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Strain: BN/SsNHsd

Symbol: BN/SsNHsd
Strain: BN
Substrain: SsNHsd
RGD ID: 10008
RRID: RGD_10008
Ontology ID: RS:0000155
Also known as: BN (22); MDC-03-30
Type: inbred
Source: Harlan
Origin: Obtained by HSD from nucleus colony at NIH
Last Known Status: Unknown





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Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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Clinical Measurement
heart rate
systolic blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
timed urine volume
mean corpuscular hemoglobin level
mean corpuscular hemoglobin concentration
mammary tumor number
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
plasma creatinine level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
absolute change in thymus weight
both adrenal glands weight to body weight ratio
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
pituitary gland wet weight
thymus wet weight
both testes wet weight to body weight ratio
percentage of study population developing unilateral renal agenesis during a period of time
percentage of study population developing mammary tumors during a period of time
liver tumorous lesion number
volume of individual liver tumorous lesion
volume of liver occupied by tumorous lesions as percentage of total liver volume
artery lumen area
artery tunica media area
artery tunica media thickness
artery neointimal hyperplastic lesion area
artery neointimal hyperplastic lesion area to total wall area ratio
lesioned artery residual lumen area
percentage of study population developing pituitary tumors that replace the entire gland during a period of time
percentage of study population developing pituitary tumors that replace a portion of the gland during a period of time
percentage of study population developing pituitary tumors that invade the glandular capsule during a period of time
percentage of study population developing pituitary gland hyperplastic lesions during a period of time
urine sodium excretion rate to body weight ratio
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
binary logarithm of pituitary gland wet weight
total plasma bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio
hepatocellular carcinoma tumor number
percentage of study population developing hepatocellular carcinoma during a period of time
artery neointimal hyperplastic lesion area including tunica media
circular vessel area

References

References - curated
1. Alam I, etal., Bone. 2011 May 1;48(5):1169-77. Epub 2011 Feb 18.
2. Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252.
