Cckar (cholecystokinin A receptor) - Rat Genome Database

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Gene: Cckar (cholecystokinin A receptor) Rattus norvegicus
Analyze
Symbol: Cckar
Name: cholecystokinin A receptor
RGD ID: 2289
Description: Enables cholecystokinin receptor activity. Involved in several processes, including positive regulation of somatostatin secretion; reduction of food intake in response to dietary excess; and regulation of metal ion transport. Located in endosome and terminal bouton. Used to study obesity and type 2 diabetes mellitus. Biomarker of pancreatic cancer. Human ortholog(s) of this gene implicated in obesity. Orthologous to human CCKAR (cholecystokinin A receptor); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CCK-A receptor; Cck-ar; CCK1-R; cholecystokinin receptor type A; cholecystokinin-1 receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: QTLs:   Niddm28  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81461,505,270 - 61,513,618 (+)NCBIGRCr8
mRatBN7.21457,292,397 - 57,300,747 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1457,292,397 - 57,300,747 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1461,699,304 - 61,707,579 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01463,001,655 - 63,009,913 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01459,398,438 - 59,406,696 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01459,610,939 - 59,619,786 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1459,611,434 - 59,619,783 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01459,691,504 - 59,747,723 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41462,052,510 - 62,057,201 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11462,054,843 - 62,064,735 (+)NCBI
Celera1456,400,364 - 56,408,663 (+)NCBICelera
RH 3.4 Map14455.67RGD
Cytogenetic Map14q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Cholecystokinin-A receptors are involved in food intake suppression in rats after intake of all fats and carbohydrates tested. Bellissimo N and Anderson GH, J Nutr. 2003 Jul;133(7):2319-25.
2. Response to acute food deprivation in OLETF rats lacking CCK-A receptors. Bi S and Moran TH, Physiol Behav. 2003 Sep;79(4-5):655-61.
3. Ontogeny and species differences in the pancreatic expression and localization of the CCK(A) receptors. Bourassa J, etal., Biochem Biophys Res Commun. 1999 Jul 14;260(3):820-8.
4. Decreased gastric mechanodetection, but preserved gastric emptying, in CCK-1 receptor-deficient OLETF rats. De Jonghe BC, etal., Am J Physiol Gastrointest Liver Physiol. 2006 Oct;291(4):G640-9. Epub 2006 May 25.
5. Correlation between gene expression of CCK-A receptor and emptying dysfunction of the gallbladder in patients with gallstones and diabetes mellitus. Ding X, etal., Hepatobiliary Pancreat Dis Int. 2005 May;4(2):295-8.
6. Control of somatostatin (SS) secretion by CCK-1 and CCK-2 receptors' occupation in RIN-14B cells, a rat pancreatic islet cell line. El-Kouhen K and Morisset J, Pancreas. 2010 Mar;39(2):127-34.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Haemodynamic and exocrine effects of caerulein at submaximal and supramaximal levels on the rat pancreas: role of cholecystokinin receptor subtypes. Griesbacher T, etal., Pancreatology. 2006;6(1-2):65-75; discussion 75-6. Epub 2005 Dec 2.
10. Transient agonist-induced regulation of the cholecystokinin-A and cholecystokinin-B receptor mRNA levels in rat pancreatic acinar AR42J cells. Gunther R, etal., Pancreatology. 2003;3(1):47-54.
11. Altered taste sensitivity in obese, prediabetic OLETF rats lacking CCK-1 receptors. Hajnal A, etal., Am J Physiol Regul Integr Comp Physiol. 2005 Dec;289(6):R1675-86. Epub 2005 Aug 4.
12. Effects of cholecystokinin (CCK)-8 on hypothalamic oxytocin-secreting neurons in rats lacking CCK-A receptor. Hashimoto H, etal., Auton Neurosci. 2005 Aug 31;121(1-2):16-25.
13. Role of cholecystokinin-A and cholecystokinin-B receptors in anxiety. Hernandez-Gomez AM, etal., Amino Acids 2002;23(1-3):283-90.
