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Strain Registration

Strain: BN/SsNHsd

Symbol: BN/SsNHsd
Strain: BN
Substrain: SsNHsd
RGD ID: 10008
Citation ID: RRID:RGD_10008
Ontology ID: RS:0000155
Also Known As: BN (22); MDC-03-30
Type: inbred
Available Source: Harlan
Description: Obtained by HSD from nucleus colony at NIH
Last Known Status: Unknown






  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
BN/SsNHsdRatBreast Neoplasms MODEL: controlIAGP17 beta-estradiol1642522 RGD 
BN/SsNHsdRatIntimal Hyperplasia inducesIAGPballoon angioplasty39456133compared to SHRRGD 

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
BN/SsNHsdRatbroad femur neck  IAGP 6480192compared to females of BN/SsNHsd more ...RGD 
BN/SsNHsdRatdecreased bone mineral content  IAGP 6480192compared to female NAft:HSRGD 
BN/SsNHsdRatdecreased epididymal fat pad weight  IAGP 38548922compared to BUF/NHsd more ...RGD 
BN/SsNHsdRatdecreased pituitary gland weight inducedIAGP17 beta-estradiol1642526compared to treated ACI/SegHsdRGD 
BN/SsNHsdRatdecreased pituitary gland weight  IAGP 1642526compared to ACI/SegHsdRGD 
BN/SsNHsdRatdecreased retroperitoneal fat pad weight  IAGP 38548922compared to BUF/NHsd more ...RGD 
BN/SsNHsdRatdecreased vasoconstriction  IAGP 2316923compared to SHR/NHsd and congenicsRGD 
BN/SsNHsdRatincreased capillary density inducedIAGPdiethylstilbestrol1300042in pituitary glandRGD 
BN/SsNHsdRatincreased insulin sensitivity  IAGP 6893578 RGD 
BN/SsNHsdRatincreased lactotroph cell number inducedIAGPdiethylstilbestrol1300042 RGD 
BN/SsNHsdRatincreased pituitary gland weight inducedIAGP17 beta-estradiol1642526compared to BN/SsNHsdRGD 
BN/SsNHsdRatpituitary gland hyperplasia inducedIAGPdiethylstilbestrol1300042 RGD 
BN/SsNHsdRatshort femur  IAGP 6480192compared to female ACI/NRGD 
1 to 13 of 13 rows