3. De Miglio MR, et al., Cancer Res 1999 Sep 15;59(18):4651-7.
4. Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
5. Festing, MFW, Personal Communication Update, Feb-2000
6. Garrett MR, etal., Genome Res 1998 Jul;8(7):711-23
7. Gould KA, etal., Mamm Genome. 2005 Nov;16(11):854-64. Epub 2005 Nov 11.
8. Gould KA, etal., Mamm Genome. 2006 May;17(5):451-64.
9. Gu L, etal., J Clin Invest 1996 Feb 1;97(3):777-88
10. Joe B, etal., Immunogenetics 2000 Sep;51(11):930-44.
11. Keele GR, etal., Obesity (Silver Spring). 2018 Jan;26(1):213-222. doi: 10.1002/oby.22075. Epub 2017 Nov 28.
12. Mashimo T, etal., BMC Genet. 2006 Apr 4;7:19.
13. Nestor Kalinoski AL, etal., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21.
14. Palmer AA, etal., Psychopharmacology (Berl) 2003 Jan;165(3):270-9.
15. Pandey J, etal., Carcinogenesis 2004 May 27;.
16. Personal communication with Harlan Laboratories
17. RGD Automated Pipelines
18. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
19. Schaffer BS, etal., Cancer Res. 2006 Aug 1;66(15):7793-800.
20. Shull JD, etal., Mamm Genome. 2006 Jul;17(7):751-9. Epub 2006 Jul 14.
21. Shull JD, etal., Mamm Genome. 2007 Sep 18;.
22. Solberg Woods LC, etal., Physiol Genomics. 2012 Sep 4.
23. Stoll M, etal., Science 2001 Nov 23;294(5547):1723-6.
24. Wendell DL and Gorski J, Mamm Genome 1997;8(11):823-9
25. Wendell DL, etal., Mamm Genome 2002 Nov;13(11):664-6.

Region

Strain QTL Data
Symbol Name Trait
Bp170 Blood pressure QTL 170 arterial blood pressure trait   (VT:2000000)    
Bp171 Blood pressure QTL 171 arterial blood pressure trait   (VT:2000000)    
Bp172 Blood pressure QTL 172 arterial blood pressure trait   (VT:2000000)    
Bp173 Blood pressure QTL 173 arterial blood pressure trait   (VT:2000000)    
Bp174 Blood pressure QTL 174 arterial blood pressure trait   (VT:2000000)    
Bp175 Blood pressure QTL 175 arterial blood pressure trait   (VT:2000000)    
Bp176 Blood pressure QTL 176 arterial blood pressure trait   (VT:2000000)    
Bp177 Blood pressure QTL 177 arterial blood pressure trait   (VT:2000000)    
Bp178 Blood pressure QTL 178 arterial blood pressure trait   (VT:2000000)    
Bp179 Blood pressure QTL 179 arterial blood pressure trait   (VT:2000000)    
Bp180 Blood pressure QTL 180 arterial blood pressure trait   (VT:2000000)    
Bp181 Blood pressure QTL 181 arterial blood pressure trait   (VT:2000000)    
Bp182 Blood pressure QTL 182 arterial blood pressure trait   (VT:2000000)    
Bp183 Blood pressure QTL 183 arterial blood pressure trait   (VT:2000000)    
Bp184 Blood pressure QTL 184 arterial blood pressure trait   (VT:2000000)    
Bp185 Blood pressure QTL 185 arterial blood pressure trait   (VT:2000000)    
Bp186 Blood pressure QTL 186 arterial blood pressure trait   (VT:2000000)    
Bp187 Blood pressure QTL 187 arterial blood pressure trait   (VT:2000000)    
Bp188 Blood pressure QTL 188 arterial blood pressure trait   (VT:2000000)    
Bp189 Blood pressure QTL 189 arterial blood pressure trait   (VT:2000000)    
Bp190 Blood pressure QTL 190 arterial blood pressure trait   (VT:2000000)    
Bp191 Blood pressure QTL 191 arterial blood pressure trait   (VT:2000000)    
Bp192 Blood pressure QTL 192 arterial blood pressure trait   (VT:2000000)    
Bp193 Blood pressure QTL 193 arterial blood pressure trait   (VT:2000000)    
Bp194 Blood pressure QTL 194 arterial blood pressure trait   (VT:2000000)    
