RGD Reference Report - Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats. - Rat Genome Database

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Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats.

Authors: Moreno, C  Dumas, P  Kaldunski, ML  Tonellato, PJ  Greene, AS  Roman, RJ  Cheng, Q  Wang, Z  Jacob, HJ  Cowley Jr, AW 
Citation: Moreno C, etal., Physiol Genomics 2003 Nov 11;15(3):243-57. Epub 2003 Oct 07.
RGD ID: 727992
Pubmed: PMID:14532335   (View Abstract at PubMed)
DOI: DOI:10.1152/physiolgenomics.00105.2003   (Journal Full-text)

Genetic linkage analyses in human populations have traditionally combined the male and female progeny for determination of quantitative trait loci (QTL). In contrast, most rodent studies have focused primarily on males. The present study represents an extensive female specific linkage analysis in which 236 neuroendocrine, renal and cardiovascular traits related to arterial pressure (BP) were determined in 99 female F2 rats derived from a cross of Dahl salt sensitive SS/JrHsdMcwi (SS) and Brown Norway normotensive BN/SsNHsdMcwi (BN) rats. 126 quantitative trait loci (QTL) for 96 traits were identified on 19 of the 20 autosomal chromosomes of the female progeny. Four chromosomes (3, 6, 7 and 11) were identified as especially important in regulation of arterial pressure and renal function since aggregates of 8-11 QTL mapped together on these chromosomes. Blood pressure QTL in this female population differed considerably from those previously found in male, other female, or mixed gender population linkage analysis studies using SS rats. Kidney weight divided by body weight was identified as an intermediate phenotype that mapped to the same region of the genome as the resting diastolic blood pressure, and was correlated with that same blood pressure phenotype. Seven other phenotypes were considered as "potential intermediate phenotypes", which mapped to the same region of the genome as a blood pressure QTL but were not correlated with blood pressure. These included renal vascular responses to angiotensin II (AngII) and acetylcholine (ACh), and indices of baroreceptor responsiveness. Secondary traits were also identified that were likely to be consequences of hypertension (correlated with blood pressure but not mapped to a BP QTL). Seven such traits were found, notably heart rate, plasma cholesterol, and renal glomerular injury. The development of a female rat Systems Biology Map of Cardiovascular Function represents the first attempt to prioritize those regions of the genome important for the development of hypertension and end organ damage in female rats.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Cardf1Rataortic disease  IDA  RGD 
Cm2RatCardiomegaly  IDA  RGD 
Cm3RatCardiomegaly  IDA  RGD 
Cm4RatCardiomegaly  IDA  RGD 
Cm5RatCardiomegaly  IDA  RGD 
Cm6RatCardiomegaly  IDA  RGD 
Rf20Ratfocal segmental glomerulosclerosis  IDA  RGD 
Rf9Ratfocal segmental glomerulosclerosis  IDA  RGD 
Hrtrt1Ratheart disease  IAGP  RGD 
Hrtrt2Ratheart disease  IAGP  RGD 
Hrtrt3Ratheart disease  IAGP  RGD 
Hrtrt4Ratheart disease  IAGP  RGD 
Hrtrt5Ratheart disease  IAGP  RGD 
Hrtrt6Ratheart disease  IAGP  RGD 
Hrtrt7Ratheart disease  IAGP  RGD 
Wbc1Ratheart disease  IAGP  RGD 
SS/JrHsdMcwiRatHypercholesterolemia inducedIAGPcontrolled sodium content diet RGD 
BN/NHsdMcwiRathypertension MODEL: controlIAGPcontrolled sodium content dietcompared to SS/JrHsdMcwiRGD 
Bp170Rathypertension  IDA  RGD 
