Cacna1c (calcium voltage-gated channel subunit alpha1 C) - Rat Genome Database

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Gene: Cacna1c (calcium voltage-gated channel subunit alpha1 C) Rattus norvegicus
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Symbol: Cacna1c
Name: calcium voltage-gated channel subunit alpha1 C
RGD ID: 2245
Description: Enables several functions, including high voltage-gated calcium channel activity; protein phosphatase 2A binding activity; and transmembrane transporter binding activity. Involved in several processes, including calcium ion transport; nervous system development; and positive regulation of transport. Located in several cellular components, including T-tubule; neuronal cell body; and postsynaptic density. Part of L-type voltage-gated calcium channel complex. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Colocalizes with Z disc. Biomarker of alcohol dependence. Human ortholog(s) of this gene implicated in Brugada syndrome 3 and Timothy syndrome. Orthologous to human CACNA1C (calcium voltage-gated channel subunit alpha1 C); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,4,6-trinitrobenzenesulfonic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: brain class C; Ca channel voltage-dependent L type alpha 1c subunit; Ca channel, voltage-dependent, L type, alpha 1c subunit; calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; calcium channel, voltage-dependent, alpha 1C subunit; calcium channel, voltage-dependent, L type, alpha 1C subunit; L-type calcium channel alpha-1 subunit; RATIVS302; RBC; voltage-dependent L-type calcium channel subunit alpha-1C; voltage-gated calcium channel subunit alpha Cav1.2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Cacna1cem1Sage  
Genetic Models: SD-Cacna1cem1Sage
Candidate Gene For: Coreg2
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24151,764,138 - 152,379,454 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4151,764,138 - 152,379,648 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4158,028,661 - 158,645,825 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04153,812,328 - 154,429,518 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04152,435,662 - 153,052,854 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04150,635,808 - 151,270,790 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4150,641,066 - 150,829,913 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04216,562,477 - 217,184,927 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44154,895,691 - 155,517,389 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14155,140,531 - 155,762,230 (-)NCBI
Celera4140,633,057 - 141,244,304 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute stress disorder  (ISO)
alcohol dependence  (IEP)
Alzheimer's disease  (ISO)
amyloidosis  (ISO)
anxiety disorder  (ISO)
arrhythmogenic right ventricular cardiomyopathy  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
bipolar disorder  (ISO)
breast ductal carcinoma  (ISO)
Brugada syndrome  (ISO)
Brugada syndrome 3  (ISO)
Cardiac Arrhythmias  (ISO)
cardiomyopathy  (ISO)
catecholaminergic polymorphic ventricular tachycardia  (ISO)
cerebral palsy  (ISO)
Cognitive Dysfunction  (ISO)
Congenital Limb Deformities  (ISO)
congestive heart failure  (ISO)
dilated cardiomyopathy  (ISO)
epilepsy  (ISO)
esophageal atresia  (ISO)
Familial Ventricular Tachycardia  (ISO)
Fetal Growth Retardation  (IEP)
genetic disease  (ISO)
Genetic Predisposition to Disease  (ISO)
Heart Block  (ISO)
Hyperphosphatemic Familial Tumoral Calcinosis 1  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 1  (ISO)
hypoglycemia  (ISO)
intellectual disability  (ISO)
invasive ductal carcinoma  (ISO)
Joint Instability  (ISO)
Language Development Disorders  (ISO)
long QT syndrome  (ISO)
long QT syndrome 1  (ISO)
major depressive disorder  (ISO)
Neurodevelopmental Disorder with Dysmorphic Facies and Distal Limb Anomalies  (ISO)
NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA, LANGUAGE DELAY, AND SKELETAL DEFECTS WITH OR WITHOUT SEIZURES  (ISO)
Neurodevelopmental Disorders  (ISO)
post-traumatic stress disorder  (ISO)
primary immunodeficiency disease  (ISO)
Psychomotor Agitation  (ISO)
pulmonary valve stenosis  (ISO)
restrictive cardiomyopathy  (ISO)
Romano-Ward Syndrome  (ISO)
schizophrenia  (ISO)
short QT syndrome  (ISO)
Sudden Cardiac Death  (ISO)
Sudden Death  (ISO)
Sudden Unexpected Nocturnal Death Syndrome  (ISO)
Timothy syndrome  (ISO,ISS)
Tremor  (ISO)
Ventricular Fibrillation, Paroxysmal Familial, 1  (ISO)
Ventricular Tachycardia  (ISO)
Wolff-Parkinson-White syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-nitrophenol  (ISO)
acetamide  (EXP)
aconitine  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP)
allethrin  (EXP)
amiodarone  (ISO)
amphetamine  (EXP)
androgen antagonist  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
astragaloside IV  (ISO)
atenolol  (ISO)
atrazine  (EXP)
Bardoxolone methyl  (ISO)
barium(0)  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylparaben  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
cantharidin  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
