Ppp2cb (protein phosphatase 2 catalytic subunit beta) - Rat Genome Database

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Gene: Ppp2cb (protein phosphatase 2 catalytic subunit beta) Rattus norvegicus
Analyze
Symbol: Ppp2cb
Name: protein phosphatase 2 catalytic subunit beta
RGD ID: 3381
Description: Enables protein serine/threonine phosphatase activity and transmembrane transporter binding activity. Involved in negative regulation of Ras protein signal transduction and response to lead ion. Predicted to be located in cytoplasm. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol. Orthologous to human PPP2CB (protein phosphatase 2 catalytic subunit beta); PARTICIPATES IN dopamine signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC94855; PP2A-beta; Pp2a2; Protein phosphatase 2 (formerly 2A) catalytic subunit beta isoform; protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform; protein phosphatase 2, catalytic subunit, beta isoform; protein phosphatase 2, catalytic subunit, beta isozyme; protein phosphatase 2A catalytic alpha subunit; protein phosphatase 2a, catalytic subunit, beta isoform; protein phosphatase-2A-beta; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21658,558,119 - 58,579,325 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1658,558,122 - 58,579,576 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1663,895,707 - 63,916,635 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01667,309,372 - 67,330,300 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01662,529,938 - 62,550,866 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01662,273,276 - 62,294,767 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1662,273,276 - 62,294,769 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01661,933,984 - 61,955,475 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41662,330,513 - 62,351,968 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11662,330,587 - 62,352,043 (-)NCBI
Celera1656,594,208 - 56,615,135 (-)NCBICelera
Cytogenetic Map16q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
acrylamide  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bufalin  (ISO)
cadmium dichloride  (EXP)
chlorpyrifos  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
Echimidine  (ISO)
enniatin  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
gentamycin  (EXP)
haloperidol  (EXP)
hydrogen peroxide  (ISO)
ionomycin  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
Lasiocarpine  (ISO)
lead(0)  (ISO)
menadione  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
miconazole  (EXP)
monocrotaline  (ISO)
Morroniside  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
niclosamide  (ISO)
nitroglycerin  (EXP)
obeticholic acid  (ISO)
okadaic acid  (ISO)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
riddelliine  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulindac  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetrahydropalmatine  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
tunicamycin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain. Gong CX, etal., Brain Res. 2000 Jan 24;853(2):299-309.
3. Binding of protein phosphatase 2A to the L-type calcium channel Cav1.2 next to Ser1928, its main PKA site, is critical for Ser1928 dephosphorylation. Hall DD, etal., Biochemistry. 2006 Mar 14;45(10):3448-59.
4. Molecular cloning of rat phosphoprotein phosphatase 2A beta cDNA and increased expressions of phosphatase 2A alpha and 2A beta in rat liver tumors. Kitagawa Y, etal., Biochem Biophys Res Commun 1988 Dec 15;157(2):821-7.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Regulation of protein phosphatase 2A catalytic activity by alpha4 protein and its yeast homolog Tap42. Nanahoshi M, etal., Biochem Biophys Res Commun. 1998 Oct 20;251(2):520-6.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats. Rahman A, etal., Neurotoxicology. 2012 Jun;33(3):370-83. doi: 10.1016/j.neuro.2012.02.014. Epub 2012 Mar 1.
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Production of shorter mRNA for protein phosphatase 2A beta by alternative poly(A) addition. Sasaki K, etal., Biochem Biophys Res Commun 1990 Jul 16;170(1):169-75.
14. Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer. Seshacharyulu P, etal., Cancer Lett. 2013 Jul 10;335(1):9-18. doi: 10.1016/j.canlet.2013.02.036. Epub 2013 Feb 20.
15. Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling. Ugi S, etal., Mol Cell Biol 2002 Apr;22(7):2375-87.
16. DARPP-32, Jack of All Trades... Master of Which? Yger M and Girault JA, Front Behav Neurosci. 2011 Sep 8;5:56. doi: 10.3389/fnbeh.2011.00056. eCollection 2011.
Additional References at PubMed
PMID:2174876   PMID:2554256   PMID:10781942   PMID:12477932   PMID:12716901   PMID:15375154   PMID:15489334   PMID:16717086   PMID:16875859   PMID:17085438   PMID:17906371   PMID:18245083  
PMID:22871113   PMID:23349830   PMID:23376485   PMID:30361391  