Bp171Rathypertension  IDA  RGD 
Bp172Rathypertension  IDA  RGD 
Bp173Rathypertension  IDA  RGD 
Bp174Rathypertension  IDA  RGD 
Bp175Rathypertension  IDA  RGD 
Bp176Rathypertension  IDA  RGD 
Bp177Rathypertension  IDA  RGD 
Bp178Rathypertension  IDA  RGD 
Bp179Rathypertension  IDA  RGD 
Bp180Rathypertension  IDA  RGD 
Bp181Rathypertension  IDA  RGD 
Bp182Rathypertension  IDA  RGD 
Bp183Rathypertension  IDA  RGD 
Bp184Rathypertension  IDA  RGD 
Bp185Rathypertension  IDA  RGD 
Bp186Rathypertension  IDA  RGD 
Bp187Rathypertension  IDA  RGD 
Bp188Rathypertension  IDA  RGD 
Bp189Rathypertension  IDA  RGD 
Bp190Rathypertension  IDA  RGD 
Bp191Rathypertension  IDA  RGD 
Bp192Rathypertension  IDA  RGD 
Bp193Rathypertension  IDA  RGD 
Bp194Rathypertension  IDA  RGD 
Bp195Rathypertension  IDA  RGD 
Cm2Rathypertension  IDA  RGD 
Cm4Rathypertension  IDA  RGD 
Hrtrt10Rathypertension  IDA  RGD 
Hrtrt3Rathypertension  IAGP  RGD 
Hrtrt9Rathypertension  IDA  RGD 
Kidm4Rathypertension  IDA  RGD 
Kidm7Rathypertension  IDA  RGD 
Rf10Rathypertension  IDA  RGD 
Rf11Rathypertension  IDA  RGD 
Rf12Rathypertension  IDA  RGD 
Rf13Rathypertension  IDA  RGD 
Rf15Rathypertension  IDA  RGD 
Rf19Rathypertension  IDA  RGD 
Rf20Rathypertension  IDA  RGD 
Rf21Rathypertension  IDA  RGD 
Rf24Rathypertension  IDA  RGD 
Rf9Rathypertension  IDA  RGD 
SS/JrHsdMcwiRathypertension MODEL: inducedIAGPcontrolled sodium content dietcompared to BN/NHsdMcwiRGD 
Hrtrt8RatHypertriglyceridemia  IDA  RGD 
SS/JrHsdMcwiRatHypertriglyceridemia inducedIAGPcontrolled sodium content diet RGD 
Stl7RatHypertriglyceridemia  IDA  RGD 
Wbc1RatInflammation  IAGP  RGD 
Kidm5Ratkidney disease  IAGP  RGD 
Kidm6Ratkidney disease  IAGP  RGD 
Rf12Ratkidney disease  IDA  RGD 
Rf14Ratkidney disease  IAGP  RGD 
Rf16Ratkidney disease  IAGP  RGD 
Rf17Ratkidney disease  IAGP  RGD 
Rf18Ratkidney disease  IAGP  RGD 
Rf21Ratkidney disease  IDA  RGD 
Rf22Ratkidney disease  IAGP  RGD 
Rf23Ratkidney disease  IAGP  RGD 
Rf25Ratkidney disease  IAGP  RGD 
Rf26Ratkidney disease  IAGP  RGD 
Rf6Ratkidney disease  IAGP  RGD 
Rf7Ratkidney disease  IAGP  RGD 
Rf8Ratkidney disease  IAGP  RGD 
Srn1Ratkidney disease  IAGP  RGD 
Srn2Ratkidney disease  IAGP  RGD 
Srn3Ratkidney disease  IAGP  RGD 
SS/JrHsdMcwiRatLeft Ventricular Hypertrophy inducedIAGPcontrolled sodium content diet RGD 
Rf18RatPolyuria  IAGP  RGD 
Bp174Ratproteinuria  IDA  RGD 
Rf19Ratproteinuria  IDA  RGD 
Rf22Ratrenal hypertension  IAGP  RGD 
Rf23Ratrenal hypertension  IAGP  RGD 
Rf8Ratrenal hypertension  IAGP  RGD 
SS/JrHsdMcwiRatTachycardia inducedIAGPcontrolled sodium content diet RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Cardf1Ratabnormal aorta morphology  QTM  RGD 
Bw14Ratabnormal body weight  QTM  RGD 
Bw15Ratabnormal body weight  QTM  RGD 
Rf19Ratabnormal circulating creatinine level  QTM  RGD 
Rf24Ratabnormal circulating creatinine level  QTM  RGD 
Rf25Ratabnormal circulating creatinine level  QTM  RGD 
Stl7Ratabnormal circulating creatinine level  QTM  RGD 
Cm2Ratabnormal heart rate  QTM  RGD 
Hrtrt1Ratabnormal heart rate  QTM  RGD 
Hrtrt10Ratabnormal heart rate  QTM  RGD 
Hrtrt2Ratabnormal heart rate  QTM  RGD 
Hrtrt3Ratabnormal heart rate  QTM  RGD 
Hrtrt4Ratabnormal heart rate  QTM  RGD 
Hrtrt5Ratabnormal heart rate  QTM  RGD 
Hrtrt6Ratabnormal heart rate  QTM  RGD 
Hrtrt7Ratabnormal heart rate  QTM  RGD 
Hrtrt8Ratabnormal heart rate  QTM  RGD 
Hrtrt9Ratabnormal heart rate  QTM  RGD 
Cm2Ratabnormal heart size  QTM  RGD 
Cm3Ratabnormal heart size  QTM  RGD 
