Ppp2cb (protein phosphatase 2 catalytic subunit beta)

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Gene: Ppp2cb (protein phosphatase 2 catalytic subunit beta) Rattus norvegicus

Analyze

Symbol:

Ppp2cb

Name:

protein phosphatase 2 catalytic subunit beta

RGD ID:

3381

Description:

Exhibits protein C-terminus binding activity and protein serine/threonine phosphatase activity. Involved in several processes, including negative regulation of Ras protein signal transduction; positive regulation of microtubule binding activity; and response to lead ion. Predicted to localize to cytoplasm and protein phosphatase type 2A complex. Orthologous to human PPP2CB (protein phosphatase 2 catalytic subunit beta); PARTICIPATES IN dopamine signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

MGC94855; PP2A-beta; Pp2a2; Protein phosphatase 2 (formerly 2A) catalytic subunit beta isoform; protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform; protein phosphatase 2, catalytic subunit, beta isoform; protein phosphatase 2, catalytic subunit, beta isozyme; protein phosphatase 2A catalytic alpha subunit; protein phosphatase 2a, catalytic subunit, beta isoform; protein phosphatase-2A-beta; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	58,558,119 - 58,579,325 (-)	NCBI
Rnor_6.0 Ensembl	16	62,273,276 - 62,294,769 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	16	62,273,276 - 62,294,767 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	16	61,933,984 - 61,955,475 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	62,330,513 - 62,351,968 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	16	62,330,587 - 62,352,043 (-)	NCBI
Celera	16	56,594,208 - 56,615,135 (-)	NCBI		Celera
Cytogenetic Map	16	q12.3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

5-aza-2'-deoxycytidine (ISO)

5-fluorouracil (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

atrazine (ISO)

bexarotene (EXP)

bisphenol A (EXP,ISO)

bufalin (ISO)

cadmium dichloride (EXP)

clozapine (EXP)

cobalt dichloride (ISO)

cocaine (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

diazinon (ISO)

dibutyl phthalate (EXP)

dichlorine (EXP)

enniatin (EXP)

ethanol (ISO)

ethyl methanesulfonate (ISO)

finasteride (EXP)

flavonoids (EXP)

flutamide (EXP)

haloperidol (EXP)

hydrogen peroxide (ISO)

ionomycin (ISO)

ketoconazole (EXP)

lead(0) (ISO)

lead(2+) (ISO)

menadione (ISO)

methotrexate (ISO)

methyl methanesulfonate (ISO)

miconazole (EXP)

N-methyl-4-phenylpyridinium (ISO)

nefazodone (EXP)

nickel atom (ISO)

niclosamide (ISO)

nitroglycerin (EXP)

obeticholic acid (ISO)

ozone (EXP)

paracetamol (ISO)

paraquat (ISO)

phenobarbital (ISO)

phorbol 13-acetate 12-myristate (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

resveratrol (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

streptozocin (ISO)

sulindac (EXP)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP,ISO)

tetrahydropalmatine (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (ISO)

tunicamycin (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic mitochondrial changes (ISO)

negative regulation of Ras protein signal transduction (IDA)

positive regulation of microtubule binding (IMP)

proteasome-mediated ubiquitin-dependent protein catabolic process (ISO)

protein dephosphorylation (IDA)

regulation of gene expression (ISO)

response to antibiotic (ISO)

response to endoplasmic reticulum stress (ISO)

response to hydrogen peroxide (ISO)

response to lead ion (IDA)

Cellular Component

chromosome, centromeric region (IEA)

cytoplasm (ISO)

nucleus (IEA)

protein phosphatase type 2A complex (ISO)

spindle pole (IEA)

Molecular Function

metal ion binding (IEA)

phosphoprotein phosphatase activity (IDA)

protein binding (ISO)

protein C-terminus binding (IPI)

protein heterodimerization activity (ISS)

protein serine phosphatase activity (IEA)

protein serine/threonine phosphatase activity (IDA,IMP)

protein threonine phosphatase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

