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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Experimental Liver Cirrhosis | | ISO | RGD:733238 | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:25380136 | |
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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Experimental Liver Cirrhosis | | ISO | RGD:733238 | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:25380136 | |
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# | Reference Title | Reference Citation |
1. | LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalysed phosphorylation at threonine-505. | Amano T, etal., Biochem J 2001 Feb 15;354(Pt 1):149-59. |
2. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
3. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
4. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
5. | Comparison of tissue distribution of two novel serine/threonine kinase genes containing the LIM motif (LIMK-1 and LIMK-2) in the developing rat. | Mori T, etal., Brain Res Mol Brain Res 1997 May;45(2):247-54. |
6. | LIMK-1 and LIMK-2, two members of a LIM motif-containing protein kinase family. | Nunoue K, etal., Oncogene 1995 Aug 17;11(4):701-10. |
7. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
8. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
9. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
10. | Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis. | Rosok O, etal., Genomics 1999 Oct 1;61(1):44-54. |
11. | Cloning and biochemical characterization of LIMK-2, a protein kinase containing two LIM domains. | Smolich B, etal., J Biochem (Tokyo) 1997 Feb;121(2):382-8. |
12. | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
13. | Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2. | Sumi T, etal., J Cell Biol 1999 Dec 27;147(7):1519-32. |
PMID:11784110 | PMID:16399995 | PMID:22328514 | PMID:22405825 | PMID:24561342 | PMID:24962708 | PMID:26234751 | PMID:26438559 | PMID:30870492 |
Limk2 (Rattus norvegicus - Norway rat) |
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LIMK2 (Homo sapiens - human) |
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Limk2 (Mus musculus - house mouse) |
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Limk2 (Chinchilla lanigera - long-tailed chinchilla) |
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LIMK2 (Pan paniscus - bonobo/pygmy chimpanzee) |
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LIMK2 (Canis lupus familiaris - dog) |
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Limk2 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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LIMK2 (Sus scrofa - pig) |
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LIMK2 (Chlorocebus sabaeus - green monkey) |
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Limk2 (Heterocephalus glaber - naked mole-rat) |
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Variants in Limk2
339 total Variants ![]() |
The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
RH127162 |
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AI058790 |
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alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 3 | 26 | 19 | 12 | 11 | 12 | 74 | 30 | 32 | 11 | |||
Low | 17 | 38 | 29 | 8 | 29 | 8 | 11 | 5 | 9 | 8 | |||
Below cutoff |
RefSeq Transcripts | NM_024135 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_006251236 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_008770275 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_008770276 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_008770277 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_008770278 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_008770279 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039091790 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XR_005492924 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XR_005492925 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XR_595861 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AC094950 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AY489563 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC065578 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH473963 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
D31874 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
D31875 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
D31876 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
D31877 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JACYVU010000254 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000026032 ⟹ ENSRNOP00000026032 | ||||||||||||
RefSeq Status: | |||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000050005 ⟹ ENSRNOP00000044951 | ||||||||||||
RefSeq Status: | |||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000057673 ⟹ ENSRNOP00000054482 | ||||||||||||
RefSeq Status: | |||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | NM_024135 ⟹ NP_077049 | ||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_006251236 ⟹ XP_006251298 | ||||||||||||||||
RefSeq Status: | |||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_008770275 ⟹ XP_008768497 | ||||||||||||
RefSeq Status: | |||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_008770276 ⟹ XP_008768498 | ||||||||||||
RefSeq Status: | |||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_008770277 ⟹ XP_008768499 | ||||||||||||
RefSeq Status: | |||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_008770278 ⟹ XP_008768500 | ||||||||||||
RefSeq Status: | |||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_008770279 ⟹ XP_008768501 | ||||||||||||
RefSeq Status: | |||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_039091790 ⟹ XP_038947718 | ||||||||
RefSeq Status: | |||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XR_005492924 | ||||||||
RefSeq Status: | |||||||||
Type: | NON-CODING | ||||||||
Position: |
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RefSeq Acc Id: | XR_005492925 | ||||||||
RefSeq Status: | |||||||||
Type: | NON-CODING | ||||||||
Position: |
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RefSeq Acc Id: | XR_595861 | ||||||||||||
RefSeq Status: | |||||||||||||
Type: | NON-CODING | ||||||||||||
Position: |
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Sequence: |