crizotinib  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
DDE  (EXP)
deferiprone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diltiazem  (ISO)
dioxygen  (EXP)
disodium selenite  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
enzacamene  (EXP)
epoxiconazole  (EXP,ISO)
ethanol  (ISO)
ezogabine  (ISO)
fenvalerate  (EXP)
ferrostatin-1  (ISO)
formaldehyde  (EXP)
fulvestrant  (ISO)
furan  (EXP)
iron atom  (ISO)
iron dextran  (ISO)
iron(0)  (ISO)
isoprenaline  (EXP)
lead(0)  (ISO)
linsidomine  (ISO)
linuron  (EXP)
malathion  (ISO)
maneb  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methylene blue  (ISO)
mevalonic acid  (EXP)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nicotine  (ISO)
nifedipine  (ISO)
nimodipine  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
paracetamol  (EXP)
paraquat  (EXP,ISO)
peroxynitrous acid  (ISO)
pioglitazone  (ISO)
potassium chloride  (ISO)
pregabalin  (EXP)
prochloraz  (EXP)
procymidone  (EXP)
progesterone  (EXP)
Ptaquiloside  (ISO)
pyrethrins  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium cyanide  (ISO)
sodium disulfite  (EXP)
streptozocin  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP)
thalidomide  (ISO)
torcetrapib  (ISO)
trichloroethene  (EXP,ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
verapamil  (EXP,ISO)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult walking behavior  (ISO)
axon development  (IEP)
calcium ion import  (IMP)
calcium ion import across plasma membrane  (IBA,ISO)
calcium ion transmembrane transport  (IEA,ISO)
calcium ion transmembrane transport via high voltage-gated calcium channel  (IDA,IMP,ISO,ISS)
calcium ion transport  (IMP,ISO)
calcium ion transport into cytosol  (ISS)
calcium-ion regulated exocytosis  (ISO)
camera-type eye development  (ISO)
cardiac conduction  (ISO,ISS)
cardiac muscle cell action potential involved in contraction  (ISO,ISS)
cell communication involved in cardiac conduction  (ISO)
cellular response to amyloid-beta  (IEP)
cerebral cortex development  (IEP)
chemical synaptic transmission  (ISO)
corpus callosum development  (IEP)
embryonic forelimb morphogenesis  (ISO)
establishment of localization in cell  (ISO)
exocytosis  (IMP)
glucose homeostasis  (ISO)
growth hormone secretion  (ISO)
heart development  (ISO)
immune system development  (ISO)
insulin secretion  (ISO)
intracellular calcium ion homeostasis  (ISO)
membrane depolarization during atrial cardiac muscle cell action potential  (ISO,ISS)
membrane depolarization during AV node cell action potential  (ISO,ISS)
membrane depolarization during cardiac muscle cell action potential  (ISO,ISS)
optic nerve development  (IEP)
positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  (IMP)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of insulin secretion  (IMP)
positive regulation of membrane depolarization  (IMP)
regulation of blood pressure  (ISO)
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  (ISS)
regulation of heart rate by cardiac conduction  (ISO,ISS)
regulation of organ growth  (ISO)
regulation of postsynaptic membrane potential  (IEA)
regulation of vasoconstriction  (ISO)
regulation of ventricular cardiac muscle cell action potential  (ISO,ISS)
response to alcohol  (IEP)
response to nutrient levels  (IEP)
response to organic cyclic compound  (IDA)
smooth muscle contraction  (ISO)
smooth muscle contraction involved in micturition  (ISO)
visual learning  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
Alzheimer's disease pathway  (IEA)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
arrhythmogenic right ventricular cardiomyopathy pathway  (IEA)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
calcium transport pathway  (ISO)
calcium/calcium-mediated signaling pathway  (IEA,ISO)
calcium/calmodulin dependent kinase 2 signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
dilated cardiomyopathy pathway  (IEA)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
felodipine pharmacokinetics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
glutamate signaling pathway  (IEA)
gonadotropin-releasing hormone signaling pathway  (IEA)
hypertrophic cardiomyopathy pathway  (IEA)
ibutilide pharmacodynamics pathway  (ISO)
insulin secretion pathway  (TAS)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
long term potentiation  (IEA)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
mitogen activated protein kinase signaling pathway  (IEA)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
type 2 diabetes mellitus pathway  (IEA)
verapamil pharmacodynamics pathway  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Multiple calcium channel transcripts in rat osteosarcoma cells: selective activation of alpha 1D isoform by parathyroid hormone. Barry EL, etal., Proc Natl Acad Sci U S A 1995 Nov 21;92(24):10914-8.
2. BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signaling. Berkefeld H, etal., Science. 2006 Oct 27;314(5799):615-20.
3. Sex-specific effects of Cacna1c haploinsufficiency on object recognition, spatial memory, and reversal learning capabilities in rats. Braun MD, etal., Neurobiol Learn Mem. 2018 Nov;155:543-555. doi: 10.1016/j.nlm.2018.05.012. Epub 2018 May 23.
