasopressin and vasopressin 1b receptor mRNA in the hypothalamus and choroid plexus. Zemo DA and McCabe JT, Neuropeptides 2001 Jun-Aug;35(3-4):181-8.
Additional References at PubMed
PMID:7626108   PMID:9322919   PMID:10792583   PMID:11287361   PMID:12486173   PMID:12869588   PMID:15528211   PMID:15632090   PMID:17355321   PMID:18508119   PMID:19033533   PMID:21858088  
PMID:22178035   PMID:23488898   PMID:23580725   PMID:25283607   PMID:25560210   PMID:25605313   PMID:26651338   PMID:27998960   PMID:32415179   PMID:33264070  


Genomics

Comparative Map Data
Avpr1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81345,598,116 - 45,611,680 (+)NCBIGRCr8
mRatBN7.21343,046,531 - 43,059,046 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1343,046,267 - 43,057,792 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01348,390,434 - 48,400,583 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1348,390,417 - 48,400,632 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1348,367,307 - 48,378,831 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01353,465,718 - 53,475,867 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Cytogenetic Map13q13NCBI
AVPR1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381206,106,936 - 206,117,388 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1206,106,936 - 206,117,699 (-)EnsemblGRCh38hg38GRCh38
GRCh371206,223,943 - 206,234,395 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361204,390,567 - 204,398,262 (+)NCBINCBI36Build 36hg18NCBI36
Build 341202,767,010 - 202,774,698NCBI
Celera1179,215,868 - 179,223,067 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1177,157,341 - 177,164,470 (+)NCBIHuRef
CHM1_11207,555,388 - 207,562,587 (-)NCBICHM1_1
T2T-CHM13v2.01205,370,978 - 205,381,434 (-)NCBIT2T-CHM13v2.0
Avpr1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391131,526,908 - 131,539,740 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1131,526,977 - 131,539,738 (+)EnsemblGRCm39 Ensembl
GRCm381131,599,114 - 131,612,000 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1131,599,239 - 131,612,000 (+)EnsemblGRCm38mm10GRCm38
MGSCv371133,495,691 - 133,508,577 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361133,426,660 - 133,439,546 (+)NCBIMGSCv36mm8
Celera1134,211,156 - 134,224,033 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map157.09NCBI
Avpr1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540641,705,305 - 41,716,173 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540641,706,088 - 41,716,173 (-)NCBIChiLan1.0ChiLan1.0
AVPR1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2143,254,921 - 43,264,892 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1143,220,427 - 43,230,407 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01181,713,548 - 181,723,645 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11185,996,869 - 186,007,043 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1185,999,627 - 186,007,043 (-)Ensemblpanpan1.1panPan2
AVPR1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1382,440,574 - 2,446,037 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl382,440,615 - 2,446,037 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha382,527,072 - 2,539,143 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0382,432,354 - 2,444,078 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl382,438,108 - 2,443,530 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1382,426,053 - 2,437,770 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0382,818,206 - 2,830,306 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0383,018,527 - 3,030,626 (-)NCBIUU_Cfam_GSD_1.0
Avpr1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934469,175,333 - 69,183,581 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365576,415,547 - 6,424,711 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365576,415,544 - 6,423,863 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AVPR1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl966,772,591 - 66,776,931 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1966,769,472 - 66,776,916 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2973,019,057 - 73,024,469 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AVPR1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12523,234,651 - 23,244,403 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2523,234,823 - 23,241,159 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605523,931,432 - 23,942,062 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Avpr1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248075,237,036 - 5,241,845 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248075,237,036 - 5,247,383 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Avpr1b
84 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
2303032Bp328Blood pressure QTL 328arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134118402245417941Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
12 12 51 46 38 14 12 14 12 76 48 27 2 26 24

