Gene: Cacna1c (calcium voltage-gated channel subunit alpha1 C) Rattus norvegicus
Analyze
Symbol:
Cacna1c
Name:
calcium voltage-gated channel subunit alpha1 C
Description:
Exhibits several functions, including high voltage-gated calcium channel activity; ion channel binding activity; and protein phosphatase 2A binding activity. Involved in calcium ion transport; cellular response to amyloid-beta; and positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel. Localizes to several cellular components, including L-type voltage-gated calcium channel complex; glutamatergic synapse; and integral component of synaptic membrane. Colocalizes with Z disc. Human ortholog(s) of this gene implicated in Brugada syndrome 3 and Timothy syndrome. Orthologous to human CACNA1C (calcium voltage-gated channel subunit alpha1 C); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (R)-mevalonic acid; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
brain class C; Ca channel voltage-dependent L type alpha 1c subunit; Ca channel, voltage-dependent, L type, alpha 1c subunit; calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; calcium channel, voltage-dependent, alpha 1C subunit; calcium channel, voltage-dependent, L type, alpha 1C subunit; L-type calcium channel alpha-1 subunit; RATIVS302; RBC; voltage-dependent L-type calcium channel subunit alpha-1C; voltage-gated calcium channel subunit alpha Cav1.2
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
CACNA1C (calcium voltage-gated channel subunit alpha1 C) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Cacna1c (calcium channel, voltage-dependent, L type, alpha 1C subunit) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Cacna1c (calcium voltage-gated channel subunit alpha1 C) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
CACNA1C (calcium voltage-gated channel subunit alpha1 C) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
CACNA1C (calcium voltage-gated channel subunit alpha1 C) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Cacna1c (calcium voltage-gated channel subunit alpha1 C) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
CACNA1C (calcium voltage-gated channel subunit alpha1 C) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
CACNA1C (calcium voltage-gated channel subunit alpha1 C) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Cacna1c (calcium voltage-gated channel subunit alpha1 C) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
CACNA1D (calcium voltage-gated channel subunit alpha1 D) HGNC
OrthoDB, OrthoMCL
Homo sapiens (human):
CACNA1F (calcium voltage-gated channel subunit alpha1 F) HGNC
OrthoMCL
Homo sapiens (human):
CACNA1E (calcium voltage-gated channel subunit alpha1 E) HGNC
OrthoMCL
Homo sapiens (human):
CACNA1A (calcium voltage-gated channel subunit alpha1 A) HGNC
OrthoMCL
Homo sapiens (human):
CACNA1S (calcium voltage-gated channel subunit alpha1 S) HGNC
OrthoMCL
Homo sapiens (human):
CACNA1B (calcium voltage-gated channel subunit alpha1 B) HGNC
OrthoMCL
Alliance orthologs 3
Homo sapiens (human):
CACNA1C (calcium voltage-gated channel subunit alpha1 C)
Alliance
DIOPT (PANTHER|HGNC|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Mus musculus (house mouse):
Cacna1c (calcium channel, voltage-dependent, L type, alpha 1C subunit)
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Danio rerio (zebrafish):
cacna1c (calcium channel, voltage-dependent, L type, alpha 1C subunit)
Alliance
DIOPT (PANTHER|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Saccharomyces cerevisiae (baker's yeast):
CCH1
Alliance
DIOPT (PANTHER|PhylomeDB|OrthoFinder|OrthoInspector|Hieranoid)
Drosophila melanogaster (fruit fly):
Ca-alpha1D
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Caenorhabditis elegans (roundworm):
egl-19
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Allele / Splice:
Cacna1cem1Sage
Genetic Models:
SD-Cacna1cem1Sage
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 4 150,635,808 - 151,270,790 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 4 150,641,066 - 150,829,913 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 4 216,562,477 - 217,184,927 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 4 154,895,691 - 155,517,389 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 4 155,140,531 - 155,762,230 (-) NCBI Celera 4 140,633,057 - 141,244,304 (-) NCBI Celera Cytogenetic Map 4 q42 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
amyloidosis ISO RGD:10268 8554872 ClinVar Annotator: match by term: Amyloidosis ClinVar PMID:25741868 , PMID:28492532 arrhythmogenic right ventricular cardiomyopathy ISO RGD:10268 8554872 ClinVar Annotator: match by term: Arrhythmogenic right ventricular dysplasia ClinVar PMID:23861362 more ... breast ductal carcinoma ISO RGD:10268 8554872 ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar Brugada syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Sudden unexplained nocturnal death syndrome ClinVar PMID:25741868 , PMID:28492532 Brugada syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Sudden Unexplained Nocturnal Death Syndrome (SUNDS) ClinVar PMID:20817017 more ... Brugada syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Brugada syndrome ClinVar PMID:23631430 more ... Brugada syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Sudden Unexplained Nocturnal Death Syndrome (SUNDS) ClinVar PMID:23861362 more ... Brugada syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Sudden Unexplained Nocturnal Death Syndrome (SUNDS) ClinVar PMID:20817017 more ... Brugada syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Brugada syndrome ClinVar PMID:20817017 more ... Brugada syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Brugada syndrome ClinVar PMID:20817017 more ... Brugada syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Sudden Unexplained Nocturnal Death Syndrome (SUNDS) ClinVar PMID:20817017 more ... Brugada syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Brugada syndrome ClinVar PMID:25741868 more ... Brugada syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Sudden Unexplained Nocturnal Death Syndrome (SUNDS) ClinVar PMID:20817017 more ... Brugada syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Sudden unexplained nocturnal death syndrome ClinVar PMID:20031608 more ... Brugada syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Brugada syndrome ClinVar PMID:12166659 , PMID:28492532 Brugada syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Sudden Unexplained Nocturnal Death Syndrome (SUNDS) ClinVar PMID:23861362 more ... Brugada syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Sudden unexplained nocturnal death syndrome ClinVar PMID:25741868 Brugada syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Sudden unexplained nocturnal death syndrome ClinVar PMID:23861362 more ... Brugada syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Brugada syndrome ClinVar PMID:25637381 Brugada syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Brugada syndrome ClinVar PMID:20817017 more ... Brugada syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Brugada syndrome ClinVar PMID:17224476 more ... Brugada syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Brugada syndrome ClinVar