4. Eukaryotic translation initiation factor 3 subunit e controls intracellular calcium homeostasis by regulation of cav1.2 surface expression. Buda P, etal., PLoS One. 2013 May 30;8(5):e64462. doi: 10.1371/journal.pone.0064462. Print 2013.
5. Voltage-gated calcium channels. Catterall WA Cold Spring Harb Perspect Biol. 2011 Aug 1;3(8):a003947. doi: 10.1101/cshperspect.a003947.
6. Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels. Chen YH, etal., Nature. 2004 Jun 10;429(6992):675-80. Epub 2004 May 30.
7. Direct interaction of the rab3 effector rim with ca2+ channels, snap-25, and synaptotagmin. Coppola T, etal., J Biol Chem 2001 Aug 31;276(35):32756-62.
8. A new promoter for alpha(1C) subunit of human L-type cardiac calcium channel Ca(V)1.2. Dai B, etal., Biochem Biophys Res Commun 2002 Aug 16;296(2):429.
9. Stimulation of 5-HT(2) receptors in prefrontal pyramidal neurons inhibits Ca(v)1.2 L type Ca(2+) currents via a PLCbeta/IP3/calcineurin signaling cascade. Day M, etal., J Neurophysiol 2002 May;87(5):2490-504.
10. Evidence for multiple Src binding sites on the alpha1c L-type Ca2+ channel and their roles in activity regulation. Dubuis E, etal., Cardiovasc Res. 2006 Feb 1;69(2):391-401. Epub 2005 Dec 13.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Integrin receptor activation triggers converging regulation of Cav1.2 calcium channels by c-Src and protein kinase A pathways. Gui P, etal., J Biol Chem. 2006 May 19;281(20):14015-25. Epub 2006 Mar 22.
14. Binding of protein phosphatase 2A to the L-type calcium channel Cav1.2 next to Ser1928, its main PKA site, is critical for Ser1928 dephosphorylation. Hall DD, etal., Biochemistry. 2006 Mar 14;45(10):3448-59.
15. Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain. Huang CY, etal., J Comp Neurol. 2012 Nov 1;520(16):3650-72. doi: 10.1002/cne.23119.
16. Beta-adrenergic regulation requires direct anchoring of PKA to cardiac CaV1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 15. Hulme JT, etal., Proc Natl Acad Sci U S A 2003 Oct 28;100(22):13093-8. Epub 2003 Oct 20.
17. CSN5/Jab1 inhibits cardiac L-type Ca2+ channel activity through protein-protein interactions. Kameda K, etal., J Mol Cell Cardiol. 2006 Apr;40(4):562-9. Epub 2006 Feb 14.
18. Silencing of Cav1.2 gene in neonatal cardiomyocytes by lentiviral delivered shRNA. Karnabi E, etal., Biochem Biophys Res Commun. 2009 Jul 10;384(4):409-14. doi: 10.1016/j.bbrc.2009.04.150. Epub 2009 May 5.
19. Effects of amyloid-ß peptides on voltage-gated L-type Ca(V)1.2 and Ca(V)1.3 Ca(2+) channels. Kim S and Rhim H, Mol Cells. 2011 Sep;32(3):289-94. doi: 10.1007/s10059-011-0075-x. Epub 2011 Aug 4.
20. Cacna1c haploinsufficiency leads to pro-social 50-kHz ultrasonic communication deficits in rats. Kisko TM, etal., Dis Model Mech. 2018 Jun 20;11(6). pii: dmm.034116. doi: 10.1242/dmm.034116.
21. cDNA cloning of a dihydropyridine-sensitive calcium channel from rat aorta. Evidence for the existence of alternatively spliced forms. Koch WJ, etal., J Biol Chem 1990 Oct 15;265(29):17786-91.
22. Upregulation of the CaV 1.1-ryanodine receptor complex in a rat model of critical illness myopathy. Kraner SD, etal., Am J Physiol Regul Integr Comp Physiol. 2011 Jun;300(6):R1384-91. Epub 2011 Apr 6.
23. Expression of voltage-gated Ca2+ channel subtypes in cultured astrocytes. Latour I, etal., Glia 2003 Mar;41(4):347-53.
24. Ca(V)1.2 and Ca(V)1.3 L-type calcium channels regulate the resting membrane potential but not the expression of calcium transporters in differentiated PC12 cells. Lichvárová L and Lacinová L, Gen Physiol Biophys. 2015 Apr;34(2):157-65. doi: 10.4149/gpb_2014045. Epub 2015 Feb 12.
25. Spontaneous regenerative activity in mammalian retinal bipolar cells: roles of multiple subtypes of voltage-dependent Ca2+ channels. Ma YP and Pan ZH, Vis Neurosci 2003 Mar-Apr;20(2):131-9.
26. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
27. The alterations of Ca2+/calmodulin/CaMKII/CaV1.2 signaling in experimental models of Alzheimer's disease and vascular dementia. Min D, etal., Neurosci Lett. 2013 Mar 22;538:60-5. doi: 10.1016/j.neulet.2013.02.001. Epub 2013 Feb 8.