Bp195 Blood pressure QTL 195 arterial blood pressure trait   (VT:2000000)    
Bp199 Blood pressure QTL 199 arterial blood pressure trait   (VT:2000000)    
Bp200 Blood pressure QTL 200 arterial blood pressure trait   (VT:2000000)    
Bp201 Blood pressure QTL 201 arterial blood pressure trait   (VT:2000000)    
Bp202 Blood pressure QTL 202 arterial blood pressure trait   (VT:2000000)    
Bp203 Blood pressure QTL 203 arterial blood pressure trait   (VT:2000000)    
Bp204 Blood pressure QTL 204 arterial blood pressure trait   (VT:2000000)    
Bp205 Blood pressure QTL 205 arterial blood pressure trait   (VT:2000000)    
Bp206 Blood pressure QTL 206 arterial blood pressure trait   (VT:2000000)    
Bp207 Blood pressure QTL 207 arterial blood pressure trait   (VT:2000000)    
Bp208 Blood pressure QTL 208 arterial blood pressure trait   (VT:2000000)    
Bp209 Blood pressure QTL 209 arterial blood pressure trait   (VT:2000000)    
Bp210 Blood pressure QTL 210 arterial blood pressure trait   (VT:2000000)    
Bp211 Blood pressure QTL 211 arterial blood pressure trait   (VT:2000000)    
Bp212 Blood pressure QTL 212 arterial blood pressure trait   (VT:2000000)    
Bp213 Blood pressure QTL 213 arterial blood pressure trait   (VT:2000000)    
Bp214 Blood pressure QTL 214 arterial blood pressure trait   (VT:2000000)    
Bp215 Blood pressure QTL 215 arterial blood pressure trait   (VT:2000000)    
Bp216 Blood pressure QTL 216 arterial blood pressure trait   (VT:2000000)    
Bp217 Blood pressure QTL 217 arterial blood pressure trait   (VT:2000000)    
Bp218 Blood pressure QTL 218 arterial blood pressure trait   (VT:2000000)    
Bp219 Blood pressure QTL 219 arterial blood pressure trait   (VT:2000000)    
Bp220 Blood pressure QTL 220 arterial blood pressure trait   (VT:2000000)    
Bp221 Blood pressure QTL 221 arterial blood pressure trait   (VT:2000000)    
Bp222 Blood pressure QTL 222 arterial blood pressure trait   (VT:2000000)    
Bp223 Blood pressure QTL 223 arterial blood pressure trait   (VT:2000000)    
Bp224 Blood pressure QTL 224 arterial blood pressure trait   (VT:2000000)    
Bp225 Blood pressure QTL 225 arterial blood pressure trait   (VT:2000000)    
Bp226 Blood pressure QTL 226 arterial blood pressure trait   (VT:2000000)    
Bp227 Blood pressure QTL 227 arterial blood pressure trait   (VT:2000000)    
Bp228 Blood pressure QTL 228 arterial blood pressure trait   (VT:2000000)    
Bp229 Blood pressure QTL 229 arterial blood pressure trait   (VT:2000000)    
Bp230 Blood pressure QTL 230 arterial blood pressure trait   (VT:2000000)    
Bp231 Blood pressure QTL 231 arterial blood pressure trait   (VT:2000000)    
Bp232 Blood pressure QTL 232 arterial blood pressure trait   (VT:2000000)    
Bp233 Blood pressure QTL 233 arterial blood pressure trait   (VT:2000000)    
Bp234 Blood pressure QTL 234 arterial blood pressure trait   (VT:2000000)    
Bp235 Blood pressure QTL 235 arterial blood pressure trait   (VT:2000000)    
Bp236 Blood pressure QTL 236 arterial blood pressure trait   (VT:2000000)    
Bp237 Blood pressure QTL 237 arterial blood pressure trait   (VT:2000000)    
Bp238 Blood pressure QTL 238 arterial blood pressure trait   (VT:2000000)    
Bw14 Body weight QTL 14 body mass   (VT:0001259)    
Bw15 Body weight QTL 15 body mass   (VT:0001259)    
Bw24 Body weight QTL 24 body mass   (VT:0001259)    
Bw25 Body weight QTL 25 body mass   (VT:0001259)    
