RGD Reference Report - A genomic-systems biology map for cardiovascular function. - Rat Genome Database

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A genomic-systems biology map for cardiovascular function.

Authors: Stoll, M  Cowley AW, JR  Tonellato, PJ  Greene, AS  Kaldunski, ML  Roman, RJ  Dumas, P  Schork, NJ  Wang, Z  Jacob, HJ 
Citation: Stoll M, etal., Science 2001 Nov 23;294(5547):1723-6.
RGD ID: 70849
Pubmed: PMID:11721057   (View Abstract at PubMed)
DOI: DOI:10.1126/science.1062117   (Journal Full-text)

With the draft sequence of the human genome available, there is a need to better define gene function in the context of systems biology. We studied 239 cardiovascular and renal phenotypes in 113 male rats derived from an F2 intercross and mapped 81 of these traits onto the genome. Aggregates of traits were identified on chromosomes 1, 2, 7, and 18. Systems biology was assessed by examining patterns of correlations ("physiological profiles") that can be used for gene hunting, mechanism-based physiological studies, and, with comparative genomics, translating these data to the human genome.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Cm29RatCardiomegaly  IAGP  RGD 
Cm30RatCardiomegaly  IAGP  RGD 
Cm31RatCardiomegaly  IAGP  RGD 
Hrtrt13Ratcardiovascular system disease  IAGP  RGD 
Hrtrt14Ratcardiovascular system disease  IAGP  RGD 
Hrtrt15Ratcardiovascular system disease  IAGP  RGD 
Scl26Ratfamilial hyperlipidemia  IAGP  RGD 
Scl27Ratfamilial hyperlipidemia  IAGP  RGD 
Bp210Ratheart disease  IAGP  RGD 
Bw26Ratheart disease  IAGP  RGD 
Hrtrt11Ratheart disease  IAGP  RGD 
Hrtrt12Ratheart disease  IAGP  RGD 
Hrtrt16Ratheart disease  IAGP  RGD 
Wbc2Ratheart disease  IAGP  RGD 
Scl25RatHypercholesterolemia  IAGP  RGD 
Scl28RatHypercholesterolemia  IAGP  RGD 
Bp199Rathypertension  IAGP  RGD 
Bp200Rathypertension  IAGP  RGD 
Bp201Rathypertension  IAGP  RGD 
Bp202Rathypertension  IAGP  RGD 
Bp203Rathypertension  IAGP  RGD 
Bp204Rathypertension  IAGP  RGD 
Bp205Rathypertension  IAGP  RGD 
Bp206Rathypertension  IAGP  RGD 
Bp207Rathypertension  IAGP  RGD 
Bp208Rathypertension  IAGP  RGD 
Bp209Rathypertension  IAGP  RGD 
Bp210Rathypertension  IAGP  RGD 
Bp211Rathypertension  IAGP  RGD 
Bp212Rathypertension  IAGP  RGD 
Bp213Rathypertension  IAGP  RGD 
Bp214Rathypertension  IAGP  RGD 
Bp215Rathypertension  IAGP  RGD 
Bp216Rathypertension  IAGP  RGD 
Bp217Rathypertension  IAGP  RGD 
Bp218Rathypertension  IAGP  RGD 
Bp219Rathypertension  IAGP  RGD 
Bp220Rathypertension  IAGP  RGD 
Bp221Rathypertension  IAGP  RGD 
Bp222Rathypertension  IAGP  RGD 
Bp223Rathypertension  IAGP  RGD 
Bp224Rathypertension  IAGP  RGD 
Bp225Rathypertension  IAGP  RGD 
Bp226Rathypertension  IAGP  RGD 
Bp227Rathypertension  IAGP  RGD 
Bp228Rathypertension  IAGP  RGD 
Bp229Rathypertension  IAGP  RGD 
Bp230Rathypertension  IAGP  RGD 
Bp231Rathypertension  IAGP  RGD 
Bp232Rathypertension  IAGP  RGD 
Bp233Rathypertension  IAGP  RGD 
Bp234Rathypertension  IAGP  RGD 
Bp235Rathypertension  IAGP  RGD 
Bp236Rathypertension  IAGP  RGD 
Bp237Rathypertension  IAGP  RGD 
Bp238Rathypertension  IAGP  RGD 
Bw26Rathypertension  IAGP  RGD 
Cm31Rathypertension  IAGP  RGD 
Hrtrt13Rathypertension  IAGP  RGD 
Hrtrt14Rathypertension  IAGP  RGD 
Hrtrt15Rathypertension  IAGP  RGD 