PMID:20031608 , PMID:25741868 Brugada syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Brugada syndrome ClinVar PMID:17224476 more ... Brugada syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Sudden unexplained nocturnal death syndrome ClinVar PMID:23861362 , PMID:28492532 Brugada syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Brugada syndrome ClinVar PMID:23861362 more ... Brugada syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Brugada syndrome ClinVar Brugada syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Sudden unexplained nocturnal death syndrome ClinVar PMID:28492532 Brugada syndrome 3 ISO RGD:10268 8554872 ClinVar Annotator: match by term: Brugada syndrome 3 ClinVar PMID:20817017 more ... Brugada syndrome 3 ISO RGD:10268 8554872 ClinVar Annotator: match by term: Brugada syndrome 3 ClinVar PMID:23861362 more ... Brugada syndrome 3 ISO RGD:10268 8554872 ClinVar Annotator: match by term: Brugada syndrome 3 ClinVar PMID:17224476 more ... Brugada syndrome 3 ISO RGD:10268 8554872 ClinVar Annotator: match by term: Brugada syndrome 3 ClinVar PMID:17224476 more ... Brugada syndrome 3 ISO RGD:10268 8554872 ClinVar Annotator: match by term: Brugada syndrome 3 ClinVar PMID:25741868 , PMID:28492532 Cardiac Arrhythmias ISO RGD:10268 8554872 ClinVar Annotator: match by synonym: EXTRASYSTOLES ClinVar Cardiac Arrhythmias ISO RGD:10268 8554872 ClinVar Annotator: match by term: Cardiac arrhythmia ClinVar PMID:24690944 more ... Cardiac Arrhythmias ISO RGD:10268 8554872 ClinVar Annotator: match by term: Cardiac arrhythmia ClinVar PMID:25741868 , PMID:28492532 Cardiac Arrhythmias ISO RGD:10268 8554872 ClinVar Annotator: match by term: Cardiac arrhythmia ClinVar PMID:20031608 , PMID:25741868 Cardiac Complexes, Premature ISO RGD:10268 8554872 ClinVar Annotator: match by term: EXTRASYSTOLES ClinVar PMID:25741868 , PMID:28492532 Cardiac Complexes, Premature ISO RGD:10268 8554872 ClinVar Annotator: match by term: EXTRASYSTOLES ClinVar PMID:24690944 more ... Cardiac Complexes, Premature ISO RGD:10268 8554872 ClinVar Annotator: match by term: EXTRASYSTOLES ClinVar cardiomyopathy ISO RGD:10268 8554872 ClinVar Annotator: match by term: Cardiomyopathy ClinVar PMID:23861362 more ... catecholaminergic polymorphic ventricular tachycardia ISO RGD:10268 8554872 ClinVar Annotator: match by term: Catecholaminergic polymorphic ventricular tachycardia ClinVar PMID:25633834 more ... congestive heart failure ISO RGD:10268 8554872 ClinVar Annotator: match by term: Congestive heart failure ClinVar PMID:25741868 , PMID:28492532 dilated cardiomyopathy ISO RGD:10268 8554872 ClinVar Annotator: match by term: Dilated cardiomyopathy ClinVar PMID:23677916 more ... dilated cardiomyopathy ISO RGD:10268 8554872 ClinVar Annotator: match by term: Primary dilated cardiomyopathy ClinVar epilepsy ISO RGD:10268 8554872 ClinVar Annotator: match by term: Seizure Disorders ClinVar esophageal atresia ISO RGD:10268 8554872 ClinVar Annotator: match by term: Esophageal atresia ClinVar genetic disease ISO RGD:10268 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar genetic disease ISO RGD:10268 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:12417552 more ... Hyperphosphatemic Familial Tumoral Calcinosis 1 ISO RGD:10268 8554872 ClinVar Annotator: match by term: Hyperphosphatemic familial tumoral calcinosis 1 ClinVar PMID:25378588 , PMID:29389098 hypertrophic cardiomyopathy ISO RGD:10268 8554872 ClinVar Annotator: match by term: Hypertrophic cardiomyopathy ClinVar PMID:20817017 more ... hypertrophic cardiomyopathy ISO RGD:10268 8554872 ClinVar Annotator: match by term: Hypertrophic cardiomyopathy ClinVar PMID:23861362 more ... hypertrophic cardiomyopathy 1 ISO RGD:10268 8554872 ClinVar Annotator: match by term: Familial hypertrophic cardiomyopathy 1 ClinVar PMID:26253506 , PMID:28492532 long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:28492532 long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:15863612 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:23631430 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:15454078 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:23631430 , PMID:28492532 long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:28492532 , PMID:28600387 long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:23861362 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:26253506 , PMID:28492532 long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:25633834 , PMID:28492532 long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:23861362 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:25341504 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:24981977 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:23677916 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:25741868 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:23861362 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:25184293 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:25741868 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:25633834 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:20817017 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:24728418 , PMID:28492532 long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:25633834 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:27231019 , PMID:28492532 long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:23677916 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:23861362 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:23174487 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:27920829 , PMID:28492532 long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:20031608 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:20817017 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:25741868 long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:20817017 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:12166659 , PMID:28492532 long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:27005929 , PMID:28492532 long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:17224476 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:20817017 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:20817017 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:23861362 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:20817017 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:24690944 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:26743238 , PMID:28492532 long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:24033266 , PMID:28492532 long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:23861362 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Congenital long QT syndrome ClinVar PMID:15863612 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:20817017 more ... long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by null ClinVar long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:23861362 , PMID:28492532 long QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:25741868 , PMID:28492532 restrictive cardiomyopathy ISO RGD:10268 8554872 ClinVar Annotator: match by term: Restrictive cardiomyopathy ClinVar PMID:20817017 more ... schizophrenia ISO RGD:10268 8554872 ClinVar