28. Skeletal and cardiac ryanodine receptors bind to the Ca(2+)-sensor region of dihydropyridine receptor alpha(1C) subunit. Mouton J, etal., FEBS Lett. 2001 Sep 21;505(3):441-4.
29. Voltage-gated calcium channels in adult rat inferior colliculus neurons. N'Gouemo P and Morad M, Neuroscience 2003;120(3):815-26.
30. Alcohol Withdrawal-Induced Seizure Susceptibility is Associated with an Upregulation of CaV1.3 Channels in the Rat Inferior Colliculus. N'Gouemo P, etal., Int J Neuropsychopharmacol. 2015 Jan 2;18(7):pyu123. doi: 10.1093/ijnp/pyu123.
31. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
32. CaV1.2 rather than CaV1.3 is coupled to glucose-stimulated insulin secretion in INS-1 832/13 cells. Nitert MD, etal., J Mol Endocrinol. 2008 Jul;41(1):1-11. doi: 10.1677/JME-07-0133.
33. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
34. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
35. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
36. Chromosomal mapping of a major quantitative trait locus regulating compensatory renal growth in the rat. Pravenec M, etal., J Am Soc Nephrol 2000 Jul;11(7):1261-5
37. Effects of Cacna1c haploinsufficiency on social interaction behavior and 50-kHz ultrasonic vocalizations in adult female rats. Redecker TM, etal., Behav Brain Res. 2019 Jul 23;367:35-52. doi: 10.1016/j.bbr.2019.03.032. Epub 2019 Mar 19.
38. GOA pipeline RGD automated data pipeline
39. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. New therapeutic targets in cardiology: arrhythmias and Ca2+/calmodulin-dependent kinase II (CaMKII). Rokita AG and Anderson ME, Circulation. 2012 Oct 23;126(17):2125-39. doi: 10.1161/CIRCULATIONAHA.112.124990.
42. Distribution of proteins implicated in excitation-contraction coupling in rat ventricular myocytes. Scriven DR, etal., Biophys J. 2000 Nov;79(5):2682-91.
43. Caveolin-3 is adjacent to a group of extradyadic ryanodine receptors. Scriven DR, etal., Biophys J. 2005 Sep;89(3):1893-901. Epub 2005 Jun 24.
44. Distinct calcium channels are generated by alternative splicing and are differentially expressed in the mammalian CNS. Snutch TP, etal., Neuron 1991 Jul;7(1):45-57.
45. Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations. Splawski I, etal., Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8089-96; discussion 8086-8. Epub 2005 Apr 29.
46. Physical and functional interaction between calcineurin and the cardiac L-type Ca2+ channel. Tandan S, etal., Circ Res. 2009 Jul 2;105(1):51-60. doi: 10.1161/CIRCRESAHA.109.199828. Epub 2009 May 28.
47. Caldendrin, a neuron-specific modulator of Cav/1.2 (L-type) Ca2+ channels. Tippens AL and Lee A, J Biol Chem. 2007 Mar 16;282(11):8464-73. Epub 2007 Jan 15.
48. Ultrastructural evidence for pre- and postsynaptic localization of Cav1.2 L-type Ca2+ channels in the rat hippocampus. Tippens AL, etal., J Comp Neurol. 2008 Feb 1;506(4):569-83.
49. Differential Roles for L-Type Calcium Channel Subtypes in Alcohol Dependence. Uhrig S, etal., Neuropsychopharmacology. 2017 Apr;42(5):1058-1069. doi: 10.1038/npp.2016.266. Epub 2016 Dec 1.
50. Quantitative trait loci for estrogen-dependent pituitary tumor growth in the rat. Wendell DL and Gorski J, Mamm Genome 1997;8(11):823-9
51. The levels of Pdx1/insulin, Cacna1c and Cacna1d, and β-cell mass in a rat model of intrauterine undernutrition. Xu YP, etal., J Matern Fetal Neonatal Med. 2011 Mar;24(3):437-43. doi: 10.3109/14767058.2010.497571. Epub 2010 Sep 27.
52. Cloning of a functional splice variant of L-type calcium channel beta 2 subunit from rat heart. Yamada Y, etal., J Biol Chem 2001 Dec 14;276(50):47163-70.
53. The role of voltage-gated calcium channels in pancreatic beta-cell physiology and pathophysiology. Yang SN and Berggren PO, Endocr Rev. 2006 Oct;27(6):621-76. Epub 2006 Jul 25.
54. Ca2+-binding protein-1 facilitates and forms a postsynaptic complex with Cav1.2 (L-type) Ca2+ channels. Zhou H, etal., J Neurosci. 2004 May 12;24(19):4698-708.
