RGD Reference Report - Quantitative trait loci for estrogen-dependent pituitary tumor growth in the rat. - Rat Genome Database

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Quantitative trait loci for estrogen-dependent pituitary tumor growth in the rat.

Authors: Wendell, DL  Gorski, J 
Citation: Wendell DL and Gorski J, Mamm Genome 1997;8(11):823-9
RGD ID: 61074
Pubmed: PMID:9337394   (View Abstract at PubMed)

Growth control is of fundamental importance to biology in general and of critical importance to cancer research in particular. Tumors develop when control of the normal growth process is lost. The rat pituitary is a model system for control of estrogen-dependent growth. Chronic estrogen treatment induces uncontrolled growth in the pituitaries of Fischer 344 (F344) rats, but not of Brown Norway (BN) rats. We have identified five quantitative trait loci (QTL) for estrogen-dependent pituitary mass (Edpm) in an F2 intercross of F344 and BN. These QTL reside on rat Chromosomes (Chrs) 2, 3, 5, and 9 and explain a total of 55% of the genetic variance in the F2. We have also detected suggestive evidence for a QTL on rat Chr 14. For Edpm2-1, Edpm2-2, Edpm3, and Edpm5, the F344 allele corresponds with increased pituitary mass, as expected. Surprisingly, for Edpm9 and the suggested QTL on Chr 14, the BN allele corresponds with increased pituitary mass. We also find evidence for interaction (epistasis) between Edpm3 and Edpm9 and between Edpm5 and the suggested QTL on Chr 14.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Edpm1RatNeoplasms, Hormone-Dependent  IDA  RGD 
Edpm2RatNeoplasms, Hormone-Dependent  IDA  RGD 
Edpm3RatNeoplasms, Hormone-Dependent  IDA  RGD 
Edpm5RatNeoplasms, Hormone-Dependent  IDA  RGD 
Edpm9RatNeoplasms, Hormone-Dependent  IDA  RGD 
Edpm10RatPituitary Neoplasms  IAGP  RGD 
Edpm5RatPituitary Neoplasms  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Edpm1Ratpituitary gland hyperplasia  IAGP  RGD 
Edpm10Ratpituitary gland hyperplasia  QTM  RGD 
Edpm2Ratpituitary gland hyperplasia  QTM  RGD 
Edpm3Ratpituitary gland hyperplasia  QTM  RGD 
Edpm5Ratpituitary gland hyperplasia  QTM  RGD 
Edpm9Ratpituitary gland hyperplasia  QTM  RGD 
F344/NHsdRatpituitary gland hyperplasia  IAGP as compared to BN/SsNHsdRGD 
Objects Annotated

QTLs
Edpm1  (Estrogen-dependent pituitary mass QTL 1)
Edpm10  (Estrogen-dependent pituitary mass QTL 10)
Edpm2  (Estrogen-dependent pituitary mass QTL 2)
Edpm3  (Estrogen-dependent pituitary mass QTL 3)
Edpm5  (Estrogen-dependent pituitary mass QTL 5)
Edpm9  (Estrogen-dependent pituitary mass QTL 9)

Strains
BN/SsNHsd  (NA)
F344/NHsd  (F344/NHsd)

Objects referenced in this article
Marker D3Mit7 D3Mit7 Rattus norvegicus
Marker D2Mit4 D2Mit4 Rattus norvegicus
Marker D5Mit11 D5Mit11 Rattus norvegicus
Marker D5Mit5 D5Mit5 Rattus norvegicus
Marker D2Mgh15 D2Mgh15 Rattus norvegicus
Marker D3Mgh6 D3Mgh6 Rattus norvegicus
Marker D5Mgh6 D5Mgh6 Rattus norvegicus
Marker D2Mgh14 D2Mgh14 Rattus norvegicus
Gene Cacna1c calcium voltage-gated channel subunit alpha1 C Rattus norvegicus

Additional Information