Cm4Ratabnormal heart size  QTM  RGD 
Cm5Ratabnormal heart size  QTM  RGD 
Cm6Ratabnormal heart size  QTM  RGD 
Cm6Ratabnormal heart ventricle morphology  QTM  RGD 
Cm6Ratabnormal hematocrit  QTM  RGD 
Bp176Ratabnormal kidney size  QTM  RGD 
Kidm4Ratabnormal kidney size  QTM  RGD 
Kidm5Ratabnormal kidney weight  QTM  RGD 
Kidm6Ratabnormal kidney weight  QTM  RGD 
Kidm7Ratabnormal kidney weight  QTM  RGD 
Cm6Ratabnormal leukocyte cell number  QTM  RGD 
Wbc1Ratabnormal leukocyte cell number  QTM  RGD 
Rf19Ratabnormal renal filtration rate  QTM  RGD 
Rf24Ratabnormal renal filtration rate  QTM  RGD 
Rf25Ratabnormal renal filtration rate  QTM  RGD 
Rf7Ratabnormal renal filtration rate  QTM  RGD 
Rf12Ratabnormal renal glomerulus morphology  QTM  RGD 
Rf20Ratabnormal renal glomerulus morphology  QTM  RGD 
Rf9Ratabnormal renal glomerulus morphology  QTM  RGD 
Cm4Ratabnormal renal plasma flow rate  QTM  RGD 
Cm5Ratabnormal renal plasma flow rate  QTM  RGD 
Kidm4Ratabnormal renal plasma flow rate  QTM  RGD 
Kidm7Ratabnormal renal plasma flow rate  QTM  RGD 
Rf10Ratabnormal renal plasma flow rate  QTM  RGD 
Rf11Ratabnormal renal plasma flow rate  QTM  RGD 
Rf12Ratabnormal renal plasma flow rate  QTM  RGD 
Rf13Ratabnormal renal plasma flow rate  QTM  RGD 
Rf14Ratabnormal renal plasma flow rate  QTM  RGD 
Rf15Ratabnormal renal plasma flow rate  QTM  RGD 
Rf16Ratabnormal renal plasma flow rate  QTM  RGD 
Rf17Ratabnormal renal plasma flow rate  QTM  RGD 
Rf22Ratabnormal renal plasma flow rate  QTM  RGD 
Rf23Ratabnormal renal plasma flow rate  QTM  RGD 
Rf6Ratabnormal renal plasma flow rate  QTM  RGD 
Rf8Ratabnormal renal plasma flow rate  QTM  RGD 
Srn1Ratabnormal renin activity  QTM  RGD 
Srn2Ratabnormal renin activity  QTM  RGD 
Srn3Ratabnormal renin activity  QTM  RGD 
Bp174Ratabnormal urine homeostasis  QTM  RGD 
Hrtrt9Ratabnormal urine homeostasis  QTM  RGD 
Rf18Ratabnormal urine homeostasis  QTM  RGD 
SS/JrHsdMcwiRatcardiac hypertrophy inducedIAGPcontrolled sodium content diet RGD 
Rf14Ratdecreased creatinine clearance  IAGP  RGD 
Rf25Ratdecreased creatinine clearance  IAGP  RGD 
Rf7Ratdecreased creatinine clearance  IAGP  RGD 
Rf16Ratdecreased renal plasma flow rate  IAGP  RGD 
Rf17Ratdecreased renal plasma flow rate  IAGP  RGD 
Rf21Ratdecreased renal plasma flow rate  QTM  RGD 
Rf6Ratdecreased renal plasma flow rate  IAGP  RGD 
Rf8Ratdecreased renal plasma flow rate  IAGP  RGD 
BN/NHsdMcwiRatdecreased renin activity inducedIAGPcontrolled sodium content dietcompared to SS/JrHsdMcwiRGD 
Rf26Ratdecreased urine potassium level  QTM  RGD 
Rf19Ratdecreased urine protein level  QTM  RGD 
SS/JrHsdMcwiRatheart left ventricle hypertrophy inducedIAGPcontrolled sodium content diet RGD 
Bw14Ratincreased body weight  IAGP  RGD 
SS/JrHsdMcwiRatincreased circulating cholesterol level inducedIAGPcontrolled sodium content dietcompared to BN/NHsdMcwiRGD 
SS/JrHsdMcwiRatincreased circulating creatinine level inducedIAGPcontrolled sodium content dietcompared to BN/NHsdMcwiRGD 
Hrtrt8Ratincreased circulating triglyceride level  QTM  RGD 
SS/JrHsdMcwiRatincreased circulating triglyceride level inducedIAGPcontrolled sodium content dietcompared to BN/NHsdMcwiRGD 
Stl7Ratincreased circulating triglyceride level  QTM  RGD 
Hrtrt1Ratincreased heart rate  IAGP  RGD 
Hrtrt2Ratincreased heart rate  IAGP  RGD 
Hrtrt3Ratincreased heart rate  IAGP  RGD 
Hrtrt4Ratincreased heart rate  IAGP  RGD 
Hrtrt5Ratincreased heart rate  IAGP  RGD 
Hrtrt6Ratincreased heart rate  IAGP  RGD 