Annotator: match by term: Schizophrenia ClinVar PMID:21681106 , PMID:30208311 short QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Short QT Syndrome 4 ClinVar PMID:25741868 , PMID:28492532 short QT syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: short QT syndrome ClinVar PMID:20031608 more ... Sudden Cardiac Death ISO RGD:10268 8554872 ClinVar Annotator: match by term: Sudden cardiac death ClinVar Sudden Death ISO RGD:10268 8554872 ClinVar Annotator: match by term: Sudden unexplained death ClinVar PMID:25741868 , PMID:28492532 Sudden Unexpected Nocturnal Death Syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Sudden unexpected nocturnal death syndrome ClinVar PMID:23861362 , PMID:28492532 Sudden Unexpected Nocturnal Death Syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Sudden unexpected nocturnal death syndrome ClinVar PMID:23861362 more ... Sudden Unexpected Nocturnal Death Syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Sudden unexpected nocturnal death syndrome ClinVar PMID:23861362 more ... Sudden Unexpected Nocturnal Death Syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Sudden unexpected nocturnal death syndrome ClinVar PMID:23861362 more ... Sudden Unexpected Nocturnal Death Syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Sudden unexpected nocturnal death syndrome ClinVar PMID:17224476 more ... Sudden Unexpected Nocturnal Death Syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Sudden unexpected nocturnal death syndrome ClinVar PMID:20031608 more ... Sudden Unexpected Nocturnal Death Syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Sudden unexpected nocturnal death syndrome ClinVar Sudden Unexpected Nocturnal Death Syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Sudden unexpected nocturnal death syndrome ClinVar PMID:12166659 , PMID:28492532 Sudden Unexpected Nocturnal Death Syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Sudden unexpected nocturnal death syndrome ClinVar PMID:20817017 more ... Sudden Unexpected Nocturnal Death Syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Sudden unexpected nocturnal death syndrome ClinVar PMID:20817017 more ... Sudden Unexpected Nocturnal Death Syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Sudden unexpected nocturnal death syndrome ClinVar PMID:20817017 more ... Sudden Unexpected Nocturnal Death Syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Sudden unexpected nocturnal death syndrome ClinVar PMID:23861362 more ... Sudden Unexpected Nocturnal Death Syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Sudden unexpected nocturnal death syndrome ClinVar PMID:25741868 , PMID:28492532 Sudden Unexpected Nocturnal Death Syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Sudden unexpected nocturnal death syndrome ClinVar PMID:28492532 Sudden Unexpected Nocturnal Death Syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Sudden unexpected nocturnal death syndrome ClinVar PMID:20817017 more ... Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Timothy syndrome ClinVar PMID:20817017 more ... Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Timothy syndrome ClinVar PMID:23631430 more ... Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Timothy syndrome ClinVar PMID:24728418 Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Timothy syndrome ClinVar PMID:25633834 Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Timothy syndrome ClinVar PMID:15454078 more ... Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Timothy syndrome ClinVar PMID:23677916 Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Timothy syndrome ClinVar PMID:23861362 more ... Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Timothy syndrome ClinVar PMID:22106044 Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Timothy syndrome ClinVar PMID:23861362 more ... Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Timothy syndrome ClinVar PMID:20817017 more ... Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Timothy syndrome ClinVar PMID:20817017 more ... Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Timothy syndrome ClinVar PMID:20817017 more ... Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Timothy syndrome ClinVar PMID:24690944 more ... Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Timothy syndrome ClinVar PMID:23861362 more ... Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Timothy syndrome ClinVar PMID:20031608 more ... Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Timothy syndrome ClinVar PMID:12166659 , PMID:28492532 Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Timothy syndrome ClinVar PMID:20817017 more ... Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Timothy syndrome ClinVar PMID:23861362 more ... Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome 8 ClinVar PMID:23174487 more ... Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Timothy syndrome ClinVar PMID:25741868 more ... Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Timothy syndrome ClinVar PMID:25633834 more ... Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Long QT syndrome 8 ClinVar PMID:23677916 more ... Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Timothy syndrome ClinVar PMID:17224476 more ... Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by OMIM:601005 ClinVar PMID:20031608 , PMID:25741868 Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by OMIM:601005 ClinVar PMID:25741868 Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Timothy syndrome ClinVar PMID:15863612 more ... Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by OMIM:601005 ClinVar Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Timothy syndrome ClinVar PMID:23861362 , PMID:28492532 Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Timothy syndrome ClinVar PMID:15454078 Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Timothy syndrome ClinVar PMID:23861362 more ... Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Timothy syndrome ClinVar PMID:28492532 Timothy syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Timothy syndrome ClinVar PMID:25741868 , PMID:28492532 Ventricular Fibrillation, Paroxysmal Familial, 1 ISO RGD:10268 8554872 ClinVar Annotator: match by term: Paroxysmal familial ventricular fibrillation 1 ClinVar PMID:15863612 more ... Ventricular Tachycardia ISO RGD:10268 8554872 ClinVar Annotator: match by term: Ventricular tachycardia ClinVar Ventricular Tachycardia ISO RGD:10268 8554872 ClinVar Annotator: match by term: Ventricular tachycardia ClinVar PMID:25741868 , PMID:28492532 Wolff-Parkinson-White syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:25633834 more ... Wolff-Parkinson-White syndrome ISO RGD:10268 8554872 ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:28492532
Imported Annotations - CTD