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
BN/SsNHsdRatBN/SsNHsd  IEA 7241799 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
BN/SsNHsdRataorta morphology trait  EXP 727992 RGD 
BN/SsNHsdRatarterial blood pressure trait  EXP 70849 RGD 
BN/SsNHsdRatarterial blood pressure trait  EXP 727992 RGD 
BN/SsNHsdRatartery morphology trait  EXP 1578306 RGD 
BN/SsNHsdRatblood cholesterol amount  EXP 70849 RGD 
BN/SsNHsdRatblood cholesterol amount  EXP 619669 RGD 
BN/SsNHsdRatblood creatinine amount  EXP 727992 RGD 
BN/SsNHsdRatblood HDL cholesterol amount  EXP 70849 RGD 
BN/SsNHsdRatblood renin amount  EXP 727992 RGD 
BN/SsNHsdRatblood triglyceride amount  EXP 727992 RGD 
BN/SsNHsdRatblood triglyceride amount  EXP 619669 RGD 
BN/SsNHsdRatbody mass  EXP 727992 RGD 
BN/SsNHsdRatbody mass  EXP 70849 RGD 
BN/SsNHsdRatheart mass  EXP 70849 RGD 
BN/SsNHsdRatheart mass  EXP 727992 RGD 
BN/SsNHsdRatheart pumping trait  EXP 70849 RGD 
BN/SsNHsdRatheart pumping trait  EXP 727992 RGD 
BN/SsNHsdRatjoint integrity trait  EXP 631168 RGD 
BN/SsNHsdRatkidney blood vessel physiology trait  EXP 70849 RGD 
BN/SsNHsdRatkidney development trait  EXP 1580355 RGD 
BN/SsNHsdRatkidney glomerulus integrity trait  EXP 727992 RGD 
BN/SsNHsdRatkidney mass  EXP 70849 RGD 
BN/SsNHsdRatkidney mass  EXP 727992 RGD 
BN/SsNHsdRatleukocyte quantity  EXP 70849 RGD 
BN/SsNHsdRatleukocyte quantity  EXP 727992 RGD 
BN/SsNHsdRatliver integrity trait  EXP 619598 RGD 
BN/SsNHsdRatmammary gland integrity trait  EXP 1642522 RGD 
BN/SsNHsdRatpituitary gland mass  EXP 61074 RGD 
BN/SsNHsdRatpituitary gland mass  EXP 1642526 RGD 
BN/SsNHsdRatpituitary gland mass  EXP 629550 RGD 
BN/SsNHsdRatprepulse inhibition trait  EXP 629579 RGD 
BN/SsNHsdRatrenal blood flow trait  EXP 727992 RGD 
BN/SsNHsdRatrenin activity  EXP 70849 RGD 
BN/SsNHsdRatthymus mass  EXP 1579780 RGD 
BN/SsNHsdRaturine creatinine amount  EXP 727992 RGD 
BN/SsNHsdRaturine output  EXP 727992 RGD 
BN/SsNHsdRaturine output  EXP 70849 RGD 
BN/SsNHsdRaturine potassium amount  EXP 727992 RGD 
BN/SsNHsdRaturine potassium amount  EXP 70849 RGD 
BN/SsNHsdRaturine sodium amount  EXP 70849 RGD 
BN/SsNHsdRaturine total protein amount  EXP 70849 RGD 
BN/SsNHsdRatuterus integrity trait  EXP 1559292 RGD 

Related Phenotype Data for Term "BN/SsNHsd" (RS:0000155)

Rat Strains:
Clinical Measurements:
Experimental Conditions:
Measurement Methods:

