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Gene: Cacna1c (calcium voltage-gated channel subunit alpha1 C) Rattus norvegicus
Symbol: Cacna1c
Name: calcium voltage-gated channel subunit alpha1 C
Description: Exhibits several functions, including high voltage-gated calcium channel activity; ion channel binding activity; and protein phosphatase 2A binding activity. Involved in calcium ion transport; cellular response to amyloid-beta; and positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel. Localizes to several cellular components, including L-type voltage-gated calcium channel complex; glutamatergic synapse; and integral component of synaptic membrane. Colocalizes with Z disc. Human ortholog(s) of this gene implicated in Brugada syndrome 3 and Timothy syndrome. Orthologous to human CACNA1C (calcium voltage-gated channel subunit alpha1 C); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (R)-mevalonic acid; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: brain class C; Ca channel voltage-dependent L type alpha 1c subunit; Ca channel, voltage-dependent, L type, alpha 1c subunit; calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; calcium channel, voltage-dependent, alpha 1C subunit; calcium channel, voltage-dependent, L type, alpha 1C subunit; L-type calcium channel alpha-1 subunit; RATIVS302; RBC; voltage-dependent L-type calcium channel subunit alpha-1C; voltage-gated calcium channel subunit alpha Cav1.2
Allele / Splice: Cacna1cem1Sage  
Genetic Models: SD-Cacna1cem1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04150,635,808 - 151,270,790 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4150,641,066 - 150,829,913 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04216,562,477 - 217,184,927 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44154,895,691 - 155,517,389 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14155,140,531 - 155,762,230 (-)NCBI
Celera4140,633,057 - 141,244,304 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Cacna1c
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2245
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.