Hrtrt7Ratincreased heart rate  IAGP  RGD 
SS/JrHsdMcwiRatincreased heart rate inducedIAGPcontrolled sodium content dietcompared to BN/NHsdMcwiRGD 
SS/JrHsdMcwiRatincreased kidney weight inducedIAGPcontrolled sodium content dietcompared to BN/NHsdMcwiRGD 
Wbc1Ratincreased leukocyte cell number  IAGP  RGD 
Rf22Ratincreased renal vascular resistance  IAGP  RGD 
Rf23Ratincreased renal vascular resistance  IAGP  RGD 
Rf8Ratincreased renal vascular resistance  IAGP  RGD 
Bp170Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp171Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp172Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp173Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp174Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp175Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp176Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp177Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp178Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp179Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp180Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp181Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp182Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp183Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp184Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp185Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp186Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp187Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp188Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp189Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp190Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp191Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp192Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp193Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp194Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp195Ratincreased systemic arterial blood pressure  QTM  RGD 
Cm2Ratincreased systemic arterial blood pressure  QTM  RGD 
Cm4Ratincreased systemic arterial blood pressure  QTM  RGD 
Cm5Ratincreased systemic arterial blood pressure  QTM  RGD 
Hrtrt10Ratincreased systemic arterial blood pressure  QTM  RGD 
Hrtrt3Ratincreased systemic arterial blood pressure  QTM  RGD 
Hrtrt8Ratincreased systemic arterial blood pressure  QTM  RGD 
Hrtrt9Ratincreased systemic arterial blood pressure  QTM  RGD 
Kidm4Ratincreased systemic arterial blood pressure  QTM  RGD 
Kidm7Ratincreased systemic arterial blood pressure  QTM  RGD 
Rf10Ratincreased systemic arterial blood pressure  QTM  RGD 
Rf11Ratincreased systemic arterial blood pressure  QTM  RGD 
Rf12Ratincreased systemic arterial blood pressure  QTM  RGD 
Rf13Ratincreased systemic arterial blood pressure  QTM  RGD 
Rf15Ratincreased systemic arterial blood pressure  QTM  RGD 
Rf19Ratincreased systemic arterial blood pressure  QTM  RGD 
Rf20Ratincreased systemic arterial blood pressure  QTM  RGD 
Rf24Ratincreased systemic arterial blood pressure  QTM  RGD 
Rf9Ratincreased systemic arterial blood pressure  QTM  RGD 
Stl7Ratincreased systemic arterial blood pressure  QTM  RGD 
SS/JrHsdMcwiRatincreased urine protein level inducedIAGPcontrolled sodium content dietcompared to BN/NHsdMcwiRGD 
Bp175Ratkidney inflammation  QTM  RGD 
Rf12Ratkidney inflammation  QTM  RGD 
Rf20Ratkidney inflammation  QTM  RGD 
Rf9Ratkidney inflammation  QTM  RGD 
Rf18Ratpolyuria  IAGP  RGD 
SS/JrHsdMcwiRatsalt-sensitive hypertension inducedIAGPcontrolled sodium content diet RGD 