14. Expression and physiological actions of cholecystokinin in rat taste receptor cells. Herness S, etal., J Neurosci. 2002 Nov 15;22(22):10018-29.
15. CCK-A receptors in the rat interpeduncular nucleus: evidence for a presynaptic location. Hill DR, etal., Brain Res. 1988 Jun 28;454(1-2):101-5.
16. Human cholecystokinin type A receptor gene: cytogenetic localization, physical mapping, and identification of two missense variants in patients with obesity and non-insulin-dependent diabetes mellitus (NIDDM). Inoue H, etal., Genomics 1997 Jun 1;42(2):331-5.
17. Exposition of newborn rats to bacterial endotoxin impairs pancreatic enzyme secretion at adult age. Jaworek J, etal., J Physiol Pharmacol. 2007 Jun;58(2):287-302.
18. Low-affinity CCK-1 receptors inhibit bombesin-stimulated secretion in rat pancreatic acini--implication of the actin cytoskeleton. Kiehne K, etal., Regul Pept. 2002 May 15;105(2):131-7.
19. The difference in mRNA expressions of hypothalamic CCK and CCK-A and -B receptors between responder and non-responder rats to high frequency electroacupuncture analgesia. Ko ES, etal., Peptides. 2006 Jul;27(7):1841-5. Epub 2006 Feb 10.
20. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
21. Adaptation to low-protein diet increases inhibition of gastric emptying by CCK. Leray V, etal., Peptides. 2003 Dec;24(12):1929-34.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. Disturbance of response to acute thermal pain in naturally occurring cholecystokinin-a receptor gene knockout Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Miyasaka K, etal., J Pharmacol Sci. 2006 Aug;101(4):280-5. Epub 2006 Aug 5.
24. Cholecystokinin-A receptor messenger RNA expression in human pancreatic cancer. Moonka R, etal., J Gastrointest Surg. 1999 Mar-Apr;3(2):134-40.
25. Hyperphagia and obesity in OLETF rats lacking CCK-1 receptors. Moran TH and Bi S, Philos Trans R Soc Lond B Biol Sci. 2006 Jul 29;361(1471):1211-8.
26. Disordered food intake and obesity in rats lacking cholecystokinin A receptors. Moran TH, etal., Am J Physiol. 1998 Mar;274(3 Pt 2):R618-25.
27. Defects of cholecystokinin (CCK)-A receptor gene expression and CCK-A receptor-mediated biological functions in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Nakamura H, etal., J Gastroenterol. 1998 Oct;33(5):702-9.
28. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
29. Absence of the cholecystokinin-A receptor deteriorates homeostasis of body temperature in response to changes in ambient temperature. Nomoto S, etal., Am J Physiol Regul Integr Comp Physiol. 2004 Sep;287(3):R556-61. Epub 2004 Jun 3.
30. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
31. Effects of peripheral CCK receptor blockade on feeding responses to duodenal nutrient infusions in rats. Reidelberger RD, etal., Am J Physiol Regul Integr Comp Physiol 2003 Feb;284(2):R389-98.
32. Effects of peripheral CCK receptor blockade on gastric emptying in rats. Reidelberger RD, etal., Am J Physiol Regul Integr Comp Physiol 2003 Jan;284(1):R66-75.
33. Distribution of CCK1 and CCK2 receptors in normal and diseased human pancreatic tissue. Reubi JC, etal., Gastroenterology. 2003 Jul;125(1):98-106.
34. GOA pipeline RGD automated data pipeline
35. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
36. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
37. Transient stabilization of cholecystokinin A receptor mRNA by glucocorticoids in pancreatic AR42J cells. Rosewicz S, etal., Am J Physiol. 1994 Nov;267(5 Pt 1):G772-7.
38. Functional expression of cholecystokinin-A receptor on ventromedial hypothalamic neurons in the immature rat brain. Sorimachi M, etal., Neurosci Lett. 2001 Mar 9;300(2):91-4.