acute stress disorder ISO RGD:10268 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28696432 anxiety disorder ISO RGD:10268 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28696432 autistic disorder ISO RGD:10268 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15454078 bipolar disorder ISO RGD:10268 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18711365 more ... Cardiac Arrhythmias ISO RGD:10268 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15454078 Cognitive Dysfunction ISO RGD:10268 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28696432 Congenital Limb Deformities ISO RGD:10268 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15454078 Genetic Predisposition to Disease ISO RGD:10268 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28696432 hypertension ISO RGD:10268 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22949532 hypoglycemia ISO RGD:10268 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15454078 major depressive disorder ISO RGD:10268 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28696432 primary immunodeficiency disease ISO RGD:10268 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15454078 Psychomotor Agitation ISO RGD:10268 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28696432 Timothy syndrome ISO RGD:10268 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15454078 Imported Annotations - OMIM
Brugada syndrome 3 ISO RGD:10268 7240710 OMIM Timothy syndrome ISO RGD:10268 7240710 OMIM
(+)-pilocarpine decreases expression ISO RGD:1550302 6480464 Pilocarpine results in decreased expression of CACNA1C protein CTD PMID:17265461 (+)-pilocarpine increases expression ISO RGD:1550302 6480464 Pilocarpine results in increased expression of CACNA1C protein CTD PMID:17265461 (R)-mevalonic acid multiple interactions EXP 6480464 Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1C mRNA] more ... CTD PMID:19791473 (S)-nicotine increases expression ISO RGD:1550302 6480464 Nicotine results in increased expression of CACNA1C protein CTD PMID:11756415 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1550302 6480464 Tetrachlorodibenzodioxin results in decreased expression of CACNA1C mRNA CTD PMID:19465110 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of CACNA1C mRNA CTD PMID:32109520 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1550302 6480464 Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CACNA1C promoter] CTD PMID:19654925 2,3,7,8-Tetrachlorodibenzofuran decreases expression EXP 6480464 2 more ... CTD PMID:32109520 2,4,6-trinitrobenzenesulfonic acid increases expression EXP 6480464 Trinitrobenzenesulfonic Acid results in increased expression of CACNA1C mRNA, Trinitrobenzenesulfonic Acid results in increased expression of CACNA1C protein CTD PMID:23537331 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile multiple interactions EXP 6480464 Mevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1C mRNA], Mevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1C protein] CTD PMID:19791473 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile multiple interactions ISO RGD:1550302 6480464 Verapamil inhibits the reaction [Iron-Dextran Complex affects the expression of CACNA1C protein] CTD PMID:27095094 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile increases response to substance ISO RGD:10268 6480464 CACNA1C gene polymorphism results in increased susceptibility to Verapamil CTD PMID:20031608 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile decreases expression EXP 6480464 Verapamil results in decreased expression of CACNA1C mRNA, Verapamil results in decreased expression of CACNA1C protein CTD PMID:19791473 4,4'-sulfonyldiphenol increases expression ISO RGD:1550302 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of CACNA1C mRNA CTD PMID:30951980 acetamide increases expression EXP 6480464 acetamide results in increased expression of CACNA1C mRNA CTD PMID:31881176 aflatoxin B1 decreases methylation ISO RGD:10268 6480464 Aflatoxin B1 results in decreased methylation of CACNA1C gene CTD PMID:27153756 aflatoxin B1 increases methylation ISO RGD:10268 6480464 Aflatoxin B1 results in increased methylation of CACNA1C exon, Aflatoxin B1 results in increased methylation of CACNA1C intron CTD PMID:30157460 aflatoxin B2 increases methylation ISO RGD:10268 6480464 aflatoxin B2 results in increased methylation of CACNA1C exon, aflatoxin B2 results in increased methylation of CACNA1C intron CTD PMID:30157460 all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of CACNA1C mRNA CTD PMID:23056435 allethrin multiple interactions EXP 6480464 Allethrins inhibits the reaction [CACNA1C protein results in increased transport of Calcium] CTD PMID:14634047 amiodarone decreases expression ISO RGD:1550302 6480464 Amiodarone results in decreased expression of CACNA1C mRNA CTD PMID:15520326 amphetamine increases expression EXP 6480464 Amphetamine results in increased expression of CACNA1C mRNA, Amphetamine results in increased expression of CACNA1C protein CTD PMID:15329393 androgen antagonist multiple interactions EXP 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] affects the expression of CACNA1C mRNA CTD PMID:25607892 arsane affects methylation ISO RGD:10268 6480464 Arsenic affects the methylation of CACNA1C gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:10268 6480464 Arsenic affects the methylation of CACNA1C gene CTD PMID:25304211 arsenous acid decreases expression ISO RGD:1550302 6480464 Arsenic Trioxide results in decreased expression of CACNA1C mRNA CTD PMID:24831965 atenolol increases response to substance ISO RGD:10268 6480464 CACNA1C gene polymorphism results in increased susceptibility to Atenolol CTD PMID:20031608 barium(0) increases transport EXP 6480464 CACNA1C protein results in increased transport of Barium CTD PMID:17569661 benzo[a]pyrene multiple interactions ISO RGD:1550302 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to CACNA1C promoter] CTD PMID:19654925 benzo[a]pyrene affects methylation ISO RGD:10268 6480464 Benzo(a)pyrene affects the methylation of CACNA1C exon, Benzo(a)pyrene affects the methylation of CACNA1C intron CTD PMID:30157460 benzo[a]pyrene decreases expression ISO RGD:10268 6480464 Benzo(a)pyrene results in decreased expression of CACNA1C mRNA CTD PMID:22316170 benzo[e]pyrene affects methylation ISO RGD:10268 6480464 benzo(e)pyrene affects the methylation of CACNA1C intron CTD PMID:30157460 benzo[e]pyrene increases methylation ISO RGD:10268 6480464 benzo(e)pyrene results in increased methylation of CACNA1C exon CTD PMID:30157460 bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of CACNA1C mRNA CTD PMID:20920545 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1C mRNA CTD PMID:25607892 bisphenol A increases expression ISO RGD:10268 6480464 bisphenol A results in increased expression of CACNA1C mRNA CTD PMID:17989879 bisphenol A multiple interactions ISO RGD:1550302 6480464 [bisphenol A co-treated with Streptozocin] results in decreased expression of CACNA1C mRNA CTD PMID:29935216 bisphenol A increases expression ISO RGD:1550302 6480464 bisphenol A results in increased expression of CACNA1C mRNA CTD PMID:30951980 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of CACNA1C mRNA CTD PMID:30816183 bisphenol A increases methylation ISO RGD:1550302 6480464 bisphenol A results in increased methylation of CACNA1C promoter CTD PMID:27312807 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of CACNA1C mRNA CTD PMID:25181051 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] affects the expression of CACNA1C mRNA, [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of CACNA1C mRNA