Related Phenotype Data for this Reference

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Select a value below to view phenotype data for a specific strain, measurment, or condition.

Rat Strains:
Clinical Measurements:
Experimental Conditions:
Measurement Methods:
Objects Annotated

Bp170  (Blood pressure QTL 170)
Bp171  (Blood pressure QTL 171)
Bp172  (Blood pressure QTL 172)
Bp173  (Blood pressure QTL 173)
Bp174  (Blood pressure QTL 174)
Bp175  (Blood pressure QTL 175)
Bp176  (Blood pressure QTL 176)
Bp177  (Blood pressure QTL 177)
Bp178  (Blood pressure QTL 178)
Bp179  (Blood pressure QTL 179)
Bp180  (Blood pressure QTL 180)
Bp181  (Blood pressure QTL 181)
Bp182  (Blood pressure QTL 182)
Bp183  (Blood pressure QTL 183)
Bp184  (Blood pressure QTL 184)
Bp185  (Blood pressure QTL 185)
Bp186  (Blood pressure QTL 186)
Bp187  (Blood pressure QTL 187)
Bp188  (Blood pressure QTL 188)
Bp189  (Blood pressure QTL 189)
Bp190  (Blood pressure QTL 190)
Bp191  (Blood pressure QTL 191)
Bp192  (Blood pressure QTL 192)
Bp193  (Blood pressure QTL 193)
Bp194  (Blood pressure QTL 194)
Bp195  (Blood pressure QTL 195)
Bw14  (Body weight QTL 14)
Bw15  (Body weight QTL 15)
Cardf1  (Cardiac cell morphology QTL 1)
Cm2  (Cardiac mass QTL 2)
Cm3  (Cardiac mass QTL 3)
Cm4  (Cardiac mass QTL 4)
Cm5  (Cardiac mass QTL 5)
Cm6  (Cardiac mass QTL 6)
Hrtrt1  (Heart rate QTL 1)
Hrtrt10  (Heart rate QTL 10)
Hrtrt2  (Heart rate QTL 2)
Hrtrt3  (Heart rate QTL 3)
Hrtrt4  (Heart rate QTL 4)
Hrtrt5  (Heart rate QTL 5)
Hrtrt6  (Heart rate QTL 6)
Hrtrt7  (Heart rate QTL 7)
Hrtrt8  (Heart rate QTL 8)
Hrtrt9  (Heart rate QTL 9)
Kidm4  (Kidney mass QTL 4)
Kidm5  (Kidney mass QTL 5)
Kidm6  (Kidney mass QTL 6)
Kidm7  (Kidney mass QTL 7)
Rf10  (Renal function QTL 10)
Rf11  (Renal function QTL 11)
Rf12  (Renal function QTL 12)
Rf13  (Renal function QTL 13)
Rf14  (Renal function QTL 14)
Rf15  (Renal function QTL 15)
Rf16  (Renal function QTL 16)
Rf17  (Renal function QTL 17)
Rf18  (Renal function QTL 18)
Rf19  (Renal function QTL 19)
Rf20  (Renal function QTL 20)
Rf21  (Renal function QTL 21)
Rf22  (Renal function QTL 22)
Rf23  (Renal function QTL 23)
Rf24  (Renal function QTL 24)
Rf25  (Renal function QTL 25)
Rf26  (Renal function QTL 26)
Rf6  (Renal function QTL 6)
Rf7  (Renal function QTL 7)
Rf8  (Renal function QTL 8)
Rf9  (Renal function QTL 9)
Srn1  (Serum renin concentration QTL 1)
Srn2  (Serum renin concentration QTL 2)
Srn3  (Serum renin concentration QTL 3)
Stl7  (Serum triglyceride level QTL 7)
Wbc1  (White blood cell count QTL 1)

BN/NHsdMcwi  (NA)
BN/SsNHsd  (NA)
SS/JrHsdMcwi  (NA)

Objects referenced in this article
Strain SS/Jr Salt Sensitive Rattus norvegicus

Additional Information