Bw26 Body weight QTL 26 body mass   (VT:0001259)    
Bw27 Body weight QTL 27 body mass   (VT:0001259)    
Cardf1 Cardiac cell morphology QTL 1 aorta morphology trait   (VT:0000272)    
Cia22 Collagen induced arthritis QTL 22 joint integrity trait   (VT:0010548)    
Cia23 Collagen induced arthritis QTL 23 joint integrity trait   (VT:0010548)    
Cm2 Cardiac mass QTL 2 heart mass   (VT:0007028)    
Cm29 Cardiac mass QTL 29 heart mass   (VT:0007028)    
Cm3 Cardiac mass QTL 3 heart mass   (VT:0007028)    
Cm30 Cardiac mass QTL 30 heart mass   (VT:0007028)    
Cm31 Cardiac mass QTL 31 heart mass   (VT:0007028)    
Cm4 Cardiac mass QTL 4 heart mass   (VT:0007028)    
Cm5 Cardiac mass QTL 5 heart mass   (VT:0007028)    
Cm6 Cardiac mass QTL 6 heart mass   (VT:0007028)    
Edpm1 Estrogen-dependent pituitary mass QTL 1 pituitary gland mass   (VT:0010496)    
Edpm10 Estrogen-dependent pituitary mass QTL 10 pituitary gland mass   (VT:0010496)    
Edpm11 Estrogen-dependent pituitary mass QTL 11 pituitary gland mass   (VT:0010496)    
Edpm12 Estrogen-dependent pituitary mass QTL 12 pituitary gland mass   (VT:0010496)    
Edpm2 Estrogen-dependent pituitary mass QTL 2 pituitary gland mass   (VT:0010496)    
Edpm3 Estrogen-dependent pituitary mass QTL 3 pituitary gland mass   (VT:0010496)    
Edpm5 Estrogen-dependent pituitary mass QTL 5 pituitary gland mass   (VT:0010496)    
Edpm9 Estrogen-dependent pituitary mass QTL 9 pituitary gland mass   (VT:0010496)    
Emca4 Estrogen-induced mammary cancer QTL 4 mammary gland integrity trait   (VT:0010552)    
Emca5 Estrogen-induced mammary cancer QTL 5 mammary gland integrity trait   (VT:0010552)    
Emca6 Estrogen-induced mammary cancer QTL 6 mammary gland integrity trait   (VT:0010552)    
Emca7 Estrogen-induced mammary cancer QTL 7 mammary gland integrity trait   (VT:0010552)    
Emca8 Estrogen-induced mammary cancer QTL 8 mammary gland integrity trait   (VT:0010552)    
Ept5 Estrogen-induced pituitary tumorigenesis QTL 5 pituitary gland mass   (VT:0010496)    
Ept7 Estrogen-induced pituitary tumorigenesis QTL 7 pituitary gland mass   (VT:0010496)    
Esta1 Estrogen-induced thymic atrophy QTL 1 thymus mass   (VT:0004954)    
Esta2 Estrogen-induced thymic atrophy QTL 2 thymus mass   (VT:0004954)    
Esta3 Estrogen-induced thymic atrophy QTL 3 thymus mass   (VT:0004954)    
Eutr1 Estrogen induced uterine response QTL 1 uterus integrity trait   (VT:0010575)    
Hcar1 Hepatocarcinoma resistance QTL 1 liver integrity trait   (VT:0010547)    
Hcar2 Hepatocarcinoma resistance QTL 2 liver integrity trait   (VT:0010547)    
Hcar3 Hepatocarcinoma resistance QTL 3 liver integrity trait   (VT:0010547)    
Hcas1 Hepatocarcinoma susceptibility QTL 1 liver integrity trait   (VT:0010547)    
Hcas2 Hepatocarcinoma susceptibility QTL 2 liver integrity trait   (VT:0010547)    
Hrtrt1 Heart rate QTL 1 heart pumping trait   (VT:2000009)    
Hrtrt10 Heart rate QTL 10 heart pumping trait   (VT:2000009)    
Hrtrt11 Heart rate QTL 11 heart pumping trait   (VT:2000009)    
Hrtrt12 Heart rate QTL 12 heart pumping trait   (VT:2000009)    
Hrtrt13 Heart rate QTL 13 heart pumping trait   (VT:2000009)    
Hrtrt14 Heart rate QTL 14 heart pumping trait   (VT:2000009)    
Hrtrt15 Heart rate QTL 15 heart pumping trait   (VT:2000009)    
Hrtrt16 Heart rate QTL 16 heart pumping trait   (VT:2000009)    
Hrtrt2 Heart rate QTL 2 heart pumping trait   (VT:2000009)    
