Limk2 (LIM domain kinase 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Limk2 (LIM domain kinase 2) Rattus norvegicus
Analyze
Symbol: Limk2
Name: LIM domain kinase 2
RGD ID: 62056
Description: Enables protein serine/threonine kinase activity. Predicted to be involved in several processes, including cytoskeleton organization; negative regulation of cilium assembly; and positive regulation of protein localization to nucleus. Predicted to act upstream of or within cornea development in camera-type eye; head development; and spermatogenesis. Predicted to be located in centrosome; cis-Golgi network; and mitotic spindle. Predicted to be active in cytoplasm and nucleus. Orthologous to human LIMK2 (LIM domain kinase 2); PARTICIPATES IN Rho/Rac/Cdc42 mediated signaling pathway; Fc gamma receptor mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LIM motif-containing protein kinase 2; LIMK-2; Limk2b; Link2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81482,384,256 - 82,509,755 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1482,435,480 - 82,509,644 (-)EnsemblGRCr8
mRatBN7.21478,208,182 - 78,286,106 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1478,218,063 - 78,286,007 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1482,659,036 - 82,727,030 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01483,899,150 - 83,967,131 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01480,344,888 - 80,412,888 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01483,564,048 - 83,641,996 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1483,573,928 - 83,641,892 (-)Ensemblrn6Rnor6.0
Rnor_5.01484,253,114 - 84,330,159 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41483,969,282 - 84,037,218 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1477,131,523 - 77,199,230 (-)NCBICelera
RGSC_v3.11483,988,426 - 84,056,363 (-)NCBI
Cytogenetic Map14q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (EXP)
CGP 52608  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fasudil  (EXP)
flutamide  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
genistein  (ISO)
leflunomide  (EXP,ISO)
lidocaine  (EXP)
maneb  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-nitrosodimethylamine  (EXP)
naled  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
Sanggenon C  (EXP)
sevoflurane  (EXP)
sodium arsenite  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
tauroursodeoxycholic acid  (EXP)
testosterone  (ISO)
testosterone enanthate  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
undecane  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
Y-27632  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (IEA,ISO,ISS)
cis-Golgi network  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
cytosol  (TAS)
mitotic spindle  (IEA,ISO,ISS)
nucleus  (IBA,IEA,ISO)
perinuclear region of cytoplasm  (IEA)
spindle  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalysed phosphorylation at threonine-505. Amano T, etal., Biochem J 2001 Feb 15;354(Pt 1):149-59.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Comparison of tissue distribution of two novel serine/threonine kinase genes containing the LIM motif (LIMK-1 and LIMK-2) in the developing rat. Mori T, etal., Brain Res Mol Brain Res 1997 May;45(2):247-54.
6. LIMK-1 and LIMK-2, two members of a LIM motif-containing protein kinase family. Nunoue K, etal., Oncogene 1995 Aug 17;11(4):701-10.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis. Rosok O, etal., Genomics 1999 Oct 1;61(1):44-54.
11. Cloning and biochemical characterization of LIMK-2, a protein kinase containing two LIM domains. Smolich B, etal., J Biochem (Tokyo) 1997 Feb;121(2):382-8.
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2. Sumi T, etal., J Cell Biol 1999 Dec 27;147(7):1519-32.
