Rf22 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Rf22 (Renal function QTL 22) Rattus norvegicus

Symbol: Rf22
Name: Renal function QTL 22
RGD ID: 1300136
Previously known as: Specialized Center of Research QTL 56,58; SCOR56; SCOR58
Trait: renal blood flow trait   (VT:2000006)    
Measurement Type: absolute change in renal vascular resistance   (CMO:0001900)    
LOD Score: 3.9
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81442,616,258 - 99,224,555RGD_MAPPER_PIPELINE
mRatBN7.21442,262,529 - 95,023,211RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01443,910,761 - 105,074,364RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01443,697,829 - 104,803,539RGDRnor5.0
RGSC_v3.41444,934,410 - 101,647,208RGDRGSC3.4
RGSC_v3.11444,992,308 - 101,666,284RGD
Cross Type: Not Available
Strains Crossed: BN/SsNHsd SS/JrHsdMcwi 
JBrowse: View Region in Genome Browser (JBrowse)
Model




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Rf22Ratkidney disease  IAGP 727992 RGD 
Rf22Ratrenal hypertension  IAGP 727992 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Rf22Ratabnormal renal plasma flow rate  QTM 727992 RGD 
Rf22Ratincreased renal vascular resistance  IAGP 727992 RGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Rf22Ratabsolute change in renal vascular resistance  IDA 727992 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Rf22Ratangiotensin II  IDA 727992 RGD 
Rf22Ratcontrolled sodium content diet  IDA 727992 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Rf22Ratelectromagnetic flowmetry  IDA 727992 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Rf22RatBN/SsNHsd  IEA 727992 RGD 
Rf22RatSS/JrHsdMcwi  IEA 727992 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Rf22Ratrenal blood flow trait  IDA 727992 RGD 


#
Reference Title
Reference Citation
1. Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats. Moreno C, etal., Physiol Genomics 2003 Nov 11;15(3):243-57. Epub 2003 Oct 07.


1 to 20 of 557 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
1598004Haus8-ps3HAUS augmin-like complex, subunit 8, pseudogene 3144232338442323749Rat
1307623Rhohras homolog family member H144234113542371971Rat
1565738N4bp2NEDD4 binding protein 2144234269042479861Rat
1307094Pds5aPDS5 cohesin associated factor A144255165342651074Rat
41034751LOC120096749U6 spliceosomal RNA144259026142590365Rat
1590581Rpl14l2ribosomal protein L14 like 2144259403942594681Rat
1311626Ube2kubiquitin-conjugating enzyme E2K144265801642718899Rat
2324107Rplp2l3ribosomal protein lateral stalk subunit P2 like 3144274528042745734Rat
1311122Smim14small integral membrane protein 14144278336142829762Rat
621879UgdhUDP-glucose 6-dehydrogenase144284870442872351Rat
1307270Liaslipoic acid synthetase144287669942893824Rat
62049Rpl9ribosomal protein L9144289394542897140Rat
1308227Klbklotho beta144289905042950788Rat
2322187Rpl32l5ribosomal protein L32 like 5144294633342946852Rat
11373177LOC10835282840S ribosomal protein S13 pseudogene144295228842952858Rat
620619Rfc1replication factor C subunit 1144296627943041372Rat
41233454LOC120096833small nucleolar RNA SNORA77144299189242992020Rat
1306997Wdr19WD repeat domain 19144304247443106337Rat
1584389Hnrnpa1-ps12heterogeneous nuclear ribonucleoprotein A1, pseudogene 12144312916643130555Rat
6496349Slc25a51l1solute carrier family 25, member 51 like 1144314091043144124Rat