Protein RefSeqs | NP_077049 | (Get FASTA) | NCBI Sequence Viewer |
XP_006251298 | (Get FASTA) | NCBI Sequence Viewer | |
XP_008768497 | (Get FASTA) | NCBI Sequence Viewer | |
XP_008768498 | (Get FASTA) | NCBI Sequence Viewer | |
XP_008768499 | (Get FASTA) | NCBI Sequence Viewer | |
XP_008768500 | (Get FASTA) | NCBI Sequence Viewer | |
XP_008768501 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038947718 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAH65578 | (Get FASTA) | NCBI Sequence Viewer |
BAA06673 | (Get FASTA) | NCBI Sequence Viewer | |
BAA06674 | (Get FASTA) | NCBI Sequence Viewer | |
BAA06675 | (Get FASTA) | NCBI Sequence Viewer | |
BAA06676 | (Get FASTA) | NCBI Sequence Viewer | |
EDM00166 | (Get FASTA) | NCBI Sequence Viewer | |
EDM00167 | (Get FASTA) | NCBI Sequence Viewer | |
EDM00168 | (Get FASTA) | NCBI Sequence Viewer | |
EDM00169 | (Get FASTA) | NCBI Sequence Viewer | |
EDM00170 | (Get FASTA) | NCBI Sequence Viewer | |
EDM00171 | (Get FASTA) | NCBI Sequence Viewer | |
EDM00172 | (Get FASTA) | NCBI Sequence Viewer | |
EDM00173 | (Get FASTA) | NCBI Sequence Viewer | |
P53670 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_077049 ⟸ NM_024135 |
- UniProtKB: | P53670 (UniProtKB/Swiss-Prot) |
- Sequence: |
RefSeq Acc Id: | XP_006251298 ⟸ XM_006251236 |
- Peptide Label: | isoform X5 |
- UniProtKB: | P53670 (UniProtKB/Swiss-Prot), Q5D047 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_008768497 ⟸ XM_008770275 |
- Peptide Label: | isoform X1 |
- Sequence: |
RefSeq Acc Id: | XP_008768500 ⟸ XM_008770278 |
- Peptide Label: | isoform X3 |
- Sequence: |
RefSeq Acc Id: | XP_008768498 ⟸ XM_008770276 |
- Peptide Label: | isoform X2 |
- Sequence: |
RefSeq Acc Id: | XP_008768499 ⟸ XM_008770277 |
- Peptide Label: | isoform X4 |
- Sequence: |
RefSeq Acc Id: | XP_008768501 ⟸ XM_008770279 |
- Peptide Label: | isoform X6 |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000054482 ⟸ ENSRNOT00000057673 |
RefSeq Acc Id: | ENSRNOP00000026032 ⟸ ENSRNOT00000026032 |
RefSeq Acc Id: | ENSRNOP00000044951 ⟸ ENSRNOT00000050005 |
RefSeq Acc Id: | XP_038947718 ⟸ XM_039091790 |
- Peptide Label: | isoform X7 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-P53670-F1-model_v2 | AlphaFold | P53670 | 1-638 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13699443 | ||||||||
Promoter ID: | EPDNEW_R9948 | ||||||||
Type: | initiation region | ||||||||
Name: | Limk2_1 | ||||||||
Description: | LIM domain kinase 2 | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Alternative Promoters: | null; see alsoEPDNEW_R9949 | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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RGD ID: | 13699424 | ||||||||
Promoter ID: | EPDNEW_R9949 | ||||||||
Type: | initiation region | ||||||||
Name: | Limk2_2 | ||||||||
Description: | LIM domain kinase 2 | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Alternative Promoters: | null; see alsoEPDNEW_R9948 | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:62056 | AgrOrtholog |
BioCyc Gene | G2FUF-15229 | BioCyc |
Ensembl Genes | ENSRNOG00000019000 | Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Ensembl Protein | ENSRNOP00000026032 | ENTREZGENE |
ENSRNOP00000026032.3 | UniProtKB/Swiss-Prot | |
ENSRNOP00000044951 | ENTREZGENE | |
ENSRNOP00000044951.2 | UniProtKB/TrEMBL | |
ENSRNOP00000054482.4 | UniProtKB/TrEMBL | |
Ensembl Transcript | ENSRNOT00000026032 | ENTREZGENE |
ENSRNOT00000026032.7 | UniProtKB/Swiss-Prot | |
ENSRNOT00000050005 | ENTREZGENE | |
ENSRNOT00000050005.4 | UniProtKB/TrEMBL | |
ENSRNOT00000057673.4 | UniProtKB/TrEMBL | |
Gene3D-CATH | 2.30.42.10 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Cysteine Rich Protein | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Transferase(Phosphotransferase) domain 1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
IMAGE_CLONE | IMAGE:5623751 | IMAGE-MGC_LOAD |
InterPro | Kinase-like_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PDZ | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PDZ_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Prot_kinase_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Protein_kinase_ATP_BS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Ser-Thr/Tyr_kinase_cat_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Znf_LIM | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:29524 | UniProtKB/Swiss-Prot |
MGC_CLONE | MGC:72430 | IMAGE-MGC_LOAD |
NCBI Gene | 29524 | ENTREZGENE |
PANTHER | LIM DOMAIN KINASE 1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
LIM DOMAIN KINASE 2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | LIM | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PDZ | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pkinase_Tyr | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PhenoGen | Limk2 | PhenoGen |
PROSITE | LIM_DOMAIN_1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
LIM_DOMAIN_2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PDZ | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PROTEIN_KINASE_ATP | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PROTEIN_KINASE_DOM | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SMART | LIM | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PDZ | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Superfamily-SCOP | Glucocorticoid receptor-like (DNA-binding domain) | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
SSF50156 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SSF56112 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
UniProt | A0A8L2QN67_RAT | UniProtKB/TrEMBL |
A0A8L2QS45_RAT | UniProtKB/TrEMBL | |
LIMK2_RAT | UniProtKB/Swiss-Prot, ENTREZGENE | |
Q5D047 | ENTREZGENE, UniProtKB/TrEMBL |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
---|---|---|---|---|---|---|---|
2008-10-30 | Limk2 | LIM domain kinase 2 | Limk2 | LIM motif-containing protein kinase 2 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2002-06-10 | Limk2 | LIM motif-containing protein kinase 2 | Name updated | 70584 | APPROVED |
Note Type | Note | Reference |
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gene_domains | contains two repeats of the LIM motif at the N-terminus and a protein kinase consensus sequence at the C-terminus | 61653 |
gene_transcript | has several alternative splicing forms | 61653 |