39. Expression of cholecystokinin A receptors in neurons innervating the rat stomach and intestine. Sternini C, etal., Gastroenterology. 1999 Nov;117(5):1136-46.
40. Disrupted cholecystokinin type-A receptor (CCKAR) gene in OLETF rats. Takiguchi S, etal., Gene 1997 Sep 15;197(1-2):169-75.
41. Cholecystokinin-stimulated tyrosine phosphorylation of PKC-delta in pancreatic acinar cells is regulated bidirectionally by PKC activation. Tapia JA, etal., Biochim Biophys Acta 2002 Dec 16;1593(1):99-113.
42. Visualization of G protein-coupled receptor trafficking with the aid of the green fluorescent protein. Endocytosis and recycling of cholecystokinin receptor type A. Tarasova NI, etal., J Biol Chem. 1997 Jun 6;272(23):14817-24.
43. Cholecystokinin, cholecystokinin-A receptor and cholecystokinin-B receptor gene polymorphisms in Parkinson's disease. Wang J, etal., Pharmacogenetics. 2003 Jun;13(6):365-9.
44. Brain and gastrointestinal cholecystokinin receptor family: structure and functional expression. Wank SA, etal., Proc Natl Acad Sci U S A 1992 Sep 15;89(18):8691-5.
45. The CCK-A receptor gene possibly associated with auditory hallucinations in schizophrenia. Wei J and Hemmings GP, Eur Psychiatry 1999 Apr;14(2):67-70.
46. Cholecystokinin A and B receptors are differentially expressed in normal pancreas and pancreatic adenocarcinoma. Weinberg DS, etal., J Clin Invest. 1997 Aug 1;100(3):597-603.
47. Effects of cholecystokinin-58 on type 1 cholecystokinin receptor function and regulation. Wu SV, etal., Am J Physiol Gastrointest Liver Physiol. 2008 Sep;295(3):G641-7.
48. Regulative effects of ovarian steroids on rat gastric motility and sensitivity. Yang X, etal., Sheng Li Xue Bao. 2006 Jun 25;58(3):275-80.
49. Overexpression of messenger RNA for cholecystokinin-A receptor and novel expression of messenger RNA for gastrin (cholecystokinin-B) receptor in azaserine-induced rat pancreatic carcinoma. Zhou W, etal., Carcinogenesis. 1993 Oct;14(10):2189-92.
Additional References at PubMed
PMID:1313582   PMID:7654260   PMID:8024583   PMID:8503909   PMID:12016125   PMID:12457239   PMID:12562931   PMID:12651850   PMID:12800239   PMID:12855414   PMID:12916469   PMID:12932815  
PMID:14607104   PMID:14698681   PMID:14700745   PMID:14988658   PMID:15117731   PMID:15123537   PMID:15152034   PMID:15358606   PMID:16099824   PMID:16112401   PMID:16289472   PMID:16491099  
PMID:16556659   PMID:17505309   PMID:19026634   PMID:19111529   PMID:19533109   PMID:19887078   PMID:19940076   PMID:20001102   PMID:20347877   PMID:20624386   PMID:20843811   PMID:20953702  
PMID:21728335   PMID:21984583   PMID:22981453   PMID:23545074   PMID:24564397   PMID:24978951   PMID:32699194   PMID:33422646   PMID:35691467   PMID:37298724  


Genomics

Comparative Map Data
Cckar
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81461,505,270 - 61,513,618 (+)NCBIGRCr8
mRatBN7.21457,292,397 - 57,300,747 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1457,292,397 - 57,300,747 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1461,699,304 - 61,707,579 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01463,001,655 - 63,009,913 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01459,398,438 - 59,406,696 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01459,610,939 - 59,619,786 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1459,611,434 - 59,619,783 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01459,691,504 - 59,747,723 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41462,052,510 - 62,057,201 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11462,054,843 - 62,064,735 (+)NCBI
Celera1456,400,364 - 56,408,663 (+)NCBICelera
RH 3.4 Map14455.67RGD
Cytogenetic Map14q11NCBI
CCKAR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38426,481,396 - 26,490,484 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl426,481,396 - 26,490,484 (-)EnsemblGRCh38hg38GRCh38
GRCh37426,483,018 - 26,492,106 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36426,092,116 - 26,101,140 (-)NCBINCBI36Build 36hg18NCBI36
Build 34426,159,286 - 26,168,311NCBI
Celera426,934,075 - 26,943,099 (-)NCBICelera
Cytogenetic Map4p15.2NCBI
HuRef425,821,291 - 25,830,315 (-)NCBIHuRef
CHM1_1426,484,379 - 26,493,404 (-)NCBICHM1_1