CTD PMID:25607892 bisphenol F increases expression ISO RGD:1550302 6480464 bisphenol F results in increased expression of CACNA1C mRNA CTD PMID:30951980 butanal increases expression ISO RGD:10268 6480464 butyraldehyde results in increased expression of CACNA1C mRNA CTD PMID:26079696 Butylparaben multiple interactions EXP 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] affects the expression of CACNA1C mRNA, [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of CACNA1C mRNA CTD PMID:25607892 calcium atom multiple interactions ISO RGD:10268 6480464 [CACNA1C protein co-treated with CACNB3 protein] results in increased transport of Calcium more ... CTD PMID:12181424 calcium atom multiple interactions EXP 6480464 Allethrins inhibits the reaction [CACNA1C protein results in increased transport of Calcium] CTD PMID:14634047 calcium atom increases transport EXP 6480464 CACNA1C protein results in increased transport of Calcium CTD PMID:14634047 calcium atom increases transport ISO RGD:10268 6480464 CACNA1C protein results in increased transport of Calcium CTD PMID:15299022 calcium(0) multiple interactions ISO RGD:10268 6480464 [CACNA1C protein co-treated with CACNB3 protein] results in increased transport of Calcium more ... CTD PMID:12181424 calcium(0) multiple interactions EXP 6480464 Allethrins inhibits the reaction [CACNA1C protein results in increased transport of Calcium] CTD PMID:14634047 calcium(0) increases transport EXP 6480464 CACNA1C protein results in increased transport of Calcium CTD PMID:14634047 calcium(0) increases transport ISO RGD:10268 6480464 CACNA1C protein results in increased transport of Calcium CTD PMID:15299022 chloroprene decreases expression ISO RGD:1550302 6480464 Chloroprene results in decreased expression of CACNA1C mRNA CTD PMID:23125180 chlorpyrifos decreases expression EXP 6480464 Chlorpyrifos results in decreased expression of CACNA1C mRNA CTD PMID:18668222 cisplatin decreases expression ISO RGD:1550302 6480464 Cisplatin results in decreased expression of CACNA1C mRNA CTD PMID:21151649 crizotinib decreases activity ISO RGD:10268 6480464 crizotinib results in decreased activity of CACNA1C protein CTD PMID:23707608 DDE multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1C mRNA CTD PMID:25607892 diarsenic trioxide decreases expression ISO RGD:1550302 6480464 Arsenic Trioxide results in decreased expression of CACNA1C mRNA CTD PMID:24831965 dibutyl phthalate multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1C mRNA CTD PMID:25607892 diltiazem multiple interactions ISO RGD:1550302 6480464 Diltiazem inhibits the reaction [Iron-Dextran Complex affects the expression of CACNA1C protein] CTD PMID:27095094 disodium selenite multiple interactions ISO RGD:1550302 6480464 [ptaquiloside co-treated with Sodium Selenite] results in decreased expression of CACNA1C mRNA CTD PMID:23274088 doxorubicin affects methylation EXP 6480464 Doxorubicin affects the methylation of CACNA1C gene CTD PMID:28962528 doxorubicin decreases expression ISO RGD:10268 6480464 Doxorubicin results in decreased expression of CACNA1C mRNA CTD PMID:29803840 enzacamene multiple interactions EXP 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] affects the expression of CACNA1C mRNA, [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of CACNA1C mRNA CTD PMID:25607892 epoxiconazole multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1C mRNA CTD PMID:25607892 ethanol increases expression ISO RGD:1550302 6480464 Ethanol results in increased expression of CACNA1C mRNA CTD PMID:30319688 ethanol affects expression ISO RGD:1550302 6480464 Ethanol affects the expression of CACNA1C mRNA CTD PMID:30319688 ezogabine affects activity ISO RGD:10268 6480464 ezogabine affects the activity of CACNA1C protein CTD PMID:28641963 formaldehyde decreases expression EXP 6480464 Formaldehyde results in decreased expression of CACNA1C protein CTD PMID:30974163 furan increases expression EXP 6480464 furan results in increased expression of CACNA1C mRNA CTD PMID:27387713 iron dextran multiple interactions ISO RGD:1550302 6480464 Diltiazem inhibits the reaction [Iron-Dextran Complex affects the expression of CACNA1C protein] more ... CTD PMID:27095094 iron dextran affects expression ISO RGD:1550302 6480464 Iron-Dextran Complex affects the expression of CACNA1C protein CTD PMID:27095094 isoprenaline increases expression EXP 6480464 Isoproterenol results in increased expression of CACNA1C mRNA CTD PMID:17526999 lead(0) affects expression ISO RGD:10268 6480464 Lead affects the expression of CACNA1C mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:10268 6480464 Lead affects the expression of CACNA1C mRNA CTD PMID:28903495 linsidomine multiple interactions ISO RGD:10268 6480464 [linsidomine co-treated with Peroxynitrous Acid] results in increased nitrosation of CACNA1C protein CTD PMID:17551092 linuron multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1C mRNA CTD PMID:25607892 methamphetamine decreases methylation ISO RGD:1550302 6480464 Methamphetamine results in decreased methylation of CACNA1C promoter CTD PMID:26307267 methamphetamine increases expression ISO RGD:1550302 6480464 Methamphetamine results in increased expression of CACNA1C mRNA, Methamphetamine results in increased expression of CACNA1C protein CTD PMID:26307267 methapyrilene increases methylation ISO RGD:10268 6480464 Methapyrilene results in increased methylation of CACNA1C exon CTD PMID:30157460 methapyrilene affects methylation ISO RGD:10268 6480464 Methapyrilene affects the methylation of CACNA1C intron CTD PMID:30157460 methotrexate increases expression ISO RGD:10268 6480464 Methotrexate results in increased expression of CACNA1C mRNA CTD PMID:21678067 methotrexate decreases expression ISO RGD:10268 6480464 Methotrexate results in decreased expression of CACNA1C mRNA CTD PMID:24449571 methylene blue multiple interactions ISO RGD:1550302 6480464 Methylene Blue inhibits the reaction [Sodium Cyanide results in increased phosphorylation of CACNA1C protein] CTD PMID:31173149 N-nitrosodiethylamine increases expression ISO RGD:1550302 6480464 Diethylnitrosamine results in increased expression of CACNA1C mRNA CTD PMID:24535843 nefazodone affects activity ISO RGD:10268 6480464 nefazodone affects the activity of CACNA1C protein CTD PMID:26821276 nicotine increases expression ISO RGD:1550302 6480464 Nicotine results in increased expression of CACNA1C protein CTD PMID:11756415 nifedipine affects response to substance ISO RGD:1550302 6480464 CACNA1C protein affects the susceptibility to Nifedipine CTD PMID:18441296 nifedipine multiple interactions ISO RGD:10268 6480464 Nifedipine inhibits the reaction [[Potassium Chloride co-treated with CACNA1C protein alternative form] results in increased phosphorylation of CREB1 protein] CTD PMID:20128810 nimodipine multiple interactions ISO RGD:1550302 6480464 Nimodipine inhibits the reaction [Iron-Dextran Complex affects the expression of CACNA1C protein] CTD PMID:27095094 paracetamol multiple interactions EXP 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] affects the expression of CACNA1C mRNA CTD PMID:25607892 paraquat increases expression EXP 6480464 Paraquat results in increased expression of CACNA1C