Additional References at PubMed
PMID:1311102   PMID:1385406   PMID:1692134   PMID:7485440   PMID:7598723   PMID:7635187   PMID:7814415   PMID:8392192   PMID:8396138   PMID:9882694   PMID:11206130   PMID:12130699  
PMID:12190108   PMID:12359330   PMID:12711087   PMID:12881419   PMID:14140941   PMID:14561827   PMID:14609949   PMID:14665691   PMID:15044319   PMID:15087548   PMID:15090038   PMID:15132976  
PMID:15454078   PMID:15504730   PMID:15728831   PMID:15750602   PMID:15755491   PMID:15786728   PMID:16251435   PMID:16267232   PMID:16319140   PMID:16530828   PMID:16636102   PMID:16636499  
PMID:16648270   PMID:16809371   PMID:16906520   PMID:16979758   PMID:16980347   PMID:17110593   PMID:17224476   PMID:17626895   PMID:17636479   PMID:17640527   PMID:17699517   PMID:17893194  
PMID:17916557   PMID:18045623   PMID:18070605   PMID:18296710   PMID:18369156   PMID:18499609   PMID:18566917   PMID:18596041   PMID:18718913   PMID:18765948   PMID:18848828   PMID:19383796  
PMID:19502562   PMID:19506339   PMID:19520861   PMID:19665524   PMID:20110531   PMID:20137275   PMID:20226536   PMID:20616314   PMID:20639649   PMID:20929812   PMID:20929813   PMID:21156134  
PMID:21178109   PMID:21186355   PMID:21408608   PMID:21486818   PMID:21619826   PMID:21670503   PMID:21674494   PMID:21745450   PMID:21804529   PMID:21998324   PMID:22329900   PMID:22355118  
PMID:22385640   PMID:22871113   PMID:23103495   PMID:23337371   PMID:23537331   PMID:23576750   PMID:23807706   PMID:23926129   PMID:23943510   PMID:24033980   PMID:24086669   PMID:24278424  
PMID:24352630   PMID:24506535   PMID:24535566   PMID:24728418   PMID:24775099   PMID:25209265   PMID:25614710   PMID:25648081   PMID:25841350   PMID:25888683   PMID:26253506   PMID:26471941  
PMID:26507659   PMID:27076616   PMID:27140189   PMID:27368804   PMID:28514967   PMID:28566490   PMID:29330129   PMID:29436604   PMID:30304534   PMID:31628460   PMID:31717392   PMID:31770099  
PMID:31862418   PMID:31926404   PMID:32047116   PMID:32473156   PMID:32506508   PMID:33030499   PMID:33291797   PMID:33597718   PMID:33843249   PMID:34431981   PMID:34906901   PMID:36270562  
PMID:36724867   PMID:36995425   PMID:37372947  


Genomics

Comparative Map Data
Cacna1c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24151,764,138 - 152,379,454 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4151,764,138 - 152,379,648 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4158,028,661 - 158,645,825 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04153,812,328 - 154,429,518 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04152,435,662 - 153,052,854 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04150,635,808 - 151,270,790 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4150,641,066 - 150,829,913 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04216,562,477 - 217,184,927 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44154,895,691 - 155,517,389 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14155,140,531 - 155,762,230 (-)NCBI
Celera4140,633,057 - 141,244,304 (-)NCBICelera
Cytogenetic Map4q42NCBI
CACNA1C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38121,970,780 - 2,697,950 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl121,970,772 - 2,697,950 (+)EnsemblGRCh38hg38GRCh38
GRCh37122,162,153 - 2,807,116 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36122,032,725 - 2,677,376 (+)NCBINCBI36Build 36hg18NCBI36
Build 34122,032,724 - 2,672,368NCBI
Celera123,770,102 - 4,421,688 (+)NCBICelera
Cytogenetic Map12p13.33NCBI
HuRef122,016,425 - 2,664,566 (+)NCBIHuRef
CHM1_1122,161,408 - 2,806,152 (+)NCBICHM1_1
T2T-CHM13v2.0121,965,666 - 2,703,402 (+)NCBIT2T-CHM13v2.0
Cacna1c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396118,564,201 - 119,174,345 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6118,564,201 - 119,173,851 (-)EnsemblGRCm39 Ensembl
GRCm386118,587,240 - 119,197,384 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6118,587,240 - 119,196,890 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl6118,587,240 - 119,196,418 (-)EnsemblGRCm38mm10GRCm38
MGSCv376118,542,314 - 119,146,427 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366118,558,083 - 119,074,173 (-)NCBIMGSCv36mm8
MGSCv366119,385,868 - 119,901,054 (-)NCBIMGSCv36mm8
Celera6120,420,625 - 121,028,854 (-)NCBICelera
Cytogenetic Map6F1NCBI
cM Map655.86NCBI
Cacna1c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554544,490,923 - 5,198,506 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554544,573,647 - 5,199,046 (+)NCBIChiLan1.0ChiLan1.0