T2T-CHM13v2.0426,466,670 - 26,475,758 (-)NCBIT2T-CHM13v2.0
Cckar
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39553,855,827 - 53,865,046 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl553,855,118 - 53,865,047 (-)EnsemblGRCm39 Ensembl
GRCm38553,698,485 - 53,707,704 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl553,697,776 - 53,707,705 (-)EnsemblGRCm38mm10GRCm38
MGSCv37554,089,724 - 54,098,943 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36553,986,735 - 53,996,350 (-)NCBIMGSCv36mm8
Celera551,081,684 - 51,090,889 (-)NCBICelera
Cytogenetic Map5C1NCBI
cM Map529.52NCBI
Cckar
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544318,737,974 - 18,748,727 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544318,738,029 - 18,748,684 (+)NCBIChiLan1.0ChiLan1.0
CCKAR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2326,733,119 - 26,745,226 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1426,924,864 - 26,936,971 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0420,881,340 - 20,890,986 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1426,157,702 - 26,166,773 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl426,157,702 - 26,166,773 (-)Ensemblpanpan1.1panPan2
CCKAR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1384,010,700 - 84,019,066 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl384,010,205 - 84,021,293 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha386,523,114 - 86,531,436 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0384,979,595 - 84,989,334 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl384,978,882 - 84,990,505 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1384,102,638 - 84,110,963 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0384,222,497 - 84,230,820 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0384,607,068 - 84,615,397 (+)NCBIUU_Cfam_GSD_1.0
Cckar
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528549,605,282 - 49,613,370 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364773,306,874 - 3,314,714 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364773,306,898 - 3,314,659 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCKAR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl820,188,830 - 20,199,344 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1820,187,324 - 20,200,273 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2820,563,652 - 20,574,944 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CCKAR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12723,855,766 - 23,866,104 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2723,856,705 - 23,865,367 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604770,369,554 - 70,378,492 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cckar
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247556,121,620 - 6,132,897 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247556,122,181 - 6,132,623 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cckar
16 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:44
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000065366
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143088377768757901Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143999825175582726Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat

Markers in Region
D14Wox26  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21457,294,664 - 57,294,870 (+)MAPPERmRatBN7.2
Rnor_6.01459,613,700 - 59,613,905NCBIRnor6.0
Rnor_5.01459,740,309 - 59,740,514UniSTSRnor5.0
RGSC_v3.41462,054,776 - 62,054,981UniSTSRGSC3.4
Celera1456,402,622 - 56,402,827UniSTS
Cytogenetic Map14q11UniSTS
D14Wox24  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21457,292,079 - 57,292,360 (+)MAPPERmRatBN7.2
Rnor_6.01459,611,115 - 59,611,397NCBIRnor6.0
Rnor_5.01459,737,724 - 59,738,006UniSTSRnor5.0
RGSC_v3.41462,052,193 - 62,052,473UniSTSRGSC3.4
Celera1456,400,067 - 56,400,327UniSTS
Cytogenetic Map14q11UniSTS
D14Wox25  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21457,293,870 - 57,293,950 (+)MAPPERmRatBN7.2
Rnor_6.01459,612,906 - 59,612,985NCBIRnor6.0
Rnor_5.01459,739,515 - 59,739,594UniSTSRnor5.0
RGSC_v3.41462,053,982 - 62,054,061UniSTSRGSC3.4
Celera1456,401,822 - 56,401,907UniSTS
Cytogenetic Map14q11UniSTS