Additional References at PubMed
PMID:11784110   PMID:16399995   PMID:22328514   PMID:22405825   PMID:24561342   PMID:24962708   PMID:26234751   PMID:26438559   PMID:30870492  


Genomics

Comparative Map Data
Limk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81482,384,256 - 82,509,755 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1482,435,480 - 82,509,644 (-)EnsemblGRCr8
mRatBN7.21478,208,182 - 78,286,106 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1478,218,063 - 78,286,007 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1482,659,036 - 82,727,030 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01483,899,150 - 83,967,131 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01480,344,888 - 80,412,888 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01483,564,048 - 83,641,996 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1483,573,928 - 83,641,892 (-)Ensemblrn6Rnor6.0
Rnor_5.01484,253,114 - 84,330,159 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41483,969,282 - 84,037,218 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1477,131,523 - 77,199,230 (-)NCBICelera
RGSC_v3.11483,988,426 - 84,056,363 (-)NCBI
Cytogenetic Map14q21NCBI
LIMK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382231,212,298 - 31,280,080 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2231,212,193 - 31,280,964 (+)Ensemblhg38GRCh38
GRCh372231,608,284 - 31,676,066 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362229,938,250 - 30,006,066 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342229,968,941 - 30,000,618NCBI
Celera2215,408,353 - 15,476,551 (+)NCBICelera
Cytogenetic Map22q12.2NCBI
HuRef2214,569,980 - 14,637,678 (+)NCBIHuRef
CHM1_12231,568,095 - 31,635,881 (+)NCBICHM1_1
T2T-CHM13v2.02231,675,859 - 31,744,063 (+)NCBIT2T-CHM13v2.0
Limk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39113,293,297 - 3,359,238 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl113,294,256 - 3,359,189 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38113,343,297 - 3,409,276 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl113,344,256 - 3,409,189 (-)Ensemblmm10GRCm38
MGSCv37113,243,300 - 3,309,238 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36113,243,300 - 3,309,238 (-)NCBIMGSCv36mm8
Celera113,834,265 - 3,899,342 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.34NCBI
Limk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554555,405,940 - 5,473,418 (+)Ensembl
ChiLan1.0NW_0049554555,406,085 - 5,473,418 (+)NCBIChiLan1.0ChiLan1.0
LIMK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22341,167,317 - 41,235,837 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12243,865,862 - 43,934,307 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02212,235,611 - 12,304,013 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12230,071,574 - 30,139,821 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2230,071,574 - 30,139,821 (+)EnsemblpanPan2panpan1.1
LIMK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12624,182,595 - 24,242,429 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2624,146,005 - 24,240,653 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2624,052,624 - 24,112,447 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02624,565,985 - 24,625,824 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2624,527,922 - 24,624,066 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12624,269,022 - 24,329,024 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02624,530,984 - 24,590,898 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02624,592,678 - 24,652,526 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Limk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118117,116,743 - 117,185,723 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936755374,235 - 443,223 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936755374,279 - 443,255 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIMK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1447,983,975 - 48,040,821 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11447,983,984 - 48,039,631 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21451,094,927 - 51,150,601 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LIMK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11914,101,051 - 14,168,210 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1914,101,054 - 14,166,570 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666045111,949,015 - 112,016,137 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Limk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247477,700,411 - 7,766,713 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247477,700,996 - 7,766,713 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Limk2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11172,338,612 - 72,405,941 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Limk2