CACNA1C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1127,591,331 - 8,243,218 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0122,166,672 - 2,817,827 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1122,031,317 - 2,745,113 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl122,114,140 - 2,744,826 (+)Ensemblpanpan1.1panPan2
CACNA1C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12744,007,363 - 44,748,251 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2744,008,020 - 44,746,429 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha271,930,129 - 2,677,673 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02744,377,759 - 45,118,301 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12744,305,678 - 45,048,124 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02744,278,568 - 45,019,930 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0271,287,600 - 2,035,369 (-)NCBIUU_Cfam_GSD_1.0
Cacna1c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945106,316,518 - 106,936,642 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366062,168,625 - 2,865,758 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366062,168,104 - 2,867,560 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CACNA1C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl569,275,176 - 69,448,430 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1569,016,954 - 69,448,428 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2571,339,366 - 71,731,255 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CACNA1C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1112,107,722 - 2,753,970 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl112,508,705 - 2,752,991 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660635,568,387 - 6,218,696 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cacna1c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473510,201,526 - 10,432,896 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473510,201,030 - 10,927,349 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cacna1c
4094 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:306
Count of miRNA genes:90
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000009268, ENSRNOT00000041571, ENSRNOT00000051846, ENSRNOT00000052017
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat

Markers in Region
D4Arb4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24151,805,502 - 151,805,662 (+)MAPPERmRatBN7.2
Rnor_6.04150,682,435 - 150,682,594NCBIRnor6.0
Rnor_5.04216,606,296 - 216,606,455UniSTSRnor5.0
RGSC_v3.44154,937,067 - 154,937,227RGDRGSC3.4
RGSC_v3.44154,937,068 - 154,937,227UniSTSRGSC3.4
RGSC_v3.14155,181,908 - 155,182,068RGD
Celera4140,674,416 - 140,674,575UniSTS
Cytogenetic Map4q42UniSTS
D4Mgh30  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24151,805,495 - 151,805,620 (+)MAPPERmRatBN7.2
Rnor_6.04150,682,428 - 150,682,552NCBIRnor6.0
Rnor_5.04216,606,289 - 216,606,413UniSTSRnor5.0
RGSC_v3.44154,937,060 - 154,937,185RGDRGSC3.4
RGSC_v3.44154,937,061 - 154,937,185UniSTSRGSC3.4
RGSC_v3.14155,181,901 - 155,182,026RGD
Celera4140,674,409 - 140,674,533UniSTS
RH 3.4 Map4971.0UniSTS
RH 3.4 Map4971.0RGD
RH 2.0 Map4962.7RGD
Cytogenetic Map4q42UniSTS
D4Rat137  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.04151,102,607 - 151,102,848NCBIRnor6.0
Rnor_5.04217,018,694 - 217,018,935UniSTSRnor5.0
RGSC_v3.44155,346,854 - 155,347,095UniSTSRGSC3.4
RGSC_v3.44155,346,853 - 155,347,095RGDRGSC3.4
RGSC_v3.14155,591,694 - 155,591,936RGD
Celera4141,077,421 - 141,077,662UniSTS
RH 3.4 Map4982.1RGD
RH 3.4 Map4982.1UniSTS
RH 2.0 Map4975.2RGD
SHRSP x BN Map475.9099RGD
Cytogenetic Map4q42UniSTS
D4Got269  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24152,006,437 - 152,006,685 (+)MAPPERmRatBN7.2
Rnor_6.04150,885,590 - 150,885,837NCBIRnor6.0
Rnor_5.04216,806,463 - 216,806,710UniSTSRnor5.0
RGSC_v3.44155,138,808 - 155,139,055UniSTSRGSC3.4
Celera4140,874,330 - 140,874,573UniSTS
Cytogenetic Map4q42UniSTS
BF387868  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24151,917,968 - 151,918,181 (+)MAPPERmRatBN7.2
Rnor_6.04150,796,460 - 150,796,672NCBIRnor6.0
Rnor_5.04216,717,763 - 216,717,975UniSTSRnor5.0
RGSC_v3.44155,050,033 - 155,050,245UniSTSRGSC3.4
Celera4140,786,880 - 140,787,092UniSTS
RH 3.4 Map4972.3UniSTS
Cytogenetic Map4q42UniSTS
RH144194  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24152,136,086 - 152,136,242 (+)MAPPERmRatBN7.2
Rnor_6.04151,017,204 - 151,017,359NCBIRnor6.0
Rnor_5.04216,935,551 - 216,935,706UniSTSRnor5.0
RGSC_v3.44155,269,083 - 155,269,238UniSTSRGSC3.4
Celera4141,003,665 - 141,003,820UniSTS
RH 3.4 Map4975.1UniSTS
Cytogenetic Map4q42UniSTS
RH144587  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24152,380,229 - 152,380,383 (+)MAPPERmRatBN7.2
Rnor_6.04151,269,935 - 151,270,088NCBIRnor6.0
Rnor_5.04217,185,703 - 217,185,856UniSTSRnor5.0