1 to 20 of 557 rows
1 to 20 of 711 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
10102D14Mco2289147546949375469784Ratregion
10102D14Mco2289147546949375470354Ratregion
10102D14Mco2289147546975275469784Ratregion
10488D14Mgh8116147248920772489324Ratregion
10773D14Mit10264148205747182057735Ratregion
11030D14Mit4139144233688142337007Ratregion
11086D14Mgh1105148068483380684938Ratregion
33965D14Mit15193148361068083610873Ratregion
33989D14Mit13147144782261847822765Ratregion
34045D14Mit8145145276462552764770Ratregion
34345D14Mgh2134147351328073513414Ratregion
34616D14Mit16137148082812980828266Ratregion
36299D14Rat20155148120475181204906Ratregion
36307D14Rat21131149119526891195399Ratregion
37230D14Rat64207146361897163619178Ratregion
37328D14Rat61238146448149264481734Ratregion
37426D14Rat62221146381613763816358Ratregion
35202D14Rat24102144246809742468199Ratregion
35319D14Rat16169144226252942262698Ratregion
36864D14Rat28141147262099372621134Ratregion
1 to 20 of 711 rows

Flank 1: (D14Rat16)
Rat AssemblyChrPosition (strand)Source
GRCr81442,616,258 - 42,616,427 (+)Marker Load Pipeline
mRatBN7.21442,262,529 - 42,262,698 (+)MAPPER
Rnor_6.01443,910,761 - 43,910,929NCBI
Rnor_5.01443,697,829 - 43,697,997UniSTS
RGSC_v3.41444,934,410 - 44,934,580RGD
RGSC_v3.41444,934,411 - 44,934,579UniSTS
RGSC_v3.11444,992,308 - 44,992,818RGD
Celera1441,415,410 - 41,415,596UniSTS
RH 2.0 Map14467.9RGD
SHRSP x BN Map1428.34RGD
FHH x ACI Map1439.47RGD
Peak: (D14Rat90)
Rat AssemblyChrPosition (strand)Source
GRCr81472,970,210 - 72,970,315 (+)Marker Load Pipeline
mRatBN7.21468,757,796 - 68,757,901 (+)MAPPER
Rnor_6.01473,391,467 - 73,391,571NCBI
Rnor_5.01473,407,669 - 73,407,773UniSTS
RGSC_v3.41473,956,596 - 73,956,701RGD
RGSC_v3.41473,956,597 - 73,956,701UniSTS
RGSC_v3.11473,958,987 - 73,959,092RGD
Celera1467,690,717 - 67,690,821UniSTS
SHRSP x BN Map1434.67RGD
SHRSP x BN Map1434.67UniSTS
Cytogenetic Map14 RGD
Flank 2: (D14Rat95)
Rat AssemblyChrPosition (strand)Source
GRCr81499,224,362 - 99,224,555 (+)Marker Load Pipeline
mRatBN7.21495,023,018 - 95,023,211 (+)MAPPER
Rnor_6.014105,074,174 - 105,074,364NCBI
Rnor_5.014104,803,349 - 104,803,539UniSTS
RGSC_v3.414101,646,881 - 101,647,073UniSTS
RGSC_v3.414101,646,814 - 101,647,208RGD
RGSC_v3.114101,666,092 - 101,666,284RGD
Celera1494,037,488 - 94,037,624UniSTS
RH 3.4 Map14751.6UniSTS
RH 3.4 Map14751.6RGD
RH 2.0 Map14831.8RGD
SHRSP x BN Map1466.1599RGD


1 to 10 of 37 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143999825175582726Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
4889951Bss92Bone structure and strength QTL 923.9tibia area (VT:1000281)tibia-fibula cortical bone total cross-sectional area (CMO:0001721)148205747195876975Rat

1 to 10 of 37 rows


Database
Acc Id
Source(s)
NCBI Gene Rf22

Note Type Note Reference
qtl_general change in renal vascular resistance following Angiotensin II dose 2 (96ng/kg/min,SCOR58) 727992
qtl_general significant linkage also found to change in renal vascular resistance following Angiotensin II dose 2 in the anaesthetized rat (SCOR56, LOD=3.03) 727992
qtl_general additional information, including phenotype and mapping information, can be found at Genomic Map of Cardiovascular Phenotypes 727992