RGD Reference Report - A new promoter for alpha(1C) subunit of human L-type cardiac calcium channel Ca(V)1.2. - Rat Genome Database

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A new promoter for alpha(1C) subunit of human L-type cardiac calcium channel Ca(V)1.2.

Authors: Dai, B  Saada, N  Echetebu, C  Dettbarn, C  Palade, P 
Citation: Dai B, etal., Biochem Biophys Res Commun 2002 Aug 16;296(2):429.
RGD ID: 625537
Pubmed: PMID:12163037   (View Abstract at PubMed)

The cardiac Ca channel known as alpha(1C) or Ca(V)1.2 is shown to express a new longer first exon equivalent to that formerly reported in rabbit heart or rat aorta. Ribonuclease protection assay indicates that this exon is found in the majority of Ca(V)1.2 transcripts in human heart RNA. The presence of this exon also suggests that expression of this transcript is driven by a promoter immediately upstream of this exon and its 5(') untranslated region. The putative promoter exhibits 69% homology to its rat counterpart and displays functional promoter activity when transfected into heart cells in culture in luciferase-expressing constructs.

Objects referenced in this article
Gene Cacna1c calcium voltage-gated channel subunit alpha1 C Rattus norvegicus

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