RGD Reference Report - Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats. - Rat Genome Database

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Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats.

Authors: Moreno, C  Dumas, P  Kaldunski, ML  Tonellato, PJ  Greene, AS  Roman, RJ  Cheng, Q  Wang, Z  Jacob, HJ  Cowley Jr, AW 
Citation: Moreno C, etal., Physiol Genomics 2003 Nov 11;15(3):243-57. Epub 2003 Oct 07.
RGD ID: 727992
Pubmed: PMID:14532335   (View Abstract at PubMed)
DOI: DOI:10.1152/physiolgenomics.00105.2003   (Journal Full-text)

Genetic linkage analyses in human populations have traditionally combined the male and female progeny for determination of quantitative trait loci (QTL). In contrast, most rodent studies have focused primarily on males. The present study represents an extensive female specific linkage analysis in which 236 neuroendocrine, renal and cardiovascular traits related to arterial pressure (BP) were determined in 99 female F2 rats derived from a cross of Dahl salt sensitive SS/JrHsdMcwi (SS) and Brown Norway normotensive BN/SsNHsdMcwi (BN) rats. 126 quantitative trait loci (QTL) for 96 traits were identified on 19 of the 20 autosomal chromosomes of the female progeny. Four chromosomes (3, 6, 7 and 11) were identified as especially important in regulation of arterial pressure and renal function since aggregates of 8-11 QTL mapped together on these chromosomes. Blood pressure QTL in this female population differed considerably from those previously found in male, other female, or mixed gender population linkage analysis studies using SS rats. Kidney weight divided by body weight was identified as an intermediate phenotype that mapped to the same region of the genome as the resting diastolic blood pressure, and was correlated with that same blood pressure phenotype. Seven other phenotypes were considered as "potential intermediate phenotypes", which mapped to the same region of the genome as a blood pressure QTL but were not correlated with blood pressure. These included renal vascular responses to angiotensin II (AngII) and acetylcholine (ACh), and indices of baroreceptor responsiveness. Secondary traits were also identified that were likely to be consequences of hypertension (correlated with blood pressure but not mapped to a BP QTL). Seven such traits were found, notably heart rate, plasma cholesterol, and renal glomerular injury. The development of a female rat Systems Biology Map of Cardiovascular Function represents the first attempt to prioritize those regions of the genome important for the development of hypertension and end organ damage in female rats.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
aortic disease  IDA 727992 RGD 
Cardiomegaly  IDA 727992; 727992; 727992; 727992; 727992 RGD 
focal segmental glomerulosclerosis  IDA 727992; 727992 RGD 
heart disease  IAGP 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992 RGD 
Hypercholesterolemia inducedIAGPcontrolled sodium content diet727992 RGD 
hypertension MODEL: controlIAGPcontrolled sodium content diet727992compared to SS/JrHsdMcwiRGD 
hypertension  IDA 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992 RGD 
hypertension  IAGP 727992 RGD 
hypertension MODEL: inducedIAGPcontrolled sodium content diet727992compared to BN/NHsdMcwiRGD 
Hypertriglyceridemia  IDA 727992; 727992 RGD 
Hypertriglyceridemia inducedIAGPcontrolled sodium content diet727992 RGD 
Inflammation  IAGP 727992 RGD 
kidney disease  IAGP 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992 RGD 
kidney disease  IDA 727992; 727992 RGD 
Left Ventricular Hypertrophy inducedIAGPcontrolled sodium content diet727992 RGD 
Polyuria  IAGP 727992 RGD 
proteinuria  IDA 727992; 727992 RGD 
renal hypertension  IAGP 727992; 727992; 727992 RGD 
Tachycardia inducedIAGPcontrolled sodium content diet727992 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
abnormal aorta morphology  QTM 727992 RGD 
abnormal body weight  QTM 727992; 727992 RGD 
abnormal circulating creatinine level  QTM 727992; 727992; 727992; 727992 RGD 
abnormal heart rate  QTM 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992 RGD 
abnormal heart size  QTM 727992; 727992; 727992; 727992; 727992 RGD 
abnormal heart ventricle morphology  QTM 727992 RGD 
abnormal hematocrit  QTM 727992 RGD 
abnormal kidney size  QTM 727992; 727992 RGD 
abnormal kidney weight  QTM 727992; 727992; 727992 RGD 
abnormal leukocyte cell number  QTM 727992; 727992 RGD 
abnormal renal filtration rate  QTM 727992; 727992; 727992; 727992 RGD 
abnormal renal glomerulus morphology  QTM 727992; 727992; 727992 RGD 
abnormal renal plasma flow rate  QTM 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992 RGD 
abnormal renin activity  QTM 727992; 727992; 727992 RGD 
abnormal urine homeostasis  QTM 727992; 727992; 727992 RGD 
cardiac hypertrophy inducedIAGPcontrolled sodium content diet727992 RGD 
decreased creatinine clearance  IAGP 727992; 727992; 727992 RGD 
decreased renal plasma flow rate  IAGP 727992; 727992; 727992; 727992 RGD 
decreased renal plasma flow rate  QTM 727992 RGD 
decreased renin activity inducedIAGPcontrolled sodium content diet727992compared to SS/JrHsdMcwiRGD 
decreased urine potassium level  QTM 727992 RGD 
decreased urine protein level  QTM 727992 RGD 
heart left ventricle hypertrophy inducedIAGPcontrolled sodium content diet727992 RGD 
increased body weight  IAGP 727992 RGD 
increased circulating cholesterol level inducedIAGPcontrolled sodium content diet727992compared to BN/NHsdMcwiRGD 
increased circulating creatinine level inducedIAGPcontrolled sodium content diet727992compared to BN/NHsdMcwiRGD 
increased circulating triglyceride level  QTM 727992; 727992 RGD 
increased circulating triglyceride level inducedIAGPcontrolled sodium content diet727992compared to BN/NHsdMcwiRGD 
increased heart rate  IAGP 727992; 727992; 727992; 727992; 727992; 727992; 727992 RGD 
increased heart rate inducedIAGPcontrolled sodium content diet727992compared to BN/NHsdMcwiRGD 
increased kidney weight inducedIAGPcontrolled sodium content diet727992compared to BN/NHsdMcwiRGD 
increased leukocyte cell number  IAGP 727992 RGD 
increased renal vascular resistance  IAGP 727992; 727992; 727992 RGD 
increased systemic arterial blood pressure  QTM 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992; 727992 RGD 
increased urine protein level inducedIAGPcontrolled sodium content diet727992compared to BN/NHsdMcwiRGD 
kidney inflammation  QTM 727992; 727992; 727992; 727992 RGD 
polyuria  IAGP 727992 RGD 
salt-sensitive hypertension inducedIAGPcontrolled sodium content diet727992 RGD 