Sequence


Ensembl Acc Id: ENSRNOT00000074204   ⟹   ENSRNOP00000067252
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1348,390,417 - 48,400,632 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000074512   ⟹   ENSRNOP00000064689
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1343,046,267 - 43,057,792 (+)Ensembl
Rnor_6.0 Ensembl1348,367,307 - 48,378,831 (+)Ensembl
RefSeq Acc Id: NM_001289800   ⟹   NP_001276729
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81345,598,763 - 45,611,277 (+)NCBI
mRatBN7.21343,046,531 - 43,059,046 (+)NCBI
Rnor_6.01348,390,434 - 48,400,583 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063271945   ⟹   XP_063128015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81345,598,116 - 45,611,680 (+)NCBI
RefSeq Acc Id: NP_001276729   ⟸   NM_001289800
- UniProtKB: P48974 (UniProtKB/Swiss-Prot),   G3V6U8 (UniProtKB/TrEMBL),   A6IC22 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067252   ⟸   ENSRNOT00000074204
Ensembl Acc Id: ENSRNOP00000064689   ⟸   ENSRNOT00000074512
RefSeq Acc Id: XP_063128015   ⟸   XM_063271945
- Peptide Label: isoform X1
- UniProtKB: P48974 (UniProtKB/Swiss-Prot),   A6IC22 (UniProtKB/TrEMBL),   G3V6U8 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48974-F1-model_v2 AlphaFold P48974 1-425 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:6502812 AgrOrtholog
BioCyc Gene G2FUF-18344 BioCyc
Ensembl Genes ENSRNOG00000048522 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000049261 Ensembl
  ENSRNOG00055020578 UniProtKB/Swiss-Prot
  ENSRNOG00060014890 UniProtKB/Swiss-Prot
  ENSRNOG00065019314 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000074512.3 UniProtKB/TrEMBL
  ENSRNOT00055035146 UniProtKB/Swiss-Prot
  ENSRNOT00060025469 UniProtKB/Swiss-Prot
  ENSRNOT00065032514 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DUF1856 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vasoprsn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vprs_rcpt_V1B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:100909648 UniProtKB/TrEMBL
NCBI Gene LOC100909648 ENTREZGENE
PANTHER NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VASOPRESSIN V1B RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF1856 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Avpr1b PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VASOPRESSINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VASOPRSNV1BR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048522 RatGTEx
  ENSRNOG00000049261 RatGTEx
  ENSRNOG00055020578 RatGTEx
  ENSRNOG00060014890 RatGTEx
  ENSRNOG00065019314 RatGTEx
SMART DUF1856 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6IC22 ENTREZGENE, UniProtKB/TrEMBL
  A6IC23_RAT UniProtKB/TrEMBL
  G3V6U8 ENTREZGENE, UniProtKB/TrEMBL
  P48974 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-07-01 Avpr1b  arginine vasopressin receptor 1B  LOC100909648  vasopressin V1b receptor-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2021-07-01 LOC100909648  vasopressin V1b receptor-like  Avpr1b  arginine vasopressin receptor 1B  Data merged from RGD:61886 737654 PROVISIONAL
2012-07-05 LOC100909648  vasopressin V1b receptor-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Avpr1b  arginine vasopressin receptor 1B    arginine vasopressin receptor 1B   Name updated 1299863 APPROVED
2002-06-10 Avpr1b  arginine vasopressin receptor 1B       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes to plasma membrane 628482
gene_expression expressed in supraoptic nucleus 70387
gene_expression expressed in hypothalamus, amygdala, crebellum; after colchicine treatment expressed in hippocampus,cortex,olfactory bulb and cerebellum 628482
gene_process functions in water balance 61542
gene_process functions in water balance 70387
gene_process may be involved in vasopressin effects on thermoregulation and stimulation of CRH secretion from hypothalamus 628482
gene_product 127kDa protein 625573
gene_protein 127kDa in size 625573
gene_regulation GAGA binding proteins bind to the GAGA box (present at the proximal end) to activate the gene 625573
gene_regulation GAGA binding proteins bind to the GAGA box ( present at the proximal end) to activate the gene 628482
gene_transcript contains several GAGA repeats upstream of the main GAGA box that may be involved in the transcriptional regulation of mammalian genes 625573
gene_transcript contains several GAGA repeats upstream of the main GAGA box that may be involved in the transcriptional regulation of mammalian genes 628482