Kidm11Rathypertension  IAGP  RGD 
Rf30Rathypertension  IAGP  RGD 
Rf31Rathypertension  IAGP  RGD 
Rf32Rathypertension  IAGP  RGD 
Rf33Rathypertension  IAGP  RGD 
Rf35Rathypertension  IAGP  RGD 
Rf36Rathypertension  IAGP  RGD 
Rf38Rathypertension  IAGP  RGD 
Rf41Rathypertension  IAGP  RGD 
Rf45Rathypertension  IAGP  RGD 
Srn5Rathypertension  IAGP  RGD 
Wbc2RatInflammation  IAGP  RGD 
Bp208Ratkidney disease  IAGP  RGD 
Kidm10Ratkidney disease  IAGP  RGD 
Kidm9Ratkidney disease  IAGP  RGD 
Rf27Ratkidney disease  IAGP  RGD 
Rf28Ratkidney disease  IAGP  RGD 
Rf29Ratkidney disease  IAGP  RGD 
Rf34Ratkidney disease  IAGP  RGD 
Rf39Ratkidney disease  IAGP  RGD 
Rf40Ratkidney disease  IAGP  RGD 
Rf42Ratkidney disease  IAGP  RGD 
Rf43Ratkidney disease  IAGP  RGD 
Srn4Ratkidney disease  IAGP  RGD 
Bw24Ratobesity  IDA  RGD 
Bw25Ratobesity  IDA  RGD 
Bw26Ratobesity  IAGP  RGD 
Bw27Ratobesity  IAGP  RGD 
Cm30Ratobesity  IAGP  RGD 
Bp217Ratproteinuria  IAGP  RGD 
Rf44Ratproteinuria  IAGP  RGD 
Rf27Ratrenal hypertension  IAGP  RGD 
Rf40Ratrenal hypertension  IAGP  RGD 
Rf42Ratrenal hypertension  IAGP  RGD 
Rf43Ratrenal hypertension  IAGP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Srn5Ratabnormal circulating renin level  IAGP  RGD 
Rf36Ratabnormal renal plasma flow rate  IAGP  RGD 
Rf41Ratabnormal renal plasma flow rate  IAGP  RGD 
Rf45Ratabnormal renal plasma flow rate  IAGP  RGD 
Rf32Ratabnormal renal vascular resistance  IAGP  RGD 
Rf33Ratabnormal renal vascular resistance  IAGP  RGD 
Rf37Ratabnormal renal vascular resistance  IAGP  RGD 
Rf38Ratabnormal renal vascular resistance  IAGP  RGD 
Rf37Ratabnormal urination pattern  IAGP  RGD 
Rf30Ratabnormal urine homeostasis  IDA  RGD 
Rf31Ratabnormal urine homeostasis  IDA  RGD 
Rf30Ratabnormal urine osmolality  IAGP  RGD 
Rf31Ratabnormal urine osmolality  IAGP  RGD 
Bp208Ratdecreased renal plasma flow rate  IAGP  RGD 
Rf34Ratdecreased renal plasma flow rate  IAGP  RGD 
Rf42Ratdecreased renal plasma flow rate  IAGP  RGD 
Kidm10Ratenlarged kidney  IAGP  RGD 
Kidm11Ratenlarged kidney  IAGP  RGD 
Kidm9Ratenlarged kidney  IAGP  RGD 
Bw26Ratheart left ventricle hypertrophy  IAGP  RGD 
Bw24Ratincreased body weight  IAGP  RGD 
Bw25Ratincreased body weight  IAGP  RGD 
Bw26Ratincreased body weight  IAGP  RGD 
Bw27Ratincreased body weight  IAGP  RGD 
Cm30Ratincreased body weight  IAGP  RGD 
Scl25Ratincreased circulating cholesterol level  IAGP  RGD 
Scl26Ratincreased circulating cholesterol level  IAGP  RGD 
Scl28Ratincreased circulating cholesterol level  IAGP  RGD 
Scl27Ratincreased circulating HDL cholesterol level  IAGP  RGD 
Srn4Ratincreased circulating renin level  IAGP  RGD 
Bp210Ratincreased heart rate  IAGP  RGD 
Hrtrt11Ratincreased heart rate  IAGP  RGD 
Hrtrt12Ratincreased heart rate  IAGP  RGD 
Hrtrt13Ratincreased heart rate  IAGP  RGD 
Hrtrt14Ratincreased heart rate  IAGP  RGD 
Hrtrt15Ratincreased heart rate  IAGP  RGD 
Hrtrt16Ratincreased heart rate  IAGP  RGD 
Hrtrt13Ratincreased heart rate variability  IAGP  RGD 
Hrtrt14Ratincreased heart rate variability  IAGP  RGD 
Hrtrt15Ratincreased heart rate variability  IAGP  RGD 
Cm29Ratincreased heart weight  IAGP  RGD 
Cm30Ratincreased heart weight  IAGP  RGD 
Cm31Ratincreased heart weight  IAGP  RGD 
Kidm11Ratincreased kidney weight  IAGP  RGD 
Wbc2Ratincreased leukocyte cell number  IAGP  RGD 