1214 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:409
Count of miRNA genes:172
Interacting mature miRNAs:202
Transcripts:ENSRNOT00000026032, ENSRNOT00000050005, ENSRNOT00000057673
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143802371083023710Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1477914838104348525Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143900944484009444Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)147297021087582095Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147764007196755654Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143802371083023710Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1477640071100078267Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147764007196755654Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143802371083023710Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)146592028399224555Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143941117087582095Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143802371083023710Rat

Markers in Region
RH127162  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21478,218,067 - 78,218,316 (+)MAPPERmRatBN7.2
Rnor_6.01483,573,933 - 83,574,181NCBIRnor6.0
Rnor_5.01484,262,205 - 84,262,453UniSTSRnor5.0
RGSC_v3.41483,969,287 - 83,969,535UniSTSRGSC3.4
Celera1477,131,528 - 77,131,776UniSTS
Cytogenetic Map14q21UniSTS
AI058790  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21478,218,082 - 78,218,191 (+)MAPPERmRatBN7.2
Rnor_6.01483,573,948 - 83,574,056NCBIRnor6.0
Rnor_5.01484,262,220 - 84,262,328UniSTSRnor5.0
RGSC_v3.41483,969,302 - 83,969,410UniSTSRGSC3.4
Celera1477,131,543 - 77,131,651UniSTS
RH 3.4 Map14532.3UniSTS
Cytogenetic Map14q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_024135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010057356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010057358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010057359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010057360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010057361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_595861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC094950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY489563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC065578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D31874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D31875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D31876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D31877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000026032   ⟹   ENSRNOP00000026032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1482,441,708 - 82,509,644 (-)Ensembl
mRatBN7.2 Ensembl1478,218,063 - 78,286,007 (-)Ensembl
Rnor_6.0 Ensembl1483,573,928 - 83,641,892 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000050005   ⟹   ENSRNOP00000044951
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1482,441,708 - 82,470,827 (-)Ensembl
mRatBN7.2 Ensembl1478,218,063 - 78,247,186 (-)Ensembl
Rnor_6.0 Ensembl1483,573,931 - 83,603,003 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000057673   ⟹   ENSRNOP00000054482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1482,441,708 - 82,509,644 (-)Ensembl
mRatBN7.2 Ensembl1478,218,063 - 78,271,530 (-)Ensembl
Rnor_6.0 Ensembl1483,573,928 - 83,603,047 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000123429   ⟹   ENSRNOP00000108912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1482,441,708 - 82,470,827 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000139208   ⟹   ENSRNOP00000106502
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1482,435,480 - 82,470,827 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000163662   ⟹   ENSRNOP00000109319
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1482,441,708 - 82,483,909 (-)Ensembl
RefSeq Acc Id: NM_024135   ⟹   NP_077049
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81482,441,708 - 82,509,644 (-)NCBI
mRatBN7.21478,218,063 - 78,286,007 (-)NCBI
Rnor_6.01483,573,928 - 83,641,892 (-)NCBI
Rnor_5.01484,253,114 - 84,330,159 (-)NCBI
RGSC_v3.41483,969,282 - 84,037,218 (-)RGD
Celera1477,131,523 - 77,199,230 (-)RGD
Sequence:
RefSeq Acc Id: XM_006251236   ⟹   XP_006251298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81482,441,706 - 82,470,861 (-)NCBI
mRatBN7.21478,218,061 - 78,247,219 (-)NCBI
Rnor_6.01483,573,926 - 83,604,140 (-)NCBI
Rnor_5.01484,253,114 - 84,330,159 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008770279   ⟹   XP_008768501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81482,444,779 - 82,509,755 (-)NCBI
mRatBN7.21478,221,134 - 78,286,104 (-)NCBI
Rnor_6.01483,576,999 - 83,641,995 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063272999   ⟹   XP_063129069
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81482,441,706 - 82,470,860 (-)NCBI