Chagas disease pathway (IEA)

dopamine signaling pathway (ISO)

hepatitis C pathway (IEA)

long term depression (IEA)

mRNA decay pathway (IEA)

phosphatidylinositol 3-kinase-Akt signaling pathway (ISO)

transforming growth factor-beta Smad dependent signaling pathway (ISO)

transforming growth factor-beta superfamily mediated signaling pathway (IEA)

Wnt signaling pathway (IEA)

References

References - curated


1.	Gong CX, etal., Brain Res. 2000 Jan 24;853(2):299-309.
2.	Hall DD, etal., Biochemistry. 2006 Mar 14;45(10):3448-59.
3.	Kitagawa Y, etal., Biochem Biophys Res Commun 1988 Dec 15;157(2):821-7.
4.	MGD data from the GO Consortium
5.	Nanahoshi M, etal., Biochem Biophys Res Commun. 1998 Oct 20;251(2):520-6.
6.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	Pipeline to import KEGG annotations from KEGG into RGD
8.	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9.	Rahman A, etal., Neurotoxicology. 2012 Jun;33(3):370-83. doi: 10.1016/j.neuro.2012.02.014. Epub 2012 Mar 1.
10.	RGD automated data pipeline
11.	RGD automated import pipeline for gene-chemical interactions
12.	Sasaki K, etal., Biochem Biophys Res Commun 1990 Jul 16;170(1):169-75.
13.	Seshacharyulu P, etal., Cancer Lett. 2013 Jul 10;335(1):9-18. doi: 10.1016/j.canlet.2013.02.036. Epub 2013 Feb 20.
14.	Ugi S, etal., Mol Cell Biol 2002 Apr;22(7):2375-87.
15.	Yger M and Girault JA, Front Behav Neurosci. 2011 Sep 8;5:56. doi: 10.3389/fnbeh.2011.00056. eCollection 2011.

Additional References at PubMed

PMID:2174876	PMID:2554256	PMID:10781942	PMID:12477932	PMID:12716901	PMID:15375154	PMID:15489334	PMID:16717086	PMID:16875859	PMID:17085438	PMID:17906371	PMID:18245083
PMID:22871113	PMID:23349830	PMID:23376485	PMID:30361391

Genomics

Comparative Map Data

Ppp2cb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	58,558,119 - 58,579,325 (-)	NCBI
Rnor_6.0 Ensembl	16	62,273,276 - 62,294,769 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	16	62,273,276 - 62,294,767 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	16	61,933,984 - 61,955,475 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	62,330,513 - 62,351,968 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	16	62,330,587 - 62,352,043 (-)	NCBI
Celera	16	56,594,208 - 56,615,135 (-)	NCBI		Celera
Cytogenetic Map	16	q12.3	NCBI

PPP2CB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	8	30,774,457 - 30,814,314 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	8	30,785,616 - 30,812,818 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	8	30,643,132 - 30,670,334 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	30,762,668 - 30,789,894 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	8	30,762,668 - 30,789,894	NCBI
Celera	8	29,603,219 - 29,630,439 (-)	NCBI
Cytogenetic Map	8	p12	NCBI
HuRef	8	29,189,574 - 29,216,794 (-)	NCBI		HuRef
CHM1_1	8	30,844,570 - 30,871,782 (-)	NCBI		CHM1_1

Ppp2cb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	34,089,649 - 34,109,832 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	8	34,089,653 - 34,109,469 (+)	Ensembl
GRCm38	8	33,599,621 - 33,619,804 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	33,599,625 - 33,619,441 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	34,710,093 - 34,730,276 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	8	35,065,560 - 35,085,738 (+)	NCBI			mm8
Celera	8	36,244,600 - 36,253,763 (+)	NCBI		Celera
Cytogenetic Map	8	A4	NCBI
cM Map	8	20.63	NCBI

Ppp2cb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955463	7,226,912 - 7,249,490 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955463	7,229,717 - 7,249,490 (-)	NCBI	ChiLan1.0	ChiLan1.0