RGSC_v3.44155,518,165 - 155,518,318UniSTSRGSC3.4
Celera4141,245,080 - 141,245,233UniSTS
RH 3.4 Map4973.9UniSTS
Cytogenetic Map4q42UniSTS
RH138902  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24152,174,992 - 152,175,163 (+)MAPPERmRatBN7.2
Rnor_6.04151,056,101 - 151,056,271NCBIRnor6.0
Rnor_5.04216,974,448 - 216,974,618UniSTSRnor5.0
RGSC_v3.44155,308,706 - 155,308,876UniSTSRGSC3.4
Celera4141,042,560 - 141,042,730UniSTS
RH 3.4 Map4984.5UniSTS
Cytogenetic Map4q42UniSTS
BE119369  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24152,046,482 - 152,046,687 (+)MAPPERmRatBN7.2
Rnor_6.04150,925,629 - 150,925,833NCBIRnor6.0
Rnor_5.04216,846,502 - 216,846,706UniSTSRnor5.0
RGSC_v3.44155,178,850 - 155,179,054UniSTSRGSC3.4
Celera4140,914,365 - 140,914,569UniSTS
RH 3.4 Map4986.5UniSTS
Cytogenetic Map4q42UniSTS
UniSTS:259196  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24151,842,824 - 151,843,363 (+)MAPPERmRatBN7.2
Rnor_6.04150,719,769 - 150,720,307NCBIRnor6.0
Rnor_5.04216,643,630 - 216,644,168UniSTSRnor5.0
RGSC_v3.44154,974,388 - 154,974,926UniSTSRGSC3.4
Celera4140,711,716 - 140,712,254UniSTS
Cytogenetic Map4q42UniSTS
UniSTS:495979  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24151,918,691 - 151,918,782 (+)MAPPERmRatBN7.2
Rnor_6.04150,797,183 - 150,797,273NCBIRnor6.0
Rnor_5.04216,718,486 - 216,718,576UniSTSRnor5.0
RGSC_v3.44155,050,756 - 155,050,846UniSTSRGSC3.4
Celera4140,787,603 - 140,787,693UniSTS
Cytogenetic Map4q42UniSTS


Genetic Models
This gene Cacna1c is modified in the following models/strains:
SD-Cacna1cem1Sage    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 43 8 58 6 10
Low 3 16 8 18 8 8 9 16 34 35 1 8
Below cutoff 31 31 1 31 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF394938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF394939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF394940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY323810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY594691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY974797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ538522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M59786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M67515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M67516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S80558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U31815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000041571   ⟹   ENSRNOP00000051397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4151,765,017 - 151,951,258 (-)Ensembl
Rnor_6.0 Ensembl4150,642,427 - 150,829,913 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000051846   ⟹   ENSRNOP00000048580
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4151,764,138 - 151,952,153 (-)Ensembl
Rnor_6.0 Ensembl4150,641,066 - 150,829,741 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000052017   ⟹   ENSRNOP00000048790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4151,765,606 - 151,951,258 (-)Ensembl
Rnor_6.0 Ensembl4150,642,534 - 150,829,741 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106776   ⟹   ENSRNOP00000094898
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4151,764,138 - 152,379,648 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113714   ⟹   ENSRNOP00000094626
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4151,764,138 - 152,379,648 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114413   ⟹   ENSRNOP00000077418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4151,765,664 - 151,915,607 (-)Ensembl
RefSeq Acc Id: NM_012517   ⟹   NP_036649
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24151,764,138 - 152,379,454 (-)NCBI
Rnor_6.04150,641,066 - 151,269,159 (-)NCBI
Rnor_5.04216,562,477 - 217,184,927 (-)NCBI
RGSC_v3.44154,895,691 - 155,517,389 (-)RGD
Celera4140,633,057 - 141,244,304 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036649 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA18905 (Get FASTA)   NCBI Sequence Viewer  
  AAA41460 (Get FASTA)   NCBI Sequence Viewer  
  AAA42016 (Get FASTA)   NCBI Sequence Viewer  
  AAA85463 (Get FASTA)   NCBI Sequence Viewer  
  AAA89157 (Get FASTA)   NCBI Sequence Viewer  
  AAB35528 (Get FASTA)   NCBI Sequence Viewer  
  AAL47071 (Get FASTA)   NCBI Sequence Viewer  
  AAL47072 (Get FASTA)   NCBI Sequence Viewer  
  AAL47073 (Get FASTA)   NCBI Sequence Viewer  
  AAP85532 (Get FASTA)   NCBI Sequence Viewer  
  AAT06090 (Get FASTA)   NCBI Sequence Viewer  
  AAY42392 (Get FASTA)   NCBI Sequence Viewer  
  ABF85689 (Get FASTA)   NCBI Sequence Viewer  
  EDM02062 (Get FASTA)   NCBI Sequence Viewer  
  EDM02063 (Get FASTA)   NCBI Sequence Viewer  