RefSeq Acc Id: XM_063273001   ⟹   XP_063129071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81482,451,068 - 82,509,755 (-)NCBI
RefSeq Acc Id: XM_063273002   ⟹   XP_063129072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81482,451,068 - 82,470,872 (-)NCBI
RefSeq Acc Id: XR_010057356
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81482,384,256 - 82,470,877 (-)NCBI
RefSeq Acc Id: XR_010057358
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81482,384,256 - 82,473,048 (-)NCBI
RefSeq Acc Id: XR_010057359
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81482,384,256 - 82,509,755 (-)NCBI
RefSeq Acc Id: XR_010057360
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81482,384,256 - 82,470,873 (-)NCBI
RefSeq Acc Id: XR_010057361
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81482,384,256 - 82,457,422 (-)NCBI
RefSeq Acc Id: XR_595861
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81482,384,256 - 82,509,755 (-)NCBI
mRatBN7.21478,208,182 - 78,286,105 (-)NCBI
Rnor_6.01483,564,048 - 83,641,996 (-)NCBI
Sequence:
RefSeq Acc Id: NP_077049   ⟸   NM_024135
- UniProtKB: P53670 (UniProtKB/Swiss-Prot),   A6IKA2 (UniProtKB/TrEMBL),   A0A8L2QS45 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251298   ⟸   XM_006251236
- Peptide Label: isoform X2
- UniProtKB: Q5D047 (UniProtKB/TrEMBL),   A0A8L2QN67 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768501   ⟸   XM_008770279
- Peptide Label: isoform X3
- UniProtKB: A0A8L2QS45 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054482   ⟸   ENSRNOT00000057673
Ensembl Acc Id: ENSRNOP00000026032   ⟸   ENSRNOT00000026032
Ensembl Acc Id: ENSRNOP00000044951   ⟸   ENSRNOT00000050005
RefSeq Acc Id: XP_063129069   ⟸   XM_063272999
- Peptide Label: isoform X1
- UniProtKB: A6IKA4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129071   ⟸   XM_063273001
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063129072   ⟸   XM_063273002
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000108912   ⟸   ENSRNOT00000123429
Ensembl Acc Id: ENSRNOP00000109319   ⟸   ENSRNOT00000163662
Ensembl Acc Id: ENSRNOP00000106502   ⟸   ENSRNOT00000139208
Protein Domains
LIM zinc-binding   PDZ   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P53670-F1-model_v2 AlphaFold P53670 1-638 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699443
Promoter ID:EPDNEW_R9948
Type:initiation region
Name:Limk2_1
Description:LIM domain kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9949  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01483,603,015 - 83,603,075EPDNEW
RGD ID:13699424
Promoter ID:EPDNEW_R9949
Type:initiation region
Name:Limk2_2
Description:LIM domain kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9948  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01483,641,951 - 83,642,011EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62056 AgrOrtholog
BioCyc Gene G2FUF-15229 BioCyc
Ensembl Genes ENSRNOG00000019000 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026032 ENTREZGENE
  ENSRNOT00000026032.7 UniProtKB/Swiss-Prot
  ENSRNOT00000123429 ENTREZGENE
  ENSRNOT00000163662 ENTREZGENE
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot
  Cysteine Rich Protein UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5623751 IMAGE-MGC_LOAD
InterPro Actin_reg-Ser/Thr_kinase UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Znf_LIM UniProtKB/Swiss-Prot
KEGG Report rno:29524 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72430 IMAGE-MGC_LOAD
NCBI Gene 29524 ENTREZGENE
PANTHER LIM DOMAIN KINASE 1 UniProtKB/Swiss-Prot
  LIM DOMAIN KINASE 2 UniProtKB/Swiss-Prot
Pfam LIM UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  Pkinase_Tyr UniProtKB/Swiss-Prot
PhenoGen Limk2 PhenoGen
PROSITE LIM_DOMAIN_1 UniProtKB/Swiss-Prot
  LIM_DOMAIN_2 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019000 RatGTEx
SMART LIM UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
  SSF50156 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8L2QN67 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QS45 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LL93_RAT UniProtKB/TrEMBL
  A0ABK0M1N5_RAT UniProtKB/TrEMBL
  A0ABK0M2E4_RAT UniProtKB/TrEMBL
  A6IKA2 ENTREZGENE, UniProtKB/TrEMBL
  A6IKA4 ENTREZGENE, UniProtKB/TrEMBL
  A6IKA5_RAT UniProtKB/TrEMBL
  A6IKA7_RAT UniProtKB/TrEMBL
  A6IKA8_RAT UniProtKB/TrEMBL
  A6IKA9_RAT UniProtKB/TrEMBL
  LIMK2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5D047 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-30 Limk2  LIM domain kinase 2  Limk2  LIM motif-containing protein kinase 2   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Limk2  LIM motif-containing protein kinase 2       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains two repeats of the LIM motif at the N-terminus and a protein kinase consensus sequence at the C-terminus 61653
gene_transcript has several alternative splicing forms 61653