Gene: Cacna1c (calcium voltage-gated channel subunit alpha1 C) Rattus norvegicus
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Symbol: Cacna1c
Name: calcium voltage-gated channel subunit alpha1 C
Description: ENCODES a protein that exhibits high voltage-gated calcium channel activity; ion channel binding; protein domain specific binding; INVOLVED IN calcium ion import; calcium ion transmembrane transport via high voltage-gated calcium channel; calcium ion transport; PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); autistic disorder (ortholog); bipolar disorder (ortholog); FOUND IN cell surface; dendrite; glutamatergic synapse; INTERACTS WITH (R)-mevalonic acid; (RS)-amphetamine; 2,4,6-trinitrobenzenesulfonic acid
AGR Description: Exhibits several functions, including high voltage-gated calcium channel activity, ion channel binding activity, and protein domain specific binding activity; involved in cation transport, cellular response to amyloid-beta, and positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; localizes to several cellular components, including the L-type voltage-gated calcium channel complex, Z disc, and intrinsic component of plasma membrane; orthologous to human CACNA1C (calcium voltage-gated channel subunit alpha1 C).
Merged Description: Exhibits several functions, including high voltage-gated calcium channel activity, ion channel binding activity, and protein domain specific binding activity; involved in cation transport, cellular response to amyloid-beta, and positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; localizes to several cellular components, including the L-type voltage-gated calcium channel complex, Z disc, and intrinsic component of plasma membrane; orthologous to human CACNA1C (calcium voltage-gated channel subunit alpha1 C); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (R)-mevalonic acid; (RS)-amphetamine; 2,4,6-trinitrobenzenesulfonic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: brain class C; Ca channel voltage-dependent L type alpha 1c subunit; Ca channel, voltage-dependent, L type, alpha 1c subunit; calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; calcium channel, voltage-dependent, alpha 1C subunit; calcium channel, voltage-dependent, L type, alpha 1C subunit; L-type calcium channel alpha-1 subunit; RATIVS302; RBC; voltage-dependent L-type calcium channel subunit alpha-1C; voltage-gated calcium channel subunit alpha Cav1.2
Orthologs:
Homo sapiens (human) : CACNA1C (calcium voltage-gated channel subunit alpha1 C)  HGNC  Alliance
Mus musculus (house mouse) : Cacna1c (calcium channel, voltage-dependent, L type, alpha 1C subunit)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cacna1c (calcium voltage-gated channel subunit alpha1 C)
Pan paniscus (bonobo/pygmy chimpanzee) : CACNA1C (calcium voltage-gated channel subunit alpha1 C)
Canis lupus familiaris (dog) : CACNA1C (calcium voltage-gated channel subunit alpha1 C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cacna1c (calcium voltage-gated channel subunit alpha1 C)
Sus scrofa (pig) : CACNA1C (calcium voltage-gated channel subunit alpha1 C)
more info ...
Allele / Splice: Cacna1cem1Sage  
Genetic Models: SD-Cacna1cem1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04150,635,808 - 151,270,790 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04216,562,477 - 217,184,927 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44154,895,691 - 155,517,389 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14155,140,531 - 155,762,230 (-)NCBI
Celera4140,633,057 - 141,244,304 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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QTLs in Region (Rnor_6.0)
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Sequence

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Strain Sequence Variants (Rnor 5.0)
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Additional Information

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Nomenclature History
RGD Curation Notes
  
More on Cacna1c
Alliance Gene
NCBI Gene
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JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2245
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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