  EDM02064 (Get FASTA)   NCBI Sequence Viewer  
  EDM02065 (Get FASTA)   NCBI Sequence Viewer  
  EDM02066 (Get FASTA)   NCBI Sequence Viewer  
  EDM02067 (Get FASTA)   NCBI Sequence Viewer  
  EDM02068 (Get FASTA)   NCBI Sequence Viewer  
  EDM02069 (Get FASTA)   NCBI Sequence Viewer  
  EDM02070 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000048580.5
  ENSRNOP00000048790.6
  ENSRNOP00000051397.5
  ENSRNOP00000077418.1
  ENSRNOP00000094626.1
  ENSRNOP00000094898
  ENSRNOP00000094898.1
GenBank Protein P22002 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_036649   ⟸   NM_012517
- UniProtKB: Q71QJ6 (UniProtKB/TrEMBL),   F1LMN0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000048580   ⟸   ENSRNOT00000051846
RefSeq Acc Id: ENSRNOP00000051397   ⟸   ENSRNOT00000041571
RefSeq Acc Id: ENSRNOP00000048790   ⟸   ENSRNOT00000052017
RefSeq Acc Id: ENSRNOP00000077418   ⟸   ENSRNOT00000114413
RefSeq Acc Id: ENSRNOP00000094898   ⟸   ENSRNOT00000106776
RefSeq Acc Id: ENSRNOP00000094626   ⟸   ENSRNOT00000113714
Protein Domains
Ion transport   Voltage-dependent calcium channel alpha-1 subunit

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22002-F1-model_v2 AlphaFold P22002 1-2169 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2245 AgrOrtholog
BIND 128229
  130593
BioCyc Gene G2FUF-43225 BioCyc
Ensembl Genes ENSRNOG00000007090 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041571.6 UniProtKB/TrEMBL
  ENSRNOT00000051846.5 UniProtKB/TrEMBL
  ENSRNOT00000052017.7 UniProtKB/TrEMBL
  ENSRNOT00000106776 ENTREZGENE
  ENSRNOT00000106776.1 UniProtKB/TrEMBL
  ENSRNOT00000113714.1 UniProtKB/TrEMBL
  ENSRNOT00000114413.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.2180 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.2500 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CAC1F_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPHH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCC_a1su_IQ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCC_L_a1csu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCC_L_a1su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCCAlpha1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24239 ENTREZGENE
PANTHER VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ca_chan_IQ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAC1F_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPHH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CACNA1C RGD
PhenoGen Cacna1c PhenoGen
PRINTS CACHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LVDCCALPHA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LVDCCALPHA1C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007090 RatGTEx
SMART Ca_chan_IQ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2QC25_RAT UniProtKB/TrEMBL
  A0A8I5YBT4_RAT UniProtKB/TrEMBL
  A0A8I6ANR4_RAT UniProtKB/TrEMBL
  A0A8I6GKU9_RAT UniProtKB/TrEMBL
  A0PJ39_RAT UniProtKB/TrEMBL
  A0SLC4_RAT UniProtKB/TrEMBL
  A6IL70_RAT UniProtKB/TrEMBL
  A6IL71_RAT UniProtKB/TrEMBL
  A6IL72_RAT UniProtKB/TrEMBL
  A6IL73_RAT UniProtKB/TrEMBL
  A6IL74_RAT UniProtKB/TrEMBL
  A6IL75_RAT UniProtKB/TrEMBL
  CAC1C_RAT UniProtKB/Swiss-Prot
  E9PT56_RAT UniProtKB/TrEMBL
  F1LMN0 ENTREZGENE
  F1MA84_RAT UniProtKB/TrEMBL
  P22002 ENTREZGENE
  Q71QJ6 ENTREZGENE, UniProtKB/TrEMBL
  Q8VHT2_RAT UniProtKB/TrEMBL
  Q8VHT3_RAT UniProtKB/TrEMBL
UniProt Secondary F1LMN0 UniProtKB/TrEMBL
  F1M5G9 UniProtKB/TrEMBL
  P27733 UniProtKB/Swiss-Prot
  P27734 UniProtKB/Swiss-Prot
  Q62816 UniProtKB/Swiss-Prot
  Q63271 UniProtKB/Swiss-Prot
  Q64178 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Cacna1c  calcium voltage-gated channel subunit alpha1 C  Cacna1c  calcium channel, voltage-dependent, L type, alpha 1C subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cacna1c  calcium channel, voltage-dependent, L type, alpha 1C subunit    calcium channel, voltage-dependent, alpha 1C subunit  Name updated 1299863 APPROVED
2002-11-06 Cacna1c  calcium channel, voltage-dependent, alpha 1C subunit    Ca channel, voltage-dependent, L type, alpha 1c subunit  Name updated 625702 APPROVED
2002-06-10 Cacna1c  Ca channel, voltage-dependent, L type, alpha 1c subunit      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in kidney proximal tubule epithelial cells 61074
gene_expression expressed in osteoblasts 634679
gene_function subunit of an L-type Ca2+ channel 625474
gene_process may mediate compensatory renal growth 61074
gene_process may be involved in the transduction of extracellular signals regulating bone metabolism 634679
gene_transcript promoter region contains putative response elements for MEF-2, Nkx2.5, NFAT and CRE binding protein 1 625537
gene_transcript 8.6 kb mRNA 634679