Hrtrt3 Heart rate QTL 3 heart pumping trait   (VT:2000009)    
Hrtrt4 Heart rate QTL 4 heart pumping trait   (VT:2000009)    
Hrtrt5 Heart rate QTL 5 heart pumping trait   (VT:2000009)    
Hrtrt6 Heart rate QTL 6 heart pumping trait   (VT:2000009)    
Hrtrt7 Heart rate QTL 7 heart pumping trait   (VT:2000009)    
Hrtrt8 Heart rate QTL 8 heart pumping trait   (VT:2000009)    
Hrtrt9 Heart rate QTL 9 heart pumping trait   (VT:2000009)    
Kidm10 Kidney mass QTL 10 kidney mass   (VT:0002707)    
Kidm11 Kidney mass QTL 11 kidney mass   (VT:0002707)    
Kidm4 Kidney mass QTL 4 kidney mass   (VT:0002707)    
Kidm5 Kidney mass QTL 5 kidney mass   (VT:0002707)    
Kidm6 Kidney mass QTL 6 kidney mass   (VT:0002707)    
Kidm7 Kidney mass QTL 7 kidney mass   (VT:0002707)    
Kidm9 Kidney mass QTL 9 kidney mass   (VT:0002707)    
Ppulsi1 Prepulse inhibition QTL 1 prepulse inhibition trait   (VT:0003088)    
Ppulsi2 Prepulse inhibition QTL 2 prepulse inhibition trait   (VT:0003088)    
Renag1 Renal agenesis QTL 1 kidney development trait   (VT:0000527)    
Rf10 Renal function QTL 10 renal blood flow trait   (VT:2000006)    
Rf11 Renal function QTL 11 renal blood flow trait   (VT:2000006)    
Rf12 Renal function QTL 12 renal blood flow trait   (VT:2000006)    
Rf13 Renal function QTL 13 renal blood flow trait   (VT:2000006)    
Rf14 Renal function QTL 14 renal blood flow trait   (VT:2000006)    
Rf15 Renal function QTL 15 renal blood flow trait   (VT:2000006)    
Rf16 Renal function QTL 16 renal blood flow trait   (VT:2000006)    
Rf17 Renal function QTL 17 renal blood flow trait   (VT:2000006)    
Rf18 Renal function QTL 18 urine output   (VT:0003620)    
Rf19 Renal function QTL 19 blood creatinine amount   (VT:0005328)    
Rf20 Renal function QTL 20 kidney glomerulus integrity trait   (VT:0010546)    
Rf21 Renal function QTL 21 renal blood flow trait   (VT:2000006)    
Rf22 Renal function QTL 22 renal blood flow trait   (VT:2000006)    
Rf23 Renal function QTL 23 renal blood flow trait   (VT:2000006)    
Rf24 Renal function QTL 24 blood creatinine amount   (VT:0005328)    
Rf25 Renal function QTL 25 blood creatinine amount   (VT:0005328)    
Rf26 Renal function QTL 26 urine potassium amount   (VT:0010539)    
Rf27 Renal function QTL 27 urine sodium amount   (VT:0006274)    
Rf28 Renal function QTL 28 urine potassium amount   (VT:0010539)    
Rf29 Renal function QTL 29 urine potassium amount   (VT:0010539)    
Rf30 Renal function QTL 30 urine potassium amount   (VT:0010539)    
Rf31 Renal function QTL 31 urine potassium amount   (VT:0010539)    
Rf32 Renal function QTL 32 kidney blood vessel physiology trait   (VT:0100012)    
Rf33 Renal function QTL 33 kidney blood vessel physiology trait   (VT:0100012)    
Rf34 Renal function QTL 34 kidney blood vessel physiology trait   (VT:0100012)    
Rf35 Renal function QTL 35 kidney blood vessel physiology trait   (VT:0100012)    
Rf36 Renal function QTL 36 kidney blood vessel physiology trait   (VT:0100012)    
Rf37 Renal function QTL 37 kidney blood vessel physiology trait   (VT:0100012)    
Rf38 Renal function QTL 38 kidney blood vessel physiology trait   (VT:0100012)    
Rf39 Renal function QTL 39 urine output   (VT:0003620)    
Rf40 Renal function QTL 40 kidney blood vessel physiology trait   (VT:0100012)    
Rf41 Renal function QTL 41 kidney blood vessel physiology trait   (VT:0100012)    