Genomics

Comparative Map Data
Ppp2cb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21658,558,119 - 58,579,325 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1658,558,122 - 58,579,576 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1663,895,707 - 63,916,635 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01667,309,372 - 67,330,300 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01662,529,938 - 62,550,866 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01662,273,276 - 62,294,767 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1662,273,276 - 62,294,769 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01661,933,984 - 61,955,475 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41662,330,513 - 62,351,968 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11662,330,587 - 62,352,043 (-)NCBI
Celera1656,594,208 - 56,615,135 (-)NCBICelera
Cytogenetic Map16q12.3NCBI
PPP2CB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38830,785,616 - 30,812,818 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl830,774,457 - 30,814,314 (-)EnsemblGRCh38hg38GRCh38
GRCh37830,643,132 - 30,670,334 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36830,762,668 - 30,789,894 (-)NCBINCBI36Build 36hg18NCBI36
Build 34830,762,668 - 30,789,894NCBI
Celera829,603,219 - 29,630,439 (-)NCBICelera
Cytogenetic Map8p12NCBI
HuRef829,189,574 - 29,216,794 (-)NCBIHuRef
CHM1_1830,844,570 - 30,871,782 (-)NCBICHM1_1
T2T-CHM13v2.0831,066,636 - 31,093,832 (-)NCBIT2T-CHM13v2.0
Ppp2cb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39834,089,649 - 34,109,832 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl834,089,653 - 34,109,469 (+)EnsemblGRCm39 Ensembl
GRCm38833,599,621 - 33,619,804 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl833,599,625 - 33,619,441 (+)EnsemblGRCm38mm10GRCm38
MGSCv37834,710,093 - 34,730,276 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36835,065,560 - 35,085,738 (+)NCBIMGSCv36mm8
Celera836,244,600 - 36,253,763 (+)NCBICelera
Cytogenetic Map8A4NCBI
cM Map820.63NCBI
Ppp2cb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554637,226,912 - 7,249,490 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554637,229,717 - 7,249,490 (-)NCBIChiLan1.0ChiLan1.0
PPP2CB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1825,074,866 - 25,102,081 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0830,099,605 - 30,126,917 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1827,288,250 - 27,302,606 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl827,288,263 - 27,302,606 (-)Ensemblpanpan1.1panPan2
PPP2CB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11633,532,703 - 33,567,011 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1633,532,958 - 33,566,640 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1633,992,179 - 34,026,212 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01635,558,843 - 35,592,945 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1635,558,838 - 35,592,943 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11633,657,510 - 33,691,593 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01634,231,924 - 34,265,951 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01634,350,519 - 34,384,589 (+)NCBIUU_Cfam_GSD_1.0
Ppp2cb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494356,729,981 - 56,742,299 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936792622,105 - 633,800 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP2CB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1554,296,113 - 54,325,213 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11554,295,786 - 54,325,220 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21561,676,897 - 61,697,557 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP2CB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1828,903,074 - 28,930,300 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl828,903,240 - 28,930,376 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605213,168,625 - 13,195,901 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp2cb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478013,332,636 - 13,369,301 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppp2cb
154 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:99
Count of miRNA genes:76
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000020663
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat

Markers in Region
RH127900  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21658,558,146 - 58,558,353 (+)MAPPERmRatBN7.2
Rnor_6.01662,273,301 - 62,273,507NCBIRnor6.0
Rnor_5.01661,934,009 - 61,934,215UniSTSRnor5.0
RGSC_v3.41662,330,538 - 62,330,744UniSTSRGSC3.4
Celera1656,594,233 - 56,594,439UniSTS
RH 3.4 Map16542.31UniSTS
Cytogenetic Map16q12.3UniSTS
BF397059  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21658,569,971 - 58,570,146 (+)MAPPERmRatBN7.2
Rnor_6.01662,285,126 - 62,285,300NCBIRnor6.0
Rnor_5.01661,945,834 - 61,946,008UniSTSRnor5.0
RGSC_v3.41662,342,363 - 62,342,537UniSTSRGSC3.4
Celera1656,606,056 - 56,606,230UniSTS
RH 3.4 Map16542.9UniSTS
Cytogenetic Map16q12.3UniSTS
UniSTS:235869  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21658,558,404 - 58,558,590 (+)MAPPERmRatBN7.2
Rnor_6.01662,273,559 - 62,273,744NCBIRnor6.0
Rnor_5.01661,934,267 - 61,934,452UniSTSRnor5.0
RGSC_v3.41662,330,796 - 62,330,981UniSTSRGSC3.4
Celera1656,594,491 - 56,594,676UniSTS
Cytogenetic Map16q12.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000020663   ⟹   ENSRNOP00000020663
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1658,558,122 - 58,579,576 (-)Ensembl
Rnor_6.0 Ensembl1662,273,276 - 62,294,769 (-)Ensembl
RefSeq Acc Id: NM_017040   ⟹   NP_058736
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21658,558,119 - 58,579,325 (-)NCBI
Rnor_6.01662,273,276 - 62,294,767 (-)NCBI
Rnor_5.01661,933,984 - 61,955,475 (-)NCBI
RGSC_v3.41662,330,513 - 62,351,968 (-)RGD
Celera1656,594,208 - 56,615,135 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_058736   ⟸   NM_017040
- UniProtKB: Q6LDK0 (UniProtKB/Swiss-Prot),   P62716 (UniProtKB/Swiss-Prot),   A0A8I5ZZ39 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020663   ⟸   ENSRNOT00000020663
Protein Domains
Serine/threonine specific protein phosphatases

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62716-F1-model_v2 AlphaFold P62716 1-309 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3381 AgrOrtholog
BioCyc Gene G2FUF-11118 BioCyc
Ensembl Genes ENSRNOG00000005389 UniProtKB/TrEMBL
  ENSRNOG00000015182 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020663 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000101942.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.21.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7109733 IMAGE-MGC_LOAD
InterPro Calcineurin-like_PHP_ApaH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metallo-depent_PP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPA2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr-sp_prot-phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24673 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94855 IMAGE-MGC_LOAD
NCBI Gene 24673 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Metallophos UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppp2cb PhenoGen
PRINTS STPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SER_THR_PHOSPHATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005389 RatGTEx
  ENSRNOG00000015182 RatGTEx
SMART PP2Ac UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Metallo-dependent phosphatases UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A0A8I5ZZ39 ENTREZGENE, UniProtKB/TrEMBL
  A6IVT2_RAT UniProtKB/TrEMBL
  P62716 ENTREZGENE, UniProtKB/Swiss-Prot
  Q6LDK0 ENTREZGENE
UniProt Secondary P11082 UniProtKB/Swiss-Prot
  Q6LDK0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Ppp2cb  protein phosphatase 2 catalytic subunit beta  Ppp2cb  protein phosphatase 2, catalytic subunit, beta isozyme  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-06-26 Ppp2cb  protein phosphatase 2, catalytic subunit, beta isozyme  Ppp2cb  protein phosphatase 2, catalytic subunit, beta isoform  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-23 Ppp2cb  protein phosphatase 2, catalytic subunit, beta isoform  Ppp2cb  protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Ppp2cb  protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform    protein phosphatase 2a, catalytic subunit, beta isoform  Name updated 1299863 APPROVED
2002-06-10 Ppp2cb  Protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction forms complex with Shc by interacting with Shc PTB domain 729591