mRNA CTD PMID:18198484 peroxynitrous acid multiple interactions ISO RGD:10268 6480464 [linsidomine co-treated with Peroxynitrous Acid] results in increased nitrosation of CACNA1C protein more ... CTD PMID:17551092 , PMID:20128810 peroxynitrous acid increases metabolic processing ISO RGD:10268 6480464 Peroxynitrous Acid results in increased metabolism of CACNA1C protein alternative form CTD PMID:20128810 pioglitazone multiple interactions ISO RGD:1550302 6480464 [N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of CACNA1C mRNA CTD PMID:27935865 potassium chloride multiple interactions ISO RGD:10268 6480464 [Potassium Chloride co-treated with CACNA1C protein alternative form] results in increased phosphorylation of CREB1 protein more ... CTD PMID:20128810 pregabalin affects localization EXP 6480464 Pregabalin affects the localization of CACNA1C protein CTD PMID:22949532 prochloraz multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1C mRNA CTD PMID:25607892 procymidone multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1C mRNA CTD PMID:25607892 progesterone increases expression EXP 6480464 Progesterone results in increased expression of CACNA1C mRNA CTD PMID:20726854 Ptaquiloside multiple interactions ISO RGD:1550302 6480464 [ptaquiloside co-treated with Sodium Selenite] results in decreased expression of CACNA1C mRNA CTD PMID:23274088 resveratrol decreases expression ISO RGD:1550302 6480464 resveratrol results in decreased expression of CACNA1C mRNA CTD PMID:22610192 rotenone increases expression EXP 6480464 Rotenone results in increased expression of CACNA1C mRNA CTD PMID:31585160 rotenone multiple interactions EXP 6480464 [3-bromo-2-oxopropionic acid co-treated with Rotenone] results in increased expression of CACNA1C mRNA CTD PMID:31585160 silver atom decreases expression ISO RGD:1550302 6480464 Silver results in decreased expression of CACNA1C mRNA CTD PMID:27131904 silver(0) decreases expression ISO RGD:1550302 6480464 Silver results in decreased expression of CACNA1C mRNA CTD PMID:27131904 simvastatin multiple interactions EXP 6480464 Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1C mRNA], Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1C protein] CTD PMID:19791473 simvastatin decreases expression EXP 6480464 Simvastatin results in decreased expression of CACNA1C mRNA, Simvastatin results in decreased expression of CACNA1C protein CTD PMID:19791473 sodium arsenate increases expression ISO RGD:1550302 6480464 sodium arsenate results in increased expression of CACNA1C mRNA CTD PMID:21795629 sodium arsenite affects methylation ISO RGD:10268 6480464 sodium arsenite affects the methylation of CACNA1C gene CTD PMID:28589171 sodium arsenite decreases expression ISO RGD:10268 6480464 sodium arsenite results in decreased expression of CACNA1C mRNA CTD PMID:21776218 sodium cyanide increases phosphorylation ISO RGD:1550302 6480464 Sodium Cyanide results in increased phosphorylation of CACNA1C protein CTD PMID:31173149 sodium cyanide multiple interactions ISO RGD:1550302 6480464 [Sodium Cyanide results in increased activity of PRKCE protein] which results in increased phosphorylation of CACNA1C protein, Methylene Blue inhibits the reaction [Sodium Cyanide results in increased phosphorylation of CACNA1C protein] CTD PMID:31173149 streptozocin multiple interactions ISO RGD:1550302 6480464 [bisphenol A co-treated with Streptozocin] results in decreased expression of CACNA1C mRNA, [octylphenol co-treated with Streptozocin] results in decreased expression of CACNA1C mRNA CTD PMID:29935216 streptozocin increases expression ISO RGD:1550302 6480464 Streptozocin results in increased expression of CACNA1C mRNA CTD PMID:29935216 sunitinib decreases activity ISO RGD:10268 6480464 sunitinib results in decreased activity of CACNA1C protein CTD PMID:23707608 sunitinib multiple interactions ISO RGD:1550302 6480464 PIK3CA protein inhibits the reaction [Sunitinib results in decreased expression of CACNA1C protein] CTD PMID:31025080 sunitinib decreases expression ISO RGD:1550302 6480464 Sunitinib results in decreased expression of CACNA1C protein CTD PMID:31025080 sunitinib decreases expression ISO RGD:10268 6480464 Sunitinib results in decreased expression of CACNA1C mRNA CTD PMID:31533062 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of CACNA1C mRNA CTD PMID:31150632 thalidomide decreases expression ISO RGD:1550302 6480464 Thalidomide results in decreased expression of CACNA1C mRNA CTD PMID:26006729 , PMID:26217789 torcetrapib increases expression ISO RGD:10268 6480464 torcetrapib results in increased expression of CACNA1C mRNA CTD PMID:20498617 trichloroethene decreases expression ISO RGD:10268 6480464 Trichloroethylene results in decreased expression of CACNA1C mRNA CTD PMID:25847060 tunicamycin increases expression ISO RGD:1550302 6480464 Tunicamycin results in increased expression of CACNA1C mRNA CTD PMID:17127020 valproic acid decreases methylation ISO RGD:10268 6480464 Valproic Acid results in decreased methylation of CACNA1C gene CTD PMID:29154799 valproic acid increases methylation ISO RGD:10268 6480464 Valproic Acid results in increased methylation of CACNA1C gene CTD PMID:29501571 valproic acid affects splicing EXP 6480464 Valproic Acid affects the splicing of CACNA1C mRNA CTD PMID:29427782 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of CACNA1C mRNA CTD PMID:29427782 verapamil increases response to substance ISO RGD:10268 6480464 CACNA1C gene polymorphism results in increased susceptibility to Verapamil CTD PMID:20031608 verapamil multiple interactions ISO RGD:1550302 6480464 Verapamil inhibits the reaction [Iron-Dextran Complex affects the expression of CACNA1C protein] CTD PMID:27095094 verapamil decreases expression EXP 6480464 Verapamil results in decreased expression of CACNA1C mRNA, Verapamil results in decreased expression of CACNA1C protein CTD PMID:19791473 verapamil multiple interactions EXP 6480464 Mevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1C mRNA], Mevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1C protein] CTD PMID:19791473 vinclozolin multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1C mRNA CTD PMID:25607892 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of CACNA1C mRNA CTD PMID:23034163 zinc atom increases expression EXP 6480464 Zinc results in increased expression of CACNA1C mRNA CTD PMID:15159208 , PMID:17074742 zinc sulfate increases expression EXP 6480464 Zinc Sulfate results in increased expression of CACNA1C mRNA CTD PMID:17074742 zinc(0) increases expression EXP 6480464 Zinc results in increased expression of CACNA1C mRNA CTD PMID:15159208 , PMID:17074742