PPP2CB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	8	27,288,250 - 27,302,606 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	27,288,263 - 27,302,606 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	8	30,099,605 - 30,126,917 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

PPP2CB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	16	33,532,958 - 33,566,640 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	16	33,532,703 - 33,567,011 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Ppp2cb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936792	622,105 - 633,800 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PPP2CB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	54,294,995 - 54,325,213 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	54,295,786 - 54,325,220 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	61,676,897 - 61,697,557 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PPP2CB
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	28,903,074 - 28,930,300 (-)	NCBI
ChlSab1.1 Ensembl	8	28,903,240 - 28,930,376 (-)	Ensembl

Ppp2cb
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624780	13,332,636 - 13,369,301 (+)	NCBI

Position Markers

RH127900

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	16	62,273,301 - 62,273,507	NCBI	Rnor6.0
Rnor_5.0	16	61,934,009 - 61,934,215	UniSTS	Rnor5.0
RGSC_v3.4	16	62,330,538 - 62,330,744	UniSTS	RGSC3.4
Celera	16	56,594,233 - 56,594,439	UniSTS
RH 3.4 Map	16	542.31	UniSTS
Cytogenetic Map	16	q12.3	UniSTS

BF397059

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	16	62,285,126 - 62,285,300	NCBI	Rnor6.0
Rnor_5.0	16	61,945,834 - 61,946,008	UniSTS	Rnor5.0
RGSC_v3.4	16	62,342,363 - 62,342,537	UniSTS	RGSC3.4
Celera	16	56,606,056 - 56,606,230	UniSTS
RH 3.4 Map	16	542.9	UniSTS
Cytogenetic Map	16	q12.3	UniSTS

UniSTS:235869

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	16	62,273,559 - 62,273,744	NCBI	Rnor6.0
Rnor_5.0	16	61,934,267 - 61,934,452	UniSTS	Rnor5.0
RGSC_v3.4	16	62,330,796 - 62,330,981	UniSTS	RGSC3.4
Celera	16	56,594,491 - 56,594,676	UniSTS
Cytogenetic Map	16	q12.3	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	16	1090054	86162972	Rat
2312660	Bw95	Body weight QTL 95		0.05	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	16	1550187	63210301	Rat
2312663	Slep9	Serum leptin concentration QTL 9		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	1550187	63210301	Rat
2312666	Insul16	Insulin level QTL 16		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	16	1550187	63210301	Rat
2312669	Stl23	Serum triglyceride level QTL 23		0.01	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	16	1550187	63210301	Rat
737826	Alc11	Alcohol consumption QTL 11	3.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	5013802	64012784	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	19398187	70590230	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor depth of invasion (CMO:0001888)	16	19398187	70590230	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	19398187	70590230	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor depth of invasion (CMO:0001888)	16	19398187	70590230	Rat
70215	Niddm29	Non-insulin dependent diabetes mellitus QTL 29	3.54		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	16	20755556	80316424	Rat
2302057	Pia29	Pristane induced arthritis QTL 29	3.6	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)	16	24846541	69846541	Rat
8694453	Bw172	Body weight QTL 172	8.33	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	16	27519980	72519980	Rat
6903294	Stl30	Serum triglyceride level QTL 30	2.6	0.0013	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	16	28340315	73340315	Rat
1298529	Arunc1	Aerobic running capacity QTL 1	4		exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	16	35307110	63909364	Rat
1578768	Stresp22	Stress response QTL 22	2.8		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	16	39000021	84000021	Rat
2300163	Bmd64	Bone mineral density QTL 64	5.3	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	16	41512710	86512710	Rat
2293690	Bss45	Bone structure and strength QTL 45	5.13	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	16	41512710	86512710	Rat
7205510	Activ5	Activity QTL 5	3.78	0.00028	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	46558188	90668790	Rat
7411648	Foco22	Food consumption QTL 22	15	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	57816357	90668790	Rat
8694429	Bw164	Body weight QTL 164	5	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	16	57816357	90668790	Rat
8694364	Abfw7	Abdominal fat weight QTL 7	12.22	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	16	57816357	90668790	Rat
631525	Pia14	Pristane induced arthritis QTL 14	4.4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	16	59285775	89248943	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	99
Count of miRNA genes:	76
Interacting mature miRNAs:	92
Transcripts:	ENSRNOT00000020663
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_017040	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY749432	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC085926	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473970	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ225122	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ229111	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ231171	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000283	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M23591	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M58439	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X14087	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000020663 ⟹ ENSRNOP00000020663