PMC129753P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21457,293,392 - 57,293,524 (+)MAPPERmRatBN7.2
Rnor_6.01459,612,428 - 59,612,559NCBIRnor6.0
Rnor_5.01459,739,037 - 59,739,168UniSTSRnor5.0
RGSC_v3.41462,053,504 - 62,053,635UniSTSRGSC3.4
Celera1456,401,344 - 56,401,475UniSTS
Cytogenetic Map14q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 1 26 7 6 8 6 47 9 9 2
Below cutoff 1 24 17 3 17 2 2 21 18 10 8 2

Sequence


RefSeq Acc Id: ENSRNOT00000065366   ⟹   ENSRNOP00000063137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1457,292,397 - 57,300,747 (+)Ensembl
Rnor_6.0 Ensembl1459,611,434 - 59,619,783 (+)Ensembl
RefSeq Acc Id: NM_012688   ⟹   NP_036820
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81461,505,270 - 61,513,618 (+)NCBI
mRatBN7.21457,292,397 - 57,300,747 (+)NCBI
Rnor_6.01459,611,434 - 59,619,783 (+)NCBI
Rnor_5.01459,691,504 - 59,747,723 (+)NCBI
RGSC_v3.41462,052,510 - 62,057,201 (+)RGD
Celera1456,400,364 - 56,408,663 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036820 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40899 (Get FASTA)   NCBI Sequence Viewer  
  BAA09170 (Get FASTA)   NCBI Sequence Viewer  
  BAA22847 (Get FASTA)   NCBI Sequence Viewer  
  EDL99868 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000063137
  ENSRNOP00000063137.2
  ENSRNOP00060021578
GenBank Protein P30551 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036820   ⟸   NM_012688
- UniProtKB: P30551 (UniProtKB/Swiss-Prot),   F1LQR7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000063137   ⟸   ENSRNOT00000065366
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30551-F1-model_v2 AlphaFold P30551 1-444 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699328
Promoter ID:EPDNEW_R9853
Type:single initiation site
Name:Cckar_1
Description:cholecystokinin A receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01459,611,405 - 59,611,465EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2289 AgrOrtholog
BioCyc Gene G2FUF-15617 BioCyc
Ensembl Genes ENSRNOG00000043124 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00060015710 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000065366 ENTREZGENE
  ENSRNOT00000065366.3 UniProtKB/TrEMBL
  ENSRNOT00060026909 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.670.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cholcskin_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cholcy_rcpt_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CholecystokininA_recpt_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CholecystokininA_recpt_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gastrin_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24889 UniProtKB/Swiss-Prot
NCBI Gene 24889 ENTREZGENE
PANTHER CHOLECYSTOKININ RECEPTOR TYPE A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CholecysA-Rec_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cckar PhenoGen
PRINTS CCYSTOKININR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CCYSTOKNINAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GASTRINR UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000043124 RatGTEx
  ENSRNOG00060015710 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6IJF5_RAT UniProtKB/TrEMBL
  CCKAR_RAT UniProtKB/Swiss-Prot
  F1LQR7 ENTREZGENE, UniProtKB/TrEMBL
  P30551 ENTREZGENE
  V9H0R3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Cckar  Cholecystokinin A receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease deletion in gene may be associated with hyperglycemia, hyperinsulinemia and mild obesity 634705
gene_expression expressed in pancreatic acinar cells 631304
gene_expression expressed in the peripheral region of the blood-brain barrier 631304
gene_function binds sulfated cholecystokinin peptides 631304
gene_function binds sulfated cholecystokinin peptides 634707
gene_process inhibits gastric emptying 628552
gene_process may be involved in inhibiting food intake 634706
gene_process may be involved in duodenal nutrient-induced inhibition of gastric emptying 628552
gene_process activation results in the tyrosine phosphorylation of PKC delta 631304
gene_product member of G protein coupled heptahelical superfamily 631304
gene_regulation binds and is activated by a carboxy-terminal octapeptide of cholecystokinin 631304