Biological Process adult walking behavior ISO RGD:1550302 1624291 MGI:MGI:109482 (MGI:MGI:1329569 , PMID:9882694) RGD MGI:MGI:1329569 , PMID:9882694 calcium ion import IMP 7205456 RGD calcium ion import IBA PANTHER:PTN001295314 more ... 13792537 PMID:21873635 GO_Central calcium ion transmembrane transport ISO RGD:10268 1624291 (PMID:15454078), (PMID:24728418) RGD PMID:15454078 , PMID:24728418 calcium ion transmembrane transport IEA UniProtKB-KW:KW-0107 1600115 GO_REF:0000043 UniProt GO_REF:0000043 calcium ion transmembrane transport via high voltage-gated calcium channel ISO RGD:10268 1624291 (PMID:15454078) RGD PMID:15454078 calcium ion transmembrane transport via high voltage-gated calcium channel ISS UniProtKB:Q13936 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 calcium ion transmembrane transport via high voltage-gated calcium channel IEA UniProtKB:Q13936 , ensembl:ENSP000002663761600115 GO_REF:0000107 Ensembl GO_REF:0000107 calcium ion transmembrane transport via high voltage-gated calcium channel IDA 11558004 PMID:15170217 UniProt calcium ion transport IMP 1580158 RGD calcium ion transport IBA CGD:CAL0000177769 more ... 13792537 PMID:21873635 GO_Central calcium ion transport ISO RGD:1550302 1624291 MGI:MGI:2674114 more ... RGD MGI:MGI:3607037 more ... calcium ion transport into cytosol ISS UniProtKB:P15381 1600115 GO_REF:0000024 UniProt GO_REF:0000024 calcium-ion regulated exocytosis ISO RGD:1550302 1624291 MGI:MGI:2176227 more ... RGD MGI:MGI:2670808 , PMID:12881419 camera-type eye development ISO RGD:10268 1624291 (PMID:15454078) RGD PMID:15454078 camera-type eye development IEA UniProtKB:Q13936 , ensembl:ENSP000002663761600115 GO_REF:0000107 Ensembl GO_REF:0000107 cardiac conduction ISO RGD:10268 1624291 (PMID:24728418) RGD PMID:24728418 cardiac conduction ISS UniProtKB:Q13936 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cardiac muscle cell action potential involved in contraction ISO RGD:10268 1624291 (PMID:15454078) RGD PMID:15454078 cardiac muscle cell action potential involved in contraction ISS UniProtKB:Q13936 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 cellular calcium ion homeostasis ISO RGD:1550302 1624291 MGI:MGI:2674119 (MGI:MGI:3699638 , PMID:15132976) RGD MGI:MGI:3699638 , PMID:15132976 cellular response to amyloid-beta IEP 13782265 RGD chemical synaptic transmission ISO RGD:1550302 1624291 MGI:MGI:2674114 (MGI:MGI:3607037 , PMID:16251435) RGD MGI:MGI:3607037 , PMID:16251435 embryonic forelimb morphogenesis ISO RGD:10268 1624291 (PMID:15454078) RGD PMID:15454078 embryonic forelimb morphogenesis IEA UniProtKB:Q13936 , ensembl:ENSP000002663761600115 GO_REF:0000107 Ensembl GO_REF:0000107 glucose homeostasis ISO RGD:1550302 1624291 MGI:MGI:2176227 more ... RGD MGI:MGI:2670808 , PMID:12881419 growth hormone secretion ISO RGD:1550302 1624291 (MGI:MGI:51674, PMID:1385406) RGD MGI:MGI:51674 , PMID:1385406 heart development ISO RGD:10268 1624291 (PMID:15454078) RGD PMID:15454078 heart development IEA UniProtKB:Q13936 , ensembl:ENSP000002663761600115 GO_REF:0000107 Ensembl GO_REF:0000107 immune system development ISO RGD:10268 1624291 (PMID:15454078) RGD PMID:15454078 immune system development IEA UniProtKB:Q13936 , ensembl:ENSP000002663761600115 GO_REF:0000107 Ensembl GO_REF:0000107 insulin secretion ISO RGD:1550302 1624291 MGI:MGI:2176227 more ... RGD MGI:MGI:2670808 , PMID:12881419 membrane depolarization during atrial cardiac muscle cell action potential ISO RGD:10268 1624291 (PMID:17224476) RGD PMID:17224476 membrane depolarization during atrial cardiac muscle cell action potential ISS UniProtKB:Q13936 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 membrane depolarization during atrial cardiac muscle cell action potential IEA UniProtKB:Q13936 , ensembl:ENSP000002663761600115 GO_REF:0000107 Ensembl GO_REF:0000107 membrane depolarization during AV node cell action potential ISO RGD:10268 1624291 (PMID:26253506) RGD PMID:26253506 membrane depolarization during AV node cell action potential ISS UniProtKB:Q13936 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 membrane depolarization during AV node cell action potential IEA UniProtKB:Q13936 , ensembl:ENSP000002663761600115 GO_REF:0000107 Ensembl GO_REF:0000107 membrane depolarization during cardiac muscle cell action potential ISO RGD:10268 1624291 (PMID:15454078) RGD PMID:15454078 membrane depolarization during cardiac muscle cell action potential ISS UniProtKB:Q13936 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 positive regulation of adenylate cyclase activity ISS UniProtKB:Q01815 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of adenylate cyclase activity ISO RGD:1550302 1624291 (MGI:MGI:6243790, PMID:24086669) RGD MGI:MGI:6243790 , PMID:24086669 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IMP 13782366 RGD positive regulation of cytosolic calcium ion concentration ISO RGD:10268 1624291 (PMID:12130699) RGD PMID:12130699 positive regulation of cytosolic calcium ion concentration IEA UniProtKB:Q13936 , ensembl:ENSP000002663761600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of blood pressure ISO RGD:1550302 1624291 MGI:MGI:2389040 more ... RGD MGI:MGI:3663939 , PMID:14609949 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ISS UniProtKB:P15381 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of heart rate by cardiac conduction ISO RGD:10268 1624291 (PMID:15454078), (PMID:15863612), (PMID:17224476), (PMID:26253506) RGD PMID:15454078 more ... regulation of heart rate by cardiac conduction ISS UniProtKB:Q13936 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 regulation of heart rate by cardiac conduction IEA UniProtKB:Q13936 , ensembl:ENSP000002663761600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of ion transmembrane transport IEA UniProtKB-KW:KW-0851 1600115 GO_REF:0000043 UniProt GO_REF:0000043 regulation of organ growth ISO RGD:1550302 1624291 MGI:MGI:2674119 (MGI:MGI:3699638 , PMID:15132976) RGD MGI:MGI:3699638 , PMID:15132976 regulation of postsynaptic membrane potential IEA GO:1905030 1600115 GO_REF:0000108 GOC GO_REF:0000108 regulation of vasoconstriction ISO RGD:1550302 1624291 MGI:MGI:2389040 more ... RGD MGI:MGI:3663939 , PMID:14609949 regulation of ventricular cardiac muscle cell action potential ISO RGD:10268 1624291 (PMID:15454078), (PMID:26253506) RGD PMID:15454078 , PMID:26253506 regulation of ventricular cardiac muscle cell action potential ISS UniProtKB:Q13936 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 regulation of ventricular cardiac muscle cell action potential IEA UniProtKB:Q13936 , ensembl:ENSP000002663761600115 GO_REF:0000107 Ensembl GO_REF:0000107 smooth muscle contraction ISO RGD:1550302 1624291 MGI:MGI:2389040 more ... RGD MGI:MGI:3653822 , PMID:16636102 smooth muscle contraction involved in micturition ISO RGD:1550302 1624291 MGI:MGI:2674119 (MGI:MGI:3699638 , PMID:15132976) RGD MGI:MGI:3699638 , PMID:15132976 visual learning ISO RGD:1550302 1624291 MGI:MGI:2674114 (MGI:MGI:3607037 , PMID:16251435) RGD MGI:MGI:3607037 , PMID:16251435 Cellular Component axon cytoplasm ISO RGD:8700081 1624291 RGD RGD:11556226 basal pole of outer hair cell ISO RGD:8700081 1624291 RGD RGD:11554335 basolateral plasma membrane ISO RGD:8700081 1624291 RGD RGD:11556226 caveolar macromolecular signaling complex ISO RGD:1550302 1624291 (MGI:MGI:3628972, PMID:16648270) RGD MGI:MGI:3628972 , PMID:16648270 cell surface IDA 13782265 MMO:0000669 RGD cytoplasm ISO RGD:8700081 1624291 RGD RGD:11556226 cytoplasm IEA UniProtKB:Q13936 , ensembl:ENSP000002663761600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytoplasm ISO RGD:10268 1624291 (PMID:11206130) RGD PMID:11206130 dendrite ISO RGD:8700081 1624291 RGD RGD:11556226 dendrite IDA 7207146 RGD dendrite IDA 7207149 PMID:15140941 UniProt dendritic shaft ISO RGD:1550302 1624291 (MGI:MGI:3580191, PMID:15090038) RGD MGI:MGI:3580191 , PMID:15090038 glutamatergic synapse IDA 12050119 PMID:18067152 SynGO integral component of membrane ISO RGD:10268 1624291 (PMID:8392192) RGD PMID:8392192 integral component of plasma membrane ISS UniProtKB:P15381 1600115 GO_REF:0000024 UniProt GO_REF:0000024 integral component of postsynaptic membrane IDA 12050119 PMID:18067152 SynGO integral component of presynaptic membrane IDA 12050119 PMID:18067152 SynGO L-type voltage-gated calcium channel complex ISO RGD:10268 1624291 (PMID:15454078) RGD PMID:15454078 L-type voltage-gated calcium channel complex ISS UniProtKB:Q13936 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 L-type voltage-gated calcium channel complex IEA UniProtKB:Q13936 , ensembl:ENSP000002663761600115 GO_REF:0000107 Ensembl GO_REF:0000107 L-type voltage-gated calcium channel complex IDA 11558004 PMID:15170217 UniProt membrane IDA 1582610 RGD membrane ISO RGD:1550302 1624291 (MGI:MGI:3699638, PMID:15132976) RGD MGI:MGI:3699638 , PMID:15132976 neuron projection terminus ISO RGD:8700081 1624291 RGD RGD:11554335 , RGD:11556226 neuronal cell body ISO RGD:1550302 1624291 (MGI:MGI:3580191, PMID:15090038) RGD MGI:MGI:3580191 , PMID:15090038 neuronal cell body IDA 7207146 RGD neuronal cell body IDA 7207149 PMID:15140941 UniProt neuronal cell body ISO RGD:8700081 1624291 RGD RGD:11556226 nucleus NOT IDA 7207149 PMID:15140941 UniProt perikaryon IEA UniProtKB-SubCell:SL-0197 1600115 GO_REF:0000044 UniProt GO_REF:0000044 plasma membrane IDA 7205477 RGD plasma membrane ISO RGD:10268 1624291 (PMID:11206130) RGD PMID:11206130 plasma membrane ISO RGD:1550302 1624291 (MGI:MGI:3580191 more ... RGD MGI:MGI:3580191 more ... postsynaptic density IDA 7207149 PMID:15140941 UniProt postsynaptic density IEA UniProtKB:Q13936 , ensembl:ENSP000002663761600115 GO_REF:0000107 Ensembl GO_REF:0000107 postsynaptic density ISO RGD:10268 1624291 (PMID:14140941) RGD PMID:14140941 postsynaptic density membrane IEA UniProtKB-SubCell:SL-0520 1600115 GO_REF:0000044 UniProt GO_REF:0000044 postsynaptic membrane IDA 12050119 PMID:18067152 SynGO presynaptic membrane IDA 12050119 PMID:18067152 SynGO presynaptic membrane NOT IDA 7207149 PMID:15140941 UniProt protein-containing complex IDA 7205477 ; 7207146 RGD sarcolemma IDA 1580158 ; 7175530 RGD T-tubule ISO RGD:1550302 1624291 (MGI:MGI:5314827, PMID:22355118) RGD MGI:MGI:5314827 , PMID:22355118 T-tubule TAS 8554533 PMID:11053140 BHF-UCL T-tubule IDA 1304018 RGD voltage-gated calcium channel complex TAS 625474 RGD voltage-gated calcium channel complex ISO RGD:10268 1624291 (PMID:12130699), (PMID:17224476) RGD PMID:12130699 , PMID:17224476 voltage-gated calcium channel complex IEA InterPro:IPR002077 , InterPro:IPR005451 1600115 GO_REF:0000002 InterPro GO_REF:0000002 voltage-gated calcium channel complex IEA InterPro:IPR002077 more ... 1600115 GO_REF:0000002 InterPro GO_REF:0000002 voltage-gated calcium channel complex IDA 1582591 RGD Z disc colocalizes_with IDA 1600288 RGD Z disc IDA 8554533 PMID:11053140 BHF-UCL Z disc ISO RGD:1550302 1624291 (MGI:MGI:3849347, PMID:19383796) RGD MGI:MGI:3849347 , PMID:19383796 Molecular Function alpha-actinin binding ISO RGD:10268 1624291 UniProtKB:P35609 (PMID:17110593) RGD PMID:17110593 alpha-actinin binding ISS UniProtKB:Q13936 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 alpha-actinin binding IEA UniProtKB:Q13936 , ensembl:ENSP000002663761600115 GO_REF:0000107 Ensembl GO_REF:0000107 calmodulin binding ISO RGD:10268 1624291 UniProtKB:P0DP23 more ... RGD PMID:15140941 calmodulin binding IEA UniProtKB:Q13936 , ensembl:ENSP000002663761600115 GO_REF:0000107 Ensembl GO_REF:0000107 enzyme binding ISO RGD:1550302 1624291 UniProtKB:B1AWC9 more ... RGD MGI:MGI:5286798 , PMID:21670503 high voltage-gated calcium channel activity IDA 7205477 RGD high voltage-gated calcium channel activity IBA MGI:MGI:88293 more ... 13792537 PMID:21873635 GO_Central high voltage-gated calcium channel activity IEA UniProtKB:Q13936 , ensembl:ENSP000002663761600115 GO_REF:0000107 Ensembl GO_REF:0000107 high voltage-gated calcium channel activity ISO RGD:10268 1624291 (PMID:15454078) RGD PMID:15454078 ion channel binding IPI UniProtKB:F1PEE8 8553445 PMID:11576544 BHF-UCL ion channel binding IPI UniProtKB:P11716 8553445 PMID:11576544 BHF-UCL metal ion binding IEA UniProtKB-KW:KW-0479 1600115 GO_REF:0000043 UniProt GO_REF:0000043 protein binding IPI UniProtKB:Q92905 1580158 RGD protein binding ISO RGD:1550302 1624291 PR:E9Q401 more ... RGD MGI:MGI:3614746 more ... protein binding ISO RGD:10268 1624291 UniProtKB:P0DP23 more ... RGD PMID:11438518 more ... protein binding IPI UniProtKB:P54287 11558004 PMID:15170217 UniProt protein binding IPI UniProtKB:P63329 8553443 PMID:19478199 IntAct protein binding IPI UniProtKB:Q9WUD9 8553251 PMID:16352297 IntAct protein binding IPI RGD:620385 7207146 RGD protein binding IPI UniProtKB:O88751 7207149 PMID:15140941 UniProt protein domain specific binding IPI RGD:1303071 1304018 RGD protein phosphatase 2A binding IPI RGD:3380 1582610 RGD protein phosphatase 2A binding IPI RGD:3381 1582610 RGD translation initiation factor binding IPI RGD:9273439 10755504 RGD voltage-gated calcium channel activity TAS 625474 RGD voltage-gated calcium channel activity IBA FB:FBgn0001991 more ... 13792537 PMID:21873635 GO_Central voltage-gated calcium channel activity ISO RGD:1550302 1624291 MGI:MGI:2176227 more ... RGD MGI:MGI:2670808 more ... voltage-gated calcium channel activity ISO RGD:10268 1624291 (PMID:12130699), (PMID:24728418), (PMID:8392192) RGD PMID:12130699 more ... voltage-gated calcium channel activity IEA InterPro:IPR002077 , InterPro:IPR005451 1600115 GO_REF:0000002 InterPro GO_REF:0000002 voltage-gated calcium channel activity IEA InterPro:IPR002077 more ... 1600115 GO_REF:0000002 InterPro GO_REF:0000002 voltage-gated calcium channel activity IDA 1582591 RGD voltage-gated calcium channel activity IMP 1580158 RGD voltage-gated calcium channel activity involved in AV node cell action potential ISO RGD:10268 1624291 (PMID:26253506) RGD PMID:26253506 voltage-gated calcium channel activity involved in AV node cell action potential ISS UniProtKB:Q13936 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 voltage-gated calcium channel activity involved in AV node cell action potential IEA UniProtKB:Q13936 , ensembl:ENSP000002663761600115 GO_REF:0000107 Ensembl GO_REF:0000107 voltage-gated calcium channel activity involved in cardiac muscle cell action potential contributes_to ISO RGD:10268 1624291 (PMID:17224476) RGD PMID:17224476 voltage-gated calcium channel activity involved in cardiac muscle cell action potential contributes_to ISS UniProtKB:Q13936 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 voltage-gated calcium channel activity involved in cardiac muscle cell action potential ISS UniProtKB:Q13936 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 voltage-gated calcium channel activity involved in cardiac muscle cell action potential ISO RGD:10268 1624291 (PMID:15454078) RGD PMID:15454078 voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential ISO RGD:1550302 1624291 (MGI:MGI:5822987, PMID:18045623) RGD MGI:MGI:5822987 , PMID:18045623
Gene-Chemical Interaction Annotations