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	16	62,273,276 - 62,294,769 (-)	Ensembl

RefSeq Acc Id:

NM_017040 ⟹ NP_058736

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	58,558,119 - 58,579,325 (-)	NCBI
Rnor_6.0	16	62,273,276 - 62,294,767 (-)	NCBI
Rnor_5.0	16	61,933,984 - 61,955,475 (-)	NCBI
RGSC_v3.4	16	62,330,513 - 62,351,968 (-)	RGD
Celera	16	56,594,208 - 56,615,135 (-)	RGD

Sequence:

show sequence

GGCACGAGCGCCGAGAGAACCGCGGCCAGAGCGCGGAGAGGCCTGCGGGCGGCGACGGCAGCGG
GAGGGCGGGCGCCGTCGGGCCGGAGCCTCCCCCGAGCCGCGCCGCGCTCTGGCTCCGAGCCGTG
AGCCCTTTTTGCCGCGCCCCGAGCGCGTGGCCGGGGGCCGGGCGGGGCGGGCGCTCCCGGAGGC
CGGGGCCGGCGGCTGCCCGCTGGGCTTGGGCGGGGCGCGGGCTGCCCGCTCCGCGGCTCGGTGG
TCCCGCCGGGGGCCGGCGGCGGGGGAGGCGGCGGGGACGCGCGGCTCGCCGCCATGGACGACAA
GGCGTTCACCAAGGAGCTGGACCAGTGGGTGGAGCAGCTGAACGAGTGTAAGCAGCTGAACGAG
AACCAAGTGCGGACGCTGTGCGAGAAGGCTAAGGAAATTTTAACAAAAGAATCAAATGTACAAG
AGGTTCGCTGTCCTGTTACCGTCTGTGGAGATGTGCATGGCCAATTCCATGACCTTATGGAACT
CTTCAGAATTGGTGGAAAATCACCAGACACCAACTATCTATTCATGGGTGACTATGTAGACAGA
GGATATTATTCTGTGGAGACCGTGACTCTTCTTGTAGCATTAAAGGTGCGCTATCCAGAGCGTA
TCACAATATTGCGAGGAAATCATGAAAGCCGGCAGATCACACAAGTATATGGCTTTTATGATGA
ATGCCTACGAAAGTATGGGAACGCCAACGTGTGGAAATACTTTACAGATCTCTTTGATTATCTT
CCACTTACAGCTTTAGTAGATGGACAGATATTCTGCCTCCACGGTGGCCTCTCTCCATCCATAG
ATACACTGGATCACATAAGAGCCCTGGATCGCTTACAGGAAGTTCCACATGAGGGCCCAATGTG
TGATCTCTTATGGTCAGATCCAGATGACCGTGGTGGCTGGGGCATTTCTCCACGTGGTGCTGGC
TACACATTTGGACAAGACATTTCTGAAACATTTAACCATGCCAACGGCCTCACACTGGTGTCCC
GTGCTCACCAGCTTGTAATGGAAGGATATAATTGGTGCCATGATCGGAATGTGGTCACCATTTT
TAGTGCACCCAATTACTGCTACCGCTGTGGGAACCAGGCTGCTATCATGGAATTAGACGACACT
TTAAAATACTCTTTTCTTCAGTTTGACCCAGCACCTCGTCGTGGAGAGCCTCATGTGACCCGGC
GCACCCCAGACTACTTCCTATAAATTCCTCCCCAGGACCTGTCTTTGTATGTTGAAGTATACCT
GGCTTTTTAAAAAATATATATACATATATATATTTAAAAACAACAGTTATCTGTGTGTCTCTGT
AACAAATTGTGCTATGTCTTGACGTTAAAACACATCATGGACCAAAACGTGCCATACTAATGGT
GAGCCATCAGCACGGTGTGAACTTGAGTCCACTGTCCTAGCCGAGTCAACCAGGCAGCCGCCTG
CCCGCCTGCCTGCTGTAGTAGCCGTCCTTCGTGACTGGTTAAGGGAAAGGGTCACTGGTGGCTT
CATCTCCTTTGCGCTTACTTGGAAATTTAGTTACAAGTTTAACTGGCATGGATTATAGAGTTGG
AGTTTTATTTTTAAGAATTGACAAGCTGACTTCCACTTAAATTCATAACCCTTTATTTTGTTGA
AATGTATGACTAACTGAAGAAGAGATTCTTGGAGTATGTTGTCATAACACTAAGATTTCCTTTC
AAGTTTCCTGAACTGAATTACTGTTGGATGTTGACCTGCACATTCTGTATATTTGTCCTGACAG
TGTTGCATCCTCCTTGCTGTACTGAACAAATAAACTTCCCAATTTAGAGAG