Related Phenotype Data for this Reference

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Select a value below to view phenotype data for a specific strain, measurment, or condition.

Rat Strains:
Clinical Measurements:
Experimental Conditions:
Measurement Methods:
Objects Annotated

QTLs
Bp170  (Blood pressure QTL 170)
Bp171  (Blood pressure QTL 171)
Bp172  (Blood pressure QTL 172)
Bp173  (Blood pressure QTL 173)
Bp174  (Blood pressure QTL 174)
Bp175  (Blood pressure QTL 175)
Bp176  (Blood pressure QTL 176)
Bp177  (Blood pressure QTL 177)
Bp178  (Blood pressure QTL 178)
Bp179  (Blood pressure QTL 179)
Bp180  (Blood pressure QTL 180)
Bp181  (Blood pressure QTL 181)
Bp182  (Blood pressure QTL 182)
Bp183  (Blood pressure QTL 183)
Bp184  (Blood pressure QTL 184)
Bp185  (Blood pressure QTL 185)
Bp186  (Blood pressure QTL 186)
Bp187  (Blood pressure QTL 187)
Bp188  (Blood pressure QTL 188)
Bp189  (Blood pressure QTL 189)
Bp190  (Blood pressure QTL 190)
Bp191  (Blood pressure QTL 191)
Bp192  (Blood pressure QTL 192)
Bp193  (Blood pressure QTL 193)
Bp194  (Blood pressure QTL 194)
Bp195  (Blood pressure QTL 195)
Bw14  (Body weight QTL 14)
Bw15  (Body weight QTL 15)
Cardf1  (Cardiac cell morphology QTL 1)
Cm2  (Cardiac mass QTL 2)
Cm3  (Cardiac mass QTL 3)
Cm4  (Cardiac mass QTL 4)
Cm5  (Cardiac mass QTL 5)
Cm6  (Cardiac mass QTL 6)
Hrtrt1  (Heart rate QTL 1)
Hrtrt10  (Heart rate QTL 10)
Hrtrt2  (Heart rate QTL 2)
Hrtrt3  (Heart rate QTL 3)
Hrtrt4  (Heart rate QTL 4)
Hrtrt5  (Heart rate QTL 5)
Hrtrt6  (Heart rate QTL 6)
Hrtrt7  (Heart rate QTL 7)
Hrtrt8  (Heart rate QTL 8)
Hrtrt9  (Heart rate QTL 9)
Kidm4  (Kidney mass QTL 4)
Kidm5  (Kidney mass QTL 5)
Kidm6  (Kidney mass QTL 6)
Kidm7  (Kidney mass QTL 7)
Rf10  (Renal function QTL 10)
Rf11  (Renal function QTL 11)
Rf12  (Renal function QTL 12)
Rf13  (Renal function QTL 13)
Rf14  (Renal function QTL 14)
Rf15  (Renal function QTL 15)
Rf16  (Renal function QTL 16)
Rf17  (Renal function QTL 17)
Rf18  (Renal function QTL 18)
Rf19  (Renal function QTL 19)
Rf20  (Renal function QTL 20)
Rf21  (Renal function QTL 21)
Rf22  (Renal function QTL 22)
Rf23  (Renal function QTL 23)
Rf24  (Renal function QTL 24)
Rf25  (Renal function QTL 25)
Rf26  (Renal function QTL 26)
Rf6  (Renal function QTL 6)
Rf7  (Renal function QTL 7)
Rf8  (Renal function QTL 8)
Rf9  (Renal function QTL 9)
Srn1  (Serum renin concentration QTL 1)
Srn2  (Serum renin concentration QTL 2)
Srn3  (Serum renin concentration QTL 3)
Stl7  (Serum triglyceride level QTL 7)
Wbc1  (White blood cell count QTL 1)

Strains
BN/NHsdMcwi  (NA)
BN/SsNHsd  (NA)
SS/JrHsdMcwi  (NA)

Objects referenced in this article
Strain SS/Jr Salt Sensitive Rattus norvegicus

Additional Information