RGD Reference Report - Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats. - Rat Genome Database

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Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats.

Authors: Moreno, C  Dumas, P  Kaldunski, ML  Tonellato, PJ  Greene, AS  Roman, RJ  Cheng, Q  Wang, Z  Jacob, HJ  Cowley Jr, AW 
Citation: Moreno C, etal., Physiol Genomics 2003 Nov 11;15(3):243-57. Epub 2003 Oct 07.
RGD ID: 727992
Pubmed: PMID:14532335   (View Abstract at PubMed)
DOI: DOI:10.1152/physiolgenomics.00105.2003   (Journal Full-text)

Genetic linkage analyses in human populations have traditionally combined the male and female progeny for determination of quantitative trait loci (QTL). In contrast, most rodent studies have focused primarily on males. The present study represents an extensive female specific linkage analysis in which 236 neuroendocrine, renal and cardiovascular traits related to arterial pressure (BP) were determined in 99 female F2 rats derived from a cross of Dahl salt sensitive SS/JrHsdMcwi (SS) and Brown Norway normotensive BN/SsNHsdMcwi (BN) rats. 126 quantitative trait loci (QTL) for 96 traits were identified on 19 of the 20 autosomal chromosomes of the female progeny. Four chromosomes (3, 6, 7 and 11) were identified as especially important in regulation of arterial pressure and renal function since aggregates of 8-11 QTL mapped together on these chromosomes. Blood pressure QTL in this female population differed considerably from those previously found in male, other female, or mixed gender population linkage analysis studies using SS rats. Kidney weight divided by body weight was identified as an intermediate phenotype that mapped to the same region of the genome as the resting diastolic blood pressure, and was correlated with that same blood pressure phenotype. Seven other phenotypes were considered as "potential intermediate phenotypes", which mapped to the same region of the genome as a blood pressure QTL but were not correlated with blood pressure. These included renal vascular responses to angiotensin II (AngII) and acetylcholine (ACh), and indices of baroreceptor responsiveness. Secondary traits were also identified that were likely to be consequences of hypertension (correlated with blood pressure but not mapped to a BP QTL). Seven such traits were found, notably heart rate, plasma cholesterol, and renal glomerular injury. The development of a female rat Systems Biology Map of Cardiovascular Function represents the first attempt to prioritize those regions of the genome important for the development of hypertension and end organ damage in female rats.

Disease Annotations    

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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Strains with Phenominer Data Strains with phenominer data
BN/NHsdMcwi SS/JrHsdMcwi

Objects Annotated

Bp170  (Blood pressure QTL 170)
Bp171  (Blood pressure QTL 171)
Bp172  (Blood pressure QTL 172)
Bp173  (Blood pressure QTL 173)
Bp174  (Blood pressure QTL 174)
Bp175  (Blood pressure QTL 175)
Bp176  (Blood pressure QTL 176)
Bp177  (Blood pressure QTL 177)
Bp178  (Blood pressure QTL 178)
Bp179  (Blood pressure QTL 179)
Bp180  (Blood pressure QTL 180)
Bp181  (Blood pressure QTL 181)
Bp182  (Blood pressure QTL 182)
Bp183  (Blood pressure QTL 183)
Bp184  (Blood pressure QTL 184)
Bp185  (Blood pressure QTL 185)
Bp186  (Blood pressure QTL 186)
Bp187  (Blood pressure QTL 187)
Bp188  (Blood pressure QTL 188)
Bp189  (Blood pressure QTL 189)
Bp190  (Blood pressure QTL 190)
Bp191  (Blood pressure QTL 191)
Bp192  (Blood pressure QTL 192)
Bp193  (Blood pressure QTL 193)
Bp194  (Blood pressure QTL 194)
Bp195  (Blood pressure QTL 195)
Bw14  (Body weight QTL 14)
Bw15  (Body weight QTL 15)
Cardf1  (Cardiac cell morphology QTL 1)
Cm2  (Cardiac mass QTL 2)
Cm3  (Cardiac mass QTL 3)
Cm4  (Cardiac mass QTL 4)
Cm5  (Cardiac mass QTL 5)
Cm6  (Cardiac mass QTL 6)
Hrtrt1  (Heart rate QTL 1)
Hrtrt10  (Heart rate QTL 10)
Hrtrt2  (Heart rate QTL 2)
Hrtrt3  (Heart rate QTL 3)
Hrtrt4  (Heart rate QTL 4)
Hrtrt5  (Heart rate QTL 5)
Hrtrt6  (Heart rate QTL 6)
Hrtrt7  (Heart rate QTL 7)
Hrtrt8  (Heart rate QTL 8)
Hrtrt9  (Heart rate QTL 9)
Kidm4  (Kidney mass QTL 4)
Kidm5  (Kidney mass QTL 5)
Kidm6  (Kidney mass QTL 6)
Kidm7  (Kidney mass QTL 7)
Rf10  (Renal function QTL 10)
Rf11  (Renal function QTL 11)
Rf12  (Renal function QTL 12)
Rf13  (Renal function QTL 13)
Rf14  (Renal function QTL 14)
Rf15  (Renal function QTL 15)
Rf16  (Renal function QTL 16)
Rf17  (Renal function QTL 17)
Rf18  (Renal function QTL 18)
Rf19  (Renal function QTL 19)
Rf20  (Renal function QTL 20)
Rf21  (Renal function QTL 21)
Rf22  (Renal function QTL 22)
Rf23  (Renal function QTL 23)
Rf24  (Renal function QTL 24)
Rf25  (Renal function QTL 25)
Rf26  (Renal function QTL 26)
Rf6  (Renal function QTL 6)
Rf7  (Renal function QTL 7)
Rf8  (Renal function QTL 8)
Rf9  (Renal function QTL 9)
Srn1  (Serum renin concentration QTL 1)
Srn2  (Serum renin concentration QTL 2)
Srn3  (Serum renin concentration QTL 3)
Stl7  (Serum triglyceride level QTL 7)
Wbc1  (White blood cell count QTL 1)

BN/NHsdMcwi  (NA)
BN/SsNHsd  (NA)
SS/JrHsdMcwi  (NA)

Objects referenced in this article
Strain SS/Jr Salt Sensitive Rattus norvegicus

Additional Information