Rf40Ratincreased renal vascular resistance  IAGP  RGD 
Rf42Ratincreased renal vascular resistance  IAGP  RGD 
Rf43Ratincreased renal vascular resistance  IAGP  RGD 
Bp201Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp203Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp204Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp205Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp206Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp207Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp208Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp209Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp210Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp211Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp212Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp213Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp214Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp215Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp216Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp218Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp219Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp221Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp222Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp224Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp226Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp228Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp229Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp230Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp233Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp234Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp235Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp236Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp237Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp238Ratincreased systemic arterial blood pressure  IAGP  RGD 
Cm31Ratincreased systemic arterial blood pressure  IAGP  RGD 
Rf35Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp199Ratincreased systemic arterial diastolic blood pressure  IAGP  RGD 
Bp203Ratincreased systemic arterial diastolic blood pressure  IAGP  RGD 
Bp220Ratincreased systemic arterial diastolic blood pressure  IAGP  RGD 
Bp221Ratincreased systemic arterial diastolic blood pressure  IAGP  RGD 
Bp225Ratincreased systemic arterial diastolic blood pressure  IAGP  RGD 
Bp227Ratincreased systemic arterial diastolic blood pressure  IAGP  RGD 
Bp232Ratincreased systemic arterial diastolic blood pressure  IAGP  RGD 
Bw26Ratincreased systemic arterial diastolic blood pressure  IAGP  RGD 
Bp200Ratincreased systemic arterial systolic blood pressure  IAGP  RGD 
Bp202Ratincreased systemic arterial systolic blood pressure  IAGP  RGD 
Bp217Ratincreased systemic arterial systolic blood pressure  IAGP  RGD 
Bp223Ratincreased systemic arterial systolic blood pressure  IAGP  RGD 
Bp231Ratincreased systemic arterial systolic blood pressure  IAGP  RGD 
Rf28Ratincreased urine potassium level  IAGP  RGD 
Rf29Ratincreased urine potassium level  IAGP  RGD 
Bp217Ratincreased urine protein level  IDA  RGD 
Rf44Ratincreased urine protein level  IAGP  RGD 
Rf32Ratkidney failure  IAGP  RGD 
Rf33Ratkidney failure  IAGP  RGD 
Rf38Ratkidney failure  IAGP  RGD 
Rf39Ratpolyuria  IAGP  RGD 
Objects Annotated

