Rrm1-ps1 (ribonucleotide reductase M1, pseudogene 1) - Rat Genome Database

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Gene: Rrm1-ps1 (ribonucleotide reductase M1, pseudogene 1) Rattus norvegicus
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Symbol: Rrm1-ps1
Name: ribonucleotide reductase M1, pseudogene 1
RGD ID: 1598288
Description: INTERACTS WITH leflunomide
Type: pseudo
RefSeq Status: INFERRED
Previously known as: Ribonucleotide reductase 1; ribonucleotide reductase M1; ribonucleotide reductase M1 (mapped); Rrm1; Rrm1_mapped
Related Functional Gene: Rrm1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21472,177,386 - 72,180,323 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1476,619,065 - 76,622,002 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01477,859,922 - 77,862,859 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01474,299,985 - 74,302,922 (+)NCBIRnor_WKY
Rnor_6.01476,909,379 - 76,912,316 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01476,893,771 - 76,896,708 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41477,408,781 - 77,411,150 (+)ENTREZGENERGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1471,129,676 - 71,132,613 (+)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
leflunomide  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932  


Genomics

Variants

.
Variants in Rrm1-ps1
21 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143999825175582726Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat

Markers in Region
BI279462  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,847,740 - 156,847,913 (+)MAPPERmRatBN7.2
mRatBN7.21472,179,804 - 72,179,977 (+)MAPPERmRatBN7.2
Rnor_6.01476,911,798 - 76,911,970NCBIRnor6.0
Rnor_6.01167,562,167 - 167,562,339NCBIRnor6.0
Rnor_5.01476,896,190 - 76,896,362UniSTSRnor5.0
Rnor_5.01173,750,774 - 173,750,946UniSTSRnor5.0
RGSC_v3.41477,411,056 - 77,411,228UniSTSRGSC3.4
Celera1471,132,095 - 71,132,267UniSTS
Celera1154,914,652 - 154,914,824UniSTS
RH 3.4 Map11275.7UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map14q21UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NG_009757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACYVU010000254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-15394 BioCyc
IMAGE_CLONE IMAGE:7193834 IMAGE-MGC_LOAD
MGC_CLONE MGC:94742 IMAGE-MGC_LOAD
NCBI Gene 365320 ENTREZGENE
PharmGKB RRM1 RGD
PhenoGen Rrm1-ps1 PhenoGen


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-01-26 Rrm1-ps1  ribonucleotide reductase M1, pseudogene 1  Rrm1  ribonucleotide reductase M1  Symbol and Name updated 1299863 APPROVED
2007-04-12   ribonucleotide reductase M1  Rrm1  ribonucleotide reductase M1 (mapped)  Symbol updated 737654 APPROVED
2007-04-12 Rrm1  ribonucleotide reductase M1 (mapped)  Rrm1_mapped  ribonucleotide reductase M1 (mapped)  Data Merged 737654 APPROVED
2006-11-20 Rrm1  ribonucleotide reductase M1 (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Rrm1_mapped  ribonucleotide reductase M1 (mapped)      Symbol and Name updated 1556543 APPROVED
2003-04-09 Rrm1  ribonucleotide reductase M1    Ribonucleotide reductase 1  Name updated 629478 APPROVED
2002-06-10 Rrm1  Ribonucleotide reductase 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process human homolog encodes an enzyme required for production of deoxyribonucleotides prior to DNA synthesis 704405