Rf42 Renal function QTL 42 kidney blood vessel physiology trait   (VT:0100012)    
Rf43 Renal function QTL 43 kidney blood vessel physiology trait   (VT:0100012)    
Rf44 Renal function QTL 44 total urine protein amount   (VT:0000032)    
Rf45 Renal function QTL 45 kidney blood vessel physiology trait   (VT:0100012)    
Rf6 Renal function QTL 6 renal blood flow trait   (VT:2000006)    
Rf7 Renal function QTL 7 urine creatinine amount   (VT:0010540)    
Rf8 Renal function QTL 8 renal blood flow trait   (VT:2000006)    
Rf9 Renal function QTL 9 kidney glomerulus integrity trait   (VT:0010546)    
Scl25 Serum cholesterol level QTL 25 blood cholesterol amount   (VT:0000180)    
Scl26 Serum cholesterol level QTL 26 blood cholesterol amount   (VT:0000180)    
Scl27 Serum cholesterol level QTL 27 blood HDL cholesterol amount   (VT:0000184)    
Scl28 Serum cholesterol level QTL 28 blood HDL cholesterol amount   (VT:0000184)    
Scl67 Serum cholesterol level QTL 67 blood cholesterol amount   (VT:0000180)    
Srn1 Serum renin concentration QTL 1 blood renin amount   (VT:0003349)    
Srn2 Serum renin concentration QTL 2 blood renin amount   (VT:0003349)    
Srn3 Serum renin concentration QTL 3 blood renin amount   (VT:0003349)    
Srn4 Serum renin concentration QTL 4 renin activity   (VT:0005581)    
Srn5 Serum renin concentration QTL 5 renin activity   (VT:0005581)    
Stl31 Serum triglyceride level QTL 31 blood triglyceride amount   (VT:0002644)    
Stl7 Serum triglyceride level QTL 7 blood triglyceride amount   (VT:0002644)    
Vnigr1 Vascular neointimal growth QTL 1 artery morphology trait   (VT:0002191)    
Vnigr2 Vascular neointimal growth QTL 2 artery morphology trait   (VT:0002191)    
Vnigr3 Vascular neointimal growth QTL 3 artery morphology trait   (VT:0002191)    
Wbc1 White blood cell count QTL 1 leukocyte quantity   (VT:0000217)    
Wbc2 White blood cell count QTL 2 leukocyte quantity   (VT:0000217)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_behavior Displays a very low level of prepulse inhibition (PPI), which is the inhibitory modulation of a startle response that occurs when a weak stimulus is presented immediately prior to a strong startle stimulus 629579
strain_behavior Displays a very low level of prepulse inhibition (PPI), which is the inhibitory modulation of a startle response that occurs when a weak stimulus is presented immediately prior to a strong startle stimulus 629579
strain_drgs_chems These are insensitive to estrogen induced pituitary tumors; DES induces only 1.9 fold increase in pituitary weight. 1358974
strain_drgs_chems sensitive to thymic atrophy induced by the estrogen diethylstilbestrol (DES) 1579780
strain_drgs_chems displays a control of pituitary response to chronic estrogen stimulation characterized by a lack of excessive pituitary growth or pituitary tumor formation. 629581
strain_drgs_chems No significant difference was noticed in the pituitary mass of rats which were given subcutaneous implants of diethlystilbestrol (DES). 61074
strain_life_disease Susceptible to estrogen-induced uterine inflammation and infection (pyometritis) 1559292
strain_other Harlan plans to eliminate this strain, this will no longer be bred and available from Harlan Laboratories Inc. Targeted elimination and cryopreservation date is December 31, 2011. The research community should be able to purchase these from Harlan UK. 5508209