QTLs
Bp199  (Blood pressure QTL 199)
Bp200  (Blood pressure QTL 200)
Bp201  (Blood pressure QTL 201)
Bp202  (Blood pressure QTL 202)
Bp203  (Blood pressure QTL 203)
Bp204  (Blood pressure QTL 204)
Bp205  (Blood pressure QTL 205)
Bp206  (Blood pressure QTL 206)
Bp207  (Blood pressure QTL 207)
Bp208  (Blood pressure QTL 208)
Bp209  (Blood pressure QTL 209)
Bp210  (Blood pressure QTL 210)
Bp211  (Blood pressure QTL 211)
Bp212  (Blood pressure QTL 212)
Bp213  (Blood pressure QTL 213)
Bp214  (Blood pressure QTL 214)
Bp215  (Blood pressure QTL 215)
Bp216  (Blood pressure QTL 216)
Bp217  (Blood pressure QTL 217)
Bp218  (Blood pressure QTL 218)
Bp219  (Blood pressure QTL 219)
Bp220  (Blood pressure QTL 220)
Bp221  (Blood pressure QTL 221)
Bp222  (Blood pressure QTL 222)
Bp223  (Blood pressure QTL 223)
Bp224  (Blood pressure QTL 224)
Bp225  (Blood pressure QTL 225)
Bp226  (Blood pressure QTL 226)
Bp227  (Blood pressure QTL 227)
Bp228  (Blood pressure QTL 228)
Bp229  (Blood pressure QTL 229)
Bp230  (Blood pressure QTL 230)
Bp231  (Blood pressure QTL 231)
Bp232  (Blood pressure QTL 232)
Bp233  (Blood pressure QTL 233)
Bp234  (Blood pressure QTL 234)
Bp235  (Blood pressure QTL 235)
Bp236  (Blood pressure QTL 236)
Bp237  (Blood pressure QTL 237)
Bp238  (Blood pressure QTL 238)
Bw24  (Body weight QTL 24)
Bw25  (Body weight QTL 25)
Bw26  (Body weight QTL 26)
Bw27  (Body weight QTL 27)
Cm29  (Cardiac mass QTL 29)
Cm30  (Cardiac mass QTL 30)
Cm31  (Cardiac mass QTL 31)
Hrtrt11  (Heart rate QTL 11)
Hrtrt12  (Heart rate QTL 12)
Hrtrt13  (Heart rate QTL 13)
Hrtrt14  (Heart rate QTL 14)
Hrtrt15  (Heart rate QTL 15)
Hrtrt16  (Heart rate QTL 16)
Kidm10  (Kidney mass QTL 10)
Kidm11  (Kidney mass QTL 11)
Kidm9  (Kidney mass QTL 9)
Rf27  (Renal function QTL 27)
Rf28  (Renal function QTL 28)
Rf29  (Renal function QTL 29)
Rf30  (Renal function QTL 30)
Rf31  (Renal function QTL 31)
Rf32  (Renal function QTL 32)
Rf33  (Renal function QTL 33)
Rf34  (Renal function QTL 34)
Rf35  (Renal function QTL 35)
Rf36  (Renal function QTL 36)
Rf37  (Renal function QTL 37)
Rf38  (Renal function QTL 38)
Rf39  (Renal function QTL 39)
Rf40  (Renal function QTL 40)
Rf41  (Renal function QTL 41)
Rf42  (Renal function QTL 42)
Rf43  (Renal function QTL 43)
Rf44  (Renal function QTL 44)
Rf45  (Renal function QTL 45)
Scl25  (Serum cholesterol level QTL 25)
Scl26  (Serum cholesterol level QTL 26)
Scl27  (Serum cholesterol level QTL 27)
Scl28  (Serum cholesterol level QTL 28)
Srn4  (Serum renin concentration QTL 4)
Srn5  (Serum renin concentration QTL 5)
Wbc2  (White blood cell count QTL 2)

Strains
BN/SsNHsd  (NA)
SS/JrHsdMcwi  (NA)

Objects referenced in this article
QTL Cardf1 Cardiac cell morphology QTL 1 Rattus norvegicus

Additional Information