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Reference Title
Reference Citation
1. Heterogeneous stock rat: a unique animal model for mapping genes influencing bone fragility. Alam I, etal., Bone. 2011 May 1;48(5):1169-77. Epub 2011 Feb 18.
2. Strain differences in neointimal hyperplasia in the rat. Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252.
3. Identification of genetic loci controlling hepatocarcinogenesis on rat chromosomes 7 and 10. De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7.
4. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
5. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
6. Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats. Garrett MR, etal., Genome Res 1998 Jul;8(7):711-23
7. Genetic mapping of Eutr1, a locus controlling E2-induced pyometritis in the Brown Norway rat, to RNO5. Gould KA, etal., Mamm Genome. 2005 Nov;16(11):854-64. Epub 2005 Nov 11.
8. Genetic mapping of loci controlling diethylstilbestrol-induced thymic atrophy in the Brown Norway rat. Gould KA, etal., Mamm Genome. 2006 May;17(5):451-64.
9. Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1. Gu L, etal., J Clin Invest 1996 Feb 1;97(3):777-88
10. Genetic dissection of collagen-induced arthritis in Chromosome 10 quantitative trait locus speed congenic rats: evidence for more than one regulatory locus and sex influences. Joe B, etal., Immunogenetics 2000 Sep;51(11):930-44.
11. Genetic Fine-Mapping and Identification of Candidate Genes and Variants for Adiposity Traits in Outbred Rats. Keele GR, etal., Obesity (Silver Spring). 2018 Jan;26(1):213-222. doi: 10.1002/oby.22075. Epub 2017 Nov 28.
12. A set of highly informative rat simple sequence length polymorphism (SSLP) markers and genetically defined rat strains. Mashimo T, etal., BMC Genet. 2006 Apr 4;7:19.
13. Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats. Moreno C, etal., Physiol Genomics 2003 Nov 11;15(3):243-57. Epub 2003 Oct 07.
14. Linkage Analysis of Neointimal Hyperplasia and Vascular Wall Transformation Following Balloon Angioplasty. Nestor AL, etal., Physiol Genomics. 2006 Jan 24;.
15. Neointimal hyperplasia and vasoreactivity are controlled by genetic elements on rat chromosome 3. Nestor Kalinoski AL, etal., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21.
16. Identification of quantitative trait loci for prepulse inhibition in rats. Palmer AA, etal., Psychopharmacology (Berl) 2003 Jan;165(3):270-9.
17. The Edpm5 locus prevents the "angiogenic switch" in an estrogen-induced rat pituitary tumor. Pandey J, etal., Carcinogenesis 2004 May 27;.
18. Strains registered by Harlan Laboratories, Inc. Personal communication with Harlan Laboratories
19. RGD Strain RSO annotation pipeline RGD Automated Pipelines
20. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
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1 to 20 of 190 rows
Symbol
Name
Trait
Bp170 Blood pressure QTL 170 arterial blood pressure trait   (VT:2000000)    
Bp171 Blood pressure QTL 171 arterial blood pressure trait   (VT:2000000)    
Bp172 Blood pressure QTL 172 arterial blood pressure trait   (VT:2000000)    
Bp173 Blood pressure QTL 173 arterial blood pressure trait   (VT:2000000)    
Bp174 Blood pressure QTL 174 arterial blood pressure trait   (VT:2000000)    
Bp175 Blood pressure QTL 175 arterial blood pressure trait   (VT:2000000)    
Bp176 Blood pressure QTL 176 arterial blood pressure trait   (VT:2000000)    
Bp177 Blood pressure QTL 177 arterial blood pressure trait   (VT:2000000)    
Bp178 Blood pressure QTL 178 arterial blood pressure trait   (VT:2000000)    
Bp179 Blood pressure QTL 179 arterial blood pressure trait   (VT:2000000)    
Bp180 Blood pressure QTL 180 arterial blood pressure trait   (VT:2000000)    
Bp181 Blood pressure QTL 181 arterial blood pressure trait   (VT:2000000)    
Bp182 Blood pressure QTL 182 arterial blood pressure trait   (VT:2000000)    
Bp183 Blood pressure QTL 183 arterial blood pressure trait   (VT:2000000)    
Bp184 Blood pressure QTL 184 arterial blood pressure trait   (VT:2000000)    
Bp185 Blood pressure QTL 185 arterial blood pressure trait   (VT:2000000)    
Bp186 Blood pressure QTL 186 arterial blood pressure trait   (VT:2000000)    
Bp187 Blood pressure QTL 187 arterial blood pressure trait   (VT:2000000)    
Bp188 Blood pressure QTL 188 arterial blood pressure trait   (VT:2000000)    
Bp189 Blood pressure QTL 189 arterial blood pressure trait   (VT:2000000)    
1 to 20 of 190 rows


Note Type Note Reference
strain_behavior Displays a very low level of prepulse inhibition (PPI), which is the inhibitory modulation of a startle response that occurs when a weak stimulus is presented immediately prior to a strong startle stimulus 629579
strain_behavior Displays a very low level of prepulse inhibition (PPI), which is the inhibitory modulation of a startle response that occurs when a weak stimulus is presented immediately prior to a strong startle stimulus 629579
strain_drgs_chems These are insensitive to estrogen induced pituitary tumors; DES induces only 1.9 fold increase in pituitary weight. 1358974
strain_drgs_chems sensitive to thymic atrophy induced by the estrogen diethylstilbestrol (DES) 1579780
strain_drgs_chems displays a control of pituitary response to chronic estrogen stimulation characterized by a lack of excessive pituitary growth or pituitary tumor formation. 629581
strain_drgs_chems No significant difference was noticed in the pituitary mass of rats which were given subcutaneous implants of diethlystilbestrol (DES). 61074
strain_life_disease Susceptible to estrogen-induced uterine inflammation and infection (pyometritis) 1559292
strain_other Harlan plans to eliminate this strain, this will no longer be bred and available from Harlan Laboratories Inc. Targeted elimination and cryopreservation date is December 31, 2011. The research community should be able to purchase these from Harlan UK. 5508209