hide sequence

Protein Sequences


Protein RefSeqs	NP_058736	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41912	(Get FASTA)	NCBI Sequence Viewer
	AAA41913	(Get FASTA)	NCBI Sequence Viewer
	AAH85926	(Get FASTA)	NCBI Sequence Viewer
	AAV91199	(Get FASTA)	NCBI Sequence Viewer
	CAA32249	(Get FASTA)	NCBI Sequence Viewer
	EDM09140	(Get FASTA)	NCBI Sequence Viewer
	P62716	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_058736 ⟸ NM_017040

- UniProtKB:

P62716 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MDDKAFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHD
LMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYG
FYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHE
GPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNV
VTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL

hide sequence

RefSeq Acc Id:

ENSRNOP00000020663 ⟸ ENSRNOT00000020663

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3381	AgrOrtholog
Ensembl Genes	ENSRNOG00000015182	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000020663	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000020663	ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH	3.60.21.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7109733	IMAGE-MGC_LOAD
InterPro	Calcineurin-like_PHP_ApaH	UniProtKB/Swiss-Prot
	Metallo-depent_PP-like	UniProtKB/Swiss-Prot
	Ser/Thr-sp_prot-phosphatase	UniProtKB/Swiss-Prot
KEGG Report	rno:24673	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94855	IMAGE-MGC_LOAD
NCBI Gene	24673	ENTREZGENE
Pfam	Metallophos	UniProtKB/Swiss-Prot
PhenoGen	Ppp2cb	PhenoGen
PRINTS	STPHPHTASE	UniProtKB/Swiss-Prot
PROSITE	SER_THR_PHOSPHATASE	UniProtKB/Swiss-Prot
SMART	PP2Ac	UniProtKB/Swiss-Prot
UniProt	P62716	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	P11082	UniProtKB/Swiss-Prot
	Q6LDK0	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-17	Ppp2cb	protein phosphatase 2 catalytic subunit beta	Ppp2cb	protein phosphatase 2, catalytic subunit, beta isozyme	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-06-26	Ppp2cb	protein phosphatase 2, catalytic subunit, beta isozyme	Ppp2cb	protein phosphatase 2, catalytic subunit, beta isoform	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-04-23	Ppp2cb	protein phosphatase 2, catalytic subunit, beta isoform	Ppp2cb	protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Ppp2cb	protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform		protein phosphatase 2a, catalytic subunit, beta isoform	Name updated	1299863	APPROVED
2002-06-10	Ppp2cb	Protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_physical_interaction	forms complex with Shc by interacting with Shc PTB domain	729591

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)